|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
204-552 |
3.04e-118 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 358.09 E-value: 3.04e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWhkmkappiprstgmppremrfgat 283
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQ------------------------ 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdA 363
Cdd:cd17946 57 -------------------------------------------------------------------------------K 57
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 EQAGKLKqelcdqiaiykvhPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd17946 58 SSNGVGG-------------KQKPLRALILTPTRELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVA 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 444 TPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQ--YNPSRQTLVFSATLTLVHQAPARIL 521
Cdd:cd17946 125 TPGRLWELIQEGNEHLANLKSLRFLVLDEADRMLEKGHFAELEKILELLNKDRagKKRKRQTFVFSATLTLDHQLPLKLN 204
|
330 340 350
....*....|....*....|....*....|.
gi 1398331555 522 HKKHVKKMDKTDKLDLLMQKVGMRGKPKVID 552
Cdd:cd17946 205 SKKKKKKKEKKQKLELLIEKVGFRKKPKVID 235
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
197-730 |
2.23e-92 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 297.44 E-value: 2.23e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 197 DLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppr 276
Cdd:COG0513 6 DLGLSPPLLKALAELGYTTPTPIQAQAI-PLILAGRDVLGQAQTGTGKTAAFLLPLLQ---------------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 277 emrfgatahlgspckdrtesgvlpeeaRIETEAQPsdsGVQAtpetsasasaqtllvcdddagegpssleekpvpkqned 356
Cdd:COG0513 63 ---------------------------RLDPSRPR---APQA-------------------------------------- 74
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 357 geekfdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 436
Cdd:COG0513 75 ----------------------------------LILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKR 120
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 437 HPEIVIATPGRLWELVKEKHphLsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNdsqynPSRQTLVFSATLtlvhqa 516
Cdd:COG0513 121 GVDIVVATPGRLLDLIERGA--L-DLSGVETLVLDEADRMLDMGFIEDIERILKLLP-----KERQTLLFSATM------ 186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 517 PARIlhKKHVKKMdktdkldllmqkvgMRgKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQY-PGRSLVFAN 595
Cdd:COG0513 187 PPEI--RKLAKRY--------------LK-NPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEdPERAIVFCN 249
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 596 SISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRS 675
Cdd:COG0513 250 TKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRI 329
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1398331555 676 GRTARAASEGLSLMLIGPEDVINFKKIYKTLQKD---EDIPLF-PVQSKYMDVVKERIR 730
Cdd:COG0513 330 GRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKieeEELPGFePVEEKRLERLKPKIK 388
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
204-511 |
1.02e-51 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 179.17 E-value: 1.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppremrfgat 283
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAI-PLILSGRDVIGQAQTGSGKTLAFLLPILE----------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeeaRIETEAQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 363
Cdd:cd00268 51 --------------------KLLPEPKKKGRGPQA--------------------------------------------- 65
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd00268 66 ---------------------------LVLAPTRELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVG 118
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1398331555 444 TPGRLWELVKEKHPHLSNlrqLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:cd00268 119 TPGRLLDLIERGKLDLSN---VKYLVLDEADRMLDMGFEEDVEKILSAL-----PKDRQTLLFSATLP 178
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
205-702 |
5.77e-48 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 176.67 E-value: 5.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 205 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQWhkmkappiPRSTGMPPREmrfgata 284
Cdd:PRK11192 13 LEALQDKGYTRPTAIQAEAIPPALDGR-DVLGSAPTGTGKTAAFLLPALQHLLDF--------PRRKSGPPRI------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 285 hlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdae 364
Cdd:PRK11192 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 365 qagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIAT 444
Cdd:PRK11192 77 --------------------------LILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVAT 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 445 PGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGhFAELSQllEMLNDSQYNpsRQTLVFSATltlvhqapariLHKK 524
Cdd:PRK11192 131 PGRLLQYIKEEN---FDCRAVETLILDEADRMLDMG-FAQDIE--TIAAETRWR--KQTLLFSAT-----------LEGD 191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 525 HVKKMDKtdklDLLMQKVGMRGKPkvidlTRNEgtvetltETKIH-----CETDEKDLYLYYFLMQYP--GRSLVFANSI 597
Cdd:PRK11192 192 AVQDFAE----RLLNDPVEVEAEP-----SRRE-------RKKIHqwyyrADDLEHKTALLCHLLKQPevTRSIVFVRTR 255
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 598 SCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGR 677
Cdd:PRK11192 256 ERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGR 335
|
490 500
....*....|....*....|....*
gi 1398331555 678 TARAASEGLSLMLIGPEDVINFKKI 702
Cdd:PRK11192 336 TGRAGRKGTAISLVEAHDHLLLGKI 360
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
201-695 |
7.31e-47 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 174.22 E-value: 7.31e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 201 PKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVlqwhkmkappiprstgmppremrf 280
Cdd:PRK11776 12 PPALLANLNELGYTEMTPIQAQSL-PAILAGKDVIAQAKTGSGKTAAFGLGLLQKL------------------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 281 gatahlgspckdrtesgvlpeearieteaQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeek 360
Cdd:PRK11776 67 -----------------------------DVKRFRVQA------------------------------------------ 75
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 361 fdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGiNTAILV--GGMSTQKQQRMLNRHP 438
Cdd:PRK11776 76 ------------------------------LVLCPTRELADQVAKEIRRLARFIP-NIKVLTlcGGVPMGPQIDSLEHGA 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 439 EIVIATPGRLWElvkekhpHLS----NLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLtlvh 514
Cdd:PRK11776 125 HIIVGTPGRILD-------HLRkgtlDLDALNTLVLDEADRMLDMGFQDAIDAII-----RQAPARRQTLLFSATY---- 188
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 515 qaPARILHkkhvkkmdktdkldlLMQKVgMRgKPKVIdltrnegTVETLTE-TKI-----HCETDEKDLYLYYFLMQY-P 587
Cdd:PRK11776 189 --PEGIAA---------------ISQRF-QR-DPVEV-------KVESTHDlPAIeqrfyEVSPDERLPALQRLLLHHqP 242
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 588 GRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRT 667
Cdd:PRK11776 243 ESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARD 322
|
490 500
....*....|....*....|....*...
gi 1398331555 668 SEIYIHRSGRTARAASEGLSLMLIGPED 695
Cdd:PRK11776 323 PEVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
563-691 |
5.11e-45 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 158.05 E-value: 5.11e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 563 LTETKIHCETDEKDLYLYYFLMQ--YPGRSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCV 640
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEklKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 641 LLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLI 691
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
193-708 |
2.50e-43 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 164.32 E-value: 2.50e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 193 SAWRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstg 272
Cdd:PRK01297 87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGH-DAIGRAQTGTGKTAAFLISIINQLLQ-------------- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 273 mppremrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleeKPVPK 352
Cdd:PRK01297 152 ---------------------------------------------------------------------------TPPPK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 353 QNEDGEekfdaeqagklkqelcdqiaiykvhPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQR 432
Cdd:PRK01297 157 ERYMGE-------------------------PR----ALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 433 MLN-RHPEIVIATPGRLWELVKEKHPHLSnlrQLRCLVIDEADRMVEKGHFAELSQLLEMlndSQYNPSRQTLVFSATLT 511
Cdd:PRK01297 208 QLEaRFCDILVATPGRLLDFNQRGEVHLD---MVEVMVLDEADRMLDMGFIPQVRQIIRQ---TPRKEERQTLLFSATFT 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 512 lvhqaparilhkkhvkkmdkTDKLDLLMQKVgmrGKPKVIDLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYP-GRS 590
Cdd:PRK01297 282 --------------------DDVMNLAKQWT---TDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPwERV 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 591 LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEI 670
Cdd:PRK01297 339 MVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDD 418
|
490 500 510
....*....|....*....|....*....|....*...
gi 1398331555 671 YIHRSGRTARAASEGLSLMLIGPEDVINFKKIYKTLQK 708
Cdd:PRK01297 419 YVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGR 456
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
197-702 |
1.48e-41 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 157.83 E-value: 1.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 197 DLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstgmppr 276
Cdd:PRK04837 12 DFALHPQVVEALEKKGFHNCTPIQALALPLTLAGR-DVAGQAQTGTGKTMAFLTATFHYLLS------------------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 277 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleeKPVPKQNEd 356
Cdd:PRK04837 73 -----------------------------------------------------------------------HPAPEDRK- 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 357 geekfdaeqagklkqelcdqiaiyKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 436
Cdd:PRK04837 81 ------------------------VNQPR----ALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLES 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 437 HPEIVIATPGRLWELVKEKHPHLSNLRqlrCLVIDEADRMVEKGHFAELSQLLEMLNDSQynpSRQTLVFSATLTLVHQA 516
Cdd:PRK04837 133 GVDILIGTTGRLIDYAKQNHINLGAIQ---VVVLDEADRMFDLGFIKDIRWLFRRMPPAN---QRLNMLFSATLSYRVRE 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 517 PArilhkkhVKKMDKTDKLDLL-MQKVGMRgkpkvidltrnegtvetLTETKIHCETDEKDLYLYYFLMQ-YPGRSLVFA 594
Cdd:PRK04837 207 LA-------FEHMNNPEYVEVEpEQKTGHR-----------------IKEELFYPSNEEKMRLLQTLIEEeWPDRAIIFA 262
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 595 NSI-SCIKRLS---------GLLKVlDVMpltlhacmhQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQV 664
Cdd:PRK04837 263 NTKhRCEEIWGhlaadghrvGLLTG-DVA---------QKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDL 332
|
490 500 510
....*....|....*....|....*....|....*...
gi 1398331555 665 PRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKI 702
Cdd:PRK04837 333 PDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAI 370
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
201-694 |
4.64e-40 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 156.09 E-value: 4.64e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 201 PKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIP-MIHsvlqwhkmkappiprstgmppremr 279
Cdd:PTZ00110 138 PDYILKSLKNAGFTEPTPIQVQGWPIALSGR-DMIGIAETGSGKTLAFLLPaIVH------------------------- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 280 fgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasASAQTLLvcddDAGEGPssleekpvpkqnedgee 359
Cdd:PTZ00110 192 ----------------------------------------------INAQPLL----RYGDGP----------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 360 kfdaeqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPE 439
Cdd:PTZ00110 205 -----------------------------IVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 440 IVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLTLVHQAPAR 519
Cdd:PTZ00110 256 ILIACPGRLIDFLESN---VTNLRRVTYLVLDEADRMLDMGFEPQIRKIV-----SQIRPDRQTLMWSATWPKEVQSLAR 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 520 ILHKKHVKKMDktdkldllmqkVGMrgkpkvIDLTrnegTVETLTETKIHCETDEKDLYLYYFL---MQYPGRSLVFANS 596
Cdd:PTZ00110 328 DLCKEEPVHVN-----------VGS------LDLT----ACHNIKQEVFVVEEHEKRGKLKMLLqriMRDGDKILIFVET 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 597 ISCIKRLSGLLKvLDVMP-LTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRS 675
Cdd:PTZ00110 387 KKGADFLTKELR-LDGWPaLCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRI 465
|
490
....*....|....*....
gi 1398331555 676 GRTARAASEGLSLMLIGPE 694
Cdd:PTZ00110 466 GRTGRAGAKGASYTFLTPD 484
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
195-511 |
5.32e-38 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 140.91 E-value: 5.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 195 WRDLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwhkmkappiprstgmp 274
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGR-DIIGLAETGSGKTAAFALPILQALL----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 275 premrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqn 354
Cdd:cd17954 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 355 edgeekfdaeqagklkqelcdqiaiykvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRML 434
Cdd:cd17954 64 ----------------------------ENPQRFFALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIAL 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 435 NRHPEIVIATPGRLWElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPS-RQTLVFSA 508
Cdd:cd17954 116 AKKPHVIVATPGRLVD-------HLENtkgfsLKSLKFLVMDEADRLLNMDFEPEIDKILKVI------PReRTTYLFSA 182
|
...
gi 1398331555 509 TLT 511
Cdd:cd17954 183 TMT 185
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
203-739 |
1.30e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 149.33 E-value: 1.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 203 AVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstgmppremrfga 282
Cdd:PRK04537 19 ALLAGLESAGFTRCTPIQALTLPVALPGG-DVAGQAQTGTGKTLAFLVAVMNRLLS------------------------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 283 tahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddageGPSSLEEKPvpkqnEDgeekfd 362
Cdd:PRK04537 74 ----------------------------------------------------------RPALADRKP-----ED------ 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 363 aeqagklkqelcdqiaiykvhPRrpllGLVLTPTRELAIQVrqHIDAVaKF---TGINTAILVGGMSTQKQQRMLNRHPE 439
Cdd:PRK04537 85 ---------------------PR----ALILAPTRELAIQI--HKDAV-KFgadLGLRFALVYGGVDYDKQRELLQQGVD 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 440 IVIATPGRLWELVKEkHPHLSnLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqyNPSRQTLVFSATLTlvHqapaR 519
Cdd:PRK04537 137 VIIATPGRLIDYVKQ-HKVVS-LHACEICVLDEADRMFDLGFIKDIRFLLRRMPE---RGTRQTLLFSATLS--H----R 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 520 ILHKKHvKKMDKTDKLdllmqkvgmrgkpkvidLTRNEGTVETLTETKIHCETDEKDLYLYYFLMQYP--GRSLVFANSI 597
Cdd:PRK04537 206 VLELAY-EHMNEPEKL-----------------VVETETITAARVRQRIYFPADEEKQTLLLGLLSRSegARTMVFVNTK 267
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 598 SCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGR 677
Cdd:PRK04537 268 AFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGR 347
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398331555 678 TARAASEGLSLMLIGPEDVINFKKIYKTLQkdEDIPLFPVQSKYMDVVKERIRLARQIEKAE 739
Cdd:PRK04537 348 TARLGEEGDAISFACERYAMSLPDIEAYIE--QKIPVEPVTAELLTPLPRPPRVPVEGEEAD 407
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
204-511 |
1.16e-36 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 136.62 E-value: 1.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwHKMKAPPIPRstgmppremrfgat 283
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGK-DICASAVTGSGKTAAFLLPILERLL--YRPKKKAATR-------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 363
Cdd:cd17947 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd17947 64 --------------------------VLVLVPTRELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIA 117
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1398331555 444 TPGRLWELVkekHPHLS-NLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqynpSRQTLVFSATLT 511
Cdd:cd17947 118 TPGRLIDHL---RNSPSfDLDSIEILVLDEADRMLEEGFADELKEILRLCPR-----TRQTMLFSATMT 178
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
385-713 |
3.84e-36 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 142.64 E-value: 3.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 385 RRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELvkeKHPHLSNLRQ 464
Cdd:PRK10590 73 RRPVRALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDL---EHQNAVKLDQ 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 465 LRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLTLVHQAPA-RILHK-----------------KHV 526
Cdd:PRK10590 150 VEILVLDEADRMLDMGFIHDIRRVLAKL-----PAKRQNLLFSATFSDDIKALAeKLLHNpleievarrntaseqvtQHV 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 527 KKMDKTDKLDLLMQKVGMRGKPKVIDLTRNEGTVETLTETKihcetdEKDlylyyflmqypgrslvfansiscikrlsgl 606
Cdd:PRK10590 225 HFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQL------NKD------------------------------ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 607 lkvlDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGL 686
Cdd:PRK10590 269 ----GIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGE 344
|
330 340
....*....|....*....|....*..
