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Conserved domains on  [gi|1137643826|ref|NP_001335328|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 4.57e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.51  E-value: 4.57e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 195
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1137643826 276 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 321
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 4.57e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.51  E-value: 4.57e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 195
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1137643826 276 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 321
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 2.08e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.08  E-value: 2.08e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  82 SAYELPYgtKGSEDLLLRVLAITsssipkNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVS------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 162 KTTMRLFYPESA------HFDPKVENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 233 NPFFMEIAADKLLSLPMQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 1137643826 312 SQEALAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 116-321 4.57e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.51  E-value: 4.57e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 195
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23982    81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1137643826 276 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 321
Cdd:cd23982   159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 116-321 9.67e-113

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 325.40  E-value: 9.67e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKvENNPDTLLVLVAFKAM 195
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPE-EYDSDWLLVLVPFKSM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQpRKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23967    80 DLLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1137643826 275 LVHIAGFGYPDAyNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRM 321
Cdd:cd23967   159 EVDIAGFGYDPS-DPNAPLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 117-321 2.33e-80

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 243.12  E-value: 2.33e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPkVENNPDTLLVLVAFKAMD 196
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDP-SHYDPNTTVVLIPFKPHD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR-KIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23984    81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKeKKPKHPTTGIIAITLALHICNE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1137643826 276 VHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEALAIKRM 321
Cdd:cd23984   161 VHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 82-326 2.08e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.08  E-value: 2.08e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  82 SAYELPYgtKGSEDLLLRVLAITsssipkNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGS 161
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVS------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 162 KTTMRLFYPESA------HFDPKVENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 232
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 233 NPFFMEIAADKLLSLPMQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGyPDAYNKKQTIHYYEQITLKSMAGSG-HNV 311
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFG-PFLDSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 1137643826 312 SQEALAIKRMLEMGA 326
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 117-321 1.74e-64

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 203.05  E-value: 1.74e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdPKV--ENNPDTLLVLVAFKA 194
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKSeqEYDPTSLFVAVLFKS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 195 MDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR---KIKQKPTTGLLAITL 268
Cdd:cd23983    79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRlwgWDKNVPTLGVTAVVL 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1137643826 269 ALHLCDLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEALAIKRM 321
Cdd:cd23983   159 ATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 116-321 1.15e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 187.82  E-value: 1.15e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKvENNPDTLLVLVAFKAM 195
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPE-QYEKDSLFVLAGFKWQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLC 273
Cdd:cd23981    80 DFKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNC 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1137643826 274 DLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRM 321
Cdd:cd23981   160 DEVAVAGFGY-DMNTPNAPLHYYETIKMSAIKESwTHNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 116-328 9.80e-49

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 164.38  E-value: 9.80e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdpkVENNPDTLLVLVAFKAM 195
Cdd:cd23966    76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA-----VDLDPGVHLVLVPFKVL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWIETILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFFMEIAADKLLslpmqqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23966   151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 276 VHIAGFGypdAYNKKQTIHYYEQitlksMAGSG-------HNVSQEALAIKRMLEMGAIK 328
Cdd:cd23966   222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 56-328 4.00e-43

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 150.49  E-value: 4.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  56 SKLFGN-YSRDQPIFLRLEDYF--WVKTPSAYELPYGTKG-SEDLL---LRVLAITSSSIP--KNIQSLRCRRCVVVGNG 126
Cdd:cd23964    12 SPWFRErFIPDIKVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVerlLRNLNLTSSRYMfvLRGGRPRCIRCAVVGNG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 127 HRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfDPKVENNP---DTLLVLVAFKAMDFHWIETI 203
Cdd:cd23964    92 GILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLH-NSLLKHVPqdkDTKYLFIPFKIRDYDYLDAV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 204 LSDKKRVR---KGFWKQPPLIWDVNPKQIRILNPFFMeiaadkllslpmqqpRKIK---------QKPTTGLLAITLALH 271
Cdd:cd23964   171 LSGKPVPDgcdKGKRPPPLFGPKLNATNVRLLHPDFI---------------RYLFnrwlnsstsYRPTTGALMLLTALH 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1137643826 272 LCDLVHIAGFGypdaYNKKQTIHYYE-QITLKSMAGSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23964   236 TCDQVSVYGFG----YDPRFSLHYYDkTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 120-321 5.16e-40

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 139.03  E-value: 5.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 120 CVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHF--------DPKVENNPDTLLVLVA 191
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrgprcgCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 192 FKAMDFHWIetilsdkKRVRKGFWKQPPLiwdVNPKQIRILNpFFMEIaADKLLSLPMQQPRkikqKPTTGLLAITLALH 271
Cdd:cd19952    81 AAAADFKRL-------KRRKKRHDNAVLL---LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQ 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1137643826 272 LCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSgHNVSQEALAIKRM 321
Cdd:cd19952   145 LCDSVDLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 75-328 1.22e-32

