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Conserved domains on  [gi|1186518018|ref|NP_001337876|]
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WD repeat-containing protein 25 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 239-543 1.21e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 239 LFHLRGHRGPVNTIQWCPVlskSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHL 318
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 319 TDLETGTQL--FSGRSDfRITTLKFHPKDHnIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSeFLSSTd 396
Cdd:cd00200    78 WDLETGECVrtLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 397 astrdSADRTIIAWDFRTSAKISNQIFHERFtCPSLALHPREPVFLAQTNGNylalFSTVWPYRMSR-RRRYEGHkvEGY 475
Cdd:cd00200   154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1186518018 476 SVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIW 543
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 239-543 1.21e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 239 LFHLRGHRGPVNTIQWCPVlskSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHL 318
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 319 TDLETGTQL--FSGRSDfRITTLKFHPKDHnIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSeFLSSTd 396
Cdd:cd00200    78 WDLETGECVrtLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 397 astrdSADRTIIAWDFRTSAKISNQIFHERFtCPSLALHPREPVFLAQTNGNylalFSTVWPYRMSR-RRRYEGHkvEGY 475
Cdd:cd00200   154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1186518018 476 SVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIW 543
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
236-543 2.36e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.36e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 236 RKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFA 315
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 316 LHLTDLETGTQL--FSGRSDfRITTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLS 393
Cdd:COG2319   186 VRLWDLATGKLLrtLTGHTG-AVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 394 StdastrdSADRTIIAWDFRTSAKISNQIFHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMSRRRR---Y 467
Cdd:COG2319   264 G-------SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSddgTVRLWDLATGKLlrtL 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1186518018 468 EGHKVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 543
Cdd:COG2319   327 TGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-277 7.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1186518018  235 PRKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWN 277
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-277 1.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1186518018 236 RKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWN 277
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 239-543 1.21e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 239 LFHLRGHRGPVNTIQWCPVlskSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHL 318
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 319 TDLETGTQL--FSGRSDfRITTLKFHPKDHnIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSeFLSSTd 396
Cdd:cd00200    78 WDLETGECVrtLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 397 astrdSADRTIIAWDFRTSAKISNQIFHERFtCPSLALHPREPVFLAQTNGNylalFSTVWPYRMSR-RRRYEGHkvEGY 475
Cdd:cd00200   154 -----SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENG 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1186518018 476 SVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIW 543
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
236-543 2.36e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.36e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 236 RKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFA 315
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 316 LHLTDLETGTQL--FSGRSDfRITTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLS 393
Cdd:COG2319   186 VRLWDLATGKLLrtLTGHTG-AVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 394 StdastrdSADRTIIAWDFRTSAKISNQIFHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMSRRRR---Y 467
Cdd:COG2319   264 G-------SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSddgTVRLWDLATGKLlrtL 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1186518018 468 EGHKVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 543
Cdd:COG2319   327 TGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
232-544 2.32e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 2.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 232 TTVPRKVLFHLRGHRGPVNTIQWCPVlskSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGG 311
Cdd:COG2319    64 DAAAGALLATLLGHTAAVLSVAFSPD---GRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 312 FDFALHLTDLETGTQL--FSGRSDfRITTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGS 389
Cdd:COG2319   140 ADGTVRLWDLATGKLLrtLTGHSG-AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 390 EFLSStdastrdSADRTIIAWDFRTSAKISNQIFHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMS---R 463
Cdd:COG2319   218 LLASG-------SADGTVRLWDLATGKLLRTLTGHSGSVR-SVAFSP---------DGRLLASGSadgTVRLWDLAtgeL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 464 RRRYEGHKVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 543
Cdd:COG2319   281 LRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357


                  .
gi 1186518018 544 H 544
Cdd:COG2319   358 D 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-501 1.50e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 237 KVLFHLRGHRGPVNTIQWcpvLSKSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFAL 316
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAF---SPDGRILSSSSRDKTIKVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 317 HLTDLETGT--QLFSGRSDFrITTLKFHPKDHNIFLCGGfSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSS 394
Cdd:cd00200   160 KLWDLRTGKcvATLTGHTGE-VNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 395 tdastrdSADRTIIAWDFRTsakisnqifherftcpslalhpREPVflaqtngnylalfstvwpyrmsrrRRYEGHKVEG 474
Cdd:cd00200   238 -------SEDGTIRVWDLRT----------------------GECV------------------------QTLSGHTNSV 264

                         250       260
                  ....*....|....*....|....*..
gi 1186518018 475 YSVGceCSPGGDLLVTGSADGRVLMYS 501
Cdd:cd00200   265 TSLA--WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
237-414 8.82e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 8.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 237 KVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFAL 316
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 317 HLTDLETGTQL--FSGRSDfRITTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSS 394
Cdd:COG2319   271 RLWDLATGELLrtLTGHSG-GVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1186518018 395 TD----------------------------ASTRD-------SADRTIIAWDFRT 414
Cdd:COG2319   349 SDdgtvrlwdlatgellrtltghtgavtsvAFSPDgrtlasgSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
264-543 7.35e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 7.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 264 LLSTSMDKTFKVWnAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHP 343
Cdd:COG2319     9 LAAASADLALALL-AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 344 KDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQIF 423
Cdd:COG2319    88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-------SADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 424 HERfTCPSLALHPrepvflaqtNGNYLALFST-----VW-PYRMSRRRRYEGHKVEGYSVgcECSPGGDLLVTGSADGRV 497
Cdd:COG2319   161 HSG-AVTSVAFSP---------DGKLLASGSDdgtvrLWdLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTV 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1186518018 498 LMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 543
Cdd:COG2319   229 RLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
236-323 6.31e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 6.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 236 RKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFA 315
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSP---DGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                  ....*...
gi 1186518018 316 LHLTDLET 323
Cdd:COG2319   396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-544 1.51e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518018 456 VWPY-RMSRRRRYEGHKVEGysVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPvLPSVLATC 534
Cdd:cd00200    35 VWDLeTGELLRTLKGHTGPV--RDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSS 111

                          90
                  ....*....|
gi 1186518018 535 SWGGDMKIWH 544
Cdd:cd00200   112 SRDKTIKVWD 121
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-277 7.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1186518018  235 PRKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWN 277
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-277 1.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1186518018 236 RKVLFHLRGHRGPVNTIQWCPvlsKSHMLLSTSMDKTFKVWN 277
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 281-320 3.94e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1186518018  281 SGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTD 320
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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