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Conserved domains on  [gi|1060604685|ref|NP_001317537|]
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growth arrest-specific protein 2 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 1-106 7.26e-75

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21267:

Pssm-ID: 469584  Cd Length: 136  Bit Score: 224.05  E-value: 7.26e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQEKFKESM-DANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGL 79
Cdd:cd21267    30 MEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGL 109

                          90       100
                  ....*....|....*....|....*..
gi 1060604685  80 VLHKQPREVCLCLLELGRIAARYGVEP 106
Cdd:cd21267   110 VLHKQPREVCLCLLELGRIAARFGVEP 136
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 143-216 3.46e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


:

Pssm-ID: 128539  Cd Length: 73  Bit Score: 125.64  E-value: 3.46e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060604685  143 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 216
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 1-106 7.26e-75

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 224.05  E-value: 7.26e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQEKFKESM-DANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGL 79
Cdd:cd21267    30 MEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGL 109

                          90       100
                  ....*....|....*....|....*..
gi 1060604685  80 VLHKQPREVCLCLLELGRIAARYGVEP 106
Cdd:cd21267   110 VLHKQPREVCLCLLELGRIAARFGVEP 136
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 143-216 3.46e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 125.64  E-value: 3.46e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060604685  143 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 216
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 145-214 3.84e-36

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 122.71  E-value: 3.84e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604685 145 LDDAVKRISEDppCKCPTKFCVERLSQGRYRVGE--KILFIRMLHnKHVMVRVGGGWETFAGYLLKHDPCRM 214
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 1-95 1.92e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.38  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685    1 MEKLDNGALLCQLAATVQEKfkeSMDANKPaktlplkkipckaSAPSGSFFARDNTANFLSWCRDLGVDEtCLFESEGLV 80
Cdd:smart00033  23 SSDLKDGVALCALLNSLSPG---LVDKKKV-------------AASLSRFKKIENINLALSFAEKLGGKV-VLFEPEDLV 85

                           90
                   ....*....|....*.
gi 1060604685   81 L-HKQPREVCLCLLEL 95
Cdd:smart00033  86 EgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
1-101 2.65e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 40.67  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQL---AATVQEKFKESmdankpaktlplkKIPckasapsgsFFARDNTANFLSWCRDLGVDETCLFESE 77
Cdd:COG5199    37 LSLLKDGVRLCRIlneASPLDIKYKES-------------KMP---------FVQMENISSFINGLKKLRVPEYELFQTN 94

                          90       100
                  ....*....|....*....|....
gi 1060604685  78 GLVLHKQPREVCLCLLELGRIAAR 101
Cdd:COG5199    95 DLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 1-106 7.26e-75

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 224.05  E-value: 7.26e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQEKFKESM-DANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGL 79
Cdd:cd21267    30 MEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSFFARDNTANFLSWCRDVGVGDTCLFESEGL 109

                          90       100
                  ....*....|....*....|....*..
gi 1060604685  80 VLHKQPREVCLCLLELGRIAARYGVEP 106
Cdd:cd21267   110 VLHKQPREVCLCLLELGRIAARFGVEP 136
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 1-103 2.60e-55

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 173.87  E-value: 2.60e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQEKFKESMDANKpAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLV 80
Cdd:cd21269    29 MEELDNGVLLCQLIGVLQSKIKECCSTEE-LKHFPMRKVPCKKDAPSGSFFARDNTANFLSWCRAIGVDETYLFESEGLV 107

                          90       100
                  ....*....|....*....|...
gi 1060604685  81 LHKQPREVCLCLLELGRIAARYG 103
Cdd:cd21269   108 LHKDPRQVCLCLLEIGRIVSRYG 130
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 1-103 6.55e-54

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 170.14  E-value: 6.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQEKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLV 80
Cdd:cd21204    29 LDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYKLKCNENAKPGSFFARDNVANFLRWCRKLGVDEVLLFESEDLV 108

                          90       100
                  ....*....|....*....|...
gi 1060604685  81 LHKQPREVCLCLLELGRIAARYG 103
Cdd:cd21204   109 LHKNPRQVLLCLLELARIAARYG 131
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 143-216 3.46e-37

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 125.64  E-value: 3.46e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060604685  143 NLLDDAVKRISEDppCKCPTKFCVERLSQGRYRVG-EKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQ 216
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 145-214 3.84e-36

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 122.71  E-value: 3.84e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604685 145 LDDAVKRISEDppCKCPTKFCVERLSQGRYRVGE--KILFIRMLHnKHVMVRVGGGWETFAGYLLKHDPCRM 214
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 1-104 1.36e-31