gi 1398331555 687 SLMLIGPEDVINFKKIYKTLQKdeDIP 713
Cdd:PRK10590 345 ALSLVCVDEHKLLRDIEKLLKK--EIP 369
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
197-511 |
1.87e-34 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 130.81 E-value: 1.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 197 DLFVPKAVLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSvlqwhkmkappiprstgmppr 276
Cdd:cd17955 3 DLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGR-DVIGGAKTGSGKTAAFALPILQR--------------------- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 277 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssLEEKPVpkqned 356
Cdd:cd17955 61 --------------------------------------------------------------------LSEDPY------ 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 357 geekfdaeqagklkqelcdqiAIYkvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNR 436
Cdd:cd17955 67 ---------------------GIF---------ALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSK 116
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 437 HPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:cd17955 117 RPHIVVATPGRLADHLRSSDDTTKVLSRVKFLVLDEADRLLTGSFEDDLATILSAL-----PPKRQTLLFSATLT 186
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
202-510 |
3.45e-34 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 130.12 E-value: 3.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 202 KAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwhkmkappiprstgmppremrfg 281
Cdd:cd17959 10 PPLLRAIKKKGYKVPTPIQRKTI-PLILDGRDVVAMARTGSGKTAAFLIPMIE--------------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 282 atahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekf 361
Cdd:cd17959 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 362 daeqagKLKQElcdqiaiykvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIV 441
Cdd:cd17959 62 ------KLKAH----------SPTVGARALILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDII 125
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1398331555 442 IATPGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGhFAElsQLLEMLndSQYNPSRQTLVFSATL 510
Cdd:cd17959 126 IATPGRLLHLLVEMN---LKLSSVEYVVFDEADRLFEMG-FAE--QLHEIL--SRLPENRQTLLFSATL 186
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
340-710 |
1.59e-30 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 124.94 E-value: 1.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 340 EGPSSLEEKPVpKQNEDGEEKFDAEQAGKLKQELCDQIAIYKVHPR-RPLLGLVLTPTRELAIQVRQHIDAVAKFTGINT 418
Cdd:PTZ00424 49 EKPSAIQQRGI-KPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDlNACQALILAPTRELAQQIQKVVLALGDYLKVRC 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 419 AILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRqlrCLVIDEADRMVEKGHFAELSQLLEMLNdsqyn 498
Cdd:PTZ00424 128 HACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLK---LFILDEADEMLSRGFKGQIYDVFKKLP----- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 499 PSRQTLVFSATLtlvhqaPARILHkkhvkkmdktdkldlLMQKVgMRgKPKVIDLTRNEGTVETLTETKIHCETDE---- 574
Cdd:PTZ00424 200 PDVQVALFSATM------PNEILE---------------LTTKF-MR-DPKRILVKKDELTLEGIRQFYVAVEKEEwkfd 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 575 --KDLYLYYFLMQypgrSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLD 652
Cdd:PTZ00424 257 tlCDLYETLTITQ----AIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGID 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 653 IPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVINFKKI--YKTLQKDE 710
Cdd:PTZ00424 333 VQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIerHYNTQIEE 392
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
197-691 |
3.64e-30 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 126.89 E-value: 3.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 197 DLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhKMKAPPIprstgmppr 276
Cdd:PRK11634 10 DLGLKAPILEALNDLGYEKPSPIQAECI-PHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDP--ELKAPQI--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 277 emrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqned 356
Cdd:PRK11634 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 357 geekfdaeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAK-FTGINTAILVGGMSTQKQQRMLN 435
Cdd:PRK11634 78 ----------------------------------LVLAPTRELAVQVAEAMTDFSKhMRGVNVVALYGGQRYDVQLRALR 123
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 436 RHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATLTlvhQ 515
Cdd:PRK11634 124 QGPQIVVGTPGRLLDHLKRGTLDLSKLSG---LVLDEADEMLRMGFIEDVETIM-----AQIPEGHQTALFSATMP---E 192
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 516 APARILhKKHVKkmdktDKLDLLMQKvGMRGKPkviDLTRNEGTVETLtetkihcetdEKDLYLYYFLmqypgRSLVFAN 595
Cdd:PRK11634 193 AIRRIT-RRFMK-----EPQEVRIQS-SVTTRP---DISQSYWTVWGM----------RKNEALVRFL-----EAEDFDA 247
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 596 SISCIKRLSGLLKVLDVMPLT------LHACMHQKQRLRNLEqfaRLQDC---VLLATDVAARGLDIPKVQHVIHYQVPR 666
Cdd:PRK11634 248 AIIFVRTKNATLEVAEALERNgynsaaLNGDMNQALREQTLE---RLKDGrldILIATDVAARGLDVERISLVVNYDIPM 324
|
490 500
....*....|....*....|....*
gi 1398331555 667 TSEIYIHRSGRTARAASEGLSLMLI 691
Cdd:PRK11634 325 DSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
202-510 |
1.79e-29 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 116.53 E-value: 1.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 202 KAVLRALSFLGFSAPTPIQALTLAPAIRDKLDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprstgmppremrfg 281
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKTGTGKTLAFLLPAI---------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 282 atahlgspckdrtesgvlpeEARIETEAQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekf 361
Cdd:cd17964 55 --------------------QSLLNTKPAGRRSGVSA------------------------------------------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 362 daeqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQ-QRMLNRHPE 439
Cdd:cd17964 72 -----------------------------LIISPTRELALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAElNRLRRGRPD 122
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1398331555 440 IVIATPGRLwelvkekHPHLSN------LRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNPsRQTLVFSATL 510
Cdd:cd17964 123 ILVATPGRL-------IDHLENpgvakaFTDLDYLVLDEADRLLDMGFRPDLEQILRHLPEKNADP-RQTLLFSATV 191
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
192-523 |
4.78e-29 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 115.55 E-value: 4.78e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 192 VSAWRDLFVPKAVLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHsvlqwHKMKAPPIprst 271
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQAL-PAIMSGRDVIGIAKTGSGKTLAFLLPMFR-----HIKDQRPV---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 272 gmppremrfgatahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcddDAGEGPssleekpvp 351
Cdd:cd17953 81 -----------------------------------------------------------------KPGEGP--------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 352 kqnedgeekfdaeqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQ 431
Cdd:cd17953 87 -------------------------------------IGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQI 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 432 RMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSATL- 510
Cdd:cd17953 130 AELKRGAEIVVCTPGRMIDILTANNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVN-----NIRPDRQTVLFSATFp 204
|
330
....*....|...
gi 1398331555 511 TLVHQAPARILHK 523
Cdd:cd17953 205 RKVEALARKVLHK 217
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
217-511 |
5.04e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 113.88 E-value: 5.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 217 TPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVlqwhkmkappiprstgmppremrfgatahlgspckdrtes 296
Cdd:pfam00270 1 TPIQAEAIPAILEGR-DVLVQAPTGSGKTLAFLLPALEAL---------------------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 297 gvlpeearieteaQPSDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkqelcdq 376
Cdd:pfam00270 40 -------------DKLDNGPQA---------------------------------------------------------- 48
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 377 iaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLnRHPEIVIATPGRLWELVKEKH 456
Cdd:pfam00270 49 --------------LVLAPTRELAEQIYEELKKLGKGLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERK 113
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 457 phlsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:pfam00270 114 ----LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL-----PKKRQILLLSATLP 159
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
374-707 |
1.21e-28 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 121.05 E-value: 1.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 374 CDQIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVK 453
Cdd:PLN00206 183 CCTIRSGHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLS 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 454 EkhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPSRQTLVFSATLTlvhqaparilhkKHVKKMDKTD 533
Cdd:PLN00206 263 K---HDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL------SQPQVLLFSATVS------------PEVEKFASSL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 534 KLDLLMQKVGMRGKPKvidltrnegtvETLTETKIHCETDEKDLYLYYFLM---QYPGRSLVFANSISCIKRLS-GLLKV 609
Cdd:PLN00206 322 AKDIILISIGNPNRPN-----------KAVKQLAIWVETKQKKQKLFDILKskqHFKPPAVVFVSSRLGADLLAnAITVV 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 610 LDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLM 689
Cdd:PLN00206 391 TGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIV 470
|
330
....*....|....*...
gi 1398331555 690 LIGPEDVINFKKIYKTLQ 707
Cdd:PLN00206 471 FVNEEDRNLFPELVALLK 488
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
204-510 |
1.68e-28 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 113.28 E-value: 1.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhsvlqWHKMKAPPIprstgmppremrfgat 283
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGR-DMIGIAKTGSGKTAAFIWPML-----VHIMDQREL---------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcddDAGEGPssleekpvpkqnedgeekfda 363
Cdd:cd17952 59 -----------------------------------------------------EKGEGP--------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd17952 65 -------------------------IAVIVAPTRELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVA 119
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1398331555 444 TPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGhFAelSQLLEMLNdsQYNPSRQTLVFSATL 510
Cdd:cd17952 120 TPGRLIDMVKKK---ATNLQRVTYLVLDEADRMFDMG-FE--YQVRSIVG--HVRPDRQTLLFSATF 178
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
204-511 |
1.73e-27 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 111.26 E-value: 1.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLQwhkmkAPPIPRSTGMppremrfgat 283
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNR-DIIGIAETGSGKTAAFLIPLLVYISR-----LPPLDEETKD---------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagEGPssleekpvpkqnedgeekfda 363
Cdd:cd17945 65 --------------------------------------------------------DGP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd17945 68 -------------------------YALILAPTRELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIA 122
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 444 TPGRLWELVkEKhpHLSNLRQLRCLVIDEADRMVEKGhFAE-----LSQL-----------LEMLNDSQYNPSRQTLVFS 507
Cdd:cd17945 123 TPGRLLDCL-ER--RLLVLNQCTYVVLDEADRMIDMG-FEPqvtkiLDAMpvsnkkpdteeAEKLAASGKHRYRQTMMFT 198
|
....
gi 1398331555 508 ATLT 511
Cdd:cd17945 199 ATMP 202
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
204-509 |
6.62e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 108.61 E-value: 6.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPmihsvlqwhkmkappiprstgmppremrfgAT 283
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGR-DMVGIAQTGSGKTLAFLLP------------------------------AI 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 AHLgspckdrtesgvlpeearieteaqpsdsgvqatpetsasaSAQTLLvcddDAGEGPssleekpvpkqnedgeekfda 363
Cdd:cd17966 50 VHI----------------------------------------NAQPPL----ERGDGP--------------------- 64
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIA 443
Cdd:cd17966 65 -------------------------IVLVLAPTRELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIA 119
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1398331555 444 TPGRLWELVKEKHphlSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSAT 509
Cdd:cd17966 120 TPGRLIDFLDQGK---TNLRRVTYLVLDEADRMLDMGFEPQIRKIV-----DQIRPDRQTLMWSAT 177
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
204-511 |
8.29e-26 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 105.74 E-value: 8.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHSVLqwhkmkappiprstgmppremrfgat 283
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGK-DILARARTGSGKTAAYALPIIQKIL-------------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 363
Cdd:cd17961 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagKLKQELCDQIAIYkvhprrpllGLVLTPTRELAIQVRQHIDAVAKFTG--INTAILVGGMSTQKQQRMLNRHPEIV 441
Cdd:cd17961 58 ----KAKAESGEEQGTR---------ALILVPTRELAQQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIV 124
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 442 IATPGRLWELVKEKhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPSR-QTLVFSATLT 511
Cdd:cd17961 125 VSTPARLLSHLESG--SLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLSYL------PKNyQTFLMSATLS 187
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
212-510 |
1.14e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 106.03 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 212 GFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLqwhkMKAPPIPRSTGMPpremrfgatahlgspck 291
Cdd:cd17967 19 GYTKPTPVQKYAI-PIILAGRDLMACAQTGSGKTAAFLLPIISKLL----EDGPPSVGRGRRK----------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 292 drtesgvlpeearieteAQPSdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkq 371
Cdd:cd17967 77 -----------------AYPS----------------------------------------------------------- 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 372 elcdqiaiykvhprrpllGLVLTPTRELAIQvrqhIDAVA-KF---TGINTAILVGGMSTQKQQRMLNRHPEIVIATPGR 447
Cdd:cd17967 81 ------------------ALILAPTRELAIQ----IYEEArKFsyrSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGR 138
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 448 LWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGhFaeLSQLLEMLNDSQYNP--SRQTLVFSATL 510
Cdd:cd17967 139 LVDFIER---GRISLSSIKFLVLDEADRMLDMG-F--EPQIRKIVEHPDMPPkgERQTLMFSATF 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
574-681 |
5.93e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 99.98 E-value: 5.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 574 EKDLYLYYFLMQYPG-RSLVFANSISCIKrLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLD 652
Cdd:pfam00271 1 EKLEALLELLKKERGgKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100
....*....|....*....|....*....
gi 1398331555 653 IPKVQHVIHYQVPRTSEIYIHRSGRTARA 681
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
205-511 |
3.58e-23 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 98.13 E-value: 3.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 205 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIHS--VLQWhkmkappiprstgmppremrfga 282
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGR-DILGAAKTGSGKTLAFLVPLLEKlyRERW----------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 283 tahlgspckdrtesgvlpeearieteaqpsdsgvqaTPEtsasasaqtllvcdddagegpssleekpvpkqneDGeekfd 362
Cdd:cd17941 58 ------------------------------------TPE----------------------------------DG----- 62
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 363 aeqagklkqelcdqiaiykvhprrplLG-LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHpEIV 441
Cdd:cd17941 63 --------------------------LGaLIISPTRELAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NIL 115
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 442 IATPGRLWELVKEKhPHLsNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:cd17941 116 VCTPGRLLQHMDET-PGF-DTSNLQMLVLDEADRILDMGFKETLDAIVENL-----PKSRQTLLFSATQT 178
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
391-529 |
3.81e-23 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 98.16 E-value: 3.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKFTG---INTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKhphLSNLRQLRC 467
Cdd:cd17938 64 LILEPSRELAEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTG---KLDLSSVRF 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1398331555 468 LVIDEADRMVEKGHFAELSQLLEMLNDSQYNPSR-QTLVFSATltlvhqapariLHKKHVKKM 529
Cdd:cd17938 141 FVLDEADRLLSQGNLETINRIYNRIPKITSDGKRlQVIVCSAT-----------LHSFEVKKL 192
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
376-511 |
4.48e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 97.95 E-value: 4.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 376 QIAIYKVHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQ-QRMLNRHPEIVIATPGRLWELVKE 454
Cdd:smart00487 43 LPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLEN 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1398331555 455 KHPHLSNlrqLRCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:smart00487 123 DKLSLSN---VDLVILDEAHRLLDGGFGDQLEKLLKLL-----PKNVQLLLLSATPP 171
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
204-510 |
7.37e-23 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 97.41 E-value: 7.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwHKMKAPPIPrstgmppremrfgat 283
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGL-PTILSGRDMIGIAFTGSGKTLVFTLPLIMFALE-QEKKLPFIK--------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddaGEGPssleekpvpkqnedgeekfda 363
Cdd:cd17951 64 -------------------------------------------------------GEGP--------------------- 67
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrplLGLVLTPTRELAIQVRQHIDAVAK------FTGINTAILVGGMSTQKQQRMLNRH 437
Cdd:cd17951 68 -------------------------YGLIVCPSRELARQTHEVIEYYCKalqeggYPQLRCLLCIGGMSVKEQLEVIRKG 122
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1398331555 438 PEIVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSATL 510
Cdd:cd17951 123 VHIVVATPGRLMDMLNKK---KINLDICRYLCLDEADRMIDMGFEEDIRTIF-----SYFKGQRQTLLFSATM 187
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
390-511 |
1.79e-22 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 96.11 E-value: 1.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 390 GLVLTPTRELAIQVRQHIDAVAKFTG--INTAILVGGMSTQKQQRMLNRH-PEIVIATPGRLWELVKEKHpHLSNLRQLR 466
Cdd:cd17960 66 ALIISPTRELATQIYEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFKRNgPNILVGTPGRLEELLSRKA-DKVKVKSLE 144
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1398331555 467 CLVIDEADRMVEKGHFAELSQLLEMLndsqynP-SRQTLVFSATLT 511
Cdd:cd17960 145 VLVLDEADRLLDLGFEADLNRILSKL------PkQRRTGLFSATQT 184
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
205-520 |
2.47e-22 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 95.51 E-value: 2.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 205 LRALSFLGFSAPTPIQALTLAPAIRDKlDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprstgmppremrfgata 284
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGR-DVLGAAKTGSGKTLAFLIPAI------------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 285 hlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdae 364
Cdd:cd17942 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 365 qagklkqELcdqiaIYKVH--PRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVI 442
Cdd:cd17942 50 -------EL-----LYKLKfkPRNGTGVIIISPTRELALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILV 117
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 443 ATPGRLWElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLndsqynPS-RQTLVFSATLTLVHQA 516
Cdd:cd17942 118 ATPGRLLD-------HLQNtkgflYKNLQCLIIDEADRILEIGFEEEMRQIIKLL------PKrRQTMLFSATQTRKVED 184
|
....
gi 1398331555 517 PARI 520
Cdd:cd17942 185 LARI 188
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
601-681 |
2.79e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.50 E-value: 2.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 601 KRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTAR 680
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
.
gi 1398331555 681 A 681
Cdd:smart00490 81 A 81
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
376-511 |
8.32e-22 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 95.01 E-value: 8.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 376 QIAIYKVHPRrpLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMST--QKQQRMLNRH------PEIVIATPGR 447
Cdd:cd17956 59 QALSKRVVPR--LRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFkkEQKLLLVDTSgrylsrVDILVATPGR 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 448 LWELVKEKHPHlsNLRQLRCLVIDEADRMVEKGHFAELSQLLE-----------------MLNDSQYNPsrQTLVFSATL 510
Cdd:cd17956 137 LVDHLNSTPGF--TLKHLRFLVIDEADRLLNQSFQDWLETVMKalgrptapdlgsfgdanLLERSVRPL--QKLLFSATL 212
|
.
