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Conserved domains on  [gi|1383485555|ref|NP_001349640|]
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organic cation/carnitine transporter 2 isoform 2 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-277 5.72e-133

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 387.06  E-value: 5.72e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNS 80
Cdd:TIGR00898 230 VLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSS 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 TKPQlHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:TIGR00898 310 SKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTM 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:TIGR00898 389 AASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYL 468

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDT 277
Cdd:TIGR00898 469 GEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-277 5.72e-133

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 387.06  E-value: 5.72e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNS 80
Cdd:TIGR00898 230 VLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSS 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 TKPQlHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:TIGR00898 310 SKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTM 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:TIGR00898 389 AASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYL 468

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDT 277
Cdd:TIGR00898 469 GEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 1-267 2.25e-108

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 318.64  E-value: 2.25e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17376   139 MLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP--------------------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrnirVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17376   174 ------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSI 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:cd17376   236 AATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYL 315

                         250       260
                  ....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17376   316 GAYDRYLPYILMGSLTVLIGILTLFLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
13-282 2.51e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 69.99  E-value: 2.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLI 92
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELF 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  93 RTRNIRVITIMSIILWLTI------SVGYFGLSL-DTPNLHGDIYVNcFLLAAVEVPAYVLAWLLLQYLPRRYsisaALF 165
Cdd:pfam00083 247 STKTRRQRLLIGVMLQIFQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVFTFIAIFLVDRFGRRP----LLL 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 166 LGGSVLLFMQLVPSELFYLSTA-------------LVMVGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLGSI 232
Cdd:pfam00083 322 LGAAGMAICFVILGIVALLGVSksdwagivaivfiALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAANWLANF 400

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1383485555 233 LSPYF--VYLGAYDRFLPYILMGSLTILTAILTLFF-PESFGVPLpDTIDQML 282
Cdd:pfam00083 401 LIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVFFFvPETKGRTL-EEIDELF 452
xylE PRK10077
D-xylose transporter XylE; Provisional
 13-81 5.13e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 50.85  E-value: 5.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaaKINGIVAPSTIfdpseLQDLNST 81
Cdd:PRK10077  193 WRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILR---KIMGNTLATQA-----LQEIKHS 253
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-267 9.05e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 9.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  99 VITIMSIILWL-TISVGYFGLSLDTPNLHGdiyvncFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLV 177
Cdd:COG2271   193 YFALYGFLTWLpTYLVEVRGLSLAQAGLLL------SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 178 PSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRFLPYILMGSL 255
Cdd:COG2271   267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAAL 346

                         170
                  ....*....|..
gi 1383485555 256 TILTAILTLFFP 267
Cdd:COG2271   347 ALLAALLALLLL 358
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-277 5.72e-133

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 387.06  E-value: 5.72e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNS 80
Cdd:TIGR00898 230 VLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSS 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 TKPQlHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:TIGR00898 310 SKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTM 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:TIGR00898 389 AASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYL 468

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDT 277
Cdd:TIGR00898 469 GEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 1-267 2.25e-108

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 318.64  E-value: 2.25e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17376   139 MLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP--------------------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrnirVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17376   174 ------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSI 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:cd17376   236 AATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYL 315

                         250       260
                  ....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17376   316 GAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-267 6.74e-65

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 207.43  E-value: 6.74e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17317   128 MLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP--------------------------------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrnirVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17317   163 ------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTL 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:cd17317   225 SGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLL 304

                         250       260
                  ....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17317   305 GKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-267 4.79e-42

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 148.21  E-value: 4.79e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPesprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17374   138 MLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP--------------------------------------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrniRVITIMSIIlWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17374   173 -----------------KRTLILSFV-WFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQ 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:cd17374   235 AVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLL 314

                         250       260
                  ....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17374   315 GVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 101-267 8.75e-38

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 137.19  E-value: 8.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 101 TIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSE 180
Cdd:cd17375   175 TITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQD 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 181 LFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTA 260
Cdd:cd17375   255 YEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSG 334


                  ....*..
gi 1383485555 261 ILTLFFP 267
Cdd:cd17375   335 ILTLMLP 341
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 101-267 3.52e-33

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 125.28  E-value: 3.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 101 TIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLL--QYLPRRYSISAALFLGGSVLLFMQLVP 178
Cdd:cd17377   179 TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLInqKWSGRRRTLAGFLFLGGIACLLVMFVP 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 179 ----SELFYL--STALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILM 252
Cdd:cd17377   259 ekkdSGVFAVvnSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVF 338

