NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1476587958|ref|NP_001352849|]
View 

male-specific lethal 1 homolog isoform 3 [Homo sapiens]

Protein Classification

MSL1 family protein( domain architecture ID 10633776)

MSL1 (male-specific lethal 1) family protein similar to vertebrate KAT8 regulatory NSL complex subunit 1 that as part of the NSL complex, is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 459-584 5.58e-26

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


:

Pssm-ID: 464607  Cd Length: 128  Bit Score: 102.95  E-value: 5.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958 459 IPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEPEV 535
Cdd:pfam15275   3 TPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQPS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1476587958 536 TSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 584
Cdd:pfam15275  81 SPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 243-485 8.38e-04

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 8.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  243 KEKEIEELKS---------ERDTLLARIERMERRMQlvKKDNEKERHKLFQGYETEEREETELSEKIK--------LECQ 305
Cdd:PTZ00108  1114 KEKELEKLKNttpkdmwleDLDKFEEALEEQEEVEE--KEIAKEQRLKSKTKGKASKLRKPKLKKKEKkkkkssadKSKK 1191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  306 PELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCG--SLSETVCKRELRS 383
Cdd:PTZ00108  1192 ASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDndEFSSDDLSKEGKP 1271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  384 QETPEKPRSSVDTPPRLST-PQKGPSTHPKEKAFSSEIEDLPYLSTTEmylcrwhQPPPSPLPLRESSPKKEETVAIPSW 462
Cdd:PTZ00108  1272 KNAPKRVSAVQYSPPPPSKrPDGESNGGSKPSSPTKKKVKKRLEGSLA-------ALKKKKKSEKKTARKKKSKTRVKQA 1344

                          250       260
                   ....*....|....*....|...
gi 1476587958  463 RDHSVEPLRDPNPSDLLENLDDS 485
Cdd:PTZ00108  1345 SASQSSRLLRRPRKKKSDSSSED 1367
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 459-584 5.58e-26

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 102.95  E-value: 5.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958 459 IPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEPEV 535
Cdd:pfam15275   3 TPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQPS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1476587958 536 TSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 584
Cdd:pfam15275  81 SPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 243-485 8.38e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 8.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  243 KEKEIEELKS---------ERDTLLARIERMERRMQlvKKDNEKERHKLFQGYETEEREETELSEKIK--------LECQ 305
Cdd:PTZ00108  1114 KEKELEKLKNttpkdmwleDLDKFEEALEEQEEVEE--KEIAKEQRLKSKTKGKASKLRKPKLKKKEKkkkkssadKSKK 1191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  306 PELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCG--SLSETVCKRELRS 383
Cdd:PTZ00108  1192 ASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDndEFSSDDLSKEGKP 1271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  384 QETPEKPRSSVDTPPRLST-PQKGPSTHPKEKAFSSEIEDLPYLSTTEmylcrwhQPPPSPLPLRESSPKKEETVAIPSW 462
Cdd:PTZ00108  1272 KNAPKRVSAVQYSPPPPSKrPDGESNGGSKPSSPTKKKVKKRLEGSLA-------ALKKKKKSEKKTARKKKSKTRVKQA 1344

                          250       260
                   ....*....|....*....|...
gi 1476587958  463 RDHSVEPLRDPNPSDLLENLDDS 485
Cdd:PTZ00108  1345 SASQSSRLLRRPRKKKSDSSSED 1367
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 459-584 5.58e-26

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 102.95  E-value: 5.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958 459 IPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEPEV 535
Cdd:pfam15275   3 TPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQPS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1476587958 536 TSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 584
Cdd:pfam15275  81 SPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 243-485 8.38e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 8.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  243 KEKEIEELKS---------ERDTLLARIERMERRMQlvKKDNEKERHKLFQGYETEEREETELSEKIK--------LECQ 305
Cdd:PTZ00108  1114 KEKELEKLKNttpkdmwleDLDKFEEALEEQEEVEE--KEIAKEQRLKSKTKGKASKLRKPKLKKKEKkkkkssadKSKK 1191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  306 PELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCG--SLSETVCKRELRS 383
Cdd:PTZ00108  1192 ASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDndEFSSDDLSKEGKP 1271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587958  384 QETPEKPRSSVDTPPRLST-PQKGPSTHPKEKAFSSEIEDLPYLSTTEmylcrwhQPPPSPLPLRESSPKKEETVAIPSW 462
Cdd:PTZ00108  1272 KNAPKRVSAVQYSPPPPSKrPDGESNGGSKPSSPTKKKVKKRLEGSLA-------ALKKKKKSEKKTARKKKSKTRVKQA 1344

                          250       260
                   ....*....|....*....|...
gi 1476587958  463 RDHSVEPLRDPNPSDLLENLDDS 485
Cdd:PTZ00108  1345 SASQSSRLLRRPRKKKSDSSSED 1367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH