|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
6-1092 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1642.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882 5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 86 DCHGLPVscivavvfigqrgnslitnfqEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDF 165
Cdd:PLN02882 85 DCHGLPV---------------------EYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 166 DNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAW 244
Cdd:PLN02882 144 ENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 245 TTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYR 311
Cdd:PLN02882 224 TTTPWTLPSNLALCVNPNFTYVKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYE 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 312 PLFDYFLKCKENgAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYV 391
Cdd:PLN02882 304 PLFDYFSEFSDT-AFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYV 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 392 KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLK 471
Cdd:PLN02882 383 KDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLE 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 472 DARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWF 549
Cdd:PLN02882 463 NARDWAVSRSRFWGTPLPIWISDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWF 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 550 ESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNY 629
Cdd:PLN02882 543 ESGSMPYAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNY 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 630 PDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRE 708
Cdd:PLN02882 623 PDPNEVIDKYGADALRLYLINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQN 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 709 SPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCR 788
Cdd:PLN02882 703 SANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCK 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 789 LMAPYTPFLTELMYQNL-KVLidPVSVQdkdtlSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYP 867
Cdd:PLN02882 783 VMAPFTPFFTEVLYQNLrKVL--PGSEE-----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTP 855
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 868 LKEIVVIHQDPEALKDIK-SLEKYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELE 946
Cdd:PLN02882 856 LKEMVVVHPDAEFLDDITgKLKEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDIL 934
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 947 QFQKTGTIVVEGHELHDEDIRLMYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLV 1025
Cdd:PLN02882 935 EFEKAGEVTIAGHTLKAGDIKVVRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLE 1014
|
1050 1060 1070 1080 1090 1100 1110
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1811715276 1026 PTDEITVYYK--AKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1092
Cdd:PLN02882 1015 PTDKVEVFFEslDEVDESALSQVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-1024 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1133.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 85 WDCHGLPVscivavvfigqrgnslitnfqEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWID 164
Cdd:PTZ00427 148 WDCHGLPI---------------------EYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWID 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 165 FDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTF------------- 231
Cdd:PTZ00427 207 FKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeec 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 232 PLEEDETV---------------------------------SLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLI 278
Cdd:PTZ00427 287 NIEEDKQLlgekysvlynnkrensnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVI 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 279 LMEARLSALYK-LESDYE---ILERFPGAYLKGKKYRPLFDYFLKcKEN---GAFTVLVDNYVKEEEGTGVVHQAPYFGA 351
Cdd:PTZ00427 367 VGECRLEWIMKeLKWNVEdlkIVNRFKGKELKGLRYKPLFTNFYE-KYNfkeRAYKILADDFVTDDAGTGIVHCAPTYGE 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 352 EDYRVCMDFNIIRKDS-LPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIY 430
Cdd:PTZ00427 446 DDFRVCKKNGVIDPEKnIFIDPLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIY 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 431 KAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEE 510
Cdd:PTZ00427 526 RAIPAWFIRVSNSTNELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEE 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 511 LSGAK-ISDLHRESVDHLTIPSRCGKG--SLHRISEVFDCWFESGSMPYAQVHYPFENKRE-FEDAFPADFIAEGIDQTR 586
Cdd:PTZ00427 606 LSGVKnINDLHRHFIDHIEIKNPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTR 685
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 587 GWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGV 666
Cdd:PTZ00427 686 GWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGV 765
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 667 RDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVK 746
Cdd:PTZ00427 766 NEVVKSFILPFYHSFRFFSQEVTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQ 845
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 747 FVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK-VLIDPVSVQDKDT------ 819
Cdd:PTZ00427 846 FIENLTNWYIRLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRrVKSTNEHNENNETgntkeg 925
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 820 --------LSIHYLMLPRVREE-LIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKY 890
Cdd:PTZ00427 926 dlnrgvihKSVHFIMLPQVDEKyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNY 1005
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 891 IIEELNVRKVTLSTDKNkyGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDI--RL 968
Cdd:PTZ00427 1006 IKEELNVLNVECSNDTS--CLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQM 1083
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*..
gi 1811715276 969 MYTF-DQATggtaqfEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNL 1024
Cdd:PTZ00427 1084 KPNFqNDNT------DIISNNYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSL 1134
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-1018 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1021.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 86 DCHGLPVscivavvfigqrgnslitnfqEYEIDKTLGIRGPeDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDF 165
Cdd:COG0060 93 DCHGLPI---------------------ELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 166 DNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEED------ETV 239
Cdd:COG0060 151 DNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 240 SLVAWTTTPWTLPSNLAVCVNPEMQYVKIKdVARGRLLILMEARLSAL---YKLEsDYEILERFPGAYLKGKKYRPLFDY 316
Cdd:COG0060 229 YLVIWTTTPWTLPANLAVAVHPDIDYVLVE-VTGGERLILAEALVEAVlkeLGIE-DYEVLATFKGAELEGLRYEHPFYY 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 317 FLKckENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNiirkdsLPV-CPVDASGCFTTEVTDFAGQYVKDAD 395
Cdd:COG0060 307 VVG--YDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDAN 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 396 KSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWLKDARD 475
Cdd:COG0060 379 PAIIEDLKERGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPE-WGEGRFGNMLENRPD 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 476 WTISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSGAKIS---DLHRESVDHlTIPSRCGKGSLHRISEVFDCW 548
Cdd:COG0060 458 WCISRQRYWGVPIPIWVCEDCGELHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVW 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 549 FESGSMPYAQVhypfENKREFedAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKN 628
Cdd:COG0060 537 FDSGSMHFAVL----ENREEL--HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGN 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 629 YPDPVSIIQKYGADALRLYLINSPvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFLIQNvlrLQKeeeieFLYNENTVR- 707
Cdd:COG0060 611 VVDPQEVIDKYGADILRLWVASSD--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLAN---LDD-----FDPAEDAVPy 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 708 ESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGMEDCVMALETLFSVLLS 785
Cdd:COG0060 680 EDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLET 759
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 786 LCRLMAPYTPFLTELMYQNLKvlidpvsvqDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGR----VIRDRKT 861
Cdd:COG0060 760 LVRLLAPILPFTAEEIWQNLP---------GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL 830
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 862 ipIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmtsikqls 941
Cdd:COG0060 831 --IRQPLEAAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLG----------------KDALKA--------- 883
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811715276 942 seeLEQFQKTGTIVVEghelhdedirlmytfdQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 1018
Cdd:COG0060 884 ---LDVEGISVTVEVE----------------KADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-885 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 974.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392 2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 85 WDCHGLPVscivavvfigqrgnslitnfqEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWID 164
Cdd:TIGR00392 82 WDTHGLPI---------------------EHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGD 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 165 FDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVFVTFPLEEDE----- 237
Cdd:TIGR00392 141 WENPYKTMDPSYEESQWWLFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylk 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 238 --TVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALY-KLESDYEILERFPGAYLKGKKYRPLF 314
Cdd:TIGR00392 221 vkLSSLLIWTTTPWTLPSNLAIAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 315 DYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCmdfniiRKDSLPV-CPVDASGCFTTEVTDFAGQYVKD 393
Cdd:TIGR00392 301 YDFVSQLKEGAPVVIGGDHVTTEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKD 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 394 ADKSIIRT-------LKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVrEKRF 466
Cdd:TIGR00392 375 ADKDIIKAnkiiieqLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRF 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 467 GNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEEL-----SGAKISDLHRESVDHLTIPSRCGkGSLHRI 541
Cdd:TIGR00392 454 GNWLENRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGSIEELIELielkgIDAWFEDLHRDFLDKITLKSGDG-GEYRRV 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 542 SEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQK 621
Cdd:TIGR00392 533 PDVLDVWFDSGSMPYASIHYPFENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRK 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 622 MSKRKKNYPDPVSIIQKYGADALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQ--NVLRLQKEEEIEF 699
Cdd:TIGR00392 612 MSKSLGNVVDPLKVINKYGADILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVA 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 700 LYNENTVrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGMEDCVMALET 778
Cdd:TIGR00392 690 VEKFPEE-------DRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTT 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 779 LFSVLLSLCRLMAPYTPFLTELMYQNLKvlidpvsvQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRD 858
Cdd:TIGR00392 763 LYYALLTLVRLLAPFLPHTAEEIYQNLP--------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRD 834
|
890 900
....*....|....*....|....*..
