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Conserved domains on  [gi|1246764171|ref|NP_001342680|]
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carbonic anhydrase 14 isoform 3 [Mus musculus]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 10123249)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
20-269 3.32e-174

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


:

Pssm-ID: 239400  Cd Length: 249  Bit Score: 482.80  E-value: 3.32e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 99
Cdd:cd03126     1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 100 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 179
Cdd:cd03126    81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 180 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 259
Cdd:cd03126   160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                         250
                  ....*....|
gi 1246764171 260 LNQRTIFASF 269
Cdd:cd03126   240 FNERLVFASF 249
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
20-269 3.32e-174

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 482.80  E-value: 3.32e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 99
Cdd:cd03126     1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 100 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 179
Cdd:cd03126    81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 180 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 259
Cdd:cd03126   160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                         250
                  ....*....|
gi 1246764171 260 LNQRTIFASF 269
Cdd:cd03126   240 FNERLVFASF 249
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
19-269 2.36e-119

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 343.86  E-value: 2.36e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  19 HGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPlDLHNNGHTVQLSL----PPTLHLGGLPRKY 94
Cdd:pfam00194   1 LGPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKN-TLTNNGHTVQVSLddgdPSTISGGPLATRY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  95 TAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHE 174
Cdd:pfam00194  80 RLVQFHFHWGSTDS-RGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 175 IRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNY 254
Cdd:pfam00194 158 IKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNF 237
                         250
                  ....*....|....*
gi 1246764171 255 RVPQPLNQRTIFASF 269
Cdd:pfam00194 238 RPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
16-264 6.21e-101

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 296.92  E-value: 6.21e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171   16 TGPHGQDHWPTSYPE-CGGDAQSPINIQTDSVIFDPDLPAVQPHgYDQLGtePLDLHNNGHTVQLSLP---PTLHLGGLP 91
Cdd:smart01057   4 EGKNGPEHWGKLDPPfCGGKRQSPIDIVTAEAQYDPSLKPLKLS-YDQPT--AKRILNNGHTVQVNFDddgSTLSGGPLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171   92 RKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSysSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSR 171
Cdd:smart01057  81 GRYRLKQFHFHWGGSDS-EGSEHTIDGKRFPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEENPALQAILDH 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  172 LHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEdpsEPLV 251
Cdd:smart01057 158 LPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGN---EPLV 234
                          250
                   ....*....|...
gi 1246764171  252 QNYRVPQPLNQRT 264
Cdd:smart01057 235 NNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
16-268 6.52e-50

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 166.60  E-value: 6.52e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  16 TGPHGQDHWPT---SYPECG-GDAQSPINIqTDSVifDPDLPAVQPHgYdqlGTEPLDLHNNGHTVQLSLPP--TLHLGG 89
Cdd:COG3338    31 EGETGPEHWGElspEFATCAtGKNQSPIDI-RTAI--KADLPPLKFD-Y---KPTPLEIVNNGHTIQVNVDPgsTLTVDG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  90 lpRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqkPQG-LAVLGILIEVGEtENPAYDHI 168
Cdd:COG3338   104 --KRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKD-------------ADGeLAVVGVLFEEGA-ENPALAKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 169 LSRLHEIRyKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSteedpse 248
Cdd:COG3338   161 WANLPLEA-GEEVALDATIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARLYPN------- 231
                         250       260
                  ....*....|....*....|
gi 1246764171 249 plvqNYRVPQPLNQRTIFAS 268
Cdd:COG3338   232 ----NARPVQPLNGRLILES 247
PLN02202 PLN02202
carbonate dehydratase
17-265 4.34e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 77.02  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  17 GPHGQDHWPTSYPECG-GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTepldLHNngHTVQLSLPPTLHLGGL---PR 92
Cdd:PLN02202   38 GPNQWGHLNPHFTKCAvGKLQSPIDIQRRQIFYNHKLESIHRDYYFTNAT----LVN--HVCNVAMFFGEGAGDViidNK 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  93 KYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHydsqsysslseaAQKPQGLAVLGILIEVGeTENPAYDHI---L 169
Cdd:PLN02202  112 NYTLLQMHWH-------TPSEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIG-TEEPFLSQMkdkL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 170 SRLHEIRYKDQKTS---VPPFSVRELfPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDP 246
Cdd:PLN02202  172 VKLKEERFKGNHTAqveVGKIDTRHI-ERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDKSFKNN 250
                         250
                  ....*....|....*....
gi 1246764171 247 SEPLvqnyrvpQPLNQRTI 265
Cdd:PLN02202  251 SRPC-------QPLNGRRV 262
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
20-269 3.32e-174

