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Conserved domains on  [gi|1209857033|ref|NP_001339879|]
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DNA repair-scaffolding protein isoform 20 [Homo sapiens]

Protein Classification

scaffold protein involved in DNA repair( domain architecture ID 10386025)

scaffold protein involved in DNA repair (SPIDR) is a DUF4503 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
357-650 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


:

Pssm-ID: 464397  Cd Length: 385  Bit Score: 562.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 357 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 436
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 437 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 516
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 517 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 596
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1209857033 597 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRAT 650
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGT 294
DUF4502 super family cl20831
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-205 4.33e-127

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


The actual alignment was detected with superfamily member pfam14950:

Pssm-ID: 464396  Cd Length: 384  Bit Score: 380.43  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  11 EPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAK 90
Cdd:pfam14950 189 KPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  91 K-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVA 169
Cdd:pfam14950 269 KkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPA 348
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1209857033 170 PRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 205
Cdd:pfam14950 349 PRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
357-650 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 562.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 357 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 436
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 437 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 516
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 517 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 596
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1209857033 597 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRAT 650
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGT 294
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-205 4.33e-127

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 380.43  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  11 EPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAK 90
Cdd:pfam14950 189 KPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  91 K-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVA 169
Cdd:pfam14950 269 KkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPA 348
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1209857033 170 PRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 205
Cdd:pfam14950 349 PRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
357-650 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 562.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 357 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 436
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 437 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 516
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033 517 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 596
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1209857033 597 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRAT 650
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGT 294
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
11-205 4.33e-127

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 380.43  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  11 EPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAK 90
Cdd:pfam14950 189 KPSSTEILEYSSDSEKEDDPEHVLFIDSESPHKYHMDFGSDARQVMEKSKSARVKSTETILQTPQKQTAKFPKTPEDSAK 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857033  91 K-KLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVA 169
Cdd:pfam14950 269 KkKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPA 348
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1209857033 170 PRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 205
Cdd:pfam14950 349 PRPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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