gi 1811715276 859 RKTIPIKYPLKEIVVIHQDPEALKDIK 885
Cdd:TIGR00392 835 AANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-660 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 963.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 17 KILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVsciv 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPT---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 97 avvfigqrgnslitnfqEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQF 176
Cdd:pfam00133 77 -----------------EQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPEL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 177 MESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLA 256
Cdd:pfam00133 140 EAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 257 VCVNPEMQYVKikdvaRGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFdyflkckENGAFTVLVDNYVKE 336
Cdd:pfam00133 218 VAVNPEFDYVI-----TGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 337 EEGTGVVHQAPYFGAEDYRVCMDFNIirkdsLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTH 416
Cdd:pfam00133 286 EFGTGAVHIAPAHGENDYEVGQRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTH 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 417 SYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDF 496
Cdd:pfam00133 361 SYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDT 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 497 EEVVCIGSVAELEEL---SGAKISDLHRESVDHLtipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAF 573
Cdd:pfam00133 440 EEVVCRGELFELVAGrfeEEGSIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFF 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 574 PADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPV 653
Cdd:pfam00133 516 PADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDY 595
|
....*..
gi 1811715276 654 VRAENLR 660
Cdd:pfam00133 596 GRDINLS 602
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-661 |
3.17e-153 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 464.01 E-value: 3.17e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVscivavvfigqrgnslitnfqEYEID 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPI---------------------ELKVE 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 119 KTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDyktlypqfmesvwwvfkqlydkglvyrgvk 198
Cdd:cd00818 60 KELGISGKKDIEKMGIAEFNAKCREFALRYVDEQEEQFQRLGVWVDWENP------------------------------ 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 199 vmpfstacntplsnfeshqnYKdvqdpsvfvtfpleedetvslvawTTTPWTlpsnlavcvnpemqyvkikdvargrlli 278
Cdd:cd00818 110 --------------------YK------------------------TMDPEY---------------------------- 117
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 279 lMEARLSALYKLesdyeilerfpgaYLKGKKYRplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaeDYRVCM 358
Cdd:cd00818 118 -MESVWWVFKQL-------------HEKGLLYR-----------------------------------------GYKVVP 142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 359 dfniirkdslpvcpvdasgcfttevtdfagqyvkdadksiirtlkeqgrllvattfthsypfcWrsdtPLIYKAVPSWFV 438
Cdd:cd00818 143 ---------------------------------------------------------------W----PLIYRATPQWFI 155
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 439 RVENMVDQLLRNNDLCYWVPELVREkRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsvaeleelsgakisd 518
Cdd:cd00818 156 RVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV----------------- 217
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 519 lhresvdhltipsrcgkgslHRISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATA 598
Cdd:cd00818 218 --------------------RRVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTRGWFYSLLLLSTA 276
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811715276 599 LFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPvVRAENLRF 661
Cdd:cd00818 277 LFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
6-958 |
1.15e-124 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 406.75 E-value: 1.15e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 6 PENINFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:TIGR00422 2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 86 DCHGLPVSCIVavvfigqrgnslitnfqeyeiDKTLGIRGPE--DVakmGITEYNNQCRAIVMRYSAEWKSTVSRLGRWI 163
Cdd:TIGR00422 80 DHAGIATQVKV---------------------EKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 164 DFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVA 243
Cdd:TIGR00422 136 DWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEV--EYKEVKGKLYYIRYPLANGSKDYLVV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 244 WTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKcke 322
Cdd:TIGR00422 214 ATTRPETMFGDTAVAVHPE------------------------------D----ERY--KHLIGKKVIlPLTGRKIP--- 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 323 ngaftVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLP-VCPVDASGCFTTEVTDFAGQYVKDADKSIIRT 401
Cdd:TIGR00422 255 -----IIADEYVDMEFGTGAVKVTP---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVED 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 402 LKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTIS 479
Cdd:TIGR00422 324 LKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCIS 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 480 RNRYWGTPIPLWVSDDFEEVVcigsVAELEELSGAKISDlhresvdhltipsrCGKGSLHRISEVFDCWFESGSMPYAQV 559
Cdd:TIGR00422 403 RQLIWGHRIPVWYCKECGEVY----VAKEEPLPDDKTNT--------------GPSVELEQDTDVLDTWFSSSLWPFSTL 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 560 HYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKY 639
Cdd:TIGR00422 465 GWP-DETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKY 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 640 GADALRLYLINSpVVRAENLRFKE---EGVRDVLKDVllpwYNAYRFLIQNVlrlqkEEEIEFLYNENTVRESpnitDRW 716
Cdd:TIGR00422 544 GADALRFTLASL-VTPGDDINFDWkrvESARNFLNKL----WNASRFVLMNL-----SDDLELSGGEEKLSLA----DRW 609
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 717 ILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDcVMALETLFSVLLSLCRLMAPYTP 795
Cdd:TIGR00422 610 ILSKLNRTIKEVRKALDKYRFAEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAEK-KAARDTLYYVLDKALRLLHPFMP 688
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 796 FLTELMYQNLKvlidpvsvqdKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIH 875
Cdd:TIGR00422 689 FITEEIWQHFK----------EGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIY 757
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 876 QDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRL-RAEPDHMVLG--KRLKGAFKAVMTSIKQLSSEELEQFQKTG 952
Cdd:TIGR00422 758 TEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEG 837
|
....*.
