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Conserved domains on  [gi|1276740351|ref|NP_001344924|]
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zinc finger protein 76 isoform 1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 6.57e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.96  E-value: 6.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1276740351 328 EYSSlyKHHVVHTHCKPYTCSSCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 6.57e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.96  E-value: 6.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1276740351 328 EYSSlyKHHVVHTHCKPYTCSSCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 4.48e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 4.48e-06
                          10        20
                  ....*....|....*....|....*..
gi 1276740351 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-366 6.57e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.96  E-value: 6.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 254 PFRCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 327
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1276740351 328 EYSSlyKHHVVHTHCKPYTCSSCGKTYRQTSTLAMHKRS 366
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-336 4.40e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351  94 STAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTVVALEQYASKVLHDSpASHNGKGQQvgdraFRCgyKGCG 173
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS-SSEKGFSLP-----IKS--KQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 174 RLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTSGDLQ 243
Cdd:COG5048   297 ISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPPQSLQ 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 244 KHVRTHTgERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCtvpgCG 323
Cdd:COG5048   377 QYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SI 451

                         250
                  ....*....|...
gi 1276740351 324 KRFTEYSSLYKHH 336
Cdd:COG5048   452 LKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 311-368 9.48e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.72  E-value: 9.48e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740351 311 GEKPYVCTVPGCGKRFTEYSSLyKHHVVHTHC--------------------KPYTCSSCGKTYRQTSTLAMHKRSAH 368
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-340 1.66e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740351 283 RPYTCPEphCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHT 340
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-257 3.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740351 192 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRC 257
Cdd:COG5048    31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 4.48e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 4.48e-06
                          10        20
                  ....*....|....*....|....*..
gi 1276740351 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 191-280 8.78e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 8.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 191 GDRPYRCDFPSCGKAFATGYGLKSH-VRTHTGEKPYKCPEELCSKAFKTSgdlqkhvrthtgERPFRCPFegCGRSFTTS 269
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|.
gi 1276740351 270 NIRKVHvRTHT 280
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-268 4.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.14e-05
                          10        20
                  ....*....|....*....|....*...
gi 1276740351 241 DLQKHVRTHTGERPFRCPFegCGRSFTT 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 144-220 9.56e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740351 144 KVLHDSPASHNGKGQQ---VGDRAFRCGYKGCGRLYTTAHHLKVH---------------ERAHTG----DRPYRCDFps 201
Cdd:COG5189   326 KLAHGGERNIDTPSRMlkvKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV-- 403

                          90
                  ....*....|....*....
gi 1276740351 202 CGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   404 CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-327 3.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.80e-04
                          10        20
                  ....*....|....*....|....*..
gi 1276740351 301 NYKNHVRIHTGEKPYVCTVpgCGKRFT 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-208 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*...
gi 1276740351 181 HLKVHERAHTGDRPYRCdfPSCGKAFAT 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-314 2.10e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740351 253 RPFRCPFegCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKP 314
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-280 2.97e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.97e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740351 223 KPYKCPEelCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHT 280
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 3.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.33e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740351 273 KVHVRTHTGERPYTCPEphCGRGFTS 298
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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