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 482.80  E-value: 3.32e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLPRKYTAAQL 99
Cdd:cd03126     1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEQFTLTNNGHTVQLSLPPTMHIGGLPFKYTASQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 100 HLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 179
Cdd:cd03126    81 HLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGP-FNPSYEKIFSHLHEVKYKD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 180 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQP 259
Cdd:cd03126   160 QKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQP 239
                         250
                  ....*....|
gi 1246764171 260 LNQRTIFASF 269
Cdd:cd03126   240 FNERLVFASF 249
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
20-269 1.56e-157

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 440.59  E-value: 1.56e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLGGLP-RKYTAAQ 98
Cdd:cd03123     1 GEDHWPKKYPACGGKRQSPIDIQTDIVQFDPSLPPLELVGYDLPGTEEFTLTNNGHTVQLSLPPTMHIRGGPgTEYTAAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  99 LHLHWGQRGSLEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYK 178
Cdd:cd03123    81 LHLHWGGRGSLSGSEHTIDGIRFAAELHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGYPENTYYEKIISHLHEIKYK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 179 DQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEedpSEPLVQNYRVPQ 258
Cdd:cd03123   161 GQETTVPGFNVRELLPEDLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLENTLMDTH---NKTLQNNYRATQ 237
                         250
                  ....*....|.
gi 1246764171 259 PLNQRTIFASF 269
Cdd:cd03123   238 PLNGRVVEASF 248
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
19-269 2.36e-119

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 343.86  E-value: 2.36e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  19 HGQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPlDLHNNGHTVQLSL----PPTLHLGGLPRKY 94
Cdd:pfam00194   1 LGPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKN-TLTNNGHTVQVSLddgdPSTISGGPLATRY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  95 TAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHE 174
Cdd:pfam00194  80 RLVQFHFHWGSTDS-RGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 175 IRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNY 254
Cdd:pfam00194 158 IKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNF 237
                         250
                  ....*....|....*
gi 1246764171 255 RVPQPLNQRTIFASF 269
Cdd:pfam00194 238 RPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
16-264 6.21e-101

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 296.92  E-value: 6.21e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171   16 TGPHGQDHWPTSYPE-CGGDAQSPINIQTDSVIFDPDLPAVQPHgYDQLGtePLDLHNNGHTVQLSLP---PTLHLGGLP 91
Cdd:smart01057   4 EGKNGPEHWGKLDPPfCGGKRQSPIDIVTAEAQYDPSLKPLKLS-YDQPT--AKRILNNGHTVQVNFDddgSTLSGGPLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171   92 RKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSysSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSR 171
Cdd:smart01057  81 GRYRLKQFHFHWGGSDS-EGSEHTIDGKRFPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEENPALQAILDH 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  172 LHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEdpsEPLV 251
Cdd:smart01057 158 LPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGN---EPLV 234
                          250
                   ....*....|...
gi 1246764171  252 QNYRVPQPLNQRT 264
Cdd:smart01057 235 NNARPLQPLNGRV 247
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
33-266 6.10e-98

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 288.41  E-value: 6.10e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  33 GDAQSPINIQTDSVIFDPDLPAVQPHGYDqlgTEPLDLHNNGHTVQLSLP---PTLHLGGLPRKYTAAQLHLHWGQRGSl 109
Cdd:cd00326     1 GKRQSPINIVTSAVVYDPSLPPLNFDYYP---TTSLTLVNNGHTVQVNFDddgGTLSGGGLPGRYKLVQFHFHWGSENS- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 110 EGSEHQINSEATAAELHVVHYDSQSYSSlsEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSV 189
Cdd:cd00326    77 PGSEHTIDGKRYPLELHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGEKENPFLKKILDALPKIKYKGKETTLPPFDL 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246764171 190 RELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeedpSEPLVQNYRVPQPLNQRTIF 266
Cdd:cd00326   155 SDLLPSSLRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDRE----GKPLVNNYRPVQPLNGRVVY 227
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
33-267 3.58e-91

