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Conserved domains on  [gi|1018443329|ref|NP_001309754|]
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zinc finger protein 461 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-484 2.70e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 281 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 349
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 350 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 427
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018443329 428 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 484
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
KRAB super family cl42959
krueppel associated box;
15-35 1.50e-04

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 39.88  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|.
gi 1018443329   15 GLSVSKPAVISSLEQGKEPWM 35
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.06e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018443329 256 ELTLHQRIHTGEKPYECKECGKAFRQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-484 2.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 281 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 349
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 350 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 427
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018443329 428 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 484
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
KRAB smart00349
krueppel associated box;
15-35 1.50e-04

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 39.88  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|.
gi 1018443329   15 GLSVSKPAVISSLEQGKEPWM 35
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 1.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....
gi 1018443329 424 HLKRHQRIHTGEKPHECMICGKAF 447
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018443329 256 ELTLHQRIHTGEKPYECKECGKAFRQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-484 2.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 281 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 349
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 350 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 427
Cdd:COG5048   348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1018443329 428 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 484
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-530 8.81e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 8.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 198 NTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRYECNECGKAFNYG--SELTLHQRIHTGEKPYE--- 271
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLnsk 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 272 --------------------------CKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQ------------- 312
Cdd:COG5048    97 slplsnskasssslsssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpansl 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 313 ---------LTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYH------SSFSHHQKIHS 377
Cdd:COG5048   177 skdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 378 GKKPYECHECGKAFCDGLQLTLHQRIHTG-EKPYECKECGKTFRQCSHLKRHQR--IHTGE--KPHEC--MICGKAFRLH 450
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 451 SHLIQHQRIHTGEKPYECK--ECGKAFS------YHSSFSHHQRIHSGKKPYQ----CGKAFNHRLQLNLHQTLHTGEKP 518
Cdd:COG5048   337 DALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRP 416

                         410
                  ....*....|..
gi 1018443329 519 VRFPLLPPHPSL 530
Cdd:COG5048   417 YNCKNPPCSKSF 428
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
436-532 1.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 436 KPHECMICGKAFRLHSHLIQHQRIHTGEKPYEC--KECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLH 513
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90
                  ....*....|....*....
gi 1018443329 514 TGEKPVRFPLLPPHPSLAS 532
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-389 2.42e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 160 ISECKKCRKIFSYHLFFSHHKRTHSKELSECKECTEIVN-TPCLFKQQTIQNGDKCNECKECWKAF---VHCSQLKHLRI 235
Cdd:COG5048   199 SSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPkSLLSQSPSSLSSSDSSSSASESPRSSlptASSQSSSPNES 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 236 HNGE-----KRYECNECGKAFNYGSELTLHQR--IHTGE--KPYECKE--CGKAFRQRSQLTQHQRLHTGEKPYECKQC- 303
Cdd:COG5048   279 DSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLn 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 304 ------GKAFIRGFQLTEHLRLHTGEKPYEC--KECGKTFRHRSHLTIHQRIHTGEKPYECR--ECGKAFSYHSSFSHHQ 373
Cdd:COG5048   359 ssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHK 438

                         250
                  ....*....|....*.
gi 1018443329 374 KIHSGKKPYECHECGK 389
Cdd:COG5048   439 KIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
352-496 3.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 352 KPYECRECGKAFSYHSSFSHHQ--KIHSGK--KPYECHE--CGKAFCDGLQLTLHQRIHTGEKPYECK--ECGKTFRQCS 423
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 424 HLKRHQRIH-----TGEKPHEC-MICGKAFRLHSHLIQHQRI-HTGEKPYECK--ECGKAFSYHSSFSHHQRIHSGKKPY 494
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETlSNSCIRNFKRDSNLSLHIItHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ..
gi 1018443329 495 QC 496
Cdd:COG5048   448 LC 449
KRAB smart00349
krueppel associated box;
15-35 1.50e-04

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 39.88  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|.
gi 1018443329   15 GLSVSKPAVISSLEQGKEPWM 35
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 1.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....
gi 1018443329 424 HLKRHQRIHTGEKPHECMICGKAF 447
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 2.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 1018443329 452 HLIQHQRIHTGEKPYECKECGKAFSY 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-372 7.94e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 197 VNTPCLFKQQTIQNGDKCNECKECwkafvhCSQLKHLR------IHNGE--KRYECNE--CGKAFNYGSELTLHQRIHTG 266
Cdd:COG5048   275 PNESDSSSEKGFSLPIKSKQCNIS------FSRSSPLTrhlrsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 267 EKPYECK--ECGKAFRQRS-----QLTQHQRLHTGEKPYEC--KQCGKAFIRGFQLTEHLRLHTGEKPYECK--ECGKTF 335
Cdd:COG5048   349 ISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1018443329 336 RHRSHLTIHQRIHTGEKPYECRECGKaFSYHSSFSHH 372
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 9.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.69e-04
                          10        20
                  ....*....|....*....|....*.
gi 1018443329 340 HLTIHQRIHTGEKPYECRECGKAFSY 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 1018443329 256 ELTLHQRIHTGEKPYECKECGKAFRQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 410-432 1.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.25e-03
                          10        20
                  ....*....|....*....|...
gi 1018443329 410 YECKECGKTFRQCSHLKRHQRIH 432
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-309 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1018443329 285 LTQHQRLHTGEKPYECKQCGKAFIR 309
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 326-348 1.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|...
gi 1018443329 326 YECKECGKTFRHRSHLTIHQRIH 348
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-421 2.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....*
gi 1018443329 397 LTLHQRIHTGEKPYECKECGKTFRQ 421
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-337 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1018443329 313 LTEHLRLHTGEKPYECKECGKTFRH 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 406-484 2.76e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018443329 406 GEKPYECK--ECGKTFRQCSHLKRHQRI-HTGEKPHEcmicgkafrlHSHLIQHQRIHTGEKPYECKECGKAF------S 476
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYknlnglK 415


                  ....*...
gi 1018443329 477 YHSSFSHH 484
Cdd:COG5189   416 YHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 270-292 8.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|...
gi 1018443329 270 YECKECGKAFRQRSQLTQHQRLH 292
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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