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Conserved domains on  [gi|1700447615|ref|NP_001358277|]
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uncharacterized protein LOC195531 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 3.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 3.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1700447615  12 LLTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-349 5.57e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615  71 YIVHEHMNIQEKSSKWNKLSNVILESPHCVPHKCSEWDKcFSQRSHLSIHQKIHTGEKPYKCSECDKcFTEKGILRIHQK 150
Cdd:COG5048   142 SISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP-SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQN 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 151 IHSGEKSYKYHECDKCFPKKSHLSIHLRIHKGEKPYKCSDCDKCFTEKRKLRRHQKIHTGE-------KPYKCSECDKCF 223
Cdd:COG5048   220 LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISF 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 224 IQKYSLSDHQR--IHTGE--KPYKCSE--CNKCFIQKSSLNNHQSIHTGEKPYKCSECDKCFTDKRNL-------RRHQK 290
Cdd:COG5048   300 SRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYK 379

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1700447615 291 IHTGEKPYKCSECEKCFTDKG----SLRRHQKIHTGEKPYKCSECEKCYTDKGSLRRHQKIHK 349
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 3.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 3.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1700447615  12 LLTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-56 3.14e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.63  E-value: 3.14e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1700447615   13 LTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLFVENHF 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.26e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.26e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1700447615  13 LTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-349 5.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615  71 YIVHEHMNIQEKSSKWNKLSNVILESPHCVPHKCSEWDKcFSQRSHLSIHQKIHTGEKPYKCSECDKcFTEKGILRIHQK 150
Cdd:COG5048   142 SISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP-SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQN 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 151 IHSGEKSYKYHECDKCFPKKSHLSIHLRIHKGEKPYKCSDCDKCFTEKRKLRRHQKIHTGE-------KPYKCSECDKCF 223
Cdd:COG5048   220 LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISF 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 224 IQKYSLSDHQR--IHTGE--KPYKCSE--CNKCFIQKSSLNNHQSIHTGEKPYKCSECDKCFTDKRNL-------RRHQK 290
Cdd:COG5048   300 SRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYK 379

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1700447615 291 IHTGEKPYKCSECEKCFTDKG----SLRRHQKIHTGEKPYKCSECEKCYTDKGSLRRHQKIHK 349
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-308 2.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.15e-04
                          10        20
                  ....*....|....*....|....*
gi 1700447615 284 NLRRHQKIHTGEKPYKCSECEKCFT 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 3.82e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 3.82e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1700447615  12 LLTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-56 3.14e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.63  E-value: 3.14e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1700447615   13 LTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLFVENHF 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 1.26e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 1.26e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1700447615  13 LTFKDVAVEFSLEEWERLSFAQRSLYIDVMLENYNNLLF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-349 5.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615  71 YIVHEHMNIQEKSSKWNKLSNVILESPHCVPHKCSEWDKcFSQRSHLSIHQKIHTGEKPYKCSECDKcFTEKGILRIHQK 150
Cdd:COG5048   142 SISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP-SSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQN 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 151 IHSGEKSYKYHECDKCFPKKSHLSIHLRIHKGEKPYKCSDCDKCFTEKRKLRRHQKIHTGE-------KPYKCSECDKCF 223
Cdd:COG5048   220 LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISF 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 224 IQKYSLSDHQR--IHTGE--KPYKCSE--CNKCFIQKSSLNNHQSIHTGEKPYKCSECDKCFTDKRNL-------RRHQK 290
Cdd:COG5048   300 SRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYK 379

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1700447615 291 IHTGEKPYKCSECEKCFTDKG----SLRRHQKIHTGEKPYKCSECEKCYTDKGSLRRHQKIHK 349
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
66-260 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615  66 DEDSQYIVHEHMNIQEKSSKW--NKLSNVILESPHCVPHKCSEWDKCFSQRSHLSIHQ--KIHTGE--KPYKCSE--CDK 137
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSssPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 138 CFTEKGILRIHQKIHSGEKSYKYHEC------DKCFPKKSHLSIHLR-IHKGEKPYKCSDCDKCFTEKR----KLRRHQK 206
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETLSNSCIRNFKRdsnlSLHIITH 411