gi 1811715276 953 TIVVEG 958
Cdd:TIGR00422 838 KLENEG 843
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-906 |
1.16e-102 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 344.87 E-value: 1.16e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 1 MLQQVPENINFPAEEEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVD 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 81 RRFGWDCHGLPVscivavvfigqrgnslitnfqEYEIDKTLGIRgPEDVAKmgiTEYNNQCRAIVMRYSAEWKSTVSRLG 160
Cdd:PRK13208 80 FPQGWDDNGLPT---------------------ERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 161 RWIDFDNDYKTlypqfMESVWWV-----FKQLYDKGLVYRGVKVMPFSTACNTPLSNFEshQNYKDVQDPSVFVTFPLEE 235
Cdd:PRK13208 135 LSVDWSLEYQT-----ISPEYRRisqksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVED 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 236 DETVsLVAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLF 314
Cdd:PRK13208 208 GEEI-EIA-TTRPELLPACVAVVVHPD------------------------------D----ERY--KHLVGKTAIvPLF 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 315 DYFLKckengaftVLVDNYVKEEEGTGVVHqapyfgaedyrVC-----MDFNIIRKDSLPVCPV-DASGCFTTEVTDFAG 388
Cdd:PRK13208 250 GVEVP--------ILADPLVDPDFGTGAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAG 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 389 QYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGN 468
Cdd:PRK13208 311 LTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLEN 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 469 WLKD-ARDWTISRNRYWGTPIPLWVSDDFEEVVcigsVAELEELSgakisdlhresVDhltiPSR----------CGKGS 537
Cdd:PRK13208 390 WIEGlNWDWCISRQRYFGTPIPVWYCKDCGHPI----LPDEEDLP-----------VD----PTKdeppgykcpqCGSPG 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 538 LHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLA 616
Cdd:PRK13208 451 FEGETDVMDTWATSSITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLD 528
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 617 SDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVvrAENLRFKEEGV----RDVLKdvLLpwyNAYRFliqnVLRLQ 692
Cdd:PRK13208 529 PDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARL--GSDTPFDEKQVkigrRLLTK--LW---NASRF----VLHFS 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 693 KEEEIEFLYNENTVrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMED 771
Cdd:PRK13208 598 ADPEPDKAEVLEPL-------DRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEE 670
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 772 CVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKvlidpvsvqdkdTLSIHYLMLPRVREELIDKKTESAVSQMQSVIE 851
Cdd:PRK13208 671 QKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILS 738
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 1811715276 852 LGRVIRDRKTIPIKYPLKEIVVIhqDPEALKDIKSLEKYIIEELNVRKVTLSTDK 906
Cdd:PRK13208 739 AVRKYKSEAGLSLNAPLKKVEVY--GPADLELLEAAEEDLKAAGNIEELELVEGD 791
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-805 |
5.70e-102 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 347.53 E-value: 5.70e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 10 NFPAEEEKILEFWTEFNCFQECLKQSKHKPkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:PLN02843 4 NSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 90 LPVscivavvfigqrgnslitnfqeyEIdKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDY 169
Cdd:PLN02843 83 LPI-----------------------EL-KVLQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPY 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 170 KTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSnfESHQNYKDVQ-DPSVFVTFPL---------EEDE-- 237
Cdd:PLN02843 139 LTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEfl 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 238 -TVSLVAWTTTPWTLPSNLAVCVNPEMQY--VKIKDVA---------------------RGRLLILMEARLSAL-YKLES 292
Cdd:PLN02843 217 pGLSLAIWTTTPWTMPANAAVAVNDKLQYsvVEVQSFSedestsggnkkkrpgnvlkeqQKLFLIVATDLVPALeAKWGV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 293 DYEILERFPGAYLKGKKYR-PLFDYflKCKengafTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMdfniirKDSLP-V 370
Cdd:PLN02843 297 KLVVLKTFPGSDLEGCRYIhPLYNR--ESP-----VVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlL 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 371 CPVDASGCFTTEVTDFAGQYV-KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLR 449
Cdd:PLN02843 364 SPVDDAGKFTEEAGQFSGLSVlGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALD 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 450 NNDLCYWVPElVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSGA------KISDL 519
Cdd:PLN02843 444 AIDKVKWIPA-QGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGSdawwymDVEDL 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 520 HRESVDHLTipsrcgkGSLHRISEVFDCWFESGSmPYAQVhypfeNKREFEDAFPADFIAEGIDQTRGWFYTLLVLATAL 599
Cdd:PLN02843 523 LPEKYRDKA-------SDYEKGTDTMDVWFDSGS-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVAT 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 600 FGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSII-----QK----YGADALRLY----------LINSPVVR--AEN 658
Cdd:PLN02843 590 KGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLWvasvdytgdvLIGPQILKqmSDI 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 659 LRfkeeGVRDVLkdvllpwynayRFLIQNVLRLQKEEEIEFlynentvrESPNITDRWILSFMQSLIGFFETEMAAYRLY 738
Cdd:PLN02843 670 YR----KLRGTL-----------RYLLGNLHDWKPDNAVPY--------EDLPSIDKYALFQLENVVNEIEESYDNYQFF 726
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 739 TVVPRLVKFVDI-LTNWYVRMNRRRLkGENGMEDCV-MALET-LFSVLLSLCRLMAPYTPFLTELMYQNL 805
Cdd:PLN02843 727 KIFQILQRFTIVdLSNFYLDVAKDRL-YVGGTTSFTrRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNL 795
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
661-854 |
6.47e-84 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 271.35 E-value: 6.47e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 661 FKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEieflyNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTV 740
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPG-----KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 741 VPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIdpvsvqDKDTL 820
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRREL------GDAPE 149
|
170 180 190
....*....|....*....|....*....|....
gi 1811715276 821 SIHYLMLPRVREELIDKKTESAVSQMQSVIELGR 854
Cdd:cd07961 150 SVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
15-880 |
1.71e-68 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 251.45 E-value: 1.71e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 15 EEKILEFWTEFNCFQeCLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVSC 94
Cdd:PRK14900 25 EARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 95 IVavvfigqrgnslitnfqEYEIDKTLGIRGPEdvakMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYP 174
Cdd:PRK14900 104 IV-----------------EKELKKTEKKSRHD----LGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 175 QFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFE-SHQNYKDVQDPSVfvTFPLEeDETVSLVAWTTTPWTLPS 253
Cdd:PRK14900 163 GLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEvEHEEAHQGELWSF--AYPLA-DGSGEIVVATTRPETMLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 254 NLAVCVNPEmqyvkikdvargrllilmEARLSALYklesdyeilerfpgaylkGKKYR-PLFDYFLKCKengAFTVLVDn 332
Cdd:PRK14900 240 DTAVAVHPL------------------DPRYMALH------------------GKKVRhPITGRTFPIV---ADAILVD- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 333 yvkEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGrlLVA 411
Cdd:PRK14900 280 ---PKFGTGAVKVTP---AHDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDR 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 412 TTFTHSYPF--CWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVREKRFGnWLKDARDWTISRNRYWGTP 487
Cdd:PRK14900 349 GAKPHVLPLgrCQRSATILEPLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQ 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 488 IPLWVSDDFEEVVCigsvaeleelsgakisdlhRESVDHLtipSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKR 567
Cdd:PRK14900 428 IPAWYCPDGHVTVA-------------------RETPEAC---STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTD 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 568 EFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLY 647
Cdd:PRK14900 485 TLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFT 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 648 LInSPVVRAENLRFKE---EGVRDVLKDVllpwYNAYRFLIQNVLrlqkeeeiEFLYNENTVRESP-NITDRWILSFMQS 723
Cdd:PRK14900 565 LA-ALTAQGRDIKLAKeriEGYRAFANKL----WNASRFALMNLS--------GYQERGEDPARLArTPADRWILARLQR 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 724 LIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGEN-GMEDCVMAleTLFSVLLSLCRLMAPYTPFLTELM 801
Cdd:PRK14900 632 AVNETVEALEAFRFNDAANAVYAFVwHELCDWYIELAKEALASEDpEARRSVQA--VLVHCLQTSYRLLHPFMPFITEEL 709
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 802 YQNLKVLIDPVSVQDkdtlSIHYLMLPRVREelIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPL---KEIVVIHQDP 878
Cdd:PRK14900 710 WHVLRAQVGASAWAD----SVLAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADP 783
|
..