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 271.45  E-value: 3.58e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  33 GDAQSPINIQTDSVIFDPDLPAVQPHGYDqLGTEPLDLHNNGHTVQLSLPPTLHL--GGLPRKYTAAQLHLHWGQRGSlE 110
Cdd:cd03117     1 GKRQSPINIVTKKVQYDENLTPFTFTGYD-DTTTNWTITNNGHTVQVTLPDGAKIsgGGLPGTYKALQFHFHWGSNGS-P 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 111 GSEHQINSEATAAELHVVHYDSqSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYKDQKTSVPPFSVR 190
Cdd:cd03117    79 GSEHTIDGERYPMELHIVHIKE-SYNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTPFSLR 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246764171 191 ELFPQQ-LEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeEDPSEPLVQNYRVPQPLNQRTIFA 267
Cdd:cd03117   158 SLLPSVlLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFD-TDNGQPMVNNFRPVQPLNGRVVYA 234
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
20-269 9.46e-86

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 258.35  E-value: 9.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEPLDLHNNGHTVQLSLPPTLHLG-GLPRKYTAAQ 98
Cdd:cd03150     1 GQPPWPSVSPACAGRFQSPVDIRPHLVAFCPALRPLELLGFDLPPSPSLRLLNNGHTVQLSLPSGLRMAlGPGQEYRALQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  99 LHLHWGQRGsLEGSEHQINSEATAAELHVVHYDSqSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRLHEIRYK 178
Cdd:cd03150    81 LHLHWGAAG-RPGSEHTVDGHRFPAEIHVVHLST-AFANLDEALGRPGGLAVLAAFLAEGLHENSAYEQLLSRLSEISEE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 179 DQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSteedPSEPLVQ-NYRVP 257
Cdd:cd03150   159 ESETVVPGLDVSALLPSDLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSDSLWG----PHDSRLQlNFRAT 234
                         250
                  ....*....|..
gi 1246764171 258 QPLNQRTIFASF 269
Cdd:cd03150   235 QPLNGRKIEASF 246
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
20-269 3.34e-80

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 244.31  E-value: 3.34e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEpLDLHNNGHTVQLSLPPTLHLG-GLPRKYTAAQ 98
Cdd:cd03125     1 DESHWPEKYPACGGKRQSPIDIQRREVRFNPSLLQLELVGYEKEQGE-FTMTNNGHTVQIDLPPTMSITtGDGTVYTAVQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  99 LHLHWGQRGS-LEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGE-TENPAYDHILSRLHEIR 176
Cdd:cd03125    80 MHFHWGGRDSeISGSEHTIDGMRYVAELHIVHYNSK-YKSYEEAKDKPDGLAVLAFLYKVGHyAENTYYSDFISKLAKIK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 177 YKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSsteeDPSEPLVQN-YR 255
Cdd:cd03125   159 YAGQTTTLTSLDVRDMLPENLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLM----DHHNKTIRNdYR 234
                         250
                  ....*....|....
gi 1246764171 256 VPQPLNQRTIFASF 269
Cdd:cd03125   235 RTQPLNHRVVEANF 248
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
17-269 4.45e-65

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 205.75  E-value: 4.45e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  17 GPH-GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLpavQPHGYDQLGTEPLDLHNNGHTVQLSLPPT-----LHLGGL 90
Cdd:cd03119     8 DSHnGPEHWHELFPIAKGDRQSPIDIKTKDAKHDPSL---KPLSVSYDPATAKTILNNGHSFNVEFDDTddrsvLRGGPL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  91 PRKYTAAQLHLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQsYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILS 170
Cdd:cd03119    85 TGSYRLRQFHFHWGSSDD-HGSEHTVDGVKYAAELHLVHWNSK-YGSFGEAAKQPDGLAVVGVFLKVGE-ANPELQKVLD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 171 RLHEIRYKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPL 250
Cdd:cd03119   162 ALDSIKTKGKQAPFTNFDPSCLLPASLD-YWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGEPPCPM 240
                         250
                  ....*....|....*....
gi 1246764171 251 VQNYRVPQPLNQRTIFASF 269
Cdd:cd03119   241 VDNWRPPQPLKGRKVRASF 259
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
33-269 4.46e-60

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 192.36  E-value: 4.46e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  33 GDAQSPINIQTDSVIFDPDLpavQPHGYDQLGTEPLDLHNNGHTVQLSLPPT-----LHLGGLPRKYTAAQLHLHWGQRG 107
Cdd:cd03149     1 GNRQSPIDIVSSEAVYDPKL---KPLSLSYDPCTSLSISNNGHSVMVEFDDSddktvITGGPLENPYRLKQFHFHWGAKH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 108 SlEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKDQKTSVPPF 187
Cdd:cd03149    78 G-SGSEHTVDGKTFPSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGD-EHPGLNRLTDALYMVRFKGTKAQFLDF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 188 SVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFA 267
Cdd:cd03149   156 NPKCLLPKSLD-YWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNHMVNNFRPPQPLKGRTVRA 234

                  ..
gi 1246764171 268 SF 269
Cdd:cd03149   235 SF 236
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
20-267 2.78e-57

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 185.64  E-value: 2.78e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPECGGDA-QSPINIQTDSVIfdpDLPAVQPHGYDQLGTEPLD--LHNNGHTVQLSLP-----PTLHLGGLP 91
Cdd:cd03122     1 NPKHWAKKYPACGEGRqQSPIDIVEDTQV---QRQGLQPLHFDGYEELTASttLENTGKTVILRLEgnssdPFVSGGPLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  92 RKYTAAQLHLHWGQRGSLeGSEHQINSEATAAELHVVHYDSQSYSSLsEAAQKPQGLAVLGILIEVGETENPAYDHILSR 171
Cdd:cd03122    78 GRYKFSEITFHWGTCNSD-GSEHSIDGHKFPLEMQILHRNTDFFDSF-EAIKSPGGVLALAYLFELSHEDNPFLDPIIEG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 172 LHEIRYKDQKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQEtLSSTEEDPS---E 248
Cdd:cd03122   156 LRNVSRPGKEVELPPFPLSDLLPPFTDKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRE-LLTRRQDGVmsgD 234
                         250
                  ....*....|....*....
gi 1246764171 249 PLVQNYRVPQPLNQRTIFA 267
Cdd:cd03122   235 YLPNNGRPQQPLGSRTVFS 253
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
20-265 1.00e-51

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 170.14  E-value: 1.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  20 GQDHWPTSYPE---CG-GDAQSPINIQTDSVIFDPDLP-AVQPHgydqlgTEPLDLHNNGHTVQLSLPP---TLHLGGlp 91
Cdd:cd03124     1 GPEHWGNLDPEfalCAtGKNQSPIDITTKAVVSDKLPPlNYNYK------PTSATLVNNGHTIQVNFEGnggTLTIDG-- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  92 RKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqKPQGLAVLGILIEVGEtENPAYDHILSR 171
Cdd:cd03124    73 ETYQLLQFHFH-------SPSEHLINGKRYPLEAHLVHKS------------KDGQLAVVAVLFEEGK-ENPFLKKILDN 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 172 LHEIryKDQKTSVPPFS-VRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTeedpsepl 250
Cdd:cd03124   133 MPKK--EGTEVNLPAILdPNELLPESRS-YYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYPN-------- 201
                         250
                  ....*....|....*
gi 1246764171 251 vqNYRVPQPLNQRTI 265
Cdd:cd03124   202 --NARPVQPLNGREV 214
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
33-265 3.79e-51

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 169.90  E-value: 3.79e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  33 GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTEpldLHNNGHTVQLSLPPTLHL----GGLPRKYTAAQLHLHWGQRGS 108
Cdd:cd03121    18 GRRQSPVDIEPSRLLFDPFLTPLRIDTGRKVSGT---FYNTGRHVSFRPDKDPVVnisgGPLSYRYRLEEIRLHFGREDE 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 109 lEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGETENPAYDHILSRL--HEIRYKDQKTSVPP 186
Cdd:cd03121    95 -QGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETSNPELRRLTNRDtiTSIRYKGDAYFLQD 173
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246764171 187 FSVRELFPQQlEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTI 265
Cdd:cd03121   174 LSIELLLPET-DHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPMSPNFRPVQPLNNRPV 251
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
16-268 6.52e-50

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 166.60  E-value: 6.52e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  16 TGPHGQDHWPT---SYPECG-GDAQSPINIqTDSVifDPDLPAVQPHgYdqlGTEPLDLHNNGHTVQLSLPP--TLHLGG 89
Cdd:COG3338    31 EGETGPEHWGElspEFATCAtGKNQSPIDI-RTAI--KADLPPLKFD-Y---KPTPLEIVNNGHTIQVNVDPgsTLTVDG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  90 lpRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDsqsysslseaaqkPQG-LAVLGILIEVGEtENPAYDHI 168
Cdd:COG3338   104 --KRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKD-------------ADGeLAVVGVLFEEGA-ENPALAKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 169 LSRLHEIRyKDQKTSVPPFSVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSteedpse 248
Cdd:COG3338   161 WANLPLEA-GEEVALDATIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARLYPN------- 231
                         250       260
                  ....*....|....*....|
gi 1246764171 249 plvqNYRVPQPLNQRTIFAS 268
Cdd:COG3338   232 ----NARPVQPLNGRLILES 247
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
33-269 6.78e-45

