|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
6-1078 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1649.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882 5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 86 DCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882 85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 166 LYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQY 244
Cdd:PLN02882 165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 245 VKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYRPLFDYFlkpavLSFQCkenGA 311
Cdd:PLN02882 245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYF-----SEFSD---TA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 312 FTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQ 391
Cdd:PLN02882 317 FRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAK 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 392 GRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWG 471
Cdd:PLN02882 397 GRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWG 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 472 TPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWFESGSMPYAQVHYPF 549
Cdd:PLN02882 477 TPLPIWISDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPF 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 550 ENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADA 629
Cdd:PLN02882 557 ENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 630 LRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRESPNITDRWILSFMQ 708
Cdd:PLN02882 637 LRLYLINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQ 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 709 SLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMY 788
Cdd:PLN02882 717 SLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLY 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 789 QNL-KVLidPVSVQdkdtlSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEAL 867
Cdd:PLN02882 797 QNLrKVL--PGSEE-----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFL 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 868 KDIK-SLEKYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHE 946
Cdd:PLN02882 870 DDITgKLKEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHT 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 947 LHDEDIRLMYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYK--AK 1023
Cdd:PLN02882 949 LKAGDIKVVRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDE 1028
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*..
gi 1811715198 1024 SEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1078
Cdd:PLN02882 1029 VDESALSQVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-1010 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1145.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00427 148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTF-------------PLEEDETV------------- 218
Cdd:PTZ00427 228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLlgekysvlynnkr 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 219 --------------------SLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYK-LESDYE--- 274
Cdd:PTZ00427 308 ensnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKeLKWNVEdlk 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 275 ILERFPGAYLKGKKYRPLFDYFLKpavlSFQCKENgAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDS- 353
Cdd:PTZ00427 388 IVNRFKGKELKGLRYKPLFTNFYE----KYNFKER-AYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKn 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 354 LPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQL 433
Cdd:PTZ00427 463 IFIDPLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 434 LRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAK-ISDLHRESVDH 512
Cdd:PTZ00427 543 VKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDH 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 513 LTIPSRCGKG--SLHRISEVFDCWFESGSMPYAQVHYPFENKRE-FEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQP 589
Cdd:PTZ00427 623 IEIKNPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKA 702
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 590 PFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRF 669
Cdd:PTZ00427 703 PFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRF 782
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 670 LIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRL 749
Cdd:PTZ00427 783 FSQEVTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRM 862
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 750 KGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK-VLIDPVSVQDKDT--------------LSIHYLMLP 814
Cdd:PTZ00427 863 RGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRrVKSTNEHNENNETgntkegdlnrgvihKSVHFIMLP 942
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 815 RVREE-LIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKN 893
Cdd:PTZ00427 943 QVDEKyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS 1022
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 894 kyGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDI--RLMYTF-DQATggtaqfEA 970
Cdd:PTZ00427 1023 --CLDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFqNDNT------DI 1094
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|
gi 1811715198 971 HSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNL 1010
Cdd:PTZ00427 1095 ISNNYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSL 1134
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-1004 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1030.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 86 DCHGLPVEYEIDKTLGIRGPeDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:COG0060 93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 166 LYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEED------ETVSLVAWTTTPWTLPSNLAVCVN 239
Cdd:COG0060 172 LYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 240 PEMQYVKIKdVARGRLLILMEARLSAL---YKLEsDYEILERFPGAYLKGKKYRPLFDYFLKPavlsfqckeNGAFTVLV 316
Cdd:COG0060 250 PDIDYVLVE-VTGGERLILAEALVEAVlkeLGIE-DYEVLATFKGAELEGLRYEHPFYYVVGY---------DRAHPVIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 317 DNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNiirkdsLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLL 395
Cdd:COG0060 319 GDYVTTEDGTGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALL 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 396 VATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWLKDARDWTISRNRYWGTPIP 475
Cdd:COG0060 393 AREKITHSYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPE-WGEGRFGNMLENRPDWCISRQRYWGVPIP 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 476 LWVSDDFEEVV----CIGSVAELEELSGAKIS---DLHRESVDHlTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVhyp 548
Cdd:COG0060 472 IWVCEDCGELHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL--- 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 549 fENKREFedAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGAD 628
Cdd:COG0060 548 -ENREEL--HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGAD 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 629 ALRLYLINSPvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFLIQNVLrlqkeeeiEFLYNENTVR-ESPNITDRWILSFM 707
Cdd:COG0060 625 ILRLWVASSD--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLANLD--------DFDPAEDAVPyEDLPELDRWILSRL 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 708 QSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTE 785
Cdd:COG0060 694 NELIKEVTEAYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAE 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 786 LMYQNLKvlidpvsvqDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGR----VIRDRKTipIKYPLKEIVVIH 861
Cdd:COG0060 774 EIWQNLP---------GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLY 842
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 862 QDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmtsikqlsseeLEQFQKTGTIV 941
Cdd:COG0060 843 ADEELAAALESLGDLLAEELNVSEVELVDDAEDLG----------------KDALKA------------LDVEGISVTVE 894
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811715198 942 VEghelhdedirlmytfdQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 1004
Cdd:COG0060 895 VE----------------KADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-871 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 978.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392 2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:TIGR00392 82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVFVTFPLEEDE-------TVSLVAWTTTPWTLPSNLA 235
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 236 VCVNPEMQYVKIKDVARGRLLILMEARLSALY-KLESDYEILERFPGAYLKGKKYRPLFDYFLKPavlsfqcKENGAFTV 314
Cdd:TIGR00392 242 IAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQ-------LKEGAPVV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 315 LVDNYVKEEEGTGVVHQAPYFGAEDYRVCmdfniiRKDSLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRT------ 387
Cdd:TIGR00392 315 IGGDHVTTEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiie 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 388 -LKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVrEKRFGNWLKDARDWTISR 466
Cdd:TIGR00392 389 qLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISR 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 467 NRYWGTPIPLWVSDDFEEVVCIGSVAELEEL-----SGAKISDLHRESVDHLTIPSRCGkGSLHRISEVFDCWFESGSMP 541
Cdd:TIGR00392 468 QRYWGIPIPIWYCEDTGEPIVVGSIEELIELielkgIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMP 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 542 YAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSI 621
Cdd:TIGR00392 547 YASIHYPFENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKV 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 622 IQKYGADALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQ--NVLRLQKEEEIEFLYNENTVrespnit 699
Cdd:TIGR00392 626 INKYGADILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVAVEKFPEE------- 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 700 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAP 778
Cdd:TIGR00392 697 DRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAP 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 779 YTPFLTELMYQNLKvlidpvsvQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 858
Cdd:TIGR00392 777 FLPHTAEEIYQNLP--------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELV 848
|
890
....*....|...