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 122.29  E-value: 1.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  75 YFWVKTPSAYElPYGTKgseDLLLRVLAITSSSIPKNIQS-LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA 153
Cdd:cd23979    41 YWWMMLQPQFK-PHNTK---EVLSKLFQIIPGENPYRSWDpSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 154 GYEGDVGSKTTMRLFYPESAHFDPkvennPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILN 233
Cdd:cd23979   117 GFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKTLDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYN 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 234 PFFMEIAADKLlslpmqqPRKIKQKPTTGLLAITLALHLCDLVHIAGFGypdAYNKKQTIHYYEQitlKSMAG----SG- 308
Cdd:cd23979   190 PAFFKYIHDRW-------TEHHGRYPSTGMLVLFFALHVCDEVNVYGFG---ADSRGNWHHYWEN---NRYAGefrkTGv 256

                         250       260
                  ....*....|....*....|
gi 1137643826 309 HNVSQEALAIKRMLEMGAIK 328
Cdd:cd23979   257 HDADFEAHIIDMLAKAGKIK 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 114-297 3.20e-32

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 121.53  E-value: 3.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 114 SLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpkvENNPDTLLVLVAFK 193
Cdd:cd23980    78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFK 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 194 AMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLslpmqqpRKIKQKPTTGLLAITLALHLC 273
Cdd:cd23980   153 TLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-------QGHGRYPSTGILSVIFSLHVC 223

                         170       180
                  ....*....|....*....|....
gi 1137643826 274 DLVHIAGFGypdAYNKKQTIHYYE 297
Cdd:cd23980   224 DEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 118-328 2.50e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 108.12  E-value: 2.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 118 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTM---------RLFYPESAHFDPKV-----ENNP 183
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsilkRRYNSLKKNRDRDKflnrlKEYN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 184 DTLLVLVAFkamdfhwietilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLlslpmqQPRKIKQKPTTGL 263
Cdd:cd23963   144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137643826 264 LAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAGSgHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23963   206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 106-295 1.22e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 101.37  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 106 SSIPKNIQSL----------RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTmrlFYPESAH- 174
Cdd:cd23973    62 ELIPKPKEQQllalsppggdGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHs 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 175 ------------FDpKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFFMEI 239
Cdd:cd23973   139 itsslmilqkrgFK-NIPQDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRY 217

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137643826 240 AADKLL-SLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGF------GYPDAY---NKKQTIHY 295
Cdd:cd23973   218 VKNRFLrSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSAYGFitedyrKYPDHYydkKKTKLVFY 283
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-321 2.52e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 99.65  E-value: 2.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 118 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL-----FYPESAHFDPKVENNPDTLLV---- 188
Cdd:cd23968    46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLVwdps 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 189 ------LVAFKAMDFHWIET-----ILSDKKRVrkgFWKQPPLIWDVnpkqIRILNPFFmeiaadkllslpmqqPRKIKQ 257
Cdd:cd23968   126 synvnlEKWYKKPDFDFFPNyikyrRRHPEEPF---YLIDPRFLWRL----WDILQEYT---------------PEKIKP 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137643826 258 K-PTTGLLAITLALHLCDLVHIAGFGYPDAYNKKqtIHYYEQITLKSMA-GSGHNVSQEALAIKRM 321
Cdd:cd23968   184 NpPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR--CHYYDVEKDLACTlGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 117-302 3.90e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 89.99  E-value: 3.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFypesAHFD-PKVENNPDTLLVLVAFKAM 195
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 196 DFHWietiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfFMEIAADKLLSLPMQQPRKI-KQKPTTGLLAITLAL 270
Cdd:cd23965    77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSRIKsGTWLSTGWFTMLLAL 150

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1137643826 271 HLCDLVHIAGFGYPDaY-----NKKQTIHYYEQITLK 302
Cdd:cd23965   151 DVCDEIKVYGMVPEN-YcrehpNSKVPYHYYEPGGLK 186
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 116-331 2.68e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 85.93  E-value: 2.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSK---TTMrlfypesahfdpkvenNPDtlLVLVAF 192
Cdd:cd23969    63 HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKsnlTTM----------------NPS--VIPHAY 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 193 KAMDF-HWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFME------IA------ADKLLSLPMQQPRKIKqKP 259
Cdd:cd23969   125 GDLVNaTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTNEIILKhklnvkTAypplrlNHAIRGYWLTTKFRIK-RP 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137643826 260 TTGLLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAgSGHNVSQEALAIKRMLEMGAIKNLT 331
Cdd:cd23969   204 STGLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-321 1.05e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 84.50  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  63 SRDQpIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRvlaitsssIPKNIQSLR-CRRCVVVGNGHRLRNSSLGDAINKY 141
Cdd:cd23986     3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSKLHLRgFRSCAVVTSAGAILNSSLGKEIDSH 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 142 DVVIRLNNAPVAGYEGDVGSKTTMRLFYPE-----SAHF--------------DPKvennPDTLLVLVAFKAMDFHwiet 202
Cdd:cd23986    74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHFidsslykdvilvawDPA----PYSANLHKWYKKPDYN---- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 203 ILSDKKRVRKGFWKQPPLIwdVNPKQIRILNPFFMEIAADKLlslpmqQPrkikQKPTTGLLAITLALHLCDLVHIagFG 282
Cdd:cd23986   146 LFTPYVQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QP----NPPSSGFIGILIMMSMCREVHV--YE 211