gi 1398331555 511 T 511
Cdd:cd17956 213 T 213
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
212-509 |
2.68e-21 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 94.26 E-value: 2.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 212 GFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIhsvlqwhkmkappiprsTGMppreMRFGATAhlgspck 291
Cdd:cd18052 62 GYEKPTPVQKYAI-PIILAGRDLMACAQTGSGKTAAFLLPVL-----------------TGM----MKEGLTA------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 292 drtesgvlpeearieteaqPSDSGVQaTPETsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklkq 371
Cdd:cd18052 113 -------------------SSFSEVQ-EPQA------------------------------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 372 elcdqiaiykvhprrpllgLVLTPTRELAIQVrqHIDAVaKF---TGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRL 448
Cdd:cd18052 124 -------------------LIVAPTRELANQI--FLEAR-KFsygTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRL 181
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398331555 449 WELV-KEKhphlSNLRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYNpSRQTLVFSAT 509
Cdd:cd18052 182 LDFIgRGK----ISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKE-DRQTLMFSAT 238
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
390-511 |
3.75e-21 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 92.39 E-value: 3.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 390 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKhpHLSnLRQLRCLV 469
Cdd:cd17939 68 ALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRR--SLR-TDKIKMFV 144
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1398331555 470 IDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:cd17939 145 LDEADEMLSRGFKDQIYDIFQFL-----PPETQVVLFSATMP 181
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
211-511 |
5.89e-21 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 92.26 E-value: 5.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 211 LGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhkmKAPPIPRSTGmppremrfgatahlgspc 290
Cdd:cd17949 9 MGIEKPTAIQKLAI-PVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLS----LEPRVDRSDG------------------ 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 291 kdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfdaeqagklk 370
Cdd:cd17949 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 371 qelcdqiaiykvhprrpLLGLVLTPTRELAIQVRQHIDAVAK-FTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLW 449
Cdd:cd17949 66 -----------------TLALVLVPTRELALQIYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLL 128
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 450 ElvkekhpHLSN-----LRQLRCLVIDEADRMVEKGHFAELSQLLEMLNDSQYN--------PSRQTLVFSATLT 511
Cdd:cd17949 129 D-------HLKNtqsfdVSNLRWLVLDEADRLLDMGFEKDITKILELLDDKRSKaggekskpSRRQTVLVSATLT 196
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
391-511 |
8.68e-20 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 88.56 E-value: 8.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQQRML-NRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcL 468
Cdd:cd17950 74 LVICHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLkNKCPHIVVGTPGRILALVREKKLKLSHVKH---F 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1398331555 469 VIDEADRMVEKghfaelsqlLEMLNDSQ-----YNPSRQTLVFSATLT 511
Cdd:cd17950 151 VLDECDKMLEQ---------LDMRRDVQeifraTPHDKQVMMFSATLS 189
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
204-511 |
1.81e-19 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 87.26 E-value: 1.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKmkappiprstgmppremrfgat 283
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAI-PILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRK---------------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsDSGVQAtpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 363
Cdd:cd17957 58 -----------------------------KKGLRA--------------------------------------------- 63
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvhprrpllgLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMS-TQKQQRMLNRHPEIVI 442
Cdd:cd17957 64 ---------------------------LILAPTRELASQIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDILV 116
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1398331555 443 ATPGRLWELVKEKHPHLSNLRQlrcLVIDEADRMVEKGhFAElsQLLEMLNDSQyNPSRQTLVFSATLT 511
Cdd:cd17957 117 STPLRLVFLLKQGPIDLSSVEY---LVLDEADKLFEPG-FRE--QTDEILAACT-NPNLQRSLFSATIP 178
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
385-509 |
5.78e-19 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 85.78 E-value: 5.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 385 RRPLLGLVLTPTRELAIQVRQHIDAVA-KFTGINTAILVGGMSTQKQQRMLNRhPEIVIATPGRLWELVKEkhpHLSNLR 463
Cdd:cd17943 56 RRHPQVLILAPTREIAVQIHDVFKKIGkKLEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIKQLIEL---GALNVS 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1398331555 464 QLRCLVIDEADRMVEKGHFAELSQLLEMLNDsqynpSRQTLVFSAT 509
Cdd:cd17943 132 HVRLFVLDEADKLMEGSFQKDVNWIFSSLPK-----NKQVIAFSAT 172
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
204-542 |
9.94e-19 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 86.27 E-value: 9.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQWHKMKAPPIPrstgmppremrfgat 283
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGI-PSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFN--------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 284 ahlgspckdrtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagegpssleekpvpkqnedgeekfda 363
Cdd:cd17948 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 364 eqagklkqelcdqiaiykvHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGmstQKQQRMLNRH---PEI 440
Cdd:cd17948 65 -------------------APR----GLVITPSRELAEQIGSVAQSLTEGLGLKVKVITGG---RTKRQIRNPHfeeVDI 118
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 441 VIATPGRLWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGHFAELSQLLE--------MLNDSQYNPSRQTLVFSATLtl 512
Cdd:cd17948 119 LVATPGALSKLLTS---RIYSLEQLRHLVLDEADTLLDDSFNEKLSHFLRrfplasrrSENTDGLDPGTQLVLVSATM-- 193
|
330 340 350
....*....|....*....|....*....|....*...
gi 1398331555 513 vhqaPAR---ILHKkhVKKMD-----KTDKLDLLMQKV 542
Cdd:cd17948 194 ----PSGvgeVLSK--VIDVDsietvTSDKLHRLMPHV 225
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
389-527 |
2.92e-18 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 83.75 E-value: 2.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 389 LGLVLTPTRELAIQV-RQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEkhpHLSNLRQLRC 467
Cdd:cd17962 60 SALILTPTRELAVQIeDQAKELMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQ---SSVELDNIKI 136
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 468 LVIDEADRMVEKGHFAELSQLLEMLNDSQynpsrQTLVFSATLTLVHQAPARILHKKHVK 527
Cdd:cd17962 137 VVVDEADTMLKMGFQQQVLDILENISHDH-----QTILVSATIPRGIEQLAGQLLQNPVR 191
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
390-509 |
5.15e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 83.01 E-value: 5.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 390 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNrhpEIVIATPGRLWELVKEKhphLSNLRQLRCLV 469
Cdd:cd17963 67 ALCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKITA---QIVIGTPGTVLDWLKKR---QLDLKKIKILV 140
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1398331555 470 IDEADRMVEKGHFAELSQ-LLEMLndsqyNPSRQTLVFSAT 509
Cdd:cd17963 141 LDEADVMLDTQGHGDQSIrIKRML-----PRNCQILLFSAT 176
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
391-509 |
5.45e-18 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 83.91 E-value: 5.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQLRCLVI 470
Cdd:cd18049 101 LVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 177
|
90 100 110
....*....|....*....|....*....|....*....
gi 1398331555 471 DEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSAT 509
Cdd:cd18049 178 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 211
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
391-509 |
9.01e-18 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 84.29 E-value: 9.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQLRCLVI 470
Cdd:cd18050 139 LVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK---TNLRRCTYLVL 215
|
90 100 110
....*....|....*....|....*....|....*....
