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Conserved domains on  [gi|1805354099|ref|NP_001365170|]
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lymphocyte antigen 6 complex, locus A2 precursor [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 3.55e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 3.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  25 QGLECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYCPTDLEN-SPIKDPKVKVKISCCQEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYFlEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1805354099 104 CNA 106
Cdd:cd23541    81 CNA 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 3.55e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 3.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  25 QGLECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYCPTDLEN-SPIKDPKVKVKISCCQEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYFlEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1805354099 104 CNA 106
Cdd:cd23541    81 CNA 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-111 3.73e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 62.94  E-value: 3.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099   27 LECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSqRRKVKSHQCLSY--CPTDlENSPIKDPKVKVKISCCQEDLC 104
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDS-RGSVVYKGCATSpiCPGS-HGYEINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 1805354099  105 NAAVPTE 111
Cdd:smart00134  79 NAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 1.85e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.02  E-value: 1.85e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1805354099  29 CYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCL-SYCPTDLENSpIKDPKVKVKISCCQEDLCN 105
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRLLSDF-INGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 3.55e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 3.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  25 QGLECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYCPTDLEN-SPIKDPKVKVKISCCQEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYFlEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1805354099 104 CNA 106
Cdd:cd23541    81 CNA 83
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-111 3.73e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 62.94  E-value: 3.73e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099   27 LECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSqRRKVKSHQCLSY--CPTDlENSPIKDPKVKVKISCCQEDLC 104
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDS-RGSVVYKGCATSpiCPGS-HGYEINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 1805354099  105 NAAVPTE 111
Cdd:smart00134  79 NAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 1.85e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.02  E-value: 1.85e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1805354099  29 CYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCL-SYCPTDLENSpIKDPKVKVKISCCQEDLCN 105
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRLLSDF-INGGIISVSESCCQSDLCN 77
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 27-107 4.16e-07

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 44.70  E-value: 4.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  27 LECYHCPDDPRESSCNTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYCPTD---LENSPIKDPKVKVKISCCQEDL 103
Cdd:cd23551     2 LKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTnsrCEWSPGTQVIGSITRTCCSQSL 81


                  ....
gi 1805354099 104 CNAA 107
Cdd:cd23551    82 CNRA 85
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 27-106 7.80e-07

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 43.86  E-value: 7.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  27 LECYHCPDDPRESSCNT-TTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYC-PTDLENSpikdpKVKVKISCCQEDLC 104
Cdd:cd23575     3 LKCYTCVSAHSNSDCLTeTNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCtPSTRTVE-----GTKVTVSCCQTDLC 77


                  ..
gi 1805354099 105 NA 106
Cdd:cd23575    78 NV 79
TFP_LU_ECD_SLURP1_like cd23560
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ...
 27-105 4.82e-04

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467090  Cd Length: 78  Bit Score: 36.65  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  27 LECYHCPDDPRESSC-NTTTCPFPDGFCVTQ--EAEIIVDSQRRKVKSHQCLSYC-PTDLENSPIKDPkvkvkISCCQED 102
Cdd:cd23560     1 LRCYTCPEPTDSSLCtTIVNCSPNETACKTTlySVDSGYPFFGNITVTRGCASECiPSDPDGIGETHP-----ISCCNTD 75


                  ...
gi 1805354099 103 LCN 105
Cdd:cd23560    76 LCN 78
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 27-105 3.25e-03

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 34.22  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  27 LECYHCPDDPreSSCNTT-TCPfpdgfcVTQEAEIIVDSQRRKvkSHQCLSYCPTDLENSPIKDPKVKVKISCCQEDLCN 105
Cdd:cd23554     1 LKCYNCPNPT--SNCNTNvTCS------SNLDACLIVKAGNRI--YRQCWKYSDCNFDFISERFGESNFKYRCCQKDLCN 70
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 27-105 3.60e-03

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 34.25  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1805354099  27 LECYHCPDDPRESSC-NTTTCPFPDGFCVTQEAEIIVDSQRRKVKSHQCLSYCPTDLENSPIkdpkVKVKISCCQEDLCN 105
Cdd:cd23543     3 LYCYTCENQSSNWNClKPTKCSDNDKYCVTTVASGGTGSSSGVRITKKCSPKCPETNVNIGI----ASVSTSCCQSSLCN 78
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 42-109 8.29e-03

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 33.44  E-value: 8.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1805354099  42 NTTTCPFPDGFCVTQEAEIivdSQRRKVKSHQCLSYCPTDLENSPIKDPKVKVK------ISCCQEDLCNAAVP 109
Cdd:cd23550    16 NPVTCTWEETYCVLAAVRI---FPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKpmpflyIKCCRENLCNEEGP 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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