                         170
                  ....*....|....*
gi 1383485555 253 GSLTILTAILTLFFP 267
Cdd:cd17377   339 GASGLSAGLLSLLLP 353
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 100-267 5.00e-32

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 121.75  E-value: 5.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 100 ITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPS 179
Cdd:cd17446   172 ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 180 ELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILT 259
Cdd:cd17446   252 DLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILS 331


                  ....*...
gi 1383485555 260 AILTLFFP 267
Cdd:cd17446   332 GIAACFLP 339
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 1-267 2.82e-30

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 117.14  E-value: 2.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPEsprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17447   138 MLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVPK-------------------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrnirvITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17447   174 -------------------ISLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQ 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 240
Cdd:cd17447   235 AGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILL 314

                         250       260
                  ....*....|....*....|....*..
gi 1383485555 241 GAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17447   315 DDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 1-267 3.67e-29

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 113.99  E-value: 3.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESprwlisqgrikeaeviirkaakingivapstifdpselqdlns 80
Cdd:cd17379   136 LILPGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPKH------------------------------------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 tkpqlhhiydlirtrnirviTIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSI 160
Cdd:cd17379   173 --------------------TFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPF 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 161 SAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY- 239
Cdd:cd17379   233 AASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYr 312

                         250       260
                  ....*....|....*....|....*...
gi 1383485555 240 LGAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17379   313 LAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 102-267 1.43e-27

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 109.76  E-value: 1.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 102 IMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSEL 181
Cdd:cd17378   176 LAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGG 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 182 -FYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTA 260
Cdd:cd17378   256 tTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLG 335


                  ....*..
gi 1383485555 261 ILTLFFP 267
Cdd:cd17378   336 LFALGLP 342
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 97-265 1.27e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.40  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  97 IRVITIMSIILWLTISVGYFGLSLDTPNL--------HGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGG 168
Cdd:cd17316   175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 169 SVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRF 246
Cdd:cd17316   255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGGT 334

                         170
                  ....*....|....*....
gi 1383485555 247 LPYILMGSLTILTAILTLF 265
Cdd:cd17316   335 GVPALILALLAIVALIVAL 353
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 13-274 2.35e-13

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 70.06  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRK----AAKINGIVAPSTIFDPSELQDLNSTKPQLHHI 88
Cdd:TIGR00879 195 WRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARlrgtSGEDKELLDELELIDIKRSIEKRSVQPSWGSL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  89 YDLIRTRNIRVITI--MSIILWLT-ISV-----GYFGLSLDTPNLHGdiYVNCFLLAAVEVPAYVLAWLLLQYLPRR--- 157
Cdd:TIGR00879 275 FSSTRRIRRRLFLGvvLQWFQQFTgINAimyysPTIFENAGVSTDHA--FLVSIIVGAVNFAFTFVAIFLVDRFGRRpll 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 158 ---YSISAALFLGGSVLLFMQLVPSELF--YLSTALVMVGKFGI-TSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGS 231
Cdd:TIGR00879 353 ligAAGMAICLFVLGILGASFVTGSSKSsgNVAIVFILLFIAFFaMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLAN 432

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1383485555 232 IL-SPYFVY-LGAYDRFLPYILMGSLTILTAILTLFF-PESFGVPL 274
Cdd:TIGR00879 433 FIvGFLFPTmLESIGVGGVFIFFGGLNVLGLIFVYFFlPETKGRTL 478
Sugar_tr pfam00083
Sugar (and other) transporter;
13-282 2.51e-13

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 69.99  E-value: 2.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLI 92
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELF 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  93 RTRNIRVITIMSIILWLTI------SVGYFGLSL-DTPNLHGDIYVNcFLLAAVEVPAYVLAWLLLQYLPRRYsisaALF 165
Cdd:pfam00083 247 STKTRRQRLLIGVMLQIFQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVFTFIAIFLVDRFGRRP----LLL 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 166 LGGSVLLFMQLVPSELFYLSTA-------------LVMVGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLGSI 232
Cdd:pfam00083 322 LGAAGMAICFVILGIVALLGVSksdwagivaivfiALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAANWLANF 400