gi 1398331555 471 DEADRMVEKGHFAELSQLLEmlndsQYNPSRQTLVFSAT 509
Cdd:cd18050 216 DEADRMLDMGFEPQIRKIVD-----QIRPDRQTLMWSAT 249
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
386-511 |
4.43e-16 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 77.51 E-value: 4.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 386 RPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHphlSNLRQL 465
Cdd:cd18045 66 RETQALILSPTRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRS---LRTRHI 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1398331555 466 RCLVIDEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLT 511
Cdd:cd18045 143 KMLVLDEADEMLNKGFKEQIYDVYRYL-----PPATQVVLVSATLP 183
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
390-509 |
6.04e-16 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 77.34 E-value: 6.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 390 GLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLV 469
Cdd:cd17940 70 ALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKT---LV 146
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1398331555 470 IDEADRMVEKghfaELSQLLEMLNDSqYNPSRQTLVFSAT 509
Cdd:cd17940 147 LDEADKLLSQ----DFQPIIEKILNF-LPKERQILLFSAT 181
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
204-509 |
6.32e-16 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 77.12 E-value: 6.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 204 VLRALSFLGFSAPTPIQAlTLAPAIRDKLDILGAAETGSGKTLAFAIP-MIHSVLQwhkmkapPIPRstgmppremrfga 282
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQS-QAWPIILQGIDLIGVAQTGTGKTLAYLLPgFIHLDLQ-------PIPR------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 283 tahlgspckdrtesgvlpeEARIeteaqpsdsgvqatpetsasasaqtllvcdddageGPSSLeekpvpkqnedgeekfd 362
Cdd:cd17958 60 -------------------EQRN-----------------------------------GPGVL----------------- 68
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 363 aeqagklkqelcdqiaiykvhprrpllglVLTPTRELAIQVRQHIDAVaKFTGINTAILVGGMSTQKQQRMLNRHPEIVI 442
Cdd:cd17958 69 -----------------------------VLTPTRELALQIEAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIII 118
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1398331555 443 ATPGRLWELVKEkhpHLSNLRQLRCLVIDEADRMVEKGhFAelSQLLEMLNDSQynPSRQTLVFSAT 509
Cdd:cd17958 119 ATPGRLNDLQMN---NVINLKSITYLVLDEADRMLDMG-FE--PQIRKILLDIR--PDRQTIMTSAT 177
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
213-519 |
4.82e-15 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 75.85 E-value: 4.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 213 FSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQwhkmkappiprstgmppremrfgatahlgspckd 292
Cdd:cd18051 41 YTKPTPVQKHAI-PIIKSKRDLMACAQTGSGKTAAFLLPILSQIYE---------------------------------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 293 rtesgvlpeearieteaqpsdsgvqatpetsasasaqtllvcdddagEGPssleekPVPKQNEDGeekfdaeQAGKLKQe 372
Cdd:cd18051 86 -----------------------------------------------QGP------GESLPSESG-------YYGRRKQ- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 373 lcdqiaiykvHPrrplLGLVLTPTRELAIQVrqhIDAVAKFT---GINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLW 449
Cdd:cd18051 105 ----------YP----LALVLAPTRELASQI---YDEARKFAyrsRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLV 167
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1398331555 450 ELVKEKHPHLSNLRQlrcLVIDEADRMVEKGHFAELSQLLEMLNdsqYNPS--RQTLVFSATLTLVHQAPAR 519
Cdd:cd18051 168 DMLERGKIGLDYCKY---LVLDEADRMLDMGFEPQIRRIVEQDT---MPPTgeRQTLMFSATFPKEIQMLAR 233
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
391-522 |
6.58e-15 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 74.02 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQlrcLVI 470
Cdd:cd18046 71 LVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKM---FVL 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1398331555 471 DEADRMVEKGHFAELSQLLEMLndsqyNPSRQTLVFSATLtlvhqaPARILH 522
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKL-----PPDTQVVLLSATM------PNDVLE 188
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
391-509 |
6.31e-14 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 71.42 E-value: 6.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKftGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLSNLRQLrclVI 470
Cdd:cd17944 68 LVLAPTRELANQVTKDFKDITR--KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHV---VL 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1398331555 471 DEADRMVEKGhFAElsQLLEMLN-----DSQYNPsrQTLVFSAT 509
Cdd:cd17944 143 DEVDQMLDMG-FAE--QVEEILSvsykkDSEDNP--QTLLFSAT 181
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
391-809 |
7.31e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 65.82 E-value: 7.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQvrqhidAVAKFTGINTAILVGGmstqkqqRMLNRHPEIVIATPGRLWelvkeKHPHLSNLRQLRCLVI 470
Cdd:COG1061 131 LVLVPRRELLEQ------WAEELRRFLGDPLAGG-------GKKDSDAPITVATYQSLA-----RRAHLDELGDRFGLVI 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 471 -DEAdrmvekgHFAELSQLLEMLNdsqYNPSRQTLVFSATltlvhqaPARilhkkhvkkMDKTD-KLDLLMQKV------ 542
Cdd:COG1061 193 iDEA-------HHAGAPSYRRILE---AFPAAYRLGLTAT-------PFR---------SDGREiLLFLFDGIVyeyslk 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 543 -----GMRGKPKVI----DLTRNEGTVETLTET---KIHCETDEKDLYLYYFLMQYPG--RSLVFANSISCIKRLSGLLK 608
Cdd:COG1061 247 eaiedGYLAPPEYYgirvDLTDERAEYDALSERlreALAADAERKDKILRELLREHPDdrKTLVFCSSVDHAEALAELLN 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 609 VLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQvPRTSE-IYIHRSGRTARAASEG-- 685
Cdd:COG1061 327 EAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLR-PTGSPrEFIQRLGRGLRPAPGKed 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 686 LSLMLIGPEDVINFKKIYKTLQKDE------------DIPLFPVQSKYMDVVKERIRLARQIEKAEYRNFQACLHNSWIE 753
Cdd:COG1061 406 ALVYDFVGNDVPVLEELAKDLRDLAgyrvefldeeesEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLL 485
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1398331555 754 QAAAALEIELEEEMYKGGKADQQEERRRQKQMKMLKQELRHLLSQPLFQENLKTRY 809
Cdd:COG1061 486 LELLALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLEL 541
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
391-509 |
4.82e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.87 E-value: 4.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKfTGINTAILVGGMSTQKQQRMLNRHPEIVIATPGRLWELVKEKHPHLsnLRQLRCLVI 470
Cdd:cd00046 34 LVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKLGDADIIIATPDMLLNLLLREDRLF--LKDLKLIIV 110
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1398331555 471 DEADRMVEKGHFAELSQLLE---MLNDSqynpsrQTLVFSAT 509
Cdd:cd00046 111 DEAHALLIDSRGALILDLAVrkaGLKNA------QVILLSAT 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
621-683 |
6.67e-09 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 59.74 E-value: 6.67e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 621 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YIHRSGRTARAAS 683
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVP--SEIrSIQRKGRTGRKRE 457
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
621-683 |
3.67e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 57.19 E-value: 3.67e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1398331555 621 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQ-VPrtSEI-YIHRSGRTARAAS 683
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEpVP--SEIrSIQRKGRTGRQEE 469
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
621-680 |
2.76e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.43 E-value: 2.76e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 621 MHQKQRLRNLEQFARLQDCVLLATDVAARGLDIPKVQHVIHYQvPRTSEI-YIHRSGRTAR 680
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYD-ASPSPIrMIQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
640-685 |
4.43e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.08 E-value: 4.43e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1398331555 640 VLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEG 685
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
568-697 |
1.45e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 51.68 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 568 IHCETDEKDLYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATdV 646
Cdd:COG0514 210 VPKPPDDKLAQLLDFLKEHPGGSgIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-I 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1398331555 647 A-ARGLDIPKVQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDVI 697
Cdd:COG0514 289 AfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVA 340
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
589-662 |
1.89e-06 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 47.86 E-value: 1.89e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1398331555 589 RSLVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDC--VLLATDVAARGLDIPKVQHVIHY 662
Cdd:cd18793 29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNLTAANRVILY 104
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
621-690 |
5.61e-06 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 46.82 E-value: 5.61e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 621 MHQKQRLRNLEQFaRLQDC-VLLATDVAARGLDIPKVQHVIHYQVPRTSEIYIHRSGRtARAASEGLSLML 690
Cdd:cd18802 74 MTQRKQKETLDKF-RDGELnLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNSKYILMV 142
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
188-258 |
5.72e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 50.22 E-value: 5.72e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 188 QKADVSAWRDlFVPKAVLRALSFLGFSAPTPIQALTLApAIRDKLDILGAAETGSGKTLAFAIPMIHSVLQ 258
Cdd:COG1205 30 REARYAPWPD-WLPPELRAALKKRGIERLYSHQAEAIE-AARAGKNVVIATPTASGKSLAYLLPVLEALLE 98
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
572-680 |
6.38e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 46.43 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 572 TDEKDLYLYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFARLQDCVLLATdVA-AR 649
Cdd:cd18794 14 KDEKLDLLKRIKVEHLGGSgIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGM 92
|
90 100 110
....*....|....*....|....*....|.