gi 1811715198 859 VIHQDPEALKDIK 871
Cdd:TIGR00392 849 IGKSLEAVLKAVE 861
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-646 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 971.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 17 KILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEI 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 97 DKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 177 KVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvaRGRLL 256
Cdd:pfam00133 161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 257 ILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFdyflkpavlsfqckENGAFTVLVDNYVKEEEGTGVVHQAPYFG 336
Cdd:pfam00133 234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF--------------VNREIPIITDDYVDMEFGTGAVHIAPAHG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 337 AEDYRVCMDFNIirkdsLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIY 416
Cdd:pfam00133 300 ENDYEVGQRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 417 KAVPSWFVRVENMVDQLLRNNDLCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEE 496
Cdd:pfam00133 375 RATPQWFVRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 497 L---SGAKISDLHRESVDHLtipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRG 573
Cdd:pfam00133 454 GrfeEEGSIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRG 529
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811715198 574 WFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLR 646
Cdd:pfam00133 530 WFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
6-944 |
9.94e-128 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 414.84 E-value: 9.94e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 6 PENINFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:TIGR00422 2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 86 DCHGLPVEYEIDKTLGIRGPE--DVakmGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVF 163
Cdd:TIGR00422 80 DHAGIATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 164 KQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEmq 243
Cdd:TIGR00422 157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEV--EYKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 244 yvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKpavlsfqckengaftVLVDNYVKE 322
Cdd:TIGR00422 233 ----------------------------D----ERY--KHLIGKKVIlPLTGRKIP---------------IIADEYVDM 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 323 EEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLP-VCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFT 401
Cdd:TIGR00422 264 EFGTGAVKVTP---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHT 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 402 HSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLWVS 479
Cdd:TIGR00422 338 HNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYC 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 480 DDFEEVVcigsVAELEELSGAKISDlhresvdhltipsrCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAF 559
Cdd:TIGR00422 417 KECGEVY----VAKEEPLPDDKTNT--------------GPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFY 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 560 PADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpV 639
Cdd:TIGR00422 478 PTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-V 556
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 640 VRAENLRFKE---EGVRDVLKDVllpwYNAYRFLIQNVlrlqkEEEIEFLYNENTVRESpnitDRWILSFMQSLIGFFET 716
Cdd:TIGR00422 557 TPGDDINFDWkrvESARNFLNKL----WNASRFVLMNL-----SDDLELSGGEEKLSLA----DRWILSKLNRTIKEVRK 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 717 EMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDcVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKvli 795
Cdd:TIGR00422 624 ALDKYRFAEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAEK-KAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK--- 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 796 dpvsvqdKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEK 875
Cdd:TIGR00422 700 -------EGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAV 771
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1811715198 876 YIIEELNVRKVTLSTDKNKYGIRL-RAEPDHMVLG--KRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEG 944
Cdd:TIGR00422 772 DIKGAINFSEVEVVIEKPEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEG 843
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
413-647 |
2.16e-110 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 349.99 E-value: 2.16e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 413 PLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREkRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsva 492
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV----- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 493 eleelsgakisdlhresvdhltipsrcgkgslHRISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTR 572
Cdd:cd00818 218 --------------------------------RRVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTR 264
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811715198 573 GWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPvVRAENLRF 647
Cdd:cd00818 265 GWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-892 |
5.25e-106 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 353.73 E-value: 5.25e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 1 MLQQVPENINFPAEEEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVD 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 81 RRFGWDCHGLPVEYEIDKTLGIRgPEDVAKmgiTEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTlypqfMESVW 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQT-----ISPEY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 161 WV-----FKQLYDKGLVYRGVKVMPFSTACNTPLSNFEshQNYKDVQDPSVFVTFPLEEDETVsLVAwTTTPWTLPSNLA 235
