NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1008806544|ref|NP_001308259|]
View 

insulin-induced gene 2 protein isoform b [Homo sapiens]

Protein Classification

INSIG family protein( domain architecture ID 10538083)

INSIG (insulin-induced gene) family protein similar to insulin-induced gene 1 protein and 1nsulin-induced gene 2 protein, which are oxysterol-binding proteins that mediate feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 1-103 3.84e-47

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


:

Pssm-ID: 462131  Cd Length: 189  Bit Score: 149.70  E-value: 3.84e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806544   1 MRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVtqLLVYNGVYQYTSPDFLYV 80
Cdd:pfam07281  89 VRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDLMPSAQESLEV 166

                          90       100
                  ....*....|....*....|...
gi 1008806544  81 RSWLPCIFFAGGITMGNIGRQLA 103
Cdd:pfam07281 167 RSWLPSVLFCSCVCFGNIGRRLA 189
 
Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 1-103 3.84e-47

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


Pssm-ID: 462131  Cd Length: 189  Bit Score: 149.70  E-value: 3.84e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806544   1 MRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVtqLLVYNGVYQYTSPDFLYV 80
Cdd:pfam07281  89 VRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDLMPSAQESLEV 166

                          90       100
                  ....*....|....*....|...
gi 1008806544  81 RSWLPCIFFAGGITMGNIGRQLA 103
Cdd:pfam07281 167 RSWLPSVLFCSCVCFGNIGRRLA 189
 
Name Accession Description Interval E-value
INSIG pfam07281
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ...
 1-103 3.84e-47

Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.


Pssm-ID: 462131  Cd Length: 189  Bit Score: 149.70  E-value: 3.84e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806544   1 MRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVtqLLVYNGVYQYTSPDFLYV 80
Cdd:pfam07281  89 VRSIGAFVGIAFAIRKLPWQSTLQLSLTLALVNPGLWYLIDRSKPGFLLSTAVGLLGTVV--LLGLNPDLMPSAQESLEV 166

                          90       100
                  ....*....|....*....|...
gi 1008806544  81 RSWLPCIFFAGGITMGNIGRQLA 103
Cdd:pfam07281 167 RSWLPSVLFCSCVCFGNIGRRLA 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH