|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-745 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1415.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:cd00764 18 MNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFREREGRLQAAYNLIQRG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:cd00764 98 ITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDMTIGTDSALHRICEVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:cd00764 178 DAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSRGKRLNIIIVAEGAIDD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLM 320
Cdd:cd00764 258 QLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPACVVSLNGNKAVRLPLM 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 321 ECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIA 400
Cdd:cd00764 338 ECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGLA 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 401 DGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLEL 480
Cdd:cd00764 418 HGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQL 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 481 SAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAA 560
Cdd:cd00764 498 REAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLAV 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 561 GADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAP 640
Cdd:cd00764 578 GADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGVFDCRTNVLGHVQQGGAP 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 641 SPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLM 720
Cdd:cd00764 658 SPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTFEHRIPKEQWWLSLRPLL 737
|
730 740
....*....|....*....|....*
gi 1066566573 721 KILAKYKASYDVSDSGQLEHVQPWS 745
Cdd:cd00764 738 KILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
1-728 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1287.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:TIGR02478 15 MNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRERPGRLKAARNLVSNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:TIGR02478 95 IDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMTIGADSALHRICEAI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:TIGR02478 175 DAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGKRKTIVIVAEGAIDR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLM 320
Cdd:TIGR02478 255 DLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPVISLRGNKIVRKPLV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 321 ECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNC---NVAVINVGAPAAGMNAAVRSAVRV 397
Cdd:TIGR02478 335 EAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAPAGGMNAATRSAVRY 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 398 GIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGL 477
Cdd:TIGR02478 415 ALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEAL 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 478 LELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGG 557
Cdd:TIGR02478 495 YQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMAG 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 558 LAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQG 637
Cdd:TIGR02478 575 LATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGRFDARTAVLGHMQQG 654
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 638 GAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVA-ELKKQTDFEHRIPKEQWWLKL 716
Cdd:TIGR02478 655 GSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETDFEHRRPKNQWWLQL 734
|
730
....*....|..
gi 1066566573 717 RPLMKILAKYKA 728
Cdd:TIGR02478 735 RPLVRILAGRDS 746
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-354 |
4.08e-180 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 517.62 E-value: 4.08e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:cd00363 15 MNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRAKAAENLKKHG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEWSGlleelarngqidkeavqKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:cd00363 93 IDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:cd00363 156 DRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGIVIVAEGAIDF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLM 320
Cdd:cd00363 236 IPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLNENQVVRHPLT 315
|
330 340 350
....*....|....*....|....*....|....
gi 1066566573 321 ECVQMTQDVQkamderrfqdaVRLRGRSFAGNLN 354
Cdd:cd00363 316 EAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
1-292 |
1.66e-135 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 400.56 E-value: 1.66e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:pfam00365 14 MNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGREKIAENLKKLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:pfam00365 92 IDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLsENRARKKRLNIIIVAEGAIDT 240
Cdd:pfam00365 150 DRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRFSIIVVAEGASDG 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1066566573 241 qnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 292
Cdd:pfam00365 226 -------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
1-335 |
4.02e-114 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 347.45 E-value: 4.02e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:PRK03202 16 MNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKKLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:PRK03202 94 IDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:PRK03202 151 DRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGKKHAIIVVAEGVMPA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTpacVVSLNGNHAVRLPLM 320
Cdd:PRK03202 228 EEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNNKIVHVPIE 297
|
330
....*....|....*.
gi 1066566573 321 ECV-QMTQDVQKAMDE 335
Cdd:PRK03202 298 EAVeNMKHPFDKDLYE 313
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
1-344 |
1.04e-111 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 342.05 E-value: 1.04e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:COG0205 16 LNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGREKALENLKKLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:COG0205 94 IDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:COG0205 152 DRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGKGYSIIVVAEGAGDE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpDTPAC 305
Cdd:COG0205 229 DGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE---GKTGV 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 1066566573 306 VVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 344
Cdd:COG0205 306 MVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
374-657 |
2.53e-105 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 322.75 E-value: 2.53e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 374 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 450
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 451 EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREkheefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 530
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 531 SASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIqrglVLRNESCSenyTTD 610
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGE 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1066566573 611 FIYQLYsEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 657
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
1-321 |
1.18e-101 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 314.67 E-value: 1.18e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:TIGR02482 14 MNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVREKAVENLKKLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLFRKEwsglleelarnGQIdkeavqkyaylNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:TIGR02482 92 IEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRLNIIIVAEGAIDT 240
Cdd:TIGR02482 150 DKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD---IDELIQRLKEQHEAGKKHSIIIVAEGNIVG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 QNKPItSEKIKELVvtqlGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpDTPACVVSLNGNHAVRLPLM 320
Cdd:TIGR02482 227 SAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIGIQNNKIVTHPIE 298
|
.
gi 1066566573 321 E 321
Cdd:TIGR02482 299 E 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-333 |
6.91e-89 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 281.99 E-value: 6.91e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRG 80
Cdd:cd00763 15 MNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQAKAIEQLKKHG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV 160
Cdd:cd00763 93 IDALVVIGGDGSYMGAMR-----------LTEHG------------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 161 DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRLNIIIVAEGAIDt 240
Cdd:cd00763 150 DRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGKKHAIVVVAEGVYD- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 241 qnkpitSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEAtpdTPACVVSLNGNHAVRLPLM 320
Cdd:cd00763 226 ------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLAVGIQNEQLVHHDII 296
|
330
....*....|...
gi 1066566573 321 ECVQMTQDVQKAM 333
Cdd:cd00763 297 DAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
1-323 |
4.46e-73 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 240.28 E-value: 4.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYV-GAKVYFIYEGYQGMVDGGSnIAEADWESVSSILQVGGTIIGSARCQAFRT-REGRLKAACNLLQ 78
Cdd:TIGR02483 14 LNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeEDGDDKIVANLKE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 79 RGITNLCVIGGDGSLTGANlfrkewsglleELARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIE 158
Cdd:TIGR02483 93 LGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYTFGFDTAVEIATE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 159 VVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRLNIIIVAEGA- 237
Cdd:TIGR02483 150 ALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD---IDSVCEKVRERFARGKRFAIVVVAEGAk 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 238 -------IDTQNKPI--------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDT 302
Cdd:TIGR02483 227 pkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFGH 306
|
330 340
....*....|....*....|.
gi 1066566573 303 pacVVSLNGNHAVRLPLMECV 323
Cdd:TIGR02483 307 ---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
374-659 |
4.96e-52 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 184.12 E-value: 4.96e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 374 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 450
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 451 EEIATQMRTHSINALLIIGGfeaylgllE--LSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 528
Cdd:COG0205 83 EKALENLKKLGIDALVVIGG--------DgsLDGAAKLAEEYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 529 KQSASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLqsnVEHLTEKMKTTIQRGLVL--------RN 600
Cdd:COG0205 155 RDTAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDG 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1066566573 601 ESCSENYTTDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 659
Cdd:COG0205 231 EAVLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
375-716 |
1.48e-51 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 182.22 E-value: 1.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 375 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI- 453
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGq 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 454 ---ATQMRTHSINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 530
Cdd:cd00763 82 akaIEQLKKHGIDALVVIGGDGSYMGAMRLT-------EHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 531 SASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNESCsenYTTD 610
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 611 FIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAklkearGRGkkfttddSICVlGISKRNVI 690
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA------GKG-------GLAV-GIQNEQLV 291
|
330 340
....*....|....*....|....*.