Cdd:PRK13208 151 RRisqksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVEDGEEI-EIA-TTRPELLPACVA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 236 VCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKpavlsfqckengaftV 314
Cdd:PRK13208 227 VVVHPD------------------------------D----ERY--KHLVGKTAIvPLFGVEVP---------------I 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 315 LVDNYVKEEEGTGVVHqapyfgaedyrVC-----MDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTL 388
Cdd:PRK13208 256 LADPLVDPDFGTGAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDL 324
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 389 KEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKD-ARDWTISRN 467
Cdd:PRK13208 325 KSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQ 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 468 RYWGTPIPLWVSDDFEEVVcigsVAELEELSgakisdlhresVDhltiPSR----------CGKGSLHRISEVFDCWFES 537
Cdd:PRK13208 404 RYFGTPIPVWYCKDCGHPI----LPDEEDLP-----------VD----PTKdeppgykcpqCGSPGFEGETDVMDTWATS 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 538 GSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYP 616
Cdd:PRK13208 465 SITPLIVTGWE-RDEDLFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVV 542
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 617 DPVSIIQKYGADALRLYLINSPVvrAENLRFKEEGV----RDVLKdvLLpwyNAYRFliqnVLRLQKEEEIEFLYNENTV 692
Cdd:PRK13208 543 TPEELLEKYGADAVRYWAASARL--GSDTPFDEKQVkigrRLLTK--LW---NASRF----VLHFSADPEPDKAEVLEPL 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 693 respnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLS 771
Cdd:PRK13208 612 -------DRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDT 684
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 772 LCRLMAPYTPFLTELMYQNLKvlidpvsvqdkdTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIK 851
Cdd:PRK13208 685 LLRLLAPFLPFITEEVWSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLN 752
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 1811715198 852 YPLKEIVVIhqDPEALKDIKSLEKYIIEELNVRKVTLSTDK 892
Cdd:PRK13208 753 APLKKVEVY--GPADLELLEAAEEDLKAAGNIEELELVEGD 791
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-791 |
1.93e-105 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 356.77 E-value: 1.93e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 10 NFPAEEEKILEFWTEFNCFQECLKQSKHKPkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:PLN02843 4 NSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 90 LPVEYEIDKTLGirgPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDK 169
Cdd:PLN02843 83 LPIELKVLQSLD---QEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 170 GLVYRGVKVMPFSTACNTPLSnfESHQNYKDVQ-DPSVFVTFPL---------EEDE---TVSLVAWTTTPWTLPSNLAV 236
Cdd:PLN02843 160 GYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpGLSLAIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 237 CVNPEMQY--VKIKDVA---------------------RGRLLILMEARLSAL-YKLESDYEILERFPGAYLKGKKYR-P 291
Cdd:PLN02843 238 AVNDKLQYsvVEVQSFSedestsggnkkkrpgnvlkeqQKLFLIVATDLVPALeAKWGVKLVVLKTFPGSDLEGCRYIhP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 292 LFDyflkpavlsfqckeNGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMdfniirKDSLP-VCPVDASGCFTTEVT 370
Cdd:PLN02843 318 LYN--------------RESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlLSPVDDAGKFTEEAG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 371 DFAGQYV-KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVRE 449
Cdd:PLN02843 378 QFSGLSVlGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 450 KRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSGA------KISDLHRESVDHLTipsrc 519
Cdd:PLN02843 457 NRIRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGSdawwymDVEDLLPEKYRDKA----- 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 520 gkGSLHRISEVFDCWFESGSmPYAQVhypfeNKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGL 599
Cdd:PLN02843 532 --SDYEKGTDTMDVWFDSGS-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGF 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 600 VLASDGQKMSKRKKNYPDPVSII-----QK----YGADALRLY----------LINSPVVR--AENLRfkeeGVRDVLkd 658
Cdd:PLN02843 604 VLDEKGFKMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLWvasvdytgdvLIGPQILKqmSDIYR----KLRGTL-- 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 659 vllpwynayRFLIQNVLRLQKEEEIEFlynentvrESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-L 737
Cdd:PLN02843 678 ---------RYLLGNLHDWKPDNAVPY--------EDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdL 740
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 1811715198 738 TNWYVRMNRRRLkGENGMEDCV-MALET-LFSVLLSLCRLMAPYTPFLTELMYQNL 791
Cdd:PLN02843 741 SNFYLDVAKDRL-YVGGTTSFTrRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNL 795
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
647-840 |
7.93e-84 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 270.96 E-value: 7.93e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 647 FKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEieflyNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTV 726
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPG-----KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 727 VPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIdpvsvqDKDTL 806
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRREL------GDAPE 149
|
170 180 190
....*....|....*....|....*....|....
