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Conserved domains on  [gi|1189690212|ref|NP_001338293|]
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synembryn-B isoform 8 [Homo sapiens]

Protein Classification

synembryn( domain architecture ID 10562755)

synembryn is a guanine nucleotide exchange factor (GEF) which promotes exchange of bound GDP for free GTP, similar to human synembryn-A (also known as Ric-8A) and synembryn-B (also known as Ric-8B)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 26-484 7.60e-158

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


:

Pssm-ID: 462973  Cd Length: 412  Bit Score: 454.35  E-value: 7.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212  26 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEkvsefpVIVESLKCLCNIVFNSQMAQQ--LSLELNLAAK 103
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 104 LCNLLrkCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIdhngPPLSPQE 183
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSA----SSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 184 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 263
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 264 etaqeattldelpsnktaeketvlknntmvYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 343
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 344 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 422
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1189690212 423 GDNWYSEDEDTDTEEYKNAKPNINLITGHLEEPMP-NPIDEMTEEQKEYEAMKLVNMLDKLSR 484
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLKR 411
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 26-484 7.60e-158

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 454.35  E-value: 7.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212  26 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEkvsefpVIVESLKCLCNIVFNSQMAQQ--LSLELNLAAK 103
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 104 LCNLLrkCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIdhngPPLSPQE 183
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSA----SSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 184 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 263
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 264 etaqeattldelpsnktaeketvlknntmvYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 343
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 344 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 422
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1189690212 423 GDNWYSEDEDTDTEEYKNAKPNINLITGHLEEPMP-NPIDEMTEEQKEYEAMKLVNMLDKLSR 484
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLKR 411
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 26-484 7.60e-158

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 454.35  E-value: 7.60e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212  26 CLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEkvsefpVIVESLKCLCNIVFNSQMAQQ--LSLELNLAAK 103
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDSAGSSE------VSREALRCLANALLLSPEARQifVDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 104 LCNLLrkCKDRKFINDIKCFDLRLLFLLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIdhngPPLSPQE 183
Cdd:pfam10165  75 ACEKL--KLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSA----SSLSPME 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 184 TDCAIEALKALFNVTVDSWKvhKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVlicplthe 263
Cdd:pfam10165 149 DMALTETLKLLFNLTLFYPD--LVPDSAFSPALPPILRLLLLLPIPSPDPLEPPLSHLINALLNLPLTDSKK-------- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 264 etaqeattldelpsnktaeketvlknntmvYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKF 343
Cdd:pfam10165 219 ------------------------------YEGNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1189690212 344 LKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDL-GVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGR 422
Cdd:pfam10165 269 LRAKLLPPLKDRKKRLEKGDTLRGRLLRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGN 348

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1189690212 423 GDNWYSEDEDTDTEEYKNAKPNINLITGHLEEPMP-NPIDEMTEEQKEYEAMKLVNMLDKLSR 484
Cdd:pfam10165 349 AGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLKR 411
Flg_bbr_C pfam06429
Flagellar basal body rod FlgEFG protein C-terminal; This family consists of a number of ...
 423-486 1.93e-03

Flagellar basal body rod FlgEFG protein C-terminal; This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which pfam00460 is often present at the extreme N terminus.


Pssm-ID: 428939 [Multi-domain]  Cd Length: 74  Bit Score: 36.86  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1189690212 423 GDNWYSEdedTDTEEYKNAKPNINLITGHLEEPMPNPIDEMT---EEQKEYEA-MKLVNMLDKLSRRA 486
Cdd:pfam06429   7 GDNLFRE---TDGAPILGAGADGRVQQGYLEGSNVNPVEEMVnmiEAQRAYEAnSKVIQTADEMLQTA 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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