gi 1811715276 879 EA 880
Cdd:PRK14900 784 AL 785
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
158-908 |
9.58e-65 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 237.31 E-value: 9.58e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 158 RLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDE 237
Cdd:PRK05729 133 RLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADGS 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 238 TVSLVAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDY 316
Cdd:PRK05729 211 DYLVVA-TTRPETMLGDTAVAVNPE------------------------------D----ERY--KHLIGKTVIlPLVGR 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 317 FLKckengaftVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVTDFA 387
Cdd:PRK05729 254 EIP--------IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPGEYQ 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 388 GQYVKDADKSIIRTLKEQGrLLVAT-TFTHSYPFCWRSDT---PLIYKavpSWFVRVENMVDQLL---RNNDLCYwVPEl 460
Cdd:PRK05729 312 GLDRFEARKAIVADLEELG-LLVKIePHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALeavENGEIKF-VPE- 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 461 vR-EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsvAELEelsgakisdlhresvdhltiPSRCGKGSLH 539
Cdd:PRK05729 386 -RwEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYV-----GREE--------------------PEAREKALLT 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 540 RISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQ 602
Cdd:PRK05729 440 QDEDVLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGQ 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 603 PPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---Lkdvl 674
Cdd:PRK05729 502 VPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRNFankL---- 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 675 lpwYNAYRFLIQNVLRLQKEEEIEflynentvRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTN 753
Cdd:PRK05729 575 ---WNASRFVLMNLEGADVGELPD--------PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCD 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 754 WYVRMNRRRLKGENGMEdcvmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqdkdtlsihyLML---PRV 830
Cdd:PRK05729 644 WYLELAKPVLQEAAKRA----TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEES-----------IMLapwPEA 708
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715276 831 REELiDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNK 908
Cdd:PRK05729 709 DEAI-DEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-906 |
4.05e-64 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 235.72 E-value: 4.05e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 12 PAE-EEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrrfgwdchgl 90
Cdd:COG0525 9 PKEvEAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT----------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 91 pvsCIV-----------AVVfigqrgnslitnfqeyeiDKTLgirgpedvAKMGITeynnqcraivmRYSA--------- 150
Cdd:COG0525 76 ---LWQpgtdhagiatqAVV------------------ERQL--------AEEGKS-----------RHDLgrekflerv 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 151 -EWK----STVS----RLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKD 221
Cdd:COG0525 116 wEWKeesgGTITnqlrRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEE 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 222 VQDPSVFVTFPLEEDETVSLVAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFp 301
Cdd:COG0525 194 VKGHLWHIRYPLADGSGYIVVA-TTRPETMLGDTAVAVHPE------------------------------D----ERY- 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 302 gAYLKGKKYR-PLFdyflkckeNGAFTVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCP 372
Cdd:COG0525 238 -KHLIGKTVIlPLV--------GREIPIIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMIN 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 373 V-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT---PLIykavpS--WFVRVENMVDQ 446
Cdd:COG0525 295 IlDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKP 369
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 447 LL---RNNDLcYWVPElvR-EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDfEEVVcigsVAELEElsgakisdlhre 522
Cdd:COG0525 370 AIeavEDGEI-KFVPE--RwEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVY----VARTEP------------ 429
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 523 svdhlTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADfiaegidqtrgwfytllVLATA---L 599
Cdd:COG0525 430 -----EACAKAGSVNLTQDEDVLDTWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiI 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 600 F--------------GQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE 663
Cdd:COG0525 487 FfwvarmimmglhftGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDE 563
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 664 ---EGVRDV---LkdvllpWyNAYRFLIQNvlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRL 737
Cdd:COG0525 564 ervEGYRNFankL------W-NASRFVLMN--------LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRF 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 738 YTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqd 816
Cdd:COG0525 629 DEAAQALYDFVwNEFCDWYLELAKPRLYGGDEAAKRE-TRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES--- 704
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 817 kdtlsihyLML---PRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIE 893
Cdd:COG0525 705 --------IMLapwPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKR 775
|
970
....*....|...
gi 1811715276 894 ELNVRKVTLSTDK 906
Cdd:COG0525 776 LARLEEITILVDE 788
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-908 |
1.04e-51 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 198.69 E-value: 1.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 15 EEKILEFWTEFNCFQ--ECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 93 SCIVavvfigqrgnslitnfqEYEIDKTLG-IR---GPEDVAKMgITEYNNQcraivmrYSAEWKSTVSRLGRWIDFDND 168
Cdd:PTZ00419 114 QVVV-----------------EKKLMKEENkTRhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSRE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 169 YKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVF----------------VTFP 232
Cdd:PTZ00419 169 VFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 233 LEEDETVSLVAWTTTPWTLPSNLAVCVNPemqyvkiKDvargrllilmearlsalyklesdyeilERFpgAYLKGKkyrp 312
Cdd:PTZ00419 247 LEDSGQEEIVVATTRIETMLGDVAVAVHP-------KD---------------------------ERY--KKLHGK---- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 313 lfdyFLKC---KENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAG 388
Cdd:PTZ00419 287 ----ELIHpfiPDRKIPIIADDELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAG 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 389 QYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQ---LLRNNDLCYWVPELVREkr 465
Cdd:PTZ00419 357 MHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRaveAVRNGELKIIPSSHENV-- 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 466 FGNWLKDARDWTISRNRYWGTPIP-----------------LWV-SDDFEEvvCIGSVAELEELSGAKISdlhresvdhl 527
Cdd:PTZ00419 435 WYHWLENIQDWCISRQLWWGHRIPayrviskgpetdpsdeePWVvARSEEE--ALEKAKKKFGLSEEDFE---------- 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 528 tipsrcgkgsLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN 607
Cdd:PTZ00419 503 ----------LEQDEDVLDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKT 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 608 VIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------- 666
Cdd:PTZ00419 572 VFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfglla 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 667 -----RDVLKDV------------LlpWyNAYRFLIQNVLRLQKeeEIEFLYNENTVRESPNITDRWILSFMQSLI---- 725
Cdd:PTZ00419 652 ytqqgRNINLDInrvvgyrhfcnkL--W-NAVKFALMKLLKDFN--LPNSTLFKPNNVESLPWEDKWILHRLNVAIkevt 726
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 726 ------GFFETEMAAYRLYtvvprLVKFVDIltnwYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTE 799
Cdd:PTZ00419 727 egfkeyDFSEATQATYNFW-----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITE 797
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 800 LMYQNLkvlidPVSVQDKDTLSI-HYlmlPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDP 878
Cdd:PTZ00419 798 ELYQRL-----PNYLRKSESISIaKY---PQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAE 869
|
970 980 990
....*....|....*....|....*....|.
gi 1811715276 879 eaLKDIKSLEKYIIEEL-NVRKVTLSTDKNK 908
Cdd:PTZ00419 870 --LIELIESAENLISTLaKIGSVSVIPPIEE 898
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-805 |
1.98e-51 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 197.47 E-value: 1.98e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 13 AEEEKILEFWTEFNCFQECLKQSKHKpkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PLN02943 64 TSEERIYNWWESQGYFKPNFDRGGDP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 93 SCIVAVVFIGQrgnslitnfqeyeidktlGIRGPEdvakMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTL 172
Cdd:PLN02943 142 QLVVEKMLASE------------------GIKRTD----LGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 173 YPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHqnYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLP 252
Cdd:PLN02943 200 DEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 253 SNLAVCVNPE----MQYVkikdvarGRLLILmearlsalyklesdyeilerfPgayLKGKKYRPlfdyflkckengaftV 328
Cdd:PLN02943 278 GDVAIAVNPEddrySKYI-------GKMAIV---------------------P---MTYGRHVP---------------I 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 329 LVDNYVKEEEGTGVVHQAPYFGAEDYRvcmdfnIIRKDSLPVCPV---DASgcftteVTDFAGQYVKDADKSIIRTLKEQ 405
Cdd:PLN02943 312 IADRYVDKDFGTGVLKISPGHDHNDYL------LARKLGLPILNVmnkDGT------LNEVAGLYWFEAREKLWSDLEET 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 406 GRLLVATTFTHSYPFCWRSDT---PLIYKavpSWFVRVENMVDQLLR---NNDLCYwVPELVrEKRFGNWLKDARDWTIS 479
Cdd:PLN02943 380 GLAVKKEPHTLRVPRSQRGGEviePLVSK---QWFVTMEPLAEKALKaveNGELTI-IPERF-EKIYNHWLSNIKDWCIS 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 480 RNRYWGTPIPLW--VSDDFEEVVCigsVAELEELSGAKISDLHRESVDhltipsrcgkgsLHRISEVFDCWFESGSMPYA 557
Cdd:PLN02943 455 RQLWWGHRIPVWyiVGKDCEEDYI---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFS 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 558 QVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQ 637
Cdd:PLN02943 520 TLGWPDVSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIK 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 638 KYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLlpwYNAYRFLIQNVLRLQKEEEIEFLYN-----ENTVRESPnI 712
Cdd:PLN02943 600 EFGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKL---WNAGKFVLQNLPSQSDTSAWEHILAckfdkEESLLSLP-L 675
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 713 TDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMA 791
Cdd:PLN02943 676 PECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLH 755
|
810
....*....|....
gi 1811715276 792 PYTPFLTELMYQNL 805
Cdd:PLN02943 756 PFMPFVTEELWQAL 769
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
421-651 |
4.78e-50 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 182.45 E-value: 4.78e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 421 CWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEE 498
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-EKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 499 VVcigsVAELEELSGAKISDLHREsvdhltipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFI 578
Cdd:cd00817 235 WV----VAREEDEAIDKAAPEACV---------PCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLL 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811715276 579 AEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 651
Cdd:cd00817 301 VTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
411-649 |
1.23e-49 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 178.77 E-value: 1.23e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 411 ATTFTHSYPFCWRS-----DTPLIYK------AVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKDARDWTIS 479
Cdd:cd00668 106 ITTEPEYSKAVELIfsrlyEKGLIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAIS 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 480 RNRYWGTPIPLWVsddfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgslhrisevFDCWFESGSMPYAQV 559
Cdd:cd00668 185 RQRYWGTPLPEDV----------------------------------------------------FDVWFDSGIGPLGSL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 560 HYPFENkREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKY 639
Cdd:cd00668 213 GYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKY 291
|
250
....*....|
gi 1811715276 640 GADALRLYLI 649
Cdd:cd00668 292 GADALRYYLT 301
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-971 |
1.41e-40 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 162.73 E-value: 1.41e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 54 PHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPvscIVAVVFIGQRGN-SLITNFQEYeidktLGIrgPEDV-AK 131
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTP---ILGIAERIARGDpETIELYKSL-----YGI--PEEElEK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 132 MGITEYnnqcraIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLs 211
Cdd:PRK12300 71 FKDPEY------IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 212 nfESHqNYKDVQDPSV--FVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKdvARGRLLILMEArlsALYK 289
Cdd:PRK12300 144 --GDH-DLLDGEEPEIveYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE---AAEK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 290 L---ESDYEILERFPGAYLKGKKYR-PLFDyflkcKEngaFTVLVDNYVKEEEGTGVV-----HqAPYfgaeDYRVCMDF 360
Cdd:PRK12300 216 LsfqDRDVEIIEEIKGSELIGKKVKnPVTG-----KE---VPILPADFVDPDNGTGVVmsvpaH-APY----DYVALRDL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 361 NIIRKDS-----LPVCPVDASGCF----------------------TTEV--------------TDFAGQYVKDADKSII 399
Cdd:PRK12300 283 KKNKELLdviepIPLIEVEGYGEFpakevveklgiksqedpeleeaTKEVyraefhkgvlkentGEYAGKPVREAREKIT 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 400 RTLKEQGRLLVATTFTHSYPFCwRSDTPLIYKAVP-SWFV---------RVENMVDQLlrnnDLcywVPELVReKRFGN- 468
Cdd:PRK12300 363 KDLIEKGIADIMYEFSNRPVYC-RCGTECVVKVVKdQWFIdysdpewkeLAHKALDNM----EI---IPEEYR-KEFENt 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 469 --WLKDardWTISRNRYWGTPIPlWvsdDFEEVVcigsvaelEELS------------------GAKISDLHRESVDHLT 528
Cdd:PRK12300 434 idWLKD---RACARRRGLGTRLP-W---DEEWII--------ESLSdstiymayytiahkireyGIKPEQLTPEFFDYVF 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 529 IpsrcGKGSLHRISEvfdcwfESGsMPYAQVHypfENKREFEDAFPADFIAEGIDqtrgwfytlLV---LA------TAL 599
Cdd:PRK12300 499 L----GKGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAI 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 600 FGQ---PpfKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVL 670
Cdd:PRK12300 556 FPEekwP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQL 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 671 KDvllpWYNayrfLIQNVLRLQKEEEIEFLynentvrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDI 750
Cdd:PRK12300 629 ER----FYE----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYEL 685
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 751 LT--NWYvrmnRRRLKGENGmedcvMALETLFSVLLslcRLMAPYTPFLTELMYQNLKVLiDPVSVQDkdtlsihylmLP 828
Cdd:PRK12300 686 LNdlRWY----LRRVGEANN-----KVLREVLEIWI---RLLAPFTPHLAEELWHKLGGE-GFVSLEK----------WP 742
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 829 RVREELIDKKTESAVSQMQSVIElgrvirdrktipikyplkeivvihqdpealkDIKSLEKYIieELNVRKVTLST-DKN 907
Cdd:PRK12300 743 EPDESKIDEEAELAEEYVKRLIE-------------------------------DIREILKVA--KIKPKKVYIYVaPDW 789
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811715276 908 KYGIrLRAEPDHMVLGKRLKGAFKAVmtSIKQLSSEELEQFQKtgtIVVEGHELHDEDIRLMYT 971
Cdd:PRK12300 790 KYEV-LEIAAENGDVKEAIKELMKDE--ELRKHGKEVAKLAQK---IVKEVLKLDKEVRKLILK 847
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
10-891 |
3.06e-36 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 148.75 E-value: 3.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 10 NFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 90 LPVscivavvfigqrgnslitnfQEYEIDKtlGIRgPEDVAKMGITEYNNQCRAivmrysaewkstvsrLGRWIDFDNDY 169
Cdd:TIGR00396 80 LPA--------------------ENAAIKR--GIH-PAKWTYENIANMKKQLQA---------------LGFSYDWDREI 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 170 KTLYPQFMESVWWVFKQLYDKGLVYRgvKVMPF--------------------STACNTP-------------------- 209
Cdd:TIGR00396 122 ATCDPEYYKWTQWIFLELFEKGLAYV--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPvekkelkqwflkitayaeel 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 210 LSNFES----HQNYKDVQ------DPSVFVTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvargrLLIL 279
Cdd:TIGR00396 200 LNDLEEldhwPESVKEMQrnwigkSEGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVE--------KAAE 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 280 MEARLSALYKLESDYEILERFP------GAYLKGKKYRPLfdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPyfgAED 353
Cdd:TIGR00396 271 NNPKVAAFIKKILNKTVAERTKatkekkGVDTGIKAIHPL--------TGEKIPIWVANYVLMEYGTGAVMGVP---AHD 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 354 YRvcmDFNIIRKDSLPVCPVdasgcfttevTDFAGQyvkdaDKSIIRTLKEQGRLLVATTFTHSypfcwrsDTPLIYKAV 433
Cdd:TIGR00396 340 ER---DFEFAQKYGLPIKPV----------IDPAEK-----DLSLTAAYTEDGVLVNSGEFNGL-------NSSEARNAI 394
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 434 PSWFVrvENMVDQLLRNNDLcywvpelvrekrfgnwlkdaRDWTISRNRYWGTPIPLWVSDDFEEVVCIGS-----VAEL 508
Cdd:TIGR00396 395 IDMLE--KEGKGKRKVNYRL--------------------RDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPED 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 509 EELSGAKISDLHR-ESVDHLTIPSrCGKGSLhRISEVFDCWFESG--SMPYAQVHYP--FENKREFEDAFPADFIAEGID 583
Cdd:TIGR00396 453 VVYDGDGGSPLSRiPEWVNVTCPS-CGKPAL-RETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIE 530
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 584 QT-------RgWFYTLLVLATALFGQPPFKNVIVNGLVLA-------------------------------SDGQKMSKR 625
Cdd:TIGR00396 531 HAilhllyaR-FFHKFLRDIGYVNTKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKS 609
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 626 KKNYPDPVSIIQKYGADALRLYLI-NSPVvrAENLRFKEEGVRdvlkdvllpwyNAYRFLiQNVLRLQKEEEIE---FLY 701
Cdd:TIGR00396 610 KGNGIDPQEIVESYGADALRLFIMfMGPI--AASLEWNESGLE-----------GARRFL-DRVWNLVYEITGEldaASL 675
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 702 NENTVRESPNITDRWILSFMQSLIGFFEtemAAYRLYTVVPRLVKFVDILTNwyvrmnrrrlkgengMEDCVMALETLFS 781
Cdd:TIGR00396 676 TVTALEEAQKELRRDVHKFLKKVTEDLE---KRESFNTAISAMMELLNKLYK---------------AKKEALMLEYLKG 737
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 782 VLlslcRLMAPYTPFLTELMYQNLKVLidpvsvqdkdTLSIHYLMLPRVREELIDKktesavSQMQSVIELGRVIRDRKT 861
Cdd:TIGR00396 738 FV----TVLSPFAPHLAEELWEKLGSE----------PFIIDNAKWPVVDETALVE------DKTLIVVQVNGKFRAKIT 797
|
970 980 990
....*....|....*....|....*....|...
gi 1811715276 862 IPIKYPLKEIVVI-HQDPEALKDI--KSLEKYI 891
Cdd:TIGR00396 798 VPKDADEEQVEELaKQDPEVKKYLenKTIKKVI 830
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-199 |
1.35e-32 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 129.46 E-value: 1.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 40 KFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVscivavvfigqrgnslitnfqEYEIDK 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPI---------------------ELKAER 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 120 TLGIRGpedvaKMGITEYNNQ-CRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVK 198
Cdd:cd00668 60 KGGRKK-----KTIWIEEFREdPKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH 134
|
.
gi 1811715276 199 V 199
Cdd:cd00668 135 P 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-857 |
1.27e-29 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 128.09 E-value: 1.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 4 QVPENINFPAEEEKILEFWTEFNCFQECLKQSKhkPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRF 83
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 84 GWDCHGLPVSCIVAVVFIGQRgnslitNFQEYEIdktlgirGPEDVakmgITEynnqcraiVMRYSAEWKSTV----SRL 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRER------HLTRHDI-------GREEF----VSE--------VWKWKDEYGGTIlnqlRRL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 160 GRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPS------------- 226
Cdd:PLN02381 228 GASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEV--DYIDIKERTllkvpgydkpvef 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 227 -VFVTF--PLEEDETVSLVAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmEARLSALYKlesdyeileRFPGA 303
Cdd:PLN02381 306 gVLTSFayPLEGGLGEIVVA-TTRIETMLGDTAIAIHPD------------------DERYKHLHG---------KFAVH 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 304 YLKGKKYRPLFDyflkckengafTVLVD-NYvkeeeGTGVVHQAPYFGAEDYRV----CMDF-NIIRKDSlpvcPVDASG 377
Cdd:PLN02381 358 PFNGRKLPIICD-----------AILVDpNF-----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNG 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 378 CfttevTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSD---TPLIYkavPSWFVRVENMVDQLL------ 448
Cdd:PLN02381 418 G-----SEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALdaaidg 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 449 RNNDLCYWVPELVREKRfgNWLKDARDWTISRNRYWGTPIPLW---VSDDFEEVVCIGS----VAELEELSGAKISdlhr 521
Cdd:PLN02381 490 ENKKLEFIPKQYLAEWK--RWLENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNESDALLEAS---- 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 522 esvdhLTIPSRcgKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFG 601
Cdd:PLN02381 564 -----QKFPGK--KFELSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGG 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 602 QPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSII----------------------------QKY---------GADAL 644
Cdd:PLN02381 636 DVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVIngisleglhkrleegnldpkelvvakegQKKdfpngiaecGTDAL 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 645 RLYLInSPVVRAENLRFkeegvrDVLKDV-LLPW----YNAYRFLIQNVlrlqkeeEIEFLYNENTVRESPNITDRWILS 719
Cdd:PLN02381 716 RFALV-SYTAQSDKINL------DILRVVgYRQWcnklWNAVRFAMSKL-------GDDYTPPATLSVETMPFSCKWILS 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 720 FMQSLIGFFETEMAAYRLYTVVPRL-----VKFVDIltnwYVRMNRRRLKGENG--MEDCVMALETLFSVLLSLCRLMAP 792
Cdd:PLN02381 782 VLNKAISKTVSSLDAYEFSDAASTVyswwqYQFCDV----FIEAIKPYFAGDNPefASERAAAQDTLWICLDTGLRLLHP 857
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715276 793 YTPFLTELMYQNLKvlidpvsvQDKDTLSIHYLML---PRVREELIDKKTESAVSQMQSVIELGRVIR 857
Cdd:PLN02381 858 FMPFVTEELWQRLP--------QPKDHTRKDSIMIseyPSAVEAWTNEKVEYEMDLVLSTVKCLRSLR 917
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
714-872 |
1.53e-23 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 97.86 E-value: 1.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 714 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEdcvMALETLFSVLLSLCRLMAP 792
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 793 YTPFLTELMYQNlkvlidpvsvqdkdtLSIHYLMLPrVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 872
Cdd:pfam08264 78 FMPFITEELWQK---------------ESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
891-1054 |
2.68e-19 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 87.14 E-value: 2.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 891 IIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGT--IVVEGH--ELHDEDI 966
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 967 RLmytfdQATGgTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEgtyLNSV 1046
Cdd:pfam19302 83 LV-----TRQG-KEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEM---LEAA 153
|
....*...
