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Conserved domains on  [gi|1269612335|ref|NP_001344219.1|]
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transmembrane reductase CYB561D2 isoform b [Mus musculus]

Protein Classification

cytochrome b561 domain-containing protein( domain architecture ID 10171790)

cytochrome b561 domain-containing protein (CYB561D) similar to mammalian CYB561D2, also called transmembrane ascorbate ferrireductase, a two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 9-171 7.20e-36

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176491  Cd Length: 183  Bit Score: 123.55  E-value: 7.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   9 GLFSWHPVLMSLAFSFLMTEALLMFSPESSLLRsLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQ 88
Cdd:cd08761    19 SLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  89 AGLLAVLWAGLQCSGGMGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMFSLWFTATVTGGA-WYLAVLCP 165
Cdd:cd08761    98 LGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFSKNVTHVAlWYLALAVA 177


                  ....*.
gi 1269612335 166 ILTSLV 171
Cdd:cd08761   178 LALAGV 183
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 9-171 7.20e-36

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 123.55  E-value: 7.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   9 GLFSWHPVLMSLAFSFLMTEALLMFSPESSLLRsLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQ 88
Cdd:cd08761    19 SLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  89 AGLLAVLWAGLQCSGGMGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMFSLWFTATVTGGA-WYLAVLCP 165
Cdd:cd08761    98 LGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFSKNVTHVAlWYLALAVA 177


                  ....*.
gi 1269612335 166 ILTSLV 171
Cdd:cd08761   178 LALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 13-133 2.46e-23

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 89.97  E-value: 2.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  13 WHPVLMSLAFSFLMTEALLMFSpeSSLLRSLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQAGLL 92
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1269612335  93 AVLWAGLQCSGGMGLLYPKLLPRWPLAKLKLYHATSGLVGY 133
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIF 119
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 13-133 1.24e-18

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 77.66  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   13 WHPVLMSLAFSFLMTEALLMFSPessLLRSLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQAGLL 92
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARP---LTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1269612335   93 AVLWAGLQCSGGMGLLYPKLLPRWPLAKLKLYHATSGLVGY 133
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAF 118
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 9-171 7.20e-36

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 123.55  E-value: 7.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   9 GLFSWHPVLMSLAFSFLMTEALLMFSPESSLLRsLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQ 88
Cdd:cd08761    19 SLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  89 AGLLAVLWAGLQCSGGMGLLYPKLLPR--WPLAKLKLYHATSGLVGYLLGSASLLLGMFSLWFTATVTGGA-WYLAVLCP 165
Cdd:cd08761    98 LGLVTVILIVLQALGGLALLYPPGLRRgeSKAKKLKKYHRLSGYVAYLLGLATLVLGLETRWFSKNVTHVAlWYLALAVA 177


                  ....*.
gi 1269612335 166 ILTSLV 171
Cdd:cd08761   178 LALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 13-133 2.46e-23

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 89.97  E-value: 2.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  13 WHPVLMSLAFSFLMTEALLMFSpeSSLLRSLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQAGLL 92
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1269612335  93 AVLWAGLQCSGGMGLLYPKLLPRWPLAKLKLYHATSGLVGY 133
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIF 119
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 13-133 1.24e-18

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 77.66  E-value: 1.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   13 WHPVLMSLAFSFLMTEALLMFSPessLLRSLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQAGLL 92
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARP---LTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1269612335   93 AVLWAGLQCSGGMGLLYPKLLPRWPLAKLKLYHATSGLVGY 133
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAF 118
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 11-133 4.01e-17

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 73.47  E-value: 4.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335  11 FSWHPVLMSLAFSFLMTEALLMFSpessLLRSLSRKVRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLTTRHGQAG 90
Cdd:cd08554     2 FNWHPLLMVIGFVFLMGEALLVYR----VFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1269612335  91 LLAVLWAGLQCSGGMGLLYPKLLPRWPLAKLKLYHATSGLVGY 133
Cdd:cd08554    78 LATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIF 120
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 8-133 2.95e-03

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 36.92  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612335   8 PGL-FSWHPVLMSLAFSFLMTEALLMFspesSLLRSlSRKVRARC-HWVLQLLALLCALLGLGLVI--LHKEQLGKAHLT 83
Cdd:cd08764    20 PGLqFNWHPLLMVLGLIFLYGNSILVY----RVFRN-TRKKRLKLlHAVLHLLAFILAVIGLKAVFdsHNLAKPPIPNMY 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1269612335  84 TRHGQAGLLAVLWAGLQCSGG-MGLLYPKlLPRWPLAKLKLYHATSGLVGY 133
Cdd:cd08764    95 SLHSWLGLTAVILFSLQWVGGfVSFLFPG-LPETLRAAYLPLHVFFGLFIF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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