gi 1811715198 807 SIHYLMLPRVREELIDKKTESAVSQMQSVIELGR 840
Cdd:cd07961 150 SVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-181 |
2.16e-83 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 276.04 E-value: 2.16e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNN 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811715198 119 QCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPF 181
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
15-866 |
5.17e-70 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 256.07 E-value: 5.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 15 EEKILEFWTEFNCFQeCLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEY 94
Cdd:PRK14900 25 EARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 95 EIDKTLgiRGPEDVAK--MGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PRK14900 104 IVEKEL--KKTEKKSRhdLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 173 YRGVKVMPFSTACNTPLSNFE-SHQNYKDVQDPSVfvTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEmqyvkikdva 251
Cdd:PRK14900 182 YREKKLINWCPDCRTALSDLEvEHEEAHQGELWSF--AYPLA-DGSGEIVVATTRPETMLGDTAVAVHPL---------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 252 rgrllilmEARLSALYklesdyeilerfpgaylkGKKYR-PLFDYFLkPAVlsfqckengAFTVLVDnyvkEEEGTGVVH 330
Cdd:PRK14900 249 --------DPRYMALH------------------GKKVRhPITGRTF-PIV---------ADAILVD----PKFGTGAVK 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 331 QAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGrlLVATTFTHSYPF--C 407
Cdd:PRK14900 289 VTP---AHDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrC 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 408 WRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVREKRFGnWLKDARDWTISRNRYWGTPIPLWVSDDFEEV 485
Cdd:PRK14900 361 QRSATILEPLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVT 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 486 VCigsvaeleelsgakisdlhRESVDHLtipSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIA 565
Cdd:PRK14900 440 VA-------------------RETPEAC---STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVME 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 566 EGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLInSPVVRAENL 645
Cdd:PRK14900 497 TGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDI 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 646 RFKE---EGVRDVLKDVllpwYNAYRFLIQNVLrlqkeeeiEFLYNENTVRESP-NITDRWILSFMQSLIGFFETEMAAY 721
Cdd:PRK14900 576 KLAKeriEGYRAFANKL----WNASRFALMNLS--------GYQERGEDPARLArTPADRWILARLQRAVNETVEALEAF 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 722 RLYTVVPRLVKFV-DILTNWYVRMNRRRLKGEN-GMEDCVMAleTLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVS 799
Cdd:PRK14900 644 RFNDAANAVYAFVwHELCDWYIELAKEALASEDpEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASA 721
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 800 VQDkdtlSIHYLMLPRVREelIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPL---KEIVVIHQDPEA 866
Cdd:PRK14900 722 WAD----SVLAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPAL 785
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
12-894 |
1.11e-66 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 243.09 E-value: 1.11e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 12 PAE-EEKILEFWTEFNCFQeclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDrrfgWdchgL 90
Cdd:PRK05729 11 PKEvEAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK--------STVSRLGR 140
Cdd:PRK05729 80 PgtdhagiatqmvVERQLAAE------------GKS-----------RHDLgrekflekvwEWKeesggtitNQLRRLGA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:PRK05729 137 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADGSDYLV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKp 299
Cdd:PRK05729 215 VA-TTRPETMLGDTAVAVNPE------------------------------D----ERY--KHLIGKTVIlPLVGREIP- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 300 avlsfqckengaftVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVT 370
Cdd:PRK05729 257 --------------IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPG 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 371 DFAGQYVKDADKSIIRTLKEQGrLLVAT-TFTHSYPFCWRSDT---PLIYKavpSWFVRVENMVDQLL---RNNDLCYwV 443
Cdd:PRK05729 309 EYQGLDRFEARKAIVADLEELG-LLVKIePHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALeavENGEIKF-V 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 444 PElvR-EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsvAELEelsgakisdlhresvdhltiPSRCGKG 522
Cdd:PRK05729 384 PE--RwEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYV-----GREE--------------------PEAREKA 436
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 523 SLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADfiaegidqtrgwfytllVLATA---LF------------- 586
Cdd:PRK05729 437 LLTQDEDVLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhf 498
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 587 -GQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---Lk 657
Cdd:PRK05729 499 tGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRNFankL- 574
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 658 dvllpwYNAYRFLIQNVLRLQKEEEIEflynentvRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DI 736
Cdd:PRK05729 575 ------WNASRFVLMNLEGADVGELPD--------PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNE 640
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 737 LTNWYVRMNRRRLKGENGMEdcvmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqdkdtlsihyLML--- 813
Cdd:PRK05729 641 FCDWYLELAKPVLQEAAKRA----TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEES-----------IMLapw 705
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 814 PRVREELiDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKN 893
Cdd:PRK05729 706 PEADEAI-DEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDE 783
|
.
gi 1811715198 894 K 894
Cdd:PRK05729 784 E 784
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-892 |
1.03e-65 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 240.34 E-value: 1.03e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 12 PAE-EEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrrfGWdchgL 90
Cdd:COG0525 9 PKEvEAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT----LW----Q 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK----STVS----RLGR 140
Cdd:COG0525 79 PgtdhagiatqavVERQLAEE------------GKS-----------RHDLgrekflervwEWKeesgGTITnqlrRLGA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:COG0525 136 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEEVKGHLWHIRYPLADGSGYIV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLfdyflkp 299
Cdd:COG0525 214 VA-TTRPETMLGDTAVAVHPE------------------------------D----ERY--KHLIGKTVIlPL------- 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 300 aVlsfqckeNGAFTVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVT 370
