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Conserved domains on  [gi|1375023043|ref|NP_001349049|]
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WD repeat-containing protein 54 isoform b [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
68-215 1.63e-07

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  68 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 147
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043 148 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 215
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
68-215 1.63e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  68 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 147
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043 148 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 215
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-213 6.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  64 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 143
Cdd:cd00200   148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023043 144 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 213
Cdd:cd00200   218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
68-215 1.63e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  68 VGTCSGRVLVFDIPAKgpniVLSEELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWrSGPEFTLLTRIPGFGVP 147
Cdd:COG2319   263 SGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAF-SPDGKL----LASGSDDGTVRLW-DLATGKLLRTLTGHTGA 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043 148 CPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKLN 215
Cdd:COG2319   333 VRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-213 6.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  64 HFICVGTCSGRVLVFDIPakgpNIVLSEELAGHQTPITDIAteraQGQDGvADMVTADDSGVLCVWRSgPEFTLLTRIPG 143
Cdd:cd00200   148 TFVASSSQDGTIKLWDLR----TGKCVATLTGHTGEVNSVA----FSPDG-EKLLSSSSDGTIKLWDL-STGKCLGTLRG 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023043 144 FGVPCPSVQL--WQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWK 213
Cdd:cd00200   218 HENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
88-214 4.87e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 4.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  88 VLSEELAGHQTPITDIATERAQGQDGVADMVTADDSGVLCVWRSGPEFTLLTRIPGFGVPCPSVQLWQGIVAAGYGNGQV 167
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1375023043 168 RLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVHIWKL 214
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 COG2319
WD40 repeat [General function prediction only];
92-215 1.37e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  92 ELAGHQTPITDIATeRAQGQDgvadMVTADDSGVLCVWRSgPEFTLLTRIPGFGVPCPSVQLWQG--IVAAGYGNGQVRL 169
Cdd:COG2319   157 TLTGHSGAVTSVAF-SPDGKL----LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRL 230

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1375023043 170 YDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 215
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLaSGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-215 1.82e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  55 FARGIAASVHFICVGTCS--GRVLVFDIPAKgpniVLSEELAGHQTPITDIAterAQGQDGVAdmVTADDSGVLCVWrSG 132
Cdd:cd00200    53 PVRDVAASADGTYLASGSsdKTIRLWDLETG----ECVRTLTGHTSYVSSVA---FSPDGRIL--SSSSRDKTIKVW-DV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043 133 PEFTLLTRIPGF--GVPCPSVQLWQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEVGKLLSAAEDTFVH 210
Cdd:cd00200   123 ETGKCLTTLRGHtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202


                  ....*
gi 1375023043 211 IWKLN 215
Cdd:cd00200   203 LWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
73-215 1.06e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023043  73 GRVLVFDIPAKGpnivLSEELAGHQTPITDIATeraqGQDG--VAdmvTADDSGVLCVW--RSGPEFTLLTRiPGFGVPC 148
Cdd:COG2319   184 GTVRLWDLATGK----LLRTLTGHTGAVRSVAF----SPDGklLA---SGSADGTVRLWdlATGKLLRTLTG-HSGSVRS 251

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375023043 149 PSVQLWQGIVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKLN 215
Cdd:COG2319   252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLaSGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
157-214 4.61e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 4.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375023043 157 IVAAGYGNGQVRLYDASTGALHVQISAHARTISALDLAPEvGKLL-SAAEDTFVHIWKL 214
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLaSGSDDGTVRLWDL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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