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1383485555 233 LSPYF--VYLGAYDRFLPYILMGSLTILTAILTLFF-PESFGVPLpDTIDQML 282
Cdd:pfam00083 401 LIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVFFFvPETKGRTL-EEIDELF 452
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 12-235 7.36e-12

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.46  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  12 DWR-MLLLALTVPGVLCGALWWFIPESPRWLISQGRikeaeviiRKAAKINGIVAPSTIFDP-SELQDLNSTKPQLHHIY 89
Cdd:TIGR00895 169 GWRsLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRP--------ETVRRIVNAIAPQMQAEAqSALPEQKSTQGTKRSVF 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  90 DLIRTRNIRVITIMsiiLWLTIS---VGYFGLSLDTPNLH----GDIYVNCFLLAAVEVPAyVLAWLLLQYLPRRY--SI 160
Cdd:TIGR00895 241 KALFQGKTARITVL---LWLLYFmllVGVYFLTNWLPKLMvelgFSLSLAATGGALFNFGG-VIGSIIFGWLADRLgpRV 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1383485555 161 SAALFLGGSVLLFmqLVPSELFYLSTALVMVGKFGI--TSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 235
Cdd:TIGR00895 317 TALLLLLGAVFAV--LVGSTLFSPTLLLLLGAIAGFfvNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 130-236 3.15e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 57.54  E-value: 3.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 130 YVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSElfYLSTALVMVGKFGITSAYSMVYVYTAE 209
Cdd:cd17372   232 YRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSP--FILTVLLFGGRACISAAFTVVYIYTPE 309

                          90       100
                  ....*....|....*....|....*..
gi 1383485555 210 LYPTVVRNMGVGVSSTASRLGSILSPY 236
Cdd:cd17372   310 VYPTAVRALGVGTGSSVGRIGAILCPF 336
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 149-267 3.62e-08

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 54.04  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 149 LLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYlsTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASR 228
Cdd:cd17442   258 LGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL--TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 335

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1383485555 229 LGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17442   336 IGAMVAPFISqVLMSASVLGALCLFSSVCIVCAISAFTLP 375
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 13-268 4.11e-08

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 54.19  E-value: 4.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWL-ISQGRIKEAEVIIRKAAKINGIVAPStiFDPSELQDLNSTKPQLHHIYDL 91
Cdd:cd17357   172 WPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKFLRGIEDDVDQE--LEEIKKESEQMGDQKQVSLMQL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  92 IRTRNIRVITIMSIILWLTI-----------SVGYF---GLSLDTPnlhgdIYVNcFLLAAVEVPAYVLAWLLLQYLPRR 157
Cdd:cd17357   250 LRDPSLRLPLLLVLVVSASQqfsginaiffySTFIFenaGFSPQLA-----EWAN-LGIGIVNVLSTIVGPFLIEKVGRR 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 158 -------YSISAALFLgGSVLLFMQLVPSELFYLSTALVMVgkFGITsaYSMV-----YVYTAELYPTVVRNMGVGVSST 225
Cdd:cd17357   324 plllislSVCAVALLL-MSVFLFLSEQNSWMSYGCIVAIFL--FIFF--FAIGlgpipWFIGAELFPQAPRSAAQSLGSS 398

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1383485555 226 ASRLGSILSPYFVY----LGAYDRFLPYILmgsLTILTAILTLFF-PE 268
Cdd:cd17357   399 VNWTSNFIVGMAFPplqsIGGGFVFIIFAI---PCALFLLYLYRYlPE 443
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 7-125 6.98e-08

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 53.83  E-value: 6.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   7 AYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIR--------------KAAKINGIVAPSTIFDP 72
Cdd:TIGR01299 327 AYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKlihdtnmrakghpeKVFSVNHIKTIHQEDEL 406

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1383485555  73 SELQDLNST---------KPQLHHIY-DLIRTRN--IRVITIMSIILWLTISVGYFGLSLDTPNL 125
Cdd:TIGR01299 407 IEIESDTGTwyqrcfvraLSEGGGIWgNFLRCFNpeVREITIKLMGVWFTLSFGYYGLSVWFPDM 471
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 143-235 9.20e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.97  E-value: 9.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 143 AYVLAWLLLQYLPRRySISAALFLGGSVLLFMQLVPSELFYLSTALVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGV 222
Cdd:cd17365   223 SLLLGWLADRFGPKR-VLALFFALGAVSLALLGVSPASLVLLYVLVFLAG-ACVNGAQVGLYALAARFYPTEVRATGVGW 300