gi 1811715276 1047 IESHTEFI 1054
Cdd:pfam19302 154 IEKFEDYI 161
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
678-805 |
3.38e-17 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 79.14 E-value: 3.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 678 YNAYRFLIQNvlrlqkeeeIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 756
Cdd:cd07962 17 WNAARFVLMN---------LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1811715276 757 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNL 805
Cdd:cd07962 88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-647 |
9.80e-17 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 86.03 E-value: 9.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 3 QQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHVDR 81
Cdd:PLN02563 74 PAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 82 RFGWDCHGLPVscivavvfigqrgnslitnfQEYEIDKtlGIRgPEDVAKMGITEYNNQCRAIVMRYsaewkstvsrlgr 161
Cdd:PLN02563 154 PMGWDAFGLPA--------------------EQYAIET--GTH-PKITTLKNIARFRSQLKSLGFSY------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 162 wiDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFE---------SH---------------- 216
Cdd:PLN02563 198 --DWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergGHpvirkpmrqwmlkita 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 217 ---------------QNYKDVQ------------DPSVFVTFPLEEDETVSLvaWTTTPWTLPSNLAVCVNPEMQYVkik 269
Cdd:PLN02563 276 yadrlledlddldwpESIKEMQrnwigrsegaelDFSVLDGEGKERDEKITV--YTTRPDTLFGATYLVVAPEHPLL--- 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 270 dvarGRLLILMEARLSALYK-LESDYEILER----------FPGAYLKgkkyRPLfdyflkckENGAFTVLVDNYVKEEE 338
Cdd:PLN02563 351 ----SSLTTAEQKEAVEEYVdAASRKSDLERtelqkektgvFTGSYAI----NPA--------TGEAIPIWVADYVLGSY 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 339 GTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV---------DASGCFTTEVT---------DFAGQYVKDADKSIIR 400
Cdd:PLN02563 415 GTGAIMAVP---AHDTR---DFEFAQKFDLPIKWVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIE 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 401 tlkeqgrllvattfthsypfcwrsdtpliykavpswfvrvenmvdqllrnndlcyWVPELVREKRFGNWlkDARDWTISR 480
Cdd:PLN02563 489 -------------------------------------------------------WLEETGNGKKKVNY--KLRDWLFAR 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 481 NRYWGTPIPLWVSDDFEEVVCIgSVAELEelsgakisdLHRESVDHLTiPSRCGKGSLHRISE---VFDC----WF--ES 551
Cdd:PLN02563 512 QRYWGEPIPVVFLEDSGEPVPV-PESDLP---------LTLPELDDFT-PTGTGEPPLAKAVSwvnTVDPssgkPArrET 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 552 GSMP--------YAQVHYP------FENKREfEDAFPADFIAEGIDQ-------TRGW---FYTLLVLATalfgQPPFKN 607
Cdd:PLN02563 581 NTMPqwagscwyYLRFMDPknsnalVDKEKE-KYWMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQC 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 608 VIVNGLVLA---------SDGQ---------------------------------------------KMSKRKKNYPDPV 633
Cdd:PLN02563 656 LVNQGMILGeveytafkdSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPD 735
|
810
....*....|....
gi 1811715276 634 SIIQKYGADALRLY 647
Cdd:PLN02563 736 DVVSEYGADSLRLY 749
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
474-805 |
2.47e-15 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 81.25 E-value: 2.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 474 RDWTISRNRYWGTPIPLWVSDDfeevvCiGSVA-----------ELEELSGAKISDL--HRESVdHLTIPsRCGKgSLHR 540
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLarAPEWV-NVTCP-KCGG-PARR 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 541 ISEVFDCWFESgS---MPYAQVHYpfenkrefeDAFPADFIAE----GIDQ--------------TRgwFYTLLVLATAL 599
Cdd:COG0495 491 ETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTKVLRDLGL 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 600 FGQP-PFKNVIVNGLV--LASDG------QKMSKRKKNYPDPVSIIQKYGADALRLYLI-NSPVVRaeNLRFKEEGVRdv 669
Cdd:COG0495 559 VSFDePFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLEWSDSGVE-- 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 670 lkdvllpwyNAYRFLiQNVLRLQKEEEIEFLYNENTvresPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVD 749
Cdd:COG0495 635 ---------GAYRFL-NRVWRLVVDEAEALKLDVAD----LSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELVN 700
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715276 750 ILTnwyvrmnrrRLKGENGMEDCVM--ALETlfsvllsLCRLMAPYTPFLTELMYQNL 805
Cdd:COG0495 701 ALY---------KAKDSGEADRAVLreALET-------LVLLLAPFAPHIAEELWERL 742
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
434-649 |
1.73e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.97 E-value: 1.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 434 PSWFVRVENMVDQLLRnndlcywVPELVReKRFGNWLKdardwtISRNRYWGTPIPL-WVSDDFeevvcIGSvaeleels 512
Cdd:cd00812 139 TEWKEKLLKDLEKLDG-------WPEEVR-AMQENWIG------CSRQRYWGTPIPWtDTMESL-----SDS-------- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 513 gakisdlhresvdhltipsrcgkgslhrisevfdCWFESGsmpYAQVHYPF--------ENKREFEDAFPADFIAEGIDQ 584
Cdd:cd00812 192 ----------------------------------TWYYAR---YTDAHNLEqpyegdleFDREEFEYWYPVDIYIGGKEH 234
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 585 -----TRGWFYTLLVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 649
Cdd:cd00812 235 apnhlLYSRFNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-196 |
1.67e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 66.89 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPvscivavvfigqrgnslITNFQEyEIDKTlgirgPE 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLP-----------------AENAAI-KIGRD-----PE 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715276 128 DvakmgITEYNnqcraivmrySAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRG 196
Cdd:cd00812 66 D-----WTEYN----------IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
419-649 |
1.91e-10 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 65.13 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 419 PFCWRSDTPLIYKAVPSWFVRVENMVDQLL----RNNDlcyWVPELVREKRfgNWLKDA-RDWTISRNRYWGTPIPlwvs 493
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLewieENPD---IQPEVRNEVL--SWLKEGlQDLSISRDFDWGIPVP---- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 494 ddfeevvcigsvaeleelsGAKisdlhresvDHltipsrcgkgslhriseVFDCWFE------SGSMPYAQVHYPFENkr 567
Cdd:COG0143 240 -------------------GDP---------GK-----------------VFYVWFDaligyiSATKGYADDRGLPED-- 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 568 eFEDAFPAD------FIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQK 638
Cdd:COG0143 273 -FEKYWPAPdtelvhFI--GKDIIR--FHAIIwpaMLMAA--GLPLPKKVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDR 344
|
250
....*....|.