Cdd:COG0525 250 -V-------GREIPIIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINIlDEDGTINENAG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 371 DFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT---PLIykavpS--WFVRVENMVDQLL---RNNDLcYW 442
Cdd:COG0525 308 KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIeavEDGEI-KF 381
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 443 VPElvR-EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDfEEVVcigsVAELEElsgakisdlhresvdhlTIPSRCGK 521
Cdd:COG0525 382 VPE--RwEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVY----VARTEP-----------------EACAKAGS 437
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 522 GSLHRISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADfiaegidqtrgwfytllVLATA---LF------------ 586
Cdd:COG0525 438 VNLTQDEDVLDTWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglh 499
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 587 --GQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---L 656
Cdd:COG0525 500 ftGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRNFankL 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 657 kdvllpWyNAYRFLIQNvlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-D 735
Cdd:COG0525 577 ------W-NASRFVLMN--------LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwN 641
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 736 ILTNWYVRMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqdkdtlsihyLML-- 813
Cdd:COG0525 642 EFCDWYLELAKPRLYGGDEAAKRE-TRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES-----------IMLap 709
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 814 -PRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDK 892
Cdd:COG0525 710 wPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-791 |
1.05e-53 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 204.79 E-value: 1.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 13 AEEEKILEFWTEFNCFQECLKQSKHKpkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PLN02943 64 TSEERIYNWWESQGYFKPNFDRGGDP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 93 EYEIDKTLGIRGPEDVaKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PLN02943 142 QLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 173 YRGVKVMPFSTACNTPLSNFESHqnYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEmqyvkikdvar 252
Cdd:PLN02943 221 YQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE----------- 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 253 grllilmearlsalyklesdyeilerfpgaylkGKKYRplfDYFLKPAVLSFQCKENgaFTVLVDNYVKEEEGTGVVHQA 332
Cdd:PLN02943 288 ---------------------------------DDRYS---KYIGKMAIVPMTYGRH--VPIIADRYVDKDFGTGVLKIS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 333 PYFGAEDYRvcmdfnIIRKDSLPVCPV---DASgcftteVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWR 409
Cdd:PLN02943 330 PGHDHNDYL------LARKLGLPILNVmnkDGT------LNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 410 SDT---PLIYKavpSWFVRVENMVDQLLR---NNDLCYwVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLW--VSDD 481
Cdd:PLN02943 398 GGEviePLVSK---QWFVTMEPLAEKALKaveNGELTI-IPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKD 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 482 FEEVVCigsVAELEELSGAKISDLHRESVDhltipsrcgkgsLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPA 561
Cdd:PLN02943 473 CEEDYI---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPT 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 562 DFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVR 641
Cdd:PLN02943 538 TVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQ 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 642 AENLRFKEEGVRDVLKDVLlpwYNAYRFLIQNVLRLQKEEEIEFLYN-----ENTVRESPnITDRWILSFMQSLIGFFET 716
Cdd:PLN02943 618 DLNLSTERLTSNKAFTNKL---WNAGKFVLQNLPSQSDTSAWEHILAckfdkEESLLSLP-LPECWVVSKLHELIDSVTT 693
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1811715198 717 EMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL 791
Cdd:PLN02943 694 SYDKYFFGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL 769
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-894 |
4.28e-53 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 202.93 E-value: 4.28e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 15 EEKILEFWTEFNCFQ--ECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLP- 91
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAt 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 92 ---VEYEIDKTLG-IR---GPEDVAKMgITEYNNQcraivmrYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00419 114 qvvVEKKLMKEENkTRhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVF----------------VTFPLEEDETVSLVAWTTTPW 228
Cdd:PTZ00419 186 RLYEDGLIYRDTRLVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 229 TLPSNLAVCVNPemqyvkiKDvargrllilmearlsalyklesdyeilERFpgAYLKGKKYR-PLFDYFLKPAVLSfqck 307
Cdd:PTZ00419 264 TMLGDVAVAVHP-------KD---------------------------ERY--KKLHGKELIhPFIPDRKIPIIAD---- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 308 engaftvlvDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIR 386
Cdd:PTZ00419 304 ---------DELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEE 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 387 TLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQ---LLRNNDLCYWVPELVREkrFGNWLKDARDWT 463
Cdd:PTZ00419 369 ELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRaveAVRNGELKIIPSSHENV--WYHWLENIQDWC 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 464 ISRNRYWGTPIP-----------------LWV-SDDFEEvvCIGSVAELEELSGAKISdlhresvdhltipsrcgkgsLH 525
Cdd:PTZ00419 447 ISRQLWWGHRIPayrviskgpetdpsdeePWVvARSEEE--ALEKAKKKFGLSEEDFE--------------------LE 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 526 RISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDG 605
Cdd:PTZ00419 505 QDEDVLDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQG 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 606 QKMSKRKKNYPDPVSIIQKYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV 659
Cdd:PTZ00419 584 EKMSKSKGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDI 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 660 ------------LlpWyNAYRFLIQNVLRLQKeeEIEFLYNENTVRESPNITDRWILSFMQSLIG----------FFETE 717
Cdd:PTZ00419 664 nrvvgyrhfcnkL--W-NAVKFALMKLLKDFN--LPNSTLFKPNNVESLPWEDKWILHRLNVAIKevtegfkeydFSEAT 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 718 MAAYRLYtvvprLVKFVDIltnwYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLkvlidP 797
Cdd:PTZ00419 739 QATYNFW-----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----P 804
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 798 VSVQDKDTLSI-HYlmlPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPeaLKDIKSLEKY 876
Cdd:PTZ00419 805 NYLRKSESISIaKY---PQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAE--LIELIESAEN 879
|
970
....*....|....*....