gi 1066566573 691 FQPVAELkkqtdFEHRIPKEQWWLKL 716
Cdd:cd00763 292 HHDIIDA-----IENMKPFKKDWLAL 312
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
1-292 |
2.09e-50 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 180.27 E-value: 2.09e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVR--MGIYvGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQ---AFRTREGRLKAACN 75
Cdd:PRK14071 19 LNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKGdpfAFPMPDGSLRDRSQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 76 -----LLQRGITNLCVIGGDGSLtganlfrkewsGLLEELARNGQIdkeavqkyaylNVVGMVGSIDNDFCGTDMTIGTD 150
Cdd:PRK14071 98 eiidgYHSLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIPKTIDNDVGATEVSIGFD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 151 SALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPpeegWE-EQMCVKLSENRARKKRLN 229
Cdd:PRK14071 156 TAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTlENVCKKIRERQEEGKNFC 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1066566573 230 IIIVAEGAIDTQNKPITSEK-------------IKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 292
Cdd:PRK14071 232 LVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAV 307
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
374-697 |
2.34e-50 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 179.42 E-value: 2.34e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 374 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI 453
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSAR-CKEFRTEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 454 ----ATQMRTHSINALLIIGGFEAYLGLLEL-SAAREKHEEFcvPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 528
Cdd:cd00363 81 rakaAENLKKHGIDALVVIGGDGSYTGADLLtEEWPSKYQGF--NVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 529 KQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDlqsnVEHLTEKMKTTIQRG----LVLRNEScs 604
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 605 enyTTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKlkeargrgkkfTTDD 677
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEG-----------TGGT 297
|
330 340
....*....|....*....|
gi 1066566573 678 SICVLGISKRNVIFQPVAEL 697
Cdd:cd00363 298 PVGIQNLNENQVVRHPLTEA 317
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
384-657 |
9.04e-50 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 177.19 E-value: 9.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 384 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE---EIATQMRTH 460
Cdd:PRK03202 13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 461 SINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASgTKRRVF 540
Cdd:PRK03202 93 GIDALVVIGGDGSYMGAKRLT-------EHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS-SHERVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 541 IIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNES-CSENYTTDFIyqlyseE 619
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAKEI------E 235
|
250 260 270
....*....|....*....|....*....|....*...
gi 1066566573 620 GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 657
Cdd:PRK03202 236 ERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
374-701 |
1.56e-41 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 162.51 E-value: 1.56e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 374 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQ--IKEIGWTDVGGWTGQGGSILGTKRVL-----P 446
Cdd:TIGR02478 2 RIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKefrerP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 447 GKYLEeiATQMRTHSINALLIIGG---------F-EAYLGLL-EL--------SAAREKHEEFCVPMVmvpATVSNNVPG 507
Cdd:TIGR02478 82 GRLKA--ARNLVSNGIDALVVIGGdgsltgadlFrEEWPSLLeELvdtgkitaEQAEEHRHLTIVGLV---GSIDNDMCG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 508 SDFSIGADTALNTITDTCDRIKQSASGTKrRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDirdlQSNVEHLTEK 587
Cdd:TIGR02478 157 TDMTIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPE----EGWEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 588 MKTTIQRG----LVLRNE----SCSENYTTDFIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAmewI 659
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEgaidRDLNPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEA---V 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1066566573 660 TAKLKeargrgkkfTTDDSI-CVLGISKRNVIFQPVAELKKQT 701
Cdd:TIGR02478 307 LAVLE---------STPETPsPVISLRGNKIVRKPLVEAVAQT 340
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
375-743 |
2.29e-37 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 149.59 E-value: 2.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 375 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE- 451
Cdd:cd00764 6 IAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARCKEFREREg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 452 --EIATQMRTHSINALLIIGG---------FEA-YLGLLE--LSAAREKHEEF-------CVPMVmvpATVSNNVPGSDF 510
Cdd:cd00764 86 rlQAAYNLIQRGITNLCVIGGdgsltgadlFRSeWPSLLEelVKDGKITEEEVakyqhlnIVGMV---GSIDNDFCGTDM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 511 SIGADTALNTITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDiRDLQsnvEHLTEKMKT 590
Cdd:cd00764 163 TIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPE-DGWE---DQMCRRLSE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 591 TIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV------FDCRKNVLGHMQQGGAPSPFDRNFGTKisaRAMEWITAKLK 664
Cdd:cd00764 238 HRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLvverlgLDTRVTTLGHVQRGGTPSAFDRILASL---MGVEAVMALLE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 665 EargrgkkfTTDDSICVLGISKRNVIFQPVAELKKQTdfeHRIPKEQWWLKLRPLMKILAK-YKASYDVSDSGQLEHVQP 743
Cdd:cd00764 315 A--------TPDTPACVVSLNGNKAVRLPLMECVQLT---KDVQKAMDEKRFDEAAALRGKsFDKNWNLYKLLAIELPQP 383
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
1-241 |
3.24e-24 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 106.67 E-value: 3.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVVRMGIYV-GAK-VYFIYEGYQGMVDGGSniAEADWESVSSILQVGGTIIGSARcqafrTREGRLKAACNLLQ 78