gi 1398331555 650 GLDIPKVQHVIHYQVPRTSEIYIHRSGRTAR 680
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGR 123
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
342-533 |
1.24e-05 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 47.32 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 342 PSSLEEKPVPKQNEDGEEKFDAE-QAGKLKQE-----LCDQIAIYKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKF-T 414
Cdd:cd18048 41 PSKIQENALPMMLADPPQNLIAQsQSGTGKTAafvlaMLSRVDALKLYPQ----CLCLSPTFELALQTGKVVEEMGKFcV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 415 GINTAILVGGMSTQKQQRMlnrHPEIVIATPGRLWELVKEKHphLSNLRQLRCLVIDEADRMVEKGHFAELSQLLEmlnd 494
Cdd:cd18048 117 GIQVIYAIRGNRPGKGTDI---EAQIVIGTPGTVLDWCFKLR--LIDVTNISVFVLDEADVMINVQGHSDHSVRVK---- 187
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1398331555 495 sQYNPSR-QTLVFSATL-TLVHQAPARILHKKHVKKMDKTD 533
Cdd:cd18048 188 -RSMPKEcQMLLFSATFeDSVWAFAERIVPDPNIIKLKKEE 227
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
358-479 |
3.70e-05 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 46.22 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 358 EEKFDAEQAGKLKQELCDqiaiyKVHPRrpllGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQRML-NR 436
Cdd:cd17965 89 QEQEPFEEAEEEYESAKD-----TGRPR----SVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLaFK 159
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1398331555 437 HP-EIVIATPGRLWELVKEKhphLSNLRQLRCLVIDEADRMVEK 479
Cdd:cd17965 160 GRiDILVTTPGKLASLAKSR---PKILSRVTHLVVDEADTLFDR 200
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
628-701 |
4.76e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 44.60 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 628 RNLEQFARLQDCVLLAT----DVAARGLDIPK-VQHVIHYQVPRTSeiYIHRSGRTAR----AASEGLSLMLIGPEDVIN 698
Cdd:cd18798 63 KNLEKFEEGEIDVLIGVasyyGVLVRGIDLPErIKYAIFYGVPVTT--YIQASGRTSRlyagGLTKGLSVVLVDDPELFE 140
|
...
gi 1398331555 699 FKK 701
Cdd:cd18798 141 ALK 143
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
579-696 |
2.15e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 44.70 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 579 LYYFLMQYPGRS-LVFANSISCIKRLSGLLKVLDVMPLTLHACMHQKQRLRNLEQFAR--LQdcVLLATDVAARGLDIPK 655
Cdd:PRK11057 227 LMRYVQEQRGKSgIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRddLQ--IVVATVAFGMGINKPN 304
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1398331555 656 VQHVIHYQVPRTSEIYIHRSGRTARAASEGLSLMLIGPEDV 696
Cdd:PRK11057 305 VRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADM 345
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
391-510 |
5.48e-04 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 42.01 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKF-TGINTAILVGGMSTQKQQRMLNrhpEIVIATPGRLWE-LVKEKhphLSNLRQLRCL 468
Cdd:cd18047 75 LCLSPTYELALQTGKVIEQMGKFyPELKLAYAVRGNKLERGQKISE---QIVIGTPGTVLDwCSKLK---FIDPKKIKVF 148
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1398331555 469 VIDEADRMV-EKGHFAELSQLLEMLNDSQynpsrQTLVFSATL 510
Cdd:cd18047 149 VLDEADVMIaTQGHQDQSIRIQRMLPRNC-----QMLLFSATF 186
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
391-510 |
5.67e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 41.86 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 391 LVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKQQrmlNRHPEIVIATPGRlWELVKEKHPHLsNLRQLRCLVI 470
Cdd:cd17921 50 VYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKLL---LAEADILVATPEK-LDLLLRNGGER-LIQDVRLVVV 124
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1398331555 471 DEAdRMVEKGHFAE-LSQLLEMLNdsQYNPSRQTLVFSATL 510
Cdd:cd17921 125 DEA-HLIGDGERGVvLELLLSRLL--RINKNARFVGLSATL 162
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
213-247 |
1.33e-03 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 42.40 E-value: 1.33e-03
10 20 30
....*....|....*....|....*....|....*
gi 1398331555 213 FSAPTPIQALTLaPAIRDKLDILGAAETGSGKTLA 247
Cdd:COG1201 22 FGAPTPPQREAW-PAIAAGESTLLIAPTGSGKTLA 55
|
|
| DEXDc_FANCM |
cd18033 |
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ... |
393-509 |
2.49e-03 |
|
DEAH-box helicase domain of FANCM; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, it binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, it efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, it strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA. FANCM is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350791 [Multi-domain] Cd Length: 182 Bit Score: 40.00 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 393 LTPTRELaiqVRQHIDAVAKFTGI---NTAILVGgmSTQKQQRM-LNRHPEIVIATPGRLWELVKEkhpHLSNLRQLRCL 468
Cdd:cd18033 52 MAPTKPL---VSQQIEACYKITGIpssQTAELTG--SVPPTKRAeLWASKRVFFLTPQTLENDLKE---GDCDPKSIVCL 123
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1398331555 469 VIDEADRMVEKGHFAELSQLLemlndSQYNPSRQTLVFSAT 509
Cdd:cd18033 124 VIDEAHRATGNYAYCQVVREL-----MRYNSHFRILALTAT 159
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
376-510 |
7.80e-03 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 39.88 E-value: 7.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 376 QIAIYKvHPRRPLLGLVLTPTRELAIQVRQHIDAVAKFTGINTAILVGGMSTQKqqRMLNRhPEIVIATPGRLWELVKEK 455
Cdd:COG1204 56 ELAILK-ALLNGGKALYIVPLRALASEKYREFKRDFEELGIKVGVSTGDYDSDD--EWLGR-YDILVATPEKLDSLLRNG 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1398331555 456 HphlSNLRQLRCLVIDEA----DRmvEKGHFAE--LSQLLEMlndsqyNPSRQTLVFSATL 510
Cdd:COG1204 132 P---SWLRDVDLVVVDEAhlidDE--SRGPTLEvlLARLRRL------NPEAQIVALSATI 181
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
415-511 |
8.69e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 38.28 E-value: 8.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1398331555 415 GINTAILVGGMSTQKQQRMLNRHPE----IVIATPGRLW-ELVKEKHPHLSNLRQLRCLVIDEADRMVEKGH-----FAE 484
Cdd:cd17920 76 GIRAAALNSTLSPEEKREVLLRIKNgqykLLYVTPERLLsPDFLELLQRLPERKRLALIVVDEAHCVSQWGHdfrpdYLR 155
|
90 100
....*....|....*....|....*..
gi 1398331555 485 LSQLLEMLNDSqynpsrQTLVFSATLT 511
Cdd:cd17920 156 LGRLRRALPGV------PILALTATAT 176
|
|
| |