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 113.57  E-value: 1.36e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVQ----EKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCR-DLGVDETCLFE 75
Cdd:cd21268    34 FEKLETGVLLCKHANNVTraarEFQAQHPERASPLKLPPREVIFYRPSAKPGSFQARDNVSNFINWCRqLLGIPEVLLFE 113

                          90       100
                  ....*....|....*....|....*....
gi 1060604685  76 SEGLVLHKQPREVCLCLLELGRIAARYGV 104
Cdd:cd21268   114 TDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 2-97 1.34e-10

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 56.96  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   2 EKLDNGALLCQLAatvqEKFKesmdankpaktlPlKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVL 81
Cdd:cd00014    25 ESLRDGVLLCKLI----NKLS------------P-GSIPKINKKPKSPFKKRENINLFLNACKKLGLPELDLFEPEDLYE 87

                          90
                  ....*....|....*.
gi 1060604685  82 HKQPREVCLCLLELGR 97
Cdd:cd00014    88 KGNLKKVLGTLWALAL 103
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 1-95 1.92e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 45.38  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685    1 MEKLDNGALLCQLAATVQEKfkeSMDANKPaktlplkkipckaSAPSGSFFARDNTANFLSWCRDLGVDEtCLFESEGLV 80
Cdd:smart00033  23 SSDLKDGVALCALLNSLSPG---LVDKKKV-------------AASLSRFKKIENINLALSFAEKLGGKV-VLFEPEDLV 85

                           90
                   ....*....|....*.
gi 1060604685   81 L-HKQPREVCLCLLEL 95
Cdd:smart00033  86 EgPKLILGVIWTLISL 101
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 1-100 2.18e-05

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 42.71  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVqekfkesmdanKPAKtlpLKKIpckaSAPSGSFFARDNTANFLSWCRDLGVDETCLFES---- 76
Cdd:cd21208    23 RESLEDGILLCELINAI-----------KPGS---IKKI----NRLPTPIAGLDNLNLFLKACEDLGLKDSQLFDPtdlq 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1060604685  77 -------EGLVLHK----QPREVCLCLLELGRIAA 100
Cdd:cd21208    85 dlsnrriATHVRKKederRLKNVAITLYWLGRAAR 119
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 2-95 3.73e-05

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 41.81  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   2 EKLDNGALLCQLAATVQekfkesmdankpAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFeSEGLVL 81
Cdd:cd21273    27 EALSNGAVLCQLANQLR------------PRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMGVPEVDLC-SPSDVL 93

                          90
                  ....*....|....
gi 1060604685  82 HKQPREVCLCLLEL 95
Cdd:cd21273    94 LQGPAAVLRTVLAL 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 2-97 1.14e-04

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 40.43  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   2 EKLDNGALLCQLAATVqekfkesmdanKPAKTLPLKKipckASAPsgsFFARDNTANFLSWCRDLGVDETCLFESEGLVL 81
Cdd:cd21210    24 DALKDGVVLCKLANRI-----------LPADIRKYKE----SKMP---FVQMENISAFLNAARKLGVPENDLFQTVDLFE 85

                          90
                  ....*....|....*.
gi 1060604685  82 HKQPREVCLCLLELGR 97
Cdd:cd21210    86 RKNPAQVLQCLHALSR 101
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 4-97 1.27e-04

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 40.37  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   4 LDNGALLCQLAATVqekfkesmdanKPAKtlpLKKIPCKAsapsGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHK 83
Cdd:cd21207    32 LKDGVILCKLINIL-----------KPGS---VKKINTSK----MAFKLMENIENFLTACKGYGVPKTDLFQTVDLYEKK 93

                          90
                  ....*....|....
gi 1060604685  84 QPREVCLCLLELGR 97
Cdd:cd21207    94 NIPQVTNCLFALGR 107
SCP1 COG5199
Calponin [Cytoskeleton];
1-101 2.65e-04

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 40.67  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQL---AATVQEKFKESmdankpaktlplkKIPckasapsgsFFARDNTANFLSWCRDLGVDETCLFESE 77
Cdd:COG5199    37 LSLLKDGVRLCRIlneASPLDIKYKES-------------KMP---------FVQMENISSFINGLKKLRVPEYELFQTN 94

                          90       100
                  ....*....|....*....|....
gi 1060604685  78 GLVLHKQPREVCLCLLELGRIAAR 101
Cdd:COG5199    95 DLFEAKDLRQVVICLYSLSRYAQK 118
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 1-95 5.40e-04

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 38.44  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604685   1 MEKLDNGALLCQLAATVqekfkesmdanKPaKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLV 80
Cdd:cd21205    23 GEALMDGVVLCHLANHV-----------RP-RSVPSIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEERLCSPGDIL 90

                          90
                  ....*....|....*
gi 1060604685  81 LHKQPREVCLCLLEL 95
Cdd:cd21205    91 EEKGLVRVAVTVQAL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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