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Conserved domains on  [gi|1002341807|ref|NP_001307564|]
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aquaporin-9 isoform 2 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-165 4.87e-43

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 143.73  E-value: 4.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580     1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002341807 101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQ 165
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTE 137
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-165 4.87e-43

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 143.73  E-value: 4.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580     1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002341807 101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQ 165
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTE 137
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 24-165 9.27e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 137.77  E-value: 9.27e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  24 KETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002341807 104 FYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGenatahIFATYPAPYLSLANAFADQ 165
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVE 136
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 1-152 6.77e-35

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 124.47  E-value: 6.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807   1 MQPEGAEKGK------SFKQRLVLKSSLaKETLSEFLGTFILIVLGCGCVAQAILSrGRFGGVITINVGFSMAVAMAIYV 74
Cdd:PTZ00016   23 MDEEVAEAQKrppggqNFWAPREYRPNV-REYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  75 AGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDgLMSFAGGKLLI--VGENATAHIFATYP 152
Cdd:PTZ00016  101 SAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYG-FFKDHGIPELPweTMANGFAGVFATYP 179
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 28-127 1.92e-28

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 105.46  E-value: 1.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  28 SEFLGTFILIVLGCGCVAQAILSRGR----FGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100
                  ....*....|....*....|....
gi 1002341807 104 FYVGAQFLGAFVGAATVFGIYYDG 127
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL 104
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 19-163 4.56e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 97.00  E-value: 4.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  19 KSSLAKETLSEFLGTFILIVLGCGCVA--QAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002341807  97 MKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMsfaggkllivgenatAHIFATYPAPYLSLANAFA 163
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQR---------------AGLFANTLAPGVNAGQAFV 135
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-165 4.87e-43

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 143.73  E-value: 4.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580     1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002341807 101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQ 165
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTE 137
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 24-165 9.27e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 137.77  E-value: 9.27e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  24 KETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002341807 104 FYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGenatahIFATYPAPYLSLANAFADQ 165
Cdd:cd00333    81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVE 136
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 1-152 6.77e-35

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 124.47  E-value: 6.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807   1 MQPEGAEKGK------SFKQRLVLKSSLaKETLSEFLGTFILIVLGCGCVAQAILSrGRFGGVITINVGFSMAVAMAIYV 74
Cdd:PTZ00016   23 MDEEVAEAQKrppggqNFWAPREYRPNV-REYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  75 AGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDgLMSFAGGKLLI--VGENATAHIFATYP 152
Cdd:PTZ00016  101 SAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYG-FFKDHGIPELPweTMANGFAGVFATYP 179
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 28-127 1.92e-28

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 105.46  E-value: 1.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  28 SEFLGTFILIVLGCGCVAQAILSRGR----FGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100
                  ....*....|....*....|....
gi 1002341807 104 FYVGAQFLGAFVGAATVFGIYYDG 127
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL 104
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 19-163 4.56e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 97.00  E-value: 4.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  19 KSSLAKETLSEFLGTFILIVLGCGCVA--QAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002341807  97 MKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMsfaggkllivgenatAHIFATYPAPYLSLANAFA 163
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQR---------------AGLFANTLAPGVNAGQAFV 135
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 22-120 7.62e-16

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 73.40  E-value: 7.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  22 LAKETLSEFLGTFILIVLGCGCVAQAILsrgrFGGVIT---INVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMK 98
Cdd:PLN00182   41 LTQKLIAEMIGTYFIIFSGCGVVVVNVL----YGGTITfpgICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFP 116

                          90       100
                  ....*....|....*....|..
gi 1002341807  99 WFKLPFYVGAQFLGAFVGAATV 120
Cdd:PLN00182  117 WYQVPLYIGAQLTGSLLASLTL 138
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 23-126 4.65e-15

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 71.43  E-value: 4.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  23 AKETLSEFLGTFILIVLGCGCVAQAILSRGRFGgVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKL 102
Cdd:PLN00183   45 ARMVLAEMVGTFILMFCVCGIIASTQLSGGEVG-LLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKV 123

                          90       100
                  ....*....|....*....|....*..
gi 1002341807 103 PFYVGAQFLGAFVG---AATVFGIYYD 126
Cdd:PLN00183  124 PLYITAQTVGSVLAtyvGVSVYGVKAD 150
PRK05420 PRK05420
aquaporin Z; Provisional
 22-123 3.99e-12

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 62.68  E-value: 3.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  22 LAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFK 101
Cdd:PRK05420    1 MFKKLAAEFFGTFWLVFGGCGSAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                          90       100
                  ....*....|....*....|..
gi 1002341807 102 LPFYVGAQFLGAFVGAATVFGI 123
Cdd:PRK05420   81 LVPYIIAQVVGGIAAAAVLYLI 102
PLN00184 PLN00184
aquaporin NIP1; Provisional
 24-126 2.58e-11

