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Conserved domains on  [gi|1616023170|ref|NP_001356618|]
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insulin-like growth factor-binding protein 3 receptor isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM219 super family cl20824
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 7.63e-12

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


The actual alignment was detected with superfamily member pfam14940:

Pssm-ID: 464388  Cd Length: 236  Bit Score: 62.87  E-value: 7.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170  48 LRSPDIPQDWVSFLRSFGQLTLC----------------PRNGTVTGKWRGSHV--------VGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTLSASLinisvpihLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170 104 rTFQATVLGSQMGLKGSSAGQLVLIT--------------ARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 7.63e-12

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 62.87  E-value: 7.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170  48 LRSPDIPQDWVSFLRSFGQLTLC----------------PRNGTVTGKWRGSHV--------VGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTLSASLinisvpihLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170 104 rTFQATVLGSQMGLKGSSAGQLVLIT--------------ARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 7.63e-12

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 62.87  E-value: 7.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170  48 LRSPDIPQDWVSFLRSFGQLTLC----------------PRNGTVTGKWRGSHV--------VGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTLSASLinisvpihLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616023170 104 rTFQATVLGSQMGLKGSSAGQLVLIT--------------ARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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