gi 1811715276 639 YGADALRLYLI 649
Cdd:COG0143 345 YGPDALRYYLL 355
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
398-649 |
5.31e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.47 E-value: 5.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 398 IIRTLKEQGRLLVATtftHSYPFCWRSDTPL-IYKAVPSWFVRVENMVDQL---LRNNDLCYWvPELVReKRFGNWLKDA 473
Cdd:cd00814 104 FFKKLYENGYIYEGE---YEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLlewLEKNPDFIW-PENAR-NEVLSWLKEG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 474 -RDWTISR-NRYWGTPIPlwvsdDFEevvcigsvaeleelsgakisdlhresvDHltipsrcgkgslhriseVFDCWFE- 550
Cdd:cd00814 179 lKDLSITRdLFDWGIPVP-----LDP---------------------------GK-----------------VIYVWFDa 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 551 -----SGSMPYAQvhyPFENKREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVIVNGLVLAsDGQ 620
Cdd:cd00814 210 ligyiSATGYYNE---EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA--GLPLPTRIVAHGYLTV-EGK 279
|
250 260
....*....|....*....|....*....
gi 1811715276 621 KMSKRKKNYPDPVSIIQKYGADALRLYLI 649
Cdd:cd00814 280 KMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
561-649 |
3.68e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 57.89 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 561 YPFENKREFEDAFPADFIAEGIDQTRgwFYT------LLVLatalfGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVS 634
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
|
90
....*....|....*
gi 1811715276 635 IIQKYGADALRLYLI 649
Cdd:PRK12267 313 LVDRYGLDALRYYLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
678-794 |
9.27e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 51.74 E-value: 9.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 678 YNAYRFLIQNVLrlqkeeeiefLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILtNWYVR 757
Cdd:cd07375 15 YRLLSFFRKALG----------GTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLD 83
|
90 100 110
....*....|....*....|....*....|....*..
gi 1811715276 758 MNRRRLKGENGMEDCVMALETLFSVLLslcRLMAPYT 794
Cdd:cd07375 84 ELKPALQTEELREAVLAVLRAALVVLT---KLLAPFT 117
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
419-652 |
1.33e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 55.37 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 419 PFCWRSDTPLIYKAVPSWFVRVENMVDQLLRnndlcyWV-------PELVREKRFgNWLKDA-RDWTISRNRYWGTPIPl 490
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLRE------WIeennpewPENVKNMVL-EWLKEGlKDRAISRDLDWGIPVP- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 491 wvsddfeevvcigsvaeleelsGAKisdlhresvdhltipsrcGKgslhriseVFDCWFESgSMPY-AQVHYPFENKREF 569
Cdd:pfam09334 239 ----------------------GAE------------------GK--------VFYVWLDA-PIGYiSATKELSGNEEKW 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 570 EDAFPAD-------FIaeGIDQTRgwFYTLLVLATALFGQPPF-KNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGA 641
Cdd:pfam09334 270 KEWWPNDpdtelvhFI--GKDIIY--FHTIFWPAMLLGAGYRLpTTVFAHGYLTY-EGGKMSKSRGNVVWPSEALDRFPP 344
|
250
....*....|..
gi 1811715276 642 DALRLYLI-NSP 652
Cdd:pfam09334 345 DALRYYLArNRP 356
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-211 |
1.71e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 54.99 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVscivavvfigqrgnsLITNFQEyeidktlgirg 125
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPI---------------ELKAEKE----------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 126 pedvakmGITEynnqcRAIVMRYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTA 205
Cdd:pfam09334 60 -------GITP-----EELVDRYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPS 125
|
....*.
gi 1811715276 206 CNTPLS 211
Cdd:pfam09334 126 DERFLP 131
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
419-649 |
2.62e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.89 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 419 PFCWRSDTPLIYKAVPSWFVRVENMVDQLL---RNNdlcywvPELV----REKRFGNWLKD-ARDWTISRNRY-WGTPIP 489
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLelyEAN------PDFIqpasRRNEVISFVKSgLKDLSISRTNFdWGIPVP 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 490 lwvSDDfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgsLHRISEVFD--CWFESGSM-PYAQVhypfENK 566
Cdd:PRK11893 216 ---GDP------------------------------------------KHVIYVWFDalTNYLTALGyPDDEE----LLA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 567 REFEDAFPAD--FIaeGIDQTR----GWfytlLVLATALfGQPPFKNVIVNG-LVLasDGQKMSKRKKNYPDPVSIIQKY 639
Cdd:PRK11893 247 ELFNKYWPADvhLI--GKDILRfhavYW----PAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEY 317
|
250
....*....|
gi 1811715276 640 GADALRLYLI 649
Cdd:PRK11893 318 GVDAVRYFLL 327
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
714-849 |
2.07e-06 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 49.45 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 714 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV-----RM-------NRRRlkgengmedcvMALETLF 780
Cdd:cd07960 46 DRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLdiikdRLycdakdsLERR-----------SAQTVLY 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715276 781 SVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVqdkdtlsiHYLMLPRVREELIDKKTESAVSQMQSV 849
Cdd:cd07960 115 HILDALLKLLAPILPFTAEEVWEHLPGEKKEESV--------FLEDWPELPEEWKDEELEEKWEKLLAL 175
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
593-651 |
6.56e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 45.65 E-value: 6.56e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715276 593 LVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 651
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
689-805 |
1.27e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.96 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715276 689 LRLQKEEE-IEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDILT--NWYVRMnrrrlkG 765
Cdd:cd07959 11 LRLERFYElAEELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWYRER------G 82
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1811715276 766 ENGMEDCVmaletLFSVLLSLCRLMAPYTPFLTELMYQNL 805
Cdd:cd07959 83 GAGMNKDL-----LRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
597-671 |
4.48e-04 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 43.90 E-value: 4.48e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715276 597 TALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 671
Cdd:pfam01406 230 EAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
|
|
| |