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 61.19  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  24 KETLSEFLGTFILIVLGCGCVAQAIlsrgRFGGVIT---INVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:PLN00184   55 QKLIAEVLGTYFLVFTGCASVVVNM----QNDNVVTlpgIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                          90       100
                  ....*....|....*....|....*....
gi 1002341807 101 KLPFYVGAQFLGAFVGAAT---VFGIYYD 126
Cdd:PLN00184  131 QVPAYVISQVIGSTLAAATlrlLFGLDHD 159
PLN00026 PLN00026
aquaporin NIP; Provisional
 21-125 1.77e-10

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 58.72  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  21 SLAKETLSEFLGTFILIVLGcgcVAQAILSRgRFGGVITInVGFS----MAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:PLN00026   69 SLTRKLGAEFVGTFILIFAA---TAGPIVNQ-KYDGAETL-IGNAacagLAVMIVILSTGHISGAHLNPSLTIAFAALRH 143

                          90       100
                  ....*....|....*....|....*....
gi 1002341807  97 MKWFKLPFYVGAQFLGAFVGAATVFGIYY 125
Cdd:PLN00026  144 FPWKHVPAYIAAQVSASICASFALKGVFH 172
PLN00167 PLN00167
aquaporin TIP5; Provisional
 27-113 8.94e-07

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 47.59  E-value: 8.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  27 LSEFLGTFILI--VLGCGCVAQAILSRGRFG--GVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKL 102
Cdd:PLN00167   26 LAEFISTFFFVfaAVGSAMSSRKLMPDAASDpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105

                          90
                  ....*....|.
gi 1002341807 103 PFYVGAQFLGA 113
Cdd:PLN00167  106 MFYWISQMLAS 116
PLN00166 PLN00166
aquaporin TIP2; Provisional
 24-115 1.03e-06

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 47.62  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  24 KETLSEFLGTFILIVLGCG-CVAQAILSRGRF---GGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKW 99
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGsAIAFAKLTSDAAldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90
                  ....*....|....*.
gi 1002341807 100 FKLPFYVGAQFLGAFV 115
Cdd:PLN00166   99 ITGFFYWIAQCLGSIV 114
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 27-118 4.40e-05

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 42.63  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  27 LSEFLGTFILivLGCGCVAQAILSRGRFGGVITINVGFsmAVAMAIYVAGGVSGGHINPAVSLAMCLFGRM--KWFKLPF 104
Cdd:cd00333   134 FVEFIGTFIL--VLVVFATTDDPNGPPPGGLAPLAIGL--LVAAIGLAGGPITGASMNPARSLGPALFTGLarHWHYFWV 209

                          90
                  ....*....|....
gi 1002341807 105 YVGAQFLGAFVGAA 118
Cdd:cd00333   210 YWVGPLIGAIAGAL 223
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 27-118 7.84e-05

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  27 LSEFLGTFILIVLGCGCVAQAIlSRGRFGGVItinVGFsmAVAMAIYVAGGVSGGHINPAVSLAMCLF-----GRMKWFK 101
Cdd:COG0580   135 LTEIIGTFVLVFVILGITDKRA-APGGLAPLA---IGL--LVAAIGLSLGPLTGYAINPARDLGPRLFhalgkGGSDWGY 208

                          90
                  ....*....|....*..
gi 1002341807 102 LPFYVGAQFLGAFVGAA 118
Cdd:COG0580   209 LWVPIVAPILGAALAAL 225
PLN00027 PLN00027
aquaporin TIP; Provisional
 23-115 9.33e-05

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 41.70  E-value: 9.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  23 AKETLSEFLGTFILIVLGCGC-VAQAILSRGRF---GGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMK 98
Cdd:PLN00027   20 LKAALAEFISTLIFVFAGEGSgMAFNKLTDNGSttpAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                          90
                  ....*....|....*..
gi 1002341807  99 WFKLPFYVGAQFLGAFV 115
Cdd:PLN00027  100 LLRGILYWIAQLLGSVV 116
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-117 2.69e-03

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 37.28  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  27 LSEFLGTFILIvlGCGCVAQAILSRGRFGGVITINVGFSmaVAMAIYVAGGVSGGHINPAVSLAMCLF-GRMKWFKLPFY 105
Cdd:TIGR00861 126 FVEFIGTAILV--LVIFATTDDRNRVPRGGFAPLAIGLL--VFLIHLSMGPYTGTGMNPARSLGPALFaGLAGWGNHWVY 201

                          90
                  ....*....|..
gi 1002341807 106 VGAQFLGAFVGA 117
Cdd:TIGR00861 202 WVGPIIGAILGA 213
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 29-119 6.66e-03

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 36.37  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002341807  29 EFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGfsmavaMAIYVAGGVSGGHINPAVSLAMCLfgrMKW-FK-LPFYV 106
Cdd:PLN00183  167 EFIATFIVMFLAASLTSQPQSLGHLSGFVIGIAIG------LAVLITGPVSGGSMNPARSLGPAI---VSWdFKdIWIYI 237

                          90
                  ....*....|...
gi 1002341807 107 GAQFLGAFVGAAT 119
Cdd:PLN00183  238 TAPTIGAVAGALM 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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