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1700447615 207 IHTGEKPYKCSECDKCFIQKYSLSDHQRIHTgEKPYKCSECNKCFIQKSSLNNH 260
Cdd:COG5048   412 LSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 266-346 8.65e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 8.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 266 GEKPYKCS--ECDKCFTDKRNLRRHqKIHtgekpykcSECEKCFTDKGSLRRHQKIHTGEKPYKCSECEKCYTDKGSLRR 343
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1700447615 344 HQK 346
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 203-290 2.13e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 203 RHQKIhTGEKPYKCS--ECDKCFIQKYSLSDHqRIHtgekpykcSECNKCFIQKSSLNNHQSIHTGEKPYKCSECDKCFT 280
Cdd:COG5189   340 RMLKV-KDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409

                          90
                  ....*....|
gi 1700447615 281 DKRNLRRHQK 290
Cdd:COG5189   410 NLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-308 2.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.15e-04
                          10        20
                  ....*....|....*....|....*
gi 1700447615 284 NLRRHQKIHTGEKPYKCSECEKCFT 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-225 2.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.39e-04
                          10        20
                  ....*....|....*....|....*
gi 1700447615 201 LRRHQKIHTGEKPYKCSECDKCFIQ 225
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-348 2.78e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 101 PHKCSEWDKCFSQRSHLSIHQKIHTGEKPYKCS--ECDKCFTEKGILRIHQKIHSGEKSYKY-HECDKCFPKKSHLSIHL 177
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 178 RIHKGEKPYKCSDCDKCFTEKRKLRR--------------------------------------------------HQKI 207
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPdllsisnlrnnplpgnnsssvntpqsnslhpplpanslskdpssnlslliSSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 208 HTGEKPYKCSECDKCFIQKYSLSDHQRIHTGEKPYKCSECNKCFIQKSSLNNHQSIHTGEKPYKCSECDKCFTDKRNLRR 287
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1700447615 288 HQKIHTGE-------KPYKCSECEKCFTDKGSLRRHQ--KIHTGE--KPYKCSE--CEKCYTDKGSLRRHQKIH 348
Cdd:COG5048   273 SSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
69-301 1.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615  69 SQYIVHEHMNIQEKSSKWNKLSNVILESPHCvphkCSEWDKCFSQRSHLSIHQKIHTG-EKPYKCSECDKCFTEKGILRI 147
Cdd:COG5048   232 NSQLSPKSLLSQSPSSLSSSDSSSSASESPR----SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTR 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 148 HQ--KIHSGEKSY----KYHECDKCFPKKSHLSIHLRIHKGEKPYKCsdcdkcftekrKLRRHQKIHTGEKPYKCSECdk 221
Cdd:COG5048   308 HLrsVNHSGESLKpfscPYSLCGKLFSRNDALKRHILLHTSISPAKE-----------KLLNSSSKFSPLLNNEPPQS-- 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 222 cfIQKYSLSDHQRIHTGEKpykcSECNKCFIQKS--SLNNHQSIHTGEKPYKCSECDKCFTDKRNLRRHQKIHTGEKPYK 299
Cdd:COG5048   375 --LQQYKDLKNDKKSETLS----NSCIRNFKRDSnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ..
gi 1700447615 300 CS 301
Cdd:COG5048   449 CS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-336 1.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|....*
gi 1700447615 312 SLRRHQKIHTGEKPYKCSECEKCYT 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-301 2.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 2.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1700447615 240 KPYKCSECNKCFIQKSSLNNHQSIHTGEKPYKCS--ECDKCFTDKRNLRRHQKIHTGEKPYKCS 301
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
116-140 2.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....*
gi 1700447615 116 HLSIHQKIHTGEKPYKCSECDKCFT 140
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 270-292 3.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.55e-03
                          10        20
                  ....*....|....*....|...
gi 1700447615 270 YKCSECDKCFTDKRNLRRHQKIH 292
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 126-206 3.87e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 126 GEKPYKCS--ECDKCFTEKGILRIHQKihSGEKSYKYHECDKCFPKKSHLSihlrihkGEKPYKCSDCDKCFTEKRKLRR 203
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHENPSPEKMNIFSA-------KDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1700447615 204 HQK 206
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 5.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 1700447615 228 SLSDHQRIHTGEKPYKCSECNKCFIQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-329 8.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1700447615 252 IQKSSLNNHQSIHTGE----KPYKCSECDKCFTDKRNLRRHQKIHTGEKPYKCS--ECEKCFTDKGSLRRHQKIHTGEKP 325
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91


                  ....
gi 1700447615 326 YKCS 329
Cdd:COG5048    92 DLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-196 8.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 8.79e-03
                          10        20
                  ....*....|....*....|....*
gi 1700447615 172 HLSIHLRIHKGEKPYKCSDCDKCFT 196
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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