                          90
                  ....*....|...
gi 1383485555 223 SSTASRLGSILSP 235
Cdd:cd17365   301 ALGVGRLGAILGP 313
xylE PRK10077
D-xylose transporter XylE; Provisional
 13-81 5.13e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 50.85  E-value: 5.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaaKINGIVAPSTIfdpseLQDLNST 81
Cdd:PRK10077  193 WRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILR---KIMGNTLATQA-----LQEIKHS 253
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 186-267 5.27e-07

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 50.58  E-value: 5.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 186 TALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTL 264
Cdd:cd17441   290 TVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAqVMLESSVYLTLSVYSGCCLLAAIASC 369


                  ...
gi 1383485555 265 FFP 267
Cdd:cd17441   370 FLP 372
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 7-269 7.10e-07

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 50.57  E-value: 7.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   7 AYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSELQdlnstkpq 84
Cdd:cd17363   159 AYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNmrAKGHPERVFTVSHIK-------- 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  85 lhhiydlirtrniRVITIMSIILWLTISVGYFGLSLDTP----------------------------------------- 123
Cdd:cd17363   231 -------------RMNTLFLAIVWFTMSFSYYGLTVWFPdmikylqfedslfeecyfedvtstntffenctfintvfynt 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 124 ---------------------------NLHGD----IYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLL 172
Cdd:cd17363   298 dlfeykfidsrflnstfflkekcgchlNDDEEnaylIYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCF 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 173 FMQLVPSElfylSTALVMVGKFGITS--AYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRFLPY 249
Cdd:cd17363   378 FLFFGNSE----SAMIGLQCLFCGVSiaAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVGITKVIPI 453

                         330       340
                  ....*....|....*....|
gi 1383485555 250 ILMGSLTILTAILTLFFPES 269
Cdd:cd17363   454 LLASAALVCGGLLALKLPET 473
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-267 9.05e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 9.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  99 VITIMSIILWL-TISVGYFGLSLDTPNLHGdiyvncFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLV 177
Cdd:COG2271   193 YFALYGFLTWLpTYLVEVRGLSLAQAGLLL------SLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 178 PSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRFLPYILMGSL 255
Cdd:COG2271   267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAAL 346

                         170
                  ....*....|..
gi 1383485555 256 TILTAILTLFFP 267
Cdd:COG2271   347 ALLAALLALLLL 358
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 7-125 2.30e-06

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 48.76  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   7 AYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRkaakingivapstifdpsELQDLN---STKP 83
Cdd:cd17440   159 AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILK------------------QIHDTNmraRGQP 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1383485555  84 QLHHIYDLIRTRNirviTIMSIILWLTISVGYFGLSLDTPNL 125
Cdd:cd17440   221 EKVFTVNRIKKDN----TIKLTIVWLTLSFGYYGLSVWFPDV 258
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 1-268 4.81e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.57  E-value: 4.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRdWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNS 80
Cdd:cd17358   144 LLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEK 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 TKPQLhHIYDLIRTRNIRVITIMSIILWLTISVGYFGLS------LDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYL 154
Cdd:cd17358   223 EAKES-SFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIfyassiFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRL 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 155 PRRYS--ISAA------LFLGGSVLLFMQLVPSELF-YLSTALVMVGKFGITSA-YSMVYVYTAELYPTVVRNMGVGVSS 224
Cdd:cd17358   302 GRRPLllVSAIgmgiglLALGLYFYLQEHGALLSSVsWLPLVGLVIYIISFSIGlGPLPWVIMSEIFPAKIKGLAGSLVT 381

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1383485555 225 TASRLGSILSPYF-----VYLGAYdrfLPYILMGSLTILTAILTLFF-PE 268
Cdd:cd17358   382 LVNWLFAFIVTKTfpfltLAWGAS---GTFWIFAGICGLALVFVLLFvPE 428
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 7-125 2.64e-05

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 45.41  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   7 AYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVA--PSTIFDPSELQdlnstkpq 84
Cdd:cd17439   159 AYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKghPERVFSVTHIK-------- 230

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1383485555  85 lhhiydlirtrniRVITIMSIILWLTISVGYFGLSLDTPNL 125
Cdd:cd17439   231 -------------RRITLMMMAVWFTMSFSYYGLTVWFPDM 258
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 13-46 3.40e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 44.87  E-value: 3.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1383485555  13 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGR 46
Cdd:cd17359   162 WRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 8-125 1.15e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 43.37  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   8 YFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSELQDLNstkpql 85
Cdd:cd17438   160 YHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNmrAKGTPEKVFTVSNIKRKN------ 233

