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Conserved domains on  [gi|1782692247|ref|NP_001363152|]
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zinc finger protein 587B isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-55 1.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.75e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1782692247  15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLG 55
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-504 4.63e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 215 SHGDSMKHFSTKHILSQHqrllpreecyvcCECGKSFSKYVSFSNHQRVHSGKRPYECGECEkSFSQKSSLIQHQQFHTG 294
Cdd:COG5048   157 SSVNTPQSNSLHPPLPAN------------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS-SSYSIPSSSSDQNLENS 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 295 GKPYGCEECgkYFSLEGYLRRHQKVHAgKGPYECGECGKSFSSNVNLKSHQRIH----------TGERPYKCGECEKSFS 364
Cdd:COG5048   224 SSSLPLTTN--SQLSPKSLLSQSPSSL-SSSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFS 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 365 RKPSLSYHQR--IHT--EVRPYKCGE--CGKSYISKGHLRIHQRMHTGERPYKC--GDCGKSF----NEKGHLRSHQRVH 432
Cdd:COG5048   301 RSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllNNEPPQSLQQYKD 380

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1782692247 433 TTERPYKCGECGKCFSHKG---NLILHQHGHTRKRPYMC--WECGKLFKKKSHLLVHQRIHSGEKPYACEACQKFFR 504
Cdd:COG5048   381 LKNDKKSETLSNSCIRNFKrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-588 4.78e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1782692247 564 YLTSHRRVHTGQKPYECSECGKSFA 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
575-628 5.22e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1782692247 575 QKPYECSECGKSFAGISSLTNHRRVHTGEKPYGCS--ECEKKFRKSSSLRYHQRVH 628
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 6.41e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 508 HLTAHQRVHTGERPYECSDCGKSFTH 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-55 1.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.75e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1782692247  15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLG 55
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
15-56 6.82e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 6.82e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1782692247   15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLGC 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-54 2.61e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 2.61e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1782692247  15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSL 54
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-504 4.63e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 215 SHGDSMKHFSTKHILSQHqrllpreecyvcCECGKSFSKYVSFSNHQRVHSGKRPYECGECEkSFSQKSSLIQHQQFHTG 294
Cdd:COG5048   157 SSVNTPQSNSLHPPLPAN------------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS-SSYSIPSSSSDQNLENS 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 295 GKPYGCEECgkYFSLEGYLRRHQKVHAgKGPYECGECGKSFSSNVNLKSHQRIH----------TGERPYKCGECEKSFS 364
Cdd:COG5048   224 SSSLPLTTN--SQLSPKSLLSQSPSSL-SSSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFS 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 365 RKPSLSYHQR--IHT--EVRPYKCGE--CGKSYISKGHLRIHQRMHTGERPYKC--GDCGKSF----NEKGHLRSHQRVH 432
Cdd:COG5048   301 RSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllNNEPPQSLQQYKD 380

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1782692247 433 TTERPYKCGECGKCFSHKG---NLILHQHGHTRKRPYMC--WECGKLFKKKSHLLVHQRIHSGEKPYACEACQKFFR 504
Cdd:COG5048   381 LKNDKKSETLSNSCIRNFKrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 3.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 340 NLKSHQRIHTGERPYKCGECEKSFSR 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-588 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1782692247 564 YLTSHRRVHTGQKPYECSECGKSFA 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
575-628 5.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1782692247 575 QKPYECSECGKSFAGISSLTNHRRVHTGEKPYGCS--ECEKKFRKSSSLRYHQRVH 628
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 6.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 508 HLTAHQRVHTGERPYECSDCGKSFTH 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-55 1.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.75e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1782692247  15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLG 55
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
15-56 6.82e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 6.82e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1782692247   15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLGC 56
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-54 2.61e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.19  E-value: 2.61e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1782692247  15 VTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSL 54
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-504 4.63e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 215 SHGDSMKHFSTKHILSQHqrllpreecyvcCECGKSFSKYVSFSNHQRVHSGKRPYECGECEkSFSQKSSLIQHQQFHTG 294
Cdd:COG5048   157 SSVNTPQSNSLHPPLPAN------------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS-SSYSIPSSSSDQNLENS 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 295 GKPYGCEECgkYFSLEGYLRRHQKVHAgKGPYECGECGKSFSSNVNLKSHQRIH----------TGERPYKCGECEKSFS 364
Cdd:COG5048   224 SSSLPLTTN--SQLSPKSLLSQSPSSL-SSSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFS 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 365 RKPSLSYHQR--IHT--EVRPYKCGE--CGKSYISKGHLRIHQRMHTGERPYKC--GDCGKSF----NEKGHLRSHQRVH 432
Cdd:COG5048   301 RSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllNNEPPQSLQQYKD 380

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1782692247 433 TTERPYKCGECGKCFSHKG---NLILHQHGHTRKRPYMC--WECGKLFKKKSHLLVHQRIHSGEKPYACEACQKFFR 504
Cdd:COG5048   381 LKNDKKSETLSNSCIRNFKrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-624 2.54e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 240 ECYVCCECGKSFSKYVSFSNHQRVHSGKRPYECG--ECEKSFSQKSSLIQHQQFHTGGKPYGCE--ECGKYFSLEGYLRR 315
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 316 HQKVH-----AGKGPYECGECGKSFSSNVNLKSH---QRIHTGERPYKCGECEKSF-------------SRKPSLSYHQR 374
Cdd:COG5048   112 SSSSNsndnnLLSSHSLPPSSRDPQLPDLLSISNlrnNPLPGNNSSSVNTPQSNSLhpplpanslskdpSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 375 IHTEVRPYKCGECGKSYISKGHLRIHQRMHTGERPYKCGDCgkSFNEKGHLRSHQRVHTTErPYKCGECGKCFSH-KGNL 453
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSS-SDSSSSASESPRSsLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 454 ILHQHGHTRK---------RPYMCWECGKLFKKKSHLLVHQR--IHSGE--KPYAC--EACQKFFRHKCHLTAHQRVHTG 518
Cdd:COG5048   269 SSQSSSPNESdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 519 ERPYEC--SDCGKSFTH-----SCAFIVHKRVHTGQKPYEC--SECGKSFAASSYLTSHRRVHTGQKPYEC--SECGKSF 587
Cdd:COG5048   349 ISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1782692247 588 AGISSLTNHRRVHTgEKPYGCSECEKKFRKSSSLRYH 624
Cdd:COG5048   429 NRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-631 6.23e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 6.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 325 PYECGECGKSFSSNVNLKSHQRIHTGERPYKCG--ECEKSFSRKPSLSYHQRIHTE----------------VRPYKCGE 386
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnskASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 387 CGK--------SYISKGHLRIHQ-----RMHTGERPYKCGDC-GKSFNEKGHLRSHQRVHTTErpykcgECGKCFSHKGN 452
Cdd:COG5048   113 SSSnsndnnllSSHSLPPSSRDPqlpdlLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 453 LILHQHGHTRKRPYMCWECGKlFKKKSHLLVHQRIHSGEKPYACEACQkfFRHKCHLTAHQRVHTGErPYECSDCGKSFT 532
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSS-SDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 533 HSCAFIVHKR---------VHTGQ-KPYECSECGKSFAASSYLTSHRR--VHTGQ--KPYECSE--CGKSFAGISSLTNH 596
Cdd:COG5048   263 SSLPTASSQSsspnesdssSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1782692247 597 RRVHTGEKPYGC--SECEKKFRKSSSLRYHQRVHERK 631
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYK 379
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-454 2.36e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 221 KHFSTKHILSQHQRLLPREECYVCCECGKSFSKYVSFSNHQRVHSGKRPYECGECEKSFSQKSSLIQHQQFHTG-GKPYG 299
Cdd:COG5048   212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIK 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 300 CEECGKYFSLEGYLRRHQ--KVHAGKG--PYECGE--CGKSFSSNVNLKSHQRIHTGERPYKC--GECEKSFS-----RK 366
Cdd:COG5048   292 SKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEP 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 367 PSLSYHQRIHTEVRPYKC-GECGKSYISKGHLRI-HQRMHTGERP--YKCGDCGKSFNEKGHLRSHQRVHTTERPYKCge 442
Cdd:COG5048   372 PQSLQQYKDLKNDKKSETlSNSCIRNFKRDSNLSlHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         250
                  ....*....|..
gi 1782692247 443 CGKCFSHKGNLI 454
Cdd:COG5048   450 SILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 3.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 340 NLKSHQRIHTGERPYKCGECEKSFSR 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 315-405 4.93e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1782692247 315 RHQKVHAGKgPYECG--ECGKSFSSNVNLKSHqRIHtgerpykcGECEKSFSRKPSLSYHQRIHTEVRPYKCGECGKSYI 392
Cdd:COG5189   340 RMLKVKDGK-PYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409

                          90
                  ....*....|...
gi 1782692247 393 SKGHLRIHqRMHT 405
Cdd:COG5189   410 NLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-420 2.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.42e-03
                          10        20
                  ....*....|....*....|....*
gi 1782692247 396 HLRIHQRMHTGERPYKCGDCGKSFN 420
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-588 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1782692247 564 YLTSHRRVHTGQKPYECSECGKSFA 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
575-628 5.22e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1782692247 575 QKPYECSECGKSFAGISSLTNHRRVHTGEKPYGCS--ECEKKFRKSSSLRYHQRVH 628
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 6.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 508 HLTAHQRVHTGERPYECSDCGKSFTH 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 7.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 1782692247 424 HLRSHQRVHTTERPYKCGECGKCFSH 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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