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1137643826 283 YPDAYNKKQTIHYYEQ-----ITLksmaGSGHNVSQEALAIKRM 321
Cdd:cd23986   212 YIPSVRQTDLCHYHERyydaaCTL----GAYHPLLYEKLLIQRM 251
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 71-297 2.42e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 83.22  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  71 RLEDYFWVKTPSAYELPYGTKGSEDLLlrvlaiTSSSIPKNIQSLRcrRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNA 150
Cdd:cd23985     7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPLG--RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 151 PVAGYEGDVGSKTTMRLFYP-----ESAHFDPKVENNPDTLLVL--VAFKAMDFHWIET----ILSDKKRVRKgfwkqpp 219
Cdd:cd23985    79 PTAGFQQDVGTKTTIRLINSqlvttEKHKFLKDSLYNEGILIVWdpAPYHSDIPEWYKNpdynFFENYKTYRR------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 220 liwdVNPKQ-IRILNPFF--------MEIAADKLlslpmqQPrkikQKPTTGLLAITLALHLCDLVHIAGFgYPdayNKK 290
Cdd:cd23985   152 ----LNPNQpFYILHPQMqwelwdiiQENSPEEI------QP----NPPSSGMLGIILMMTLCDQVDVYEF-LP---SKR 213


                  ....*....
gi 1137643826 291 QT--IHYYE 297
Cdd:cd23985   214 KTdvCHYYQ 222
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 117-328 2.90e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 83.65  E-value: 2.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFY-------------------PESAH--- 174
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgfngpPQSKEtry 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 175 -FDPkvENNPDTLLVLVAfkamdfhwIETILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFFMEIAADKLLSLPMQQ 251
Cdd:cd23974   164 iFLP--DHDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPILN 230

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1137643826 252 P--RKIkQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTiHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23974   231 TkqRDI-YRPSTGAVMLLAALHTCDQVSAYGFMTPD-YGKYSD-HYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 82-328 1.36e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 81.79  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826  82 SAYELPYGTKG--SEDL--LLRVLAITSSS--IPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGY 155
Cdd:cd23972    41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 156 EGDVGSKTTmrlFYpesaHFDPKVENNPdtllvLVAFKAMDFH-----------WIETILSDKKRVRKGFWKQP-PLIWD 223
Cdd:cd23972   121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 224 ------------VNPKQIRILNPFFMEIAADKLLS---LPMQQPRKIkqKPTTGLLAITLALHLCDLVHIAGFGYPDaYN 288
Cdd:cd23972   189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLKsklLNTHYGHLY--MPSTGALMLLTALHTCDQVSAYGFITSN-YW 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1137643826 289 KKQTiHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23972   266 KFSD-HYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 112-297 1.50e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.29  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 112 IQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVLVA 191
Cdd:cd23970    63 FQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILE---KYYNNLLTIQDRNN 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 192 FkamdfhwietiLSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLP-----MQ------QPRKIKQKP- 259
Cdd:cd23970   140 F-----------FLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAwpgniMQhvnrywKTKHLSPKRl 208

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1137643826 260 TTGLLAITLALHLCDLVHIAGFgYPDAYNKKQT---IHYYE 297
Cdd:cd23970   209 STGILMYTLASAICEEIHLYGF-WPFGFDPTGTplpYHYYD 248
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 107-331 5.17e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 79.61  E-value: 5.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 107 SIPKNIQSL----------RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSK---TTM------RL 167
Cdd:cd23988    44 NISQNLHSLlpevspmknrRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKsdfITMnpsvvqRA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 168 F-----YPESAHFDPKVENNPDTLLVLVAF--KAMDFH--WI-ETILSDKKRVRKGFwkqPPLiwdvnpKQIRILNPFFM 237
Cdd:cd23988   124 FggfrnESDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRGYWL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 238 eiaADKLlslpmqqprKIKqKPTTGLLAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQITLKSMAGSG-HNVSQE 314
Cdd:cd23988   195 ---TNKV---------NIK-RPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHRMPLE 261

                         250
                  ....*....|....*..
gi 1137643826 315 ALAIKRMLEMGAIKNLT 331
Cdd:cd23988   262 FKTLNVLHNRGALKLTT 278
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-328 6.80e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.45  E-value: 6.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 119 RCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAgYEGDVGSKTTM--------RLFYPE----SAHFDPKVENNPDTL 186
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNlkkrRRPFVERMKVYGNAL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 187 LVLVAFKamdFHwIETILSDK-KRVRKGFWKQPPLIWdVNPKQIRILNPFFmeiaadklLSLPMQQPRkikqkPTTGLLA 265
Cdd:cd23971   145 LLLPAFS---YT-SNTEPSLRaLYTLEDFGSPQKVLF-FNPEYLRNLSRYW--------KSKGLKARR-----LSTGLML 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1137643826 266 ITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQItlksMAGSG-HNVSQEALAIKRMLEMGAIK 328
Cdd:cd23971   207 VSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNV----LPKKGvHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 117-297 2.86e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 71.04  E-value: 2.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVLVAFKAMD 196
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 197 FhW--IETILSDKKRVRKGFWKQPPLI------WDVNPKQIRILNPFF-MEIAADKllslpmqqpRKIKQKPTTGLLAIT 267
Cdd:cd23978    78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR---------KKSHSWLSTGWFTMV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1137643826 268 LALHLCDLVHIAGFGYPDAYNKKQTI-----HYYE 297
Cdd:cd23978   148 IAVELCDNVHVYGMVPPNYCSKRPTPkkmpyHYYE 182
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 116-328 3.75e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 71.51  E-value: 3.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 116 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMrlfypesahfdpkVENNPDtlLVLVAFK-A 194
Cdd:cd23987    63 HFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-------------VTMNPS--VVQRAFEdL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 195 MDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLP------------MQQPRKIKqKPTTG 262
Cdd:cd23987   128 VNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPslrllhavrgywLTNKVHIK-RPTTG 206

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 263 LLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLK-SMAGSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23987   207 LLMYTLATRFCNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-328 2.09e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 66.32  E-value: 2.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 118 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEG-DVGSKTTMRLFYP------------ESAHFDPKVENNPD 184
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNLVTANPsiisikyaklneRRKPFLETVSVYGD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 185 TLLVLVAFK-----AMDFHWIETILSDKKRVRKGFWkqppliwdvNPKQIRILNPFFmeiaadklLSLPMQQPRKikqkp 259
Cdd:cd23991   145 AFLLLPAFSyrsntALSFKVYYTLEDFKAKQKVIFF---------HPIYLKHLAQFW--------RSKGVQVYRL----- 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1137643826 260 TTGLLAITLALHLCDLVHIAGFgYPDAYN---KKQTIHYYEQITLKSmagSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23991   203 STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 117-167 4.66e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.80  E-value: 4.66e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL 167
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-297 2.11e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.27  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 115 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVlVAFKA 194
Cdd:cd23976    13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 195 MDFHWIETilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFFMeIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALH 271
Cdd:cd23976    89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 1137643826 272 LCDLVHIAGFGYP----DAYNKKQTIHYYE 297
Cdd:cd23976   166 LCDRINVYGMVPPdfcrDPNHPSVPYHYYE 195
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 115-328 3.07e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 59.84  E-value: 3.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 115 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA-GYEGDVGSKTTMRLFYPesAHFDPKVENnpdTLLVLVAF- 192
Cdd:cd23989    61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANP--SIIDKRFQN---LLWSRKSFv 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 193 ---KAMDFHWIET-ILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFFMEIAAdkllslPMQQPRKIK-QKPTTGLLAI 266
Cdd:cd23989   136 esmKVYGRSYIYMpAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLRNVG------KFWKSKGVHaKRLSTGLFLV 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1137643826 267 TLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSmagSGHNVSQEALAIKRMLEMGAIK 328
Cdd:cd23989   209 SAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNVLPDS---GFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 118-299 2.97e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 54.07  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 118 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAG-YEGDVGSKTTMRLFYP----ESAH--------FDPKVENNPD 184
Cdd:cd23990    65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137643826 185 TLLVLVAFkamdFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMeiaadkllslpMQQPRkiKQKPTTGLL 264
Cdd:cd23990   145 ASVVLPAF----YNTRNTDVSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWL-----------RQGVR--AKRISSGLM 207

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1137643826 265 AITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQI 299
Cdd:cd23990   208 LVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYDNV 244
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 117-184 6.85e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 52.63  E-value: 6.85e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1137643826 117 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdPKVENNPD 184
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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