gi 1811715198 877 IIEEL-NVRKVTLSTDKNK 894
Cdd:PTZ00419 880 LISTLaKIGSVSVIPPIEE 898
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
407-637 |
5.54e-50 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 182.06 E-value: 5.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 407 CWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEE 484
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-EKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 485 VVcigsVAELEELSGAKISDLHREsvdhltipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFI 564
Cdd:cd00817 235 WV----VAREEDEAIDKAAPEACV---------PCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLL 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811715198 565 AEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 637
Cdd:cd00817 301 VTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
397-635 |
1.57e-49 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 178.38 E-value: 1.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 397 ATTFTHSYPFCWRS-----DTPLIYK------AVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKDARDWTIS 465
Cdd:cd00668 106 ITTEPEYSKAVELIfsrlyEKGLIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAIS 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 466 RNRYWGTPIPLWVsddfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgslhrisevFDCWFESGSMPYAQV 545
Cdd:cd00668 185 RQRYWGTPLPEDV----------------------------------------------------FDVWFDSGIGPLGSL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 546 HYPFENkREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKY 625
Cdd:cd00668 213 GYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKY 291
|
250
....*....|
gi 1811715198 626 GADALRLYLI 635
Cdd:cd00668 292 GADALRYYLT 301
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-957 |
1.53e-39 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 159.65 E-value: 1.53e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 54 PHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVeyeidktLGI-----RGPEDVakmgITEYNNQCR------- 121
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-------LGIaeriaRGDPET----IELYKSLYGipeeele 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 122 ------AIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLsnfESH 195
Cdd:PRK12300 70 kfkdpeYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV---GDH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 196 qNYKDVQDPSV--FVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKdvARGRLLILMEArlsALYKL---E 270
Cdd:PRK12300 147 -DLLDGEEPEIveYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE---AAEKLsfqD 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 271 SDYEILERFPGAYLKGKKYR-PLFDyflkpavlsfqcKEngaFTVLVDNYVKEEEGTGVV-----HqAPYfgaeDYRVCM 344
Cdd:PRK12300 221 RDVEIIEEIKGSELIGKKVKnPVTG------------KE---VPILPADFVDPDNGTGVVmsvpaH-APY----DYVALR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 345 DFNIIRKDS-----LPVCPVDASGCF----------------------TTEV--------------TDFAGQYVKDADKS 383
Cdd:PRK12300 281 DLKKNKELLdviepIPLIEVEGYGEFpakevveklgiksqedpeleeaTKEVyraefhkgvlkentGEYAGKPVREAREK 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 384 IIRTLKEQGRLLVATTFTHSYPFCwRSDTPLIYKAVP-SWFV---------RVENMVDQLlrnnDLcywVPELVReKRFG 453
Cdd:PRK12300 361 ITKDLIEKGIADIMYEFSNRPVYC-RCGTECVVKVVKdQWFIdysdpewkeLAHKALDNM----EI---IPEEYR-KEFE 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 454 N---WLKDardWTISRNRYWGTPIPlWvsdDFEEVVcigsvaelEELS------------------GAKISDLHRESVDH 512
Cdd:PRK12300 432 NtidWLKD---RACARRRGLGTRLP-W---DEEWII--------ESLSdstiymayytiahkireyGIKPEQLTPEFFDY 496
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 513 LTIpsrcGKGSLHRISEvfdcwfESGsMPYAQVHypfENKREFEDAFPADFIAEGIDqtrgwfytlLV---LA------T 583
Cdd:PRK12300 497 VFL----GKGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhV 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 584 ALFGQ---PpfKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpvvrAE-----NLRFKE-EGVRD 654
Cdd:PRK12300 554 AIFPEekwP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRR 626
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 655 VLKDvllpWYNayrfLIQNVLRLQKEEEIEFLynentvrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFV 734
Cdd:PRK12300 627 QLER----FYE----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FY 683
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 735 DILT--NWYvrmnRRRLKGENGmedcvMALETLFSVLLslcRLMAPYTPFLTELMYQNLKVLiDPVSVQDkdtlsihylm 812
Cdd:PRK12300 684 ELLNdlRWY----LRRVGEANN-----KVLREVLEIWI---RLLAPFTPHLAEELWHKLGGE-GFVSLEK---------- 740
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 813 LPRVREELIDKKTESAVSQMQSVIElgrvirdrktipikyplkeivvihqdpealkDIKSLEKYIieELNVRKVTLST-D 891
Cdd:PRK12300 741 WPEPDESKIDEEAELAEEYVKRLIE-------------------------------DIREILKVA--KIKPKKVYIYVaP 787
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1811715198 892 KNKYGIrLRAEPDHMVLGKRLKGAFKAVmtSIKQLSSEELEQFQKtgtIVVEGHELHDEDIRLMYT 957
Cdd:PRK12300 788 DWKYEV-LEIAAENGDVKEAIKELMKDE--ELRKHGKEVAKLAQK---IVKEVLKLDKEVRKLILK 847
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
10-877 |
1.67e-38 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 156.06 E-value: 1.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 10 NFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 90 LPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAivmrysaewkstvsrLGRWIDFDNDYKTLYPQFMESVWWVFKQLYD 168
Cdd:TIGR00396 80 LPAEnAAIKR--GIH-PAKWTYENIANMKKQLQA---------------LGFSYDWDREIATCDPEYYKWTQWIFLELFE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 169 KGLVYRgvKVMPF--------------------STACNTP--------------------LSNFES----HQNYKDVQ-- 202
Cdd:TIGR00396 142 KGLAYV--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPvekkelkqwflkitayaeelLNDLEEldhwPESVKEMQrn 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 203 ----DPSVFVTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvargrLLILMEARLSALYKLESDYEILER 278
Cdd:TIGR00396 220 wigkSEGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVE--------KAAENNPKVAAFIKKILNKTVAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 279 FPGAYLKGkkyrplfdyFLKPAVLSFQCKENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCP 358
Cdd:TIGR00396 291 TKATKEKK---------GVDTGIKAIHPLTGEKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKP 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 359 VdasgcfttevTDFAGQyvkdaDKSIIRTLKEQGRLLVATTFTHSypfcwrsDTPLIYKAVPSWFVrvENMVDQLLRNND 438