Cdd:PTZ00286 102 LNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDW--IKLDPKDVKTIHRLGGTILGSSR-----GGFDPKVMVDTLIR 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 79 RGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIE 158
Cdd:PTZ00286 175 HGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQN 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 159 VVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPpeegWEEQMCVKLSENRARKKRLNIIIVAEG 236
Cdd:PTZ00286 238 AIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFD----IPLEGVLEYIEQRLQKKGHCVIVVAEG 313
|
....*
gi 1066566573 237 AIDTQ 241
Cdd:PTZ00286 314 AGQSL 318
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
375-661 |
1.71e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 87.82 E-value: 1.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 375 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGT-KRVLPGKY- 449
Cdd:PRK14071 7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTtNKGDPFAFp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 450 ---------LEEIATQMRTHSINALLIIGGfEAYLGLLelsaaREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNT 520
Cdd:PRK14071 87 mpdgslrdrSQEIIDGYHSLGLDALIGIGG-DGSLAIL-----RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 521 ITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIrdlqsnvEHLTEKMKTTIQRG----L 596
Cdd:PRK14071 161 ATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfcL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 597 VLRNESC----SENYTTDF---------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITA 661
Cdd:PRK14071 233 VVVSEAVrteeGEQVTKTQalgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
2-237 |
1.32e-17 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 86.08 E-value: 1.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 2 NAAVRAVVR--MGIYVGAKVYFIYEGYQGMV-DGGSNIAEADWESVSSILQVGGTIIGSARcqafrtreGRLKAAC---N 75
Cdd:PRK06830 96 NDVIRAIVLelHHHYGVRRILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEivdT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 76 LLQRGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGTDMTIGTDSALHR 155
Cdd:PRK06830 168 LERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS---VIGIPKTIDNDINFIQKSFGFETAVEK 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 156 IIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsENRARKKRLNIIIV 233
Cdd:PRK06830 231 ATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPNGLLAAL-EKRLAERGHAVIVV 309
|
....
gi 1066566573 234 AEGA 237
Cdd:PRK06830 310 AEGA 313
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
119-297 |
2.46e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 78.75 E-value: 2.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 119 EAVQKYAY-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCGYLALVSA 191
Cdd:PRK14072 124 QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAGWLAAAAA 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 192 LAC-----GADWVFLPESPPEegwEEQMCVKLSENRARKKRLnIIIVAEGAIDTQNKPITSEK----------------- 249
Cdd:PRK14072 201 LAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaqlggvapv 276
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1066566573 250 IKELVVTQLGYDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 297
Cdd:PRK14072 277 LANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
18-237 |
3.78e-14 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 75.55 E-value: 3.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 18 KVYFIYEGYQGMVdgGSNIAEADWESVSSILQVGGTIIGSARcqafrTREGRLKAACNLLQRGITNLCVIGGDGSLTGAN 97
Cdd:PLN02564 121 RILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSR-----GGHDTSKIVDSIQDRGINQVYIIGGDGTQKGAS 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 98 LfrkewsgLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVL 176
Cdd:PLN02564 194 V-------IYEEIRRRG-------LKVA---VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLV 256
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1066566573 177 EVMGRHCGYLALVSALAC-GADWVFLPESP----PEEGWEEQMCVKLSENRARkkrlnIIIVAEGA 237
Cdd:PLN02564 257 KLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
1-329 |
2.16e-12 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 69.84 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 1 MNAAVRAVV-RMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAfRTREgrlkAACNLLQR 79
Cdd:PLN02884 68 LNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRGGA-KTSD----IVDSIEAR 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 80 GITNLCVIGGDGSLTGANLfrkewsglleelarngqIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEV 159
Cdd:PLN02884 143 GINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 160 VDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsENRARKKRLNIIIVAEGA 237
Cdd:PLN02884 206 INSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHL-EHLIETKGSAVVCVAEGA 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 238 -IDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS-----------------AFDRILASRMGVEAVIAlleAT 299
Cdd:PLN02884 285 gQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAVHG---AF 361
|
330 340 350
....*....|....*....|....*....|
gi 1066566573 300 PDTPACVVSLNGNHAVRLPLMECVQMTQDV 329
Cdd:PLN02884 362 AGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
375-553 |
1.24e-09 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 61.21 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 375 VAVINVGAPAAGMNAAVRSAVRVGIADGH--RMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEE 452
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR--GGFDPKV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 453 IATQMRTHSINALLIIGGFEAYLGLLELS--AAREKHEefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 530
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGGDGTHRGALAIYkeLRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244
|
170 180
....*....|....*....|...