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1383485555  86 hhiydlirtrnirviTIMSIILWLTISVGYFGLSLDTPNL 125
Cdd:cd17438   234 ---------------TLFLAVVWFTMAFSYYGLTVWFPDM 258
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 126-267 3.39e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 41.68  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 126 HGDIYVnCFLLAaveVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELF-YLSTALVMV----GKFGITSAY 200
Cdd:cd17445   204 PSTFYL-SYLLS---TGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILLGLMdYLNDAAIKTfsilGLFSSQAAA 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1383485555 201 SMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17445   280 SLSILFAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-264 6.34e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555   1 MVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWlisqgrikeaeviirkaakingivapstifDPSELQDLNS 80
Cdd:cd06174   139 LGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE------------------------------SARAKNEEAS 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555  81 TKPQLHHIYDLIRTRNIRVITIMSII----------LWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVevpayVLAWLL 150
Cdd:cd06174   189 SKSVLKLLKRVLKNPGLWLLLLAIFLvnlayysfstLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSL-----LLGLLS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 151 LQYLPRRYSISAALFLGGSVLLFMQLVPSelFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLG 230
Cdd:cd06174   264 DRLIGRKPLLLIGLLLMALGLALLLLAPS--LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1383485555 231 SILSPY---FVYLGAYDRFLPYILMGSLTILTAILTL 264
Cdd:cd06174   342 GAIGPLlagFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 124-267 1.02e-03

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 40.14  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 124 NLHG---DIYVNCFLLAAVEVPAYVLAWLLLQYLPRR-YSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSA 199
Cdd:cd17443   196 NLAPfvpTFYLPYFLQAGLEALACIFLCLTVDRCGRRgVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAV 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1383485555 200 YSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17443   276 SMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFAVLSVLCILLLP 343
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 135-269 1.15e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 40.34  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 135 LLAAVEVPAYVLAWLLLQYLPRRYsISAALFLGGSVLLFMQLVPSELFYLSTALVMV--------GKFGitsAYSMVYVY 206
Cdd:cd17364   248 IALAGTVPGYWFTVFLIDRIGRKK-IQMMGFFGMTIFLLILAGPYDHWKISTIGFFVlygltfffSNFG---PNTTTFIV 323

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1383485555 207 TAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRFLPY-ILMGSLTILTAILTLFFPES 269
Cdd:cd17364   324 PAEVFPARVRSTCHGISAASGKIGAIVGSFlFLSLTQNIGVRNVlIILAGVALLGIILTLLFPEE 388
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 12-55 1.21e-03

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 40.25  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1383485555  12 DWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIR 55
Cdd:cd17433   154 DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 128-267 2.67e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 39.04  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 128 DIYVNCFLLAAVEVPAYVLAWLLLQYLPRR---------YSISAALFLGGSVLL-------FMQLVPSELFYLSTALVMV 191
Cdd:cd17373   193 NFYLDYYLTAGIAAVACVFLCVTVDFLGRRgglllfmilTGLASLLLLGLLNLIgkysqhpDSGMSDSVKDKFSIAFSVL 272

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1383485555 192 GKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFP 267
Cdd:cd17373   273 GLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVFACCALLCILCILLLP 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 149-269 7.49e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.79  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 149 LLLQYLPRRYSISAALFLGGSVLLFMQLVPSelFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASR 228
Cdd:cd06174    53 LLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGS 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1383485555 229 LGSILSP----YFVYLGAYDRFLPYILMGSLTILTAILTLFFPES 269
Cdd:cd06174   131 VGGILGPllggILASSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 156-266 8.96e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 37.59  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1383485555 156 RRYSISAALFLGGSVLLFMQLVPSE--LFYLSTALVMvgkFGITSAYSMVYVYTAELYPT--VVRNMGVGVSS--TASRL 229
Cdd:cd17353   278 RKNTLSIAFLIQGVAMFLLPFIGSVavLFVLGVALIG---FCYGGGFALFPALTADFFGTknAGTNYGLLYTAkgVGGLI 354

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1383485555 230 GSILSPYFVYLGAYDRflPYILMGSLTILTAILTLFF 266
Cdd:cd17353   355 GPIIAAYVLYTGGYNA--AFIIAAALSLVALALALLL 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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