Cdd:TIGR00396 356 V----------IDPAEK-----DLSLTAAYTEDGVLVNSGEFNGL-------NSSEARNAIIDMLE--KEGKGKRKVNYR 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 439 LcywvpelvrekrfgnwlkdaRDWTISRNRYWGTPIPLWVSDDFEEVVCIGS-----VAELEELSGAKISDLHR-ESVDH 512
Cdd:TIGR00396 412 L--------------------RDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPEDVVYDGDGGSPLSRiPEWVN 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 513 LTIPSrCGKGSLhRISEVFDCWFESG--SMPYAQVHYP--FENKREFEDAFPADFIAEGIDQT-------RgWFYTLLVL 581
Cdd:TIGR00396 472 VTCPS-CGKPAL-RETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaR-FFHKFLRD 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 582 ATALFGQPPFKNVIVNGLVLA-------------------------------SDGQKMSKRKKNYPDPVSIIQKYGADAL 630
Cdd:TIGR00396 549 IGYVNTKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADAL 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 631 RLYLI-NSPVvrAENLRFKEEGVRdvlkdvllpwyNAYRFLiQNVLRLQKEEEIE---FLYNENTVRESPNITDRWILSF 706
Cdd:TIGR00396 629 RLFIMfMGPI--AASLEWNESGLE-----------GARRFL-DRVWNLVYEITGEldaASLTVTALEEAQKELRRDVHKF 694
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 707 MQSLIGFFEtemAAYRLYTVVPRLVKFVDILTNwyvrmnrrrlkgengMEDCVMALETLFSVLlslcRLMAPYTPFLTEL 786
Cdd:TIGR00396 695 LKKVTEDLE---KRESFNTAISAMMELLNKLYK---------------AKKEALMLEYLKGFV----TVLSPFAPHLAEE 752
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 787 MYQNLKVLidpvsvqdkdTLSIHYLMLPRVREELIDKktesavSQMQSVIELGRVIRDRKTIPIKYPLKEIVVI-HQDPE 865
Cdd:TIGR00396 753 LWEKLGSE----------PFIIDNAKWPVVDETALVE------DKTLIVVQVNGKFRAKITVPKDADEEQVEELaKQDPE 816
|
970
....*....|....
gi 1811715198 866 ALKDI--KSLEKYI 877
Cdd:TIGR00396 817 VKKYLenKTIKKVI 830
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-178 |
9.34e-37 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 141.40 E-value: 9.34e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 40 KFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGpedvaKMGITEYNNQ 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKK-----KTIWIEEFRE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 120 -CRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKV 178
Cdd:cd00668 76 dPKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-843 |
2.28e-30 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 130.40 E-value: 2.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 4 QVPENINFPAEEEKILEFWTEFNCFQECLKQSKhkPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRF 83
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 84 GWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQcraiVMRYSAEWKSTV----SRLGRWIDFDNDYKTLYPQFMESV 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSE----VWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 160 WWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPS--------------VFVTF--PLEEDETVSLVAw 223
Cdd:PLN02381 249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEV--DYIDIKERTllkvpgydkpvefgVLTSFayPLEGGLGEIVVA- 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 224 TTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmEARLSALYKlesdyeileRFPGAYLKGKKYRPLFDyflkpavls 303
Cdd:PLN02381 326 TTRIETMLGDTAIAIHPD------------------DERYKHLHG---------KFAVHPFNGRKLPIICD--------- 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 304 fqckengafTVLVD-NYvkeeeGTGVVHQAPYFGAEDYRV----CMDF-NIIRKDSlpvcPVDASGCfttevTDFAGQYV 377
Cdd:PLN02381 370 ---------AILVDpNF-----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNGG-----SEFAGMPR 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 378 KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSD---TPLIYkavPSWFVRVENMVDQLL------RNNDLCYWVPELVR 448
Cdd:PLN02381 427 FAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALdaaidgENKKLEFIPKQYLA 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 449 EKRfgNWLKDARDWTISRNRYWGTPIPLW---VSDDFEEVVCIGS----VAELEELSGAKISdlhresvdhLTIPSRcgK 521
Cdd:PLN02381 504 EWK--RWLENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNESDALLEAS---------QKFPGK--K 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 522 GSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVL 601
Cdd:PLN02381 571 FELSQDPDVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIR 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 602 ASDGQKMSKRKKNYPDPVSII----------------------------QKY---------GADALRLYLInSPVVRAEN 644
Cdd:PLN02381 650 DAHGRKMSKSLGNVIDPLEVIngisleglhkrleegnldpkelvvakegQKKdfpngiaecGTDALRFALV-SYTAQSDK 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 645 LRFkeegvrDVLKDV-LLPW----YNAYRFLIQNVlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMA 719
Cdd:PLN02381 729 INL------DILRVVgYRQWcnklWNAVRFAMSKL-------GDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLD 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 720 AYRLYTVVPRL-----VKFVDIltnwYVRMNRRRLKGENG--MEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK 792
Cdd:PLN02381 796 AYEFSDAASTVyswwqYQFCDV----FIEAIKPYFAGDNPefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLP 871
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 1811715198 793 vlidpvsvQDKDTLSIHYLML---PRVREELIDKKTESAVSQMQSVIELGRVIR 843
Cdd:PLN02381 872 --------QPKDHTRKDSIMIseyPSAVEAWTNEKVEYEMDLVLSTVKCLRSLR 917
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
700-858 |
1.68e-23 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 97.47 E-value: 1.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 700 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEdcvMALETLFSVLLSLCRLMAP 778
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 779 YTPFLTELMYQNlkvlidpvsvqdkdtLSIHYLMLPrVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 858
Cdd:pfam08264 78 FMPFITEELWQK---------------ESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
877-1040 |
2.55e-19 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 87.14 E-value: 2.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 877 IIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGT--IVVEGH--ELHDEDI 952
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 953 RLmytfdQATGgTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEgtyLNSV 1032
Cdd:pfam19302 83 LV-----TRQG-KEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEM---LEAA 153
|
....*...