gi 1066566573 531 SASGTKRRVFIIETMGGYCGYLA 553
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
25-193 |
3.29e-09 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 59.64 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 25 GYQGMVDGGS-NIAEADWESVSSILQVGGTIIGSARCQAFRT---------REGR--LKAACNLLQR-GITNLCVIGGDG 91
Cdd:PRK06555 44 GYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVKLTNVadcvkrglvKEGEnpLKVAAERLAAdGVDILHTIGGDD 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 92 SLTGAnlfrkewSGLLEELARNGqidkeavqkYAyLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQ 171
Cdd:PRK06555 124 TNTTA-------ADLAAYLAENG---------YD-LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANP 186
|
170 180
....*....|....*....|...
gi 1066566573 172 RTFVL-EVMGRHCGYLALVSALA 193
Cdd:PRK06555 187 RMLIIhEVMGRNCGWLTAATARA 209
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
374-553 |
7.34e-06 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 49.04 E-value: 7.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 374 NVAVINVGAPAAGMNAAVRSAV-RVGIADGHRMLAIYDGFDGFAKGQIKEIGWTD--VGGWTGQGGSILGTKRvlPGKYL 450
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRkvVQNIHLSGGSLLGVSR--GGAKT 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 451 EEIATQMRTHSINALLIIGGFEAYLGllelsaAREKHEEfC------VPMVMVPATVSNNVPGSDFSIGADTALNTITDT 524
Cdd:PLN02884 133 SDIVDSIEARGINMLFVLGGNGTHAG------ANAIHNE-CrkrkmkVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRA 205
|
170 180
....*....|....*....|....*....
gi 1066566573 525 CDRIKQSASGTKRRVFIIETMGGYCGYLA 553
Cdd:PLN02884 206 INSAYIEAHSAYHGIGLVKLMGRSSGFIA 234
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
386-553 |
4.27e-05 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 46.66 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 386 GMNAAVRSAVrVGIADG---HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEEIATQMRTHSI 462
Cdd:PLN02564 101 GLNTVIREIV-CGLSYMygvTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSR--GGHDTSKIVDSIQDRGI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 463 NALLIIGGFEAYLGllelsaAREKHEE-----FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKR 537
Cdd:PLN02564 178 NQVYIIGGDGTQKG------ASVIYEEirrrgLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVEN 251
|
170
....*....|....*.
gi 1066566573 538 RVFIIETMGGYCGYLA 553
Cdd:PLN02564 252 GIGLVKLMGRYSGFIA 267
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
81-239 |
5.76e-04 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 43.49 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 81 ITNLCVIGGDGSLTGAnlfrkewsGLLEELARNGQIDkeavqkyayLNVVGMVGSIDNDFC--GTDMTIGTDSALHRIIE 158
Cdd:PTZ00287 272 LNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1066566573 159 VVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVK-----LSENRARKKRLNIII 232
Cdd:PTZ00287 335 VIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSLKDIVSnivntILKRRSLNKNYGVIL 414
|
....*..
gi 1066566573 233 VAEGAID 239
Cdd:PTZ00287 415 IPEGLIE 421
|
|
| |