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 153.08  E-value: 6.78e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  33 GDAQSPINIQTDSVIFDPDLPAVQPHgYDqlGTEPLDLHNNGHTVQLSL-----PPTLHLGGLPRKYTAAQLHLHWGQRG 107
Cdd:cd03118     1 GTRQSPINIQWRDSVYDPQLAPLRVS-YD--PATCLYIWNNGYSFQVEFddstdKSGISGGPLENHYRLKQFHFHWGANN 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 108 SLeGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKDQKTSVPPF 187
Cdd:cd03118    78 EW-GSEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGA-HHEGLQKLVDALPEVRHKDTVVEFNPF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 188 SVRELFPQQLEqFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEPLVQNYRVPQPLNQRTIFA 267
Cdd:cd03118   156 DPSCLLPACRD-YWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRS 234

                  ..
gi 1246764171 268 SF 269
Cdd:cd03118   235 SF 236
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
24-269 8.58e-45

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 153.47  E-value: 8.58e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  24 WPTSYPECGGDAQSPINIQTDSVIFDPDLPAVqPHGYDQLGTEPLDLHNNGHTVQLSLP--PTLHLGGLPR--KYTAAQL 99
Cdd:cd03120     4 WGLLFPEANGEYQSPINLNSREARYDPSLLEV-RLSPNYVVCRDCEVINDGHTIQIILKskSVLSGGPLPQghEFELAEV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 100 HLHWGQRGSlEGSEHQINSEATAAELHVVHYDSQSYSSLSEAAQKPQGLAVLGILIEVGEtENPAYDHILSRLHEIRYKD 179
Cdd:cd03120    83 RFHWGRENQ-RGSEHTVNFKAFPMELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGK-EHVGLKAVTEILQDIQYKG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 180 QKTSVPPFSVRELFPQ-QLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDPSEP-----LVQN 253
Cdd:cd03120   161 KSKTIPCFNPNTLLPDpLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEgcdglLGDN 240
                         250
                  ....*....|....*.
gi 1246764171 254 YRVPQPLNQRTIFASF 269
Cdd:cd03120   241 FRPTQPLSDRVIRAAF 256
PLN02202 PLN02202
carbonate dehydratase
17-265 4.34e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 77.02  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  17 GPHGQDHWPTSYPECG-GDAQSPINIQTDSVIFDPDLPAVQPHGYDQLGTepldLHNngHTVQLSLPPTLHLGGL---PR 92
Cdd:PLN02202   38 GPNQWGHLNPHFTKCAvGKLQSPIDIQRRQIFYNHKLESIHRDYYFTNAT----LVN--HVCNVAMFFGEGAGDViidNK 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  93 KYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHydsqsysslseaAQKPQGLAVLGILIEVGeTENPAYDHI---L 169
Cdd:PLN02202  112 NYTLLQMHWH-------TPSEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIG-TEEPFLSQMkdkL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171 170 SRLHEIRYKDQKTS---VPPFSVRELfPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEEDP 246
Cdd:PLN02202  172 VKLKEERFKGNHTAqveVGKIDTRHI-ERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDKSFKNN 250
                         250
                  ....*....|....*....
gi 1246764171 247 SEPLvqnyrvpQPLNQRTI 265
Cdd:PLN02202  251 SRPC-------QPLNGRRV 262
PLN02179 PLN02179
carbonic anhydrase
17-223 4.65e-11

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 61.92  E-value: 4.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  17 GPHGQDHWPTSYPECG-GDAQSPINIQTD--SVIFDPDLPAvqphgydQLGTEPLDLHNNGHTVQLSLPP-----TLHlg 88
Cdd:PLN02179   46 GPAEWGKLNPQWKVCStGKYQSPIDLTDErvSLIHDQALSR-------HYKPAPAVIQSRGHDVMVSWKGdagkiTIH-- 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246764171  89 glPRKYTAAQLHLHwgqrgslEGSEHQINSEATAAELHVVHYDSQSYSslseaaqkpqglAVLGILIEVGETeNPAYDHI 168
Cdd:PLN02179  117 --QTDYKLVQCHWH-------SPSEHTINGTSYDLELHMVHTSASGKT------------AVVGVLYKLGEP-DEFLTKL 174
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1246764171 169 LSRLHEIRYKDQKTS-VPPFSVRelfpQQLEQFFRYNGSLTTPPCYQSVLWTVFNR 223
Cdd:PLN02179  175 LNGIKGVGKKEINLGiVDPRDIR----FETNNFYRYIGSLTIPPCTEGVIWTVVKR 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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