gi 1811715198 1033 IESHTEFI 1040
Cdd:pfam19302 154 IEKFEDYI 161
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-633 |
5.10e-19 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 93.35 E-value: 5.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 3 QQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHVDR 81
Cdd:PLN02563 74 PAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 82 RFGWDCHGLPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAIVMRYsaewkstvsrlgrwiDFDNDYKTLYPQFMESVW 160
Cdd:PLN02563 154 PMGWDAFGLPAEqYAIET--GTH-PKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEPEYYKWTQ 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 161 WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFE---------SH-------------------------------QNYKD 200
Cdd:PLN02563 216 WIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergGHpvirkpmrqwmlkitayadrlledlddldwpESIKE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 201 VQ------------DPSVFVTFPLEEDETVSLvaWTTTPWTLPSNLAVCVNPEMQYVkikdvarGRLLILMEARLSALYK 268
Cdd:PLN02563 296 MQrnwigrsegaelDFSVLDGEGKERDEKITV--YTTRPDTLFGATYLVVAPEHPLL-------SSLTTAEQKEAVEEYV 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 269 -LESDYEILER----------FPGAYLKgkkyrplfdyflKPAvlsfqckENGAFTVLVDNYVKEEEGTGVVHQAPyfgA 337
Cdd:PLN02563 367 dAASRKSDLERtelqkektgvFTGSYAI------------NPA-------TGEAIPIWVADYVLGSYGTGAIMAVP---A 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 338 EDYRvcmDFNIIRKDSLPVCPV---------DASGCFTTEVT---------DFAGQYVKDADKSIIRtlkeqgrllvatt 399
Cdd:PLN02563 425 HDTR---DFEFAQKFDLPIKWVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIE------------- 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 400 fthsypfcwrsdtpliykavpswfvrvenmvdqllrnndlcyWVPELVREKRFGNWlkDARDWTISRNRYWGTPIPLWVS 479
Cdd:PLN02563 489 ------------------------------------------WLEETGNGKKKVNY--KLRDWLFARQRYWGEPIPVVFL 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 480 DDFEEVVCIgSVAELEelsgakisdLHRESVDHLTiPSRCGKGSLHRISE---VFDC----WF--ESGSMP--------Y 542
Cdd:PLN02563 525 EDSGEPVPV-PESDLP---------LTLPELDDFT-PTGTGEPPLAKAVSwvnTVDPssgkPArrETNTMPqwagscwyY 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 543 AQVHYP------FENKREfEDAFPADFIAEGIDQ-------TRGW---FYTLLVLATalfgQPPFKNVIVNGLVLA---- 602
Cdd:PLN02563 594 LRFMDPknsnalVDKEKE-KYWMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGevey 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 603 -----SDGQ---------------------------------------------KMSKRKKNYPDPVSIIQKYGADALRL 632
Cdd:PLN02563 669 tafkdSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRL 748
|
.
gi 1811715198 633 Y 633
Cdd:PLN02563 749 Y 749
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
664-791 |
3.47e-17 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 79.14 E-value: 3.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 664 YNAYRFLIQNvlrlqkeeeIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 742
Cdd:cd07962 17 WNAARFVLMN---------LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1811715198 743 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNL 791
Cdd:cd07962 88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
460-791 |
2.89e-15 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 81.25 E-value: 2.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 460 RDWTISRNRYWGTPIPLWVSDDfeevvCiGSVA-----------ELEELSGAKISDL--HRESVdHLTIPsRCGKgSLHR 526
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLarAPEWV-NVTCP-KCGG-PARR 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 527 ISEVFDCWFESgS---MPYAQVHYpfenkrefeDAFPADFIAE----GIDQ--------------TRgwFYTLLVLATAL 585
Cdd:COG0495 491 ETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTKVLRDLGL 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 586 FGQP-PFKNVIVNGLV--LASDG------QKMSKRKKNYPDPVSIIQKYGADALRLYLI-NSPVVRaeNLRFKEEGVRdv 655
Cdd:COG0495 559 VSFDePFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLEWSDSGVE-- 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 656 lkdvllpwyNAYRFLiQNVLRLQKEEEIEFLYNENTvresPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVD 735
Cdd:COG0495 635 ---------GAYRFL-NRVWRLVVDEAEALKLDVAD----LSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELVN 700
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715198 736 ILTnwyvrmnrrRLKGENGMEDCVM--ALETlfsvllsLCRLMAPYTPFLTELMYQNL 791
Cdd:COG0495 701 ALY---------KAKDSGEADRAVLreALET-------LVLLLAPFAPHIAEELWERL 742
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-175 |
1.60e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 76.13 E-value: 1.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTlgIRGPEDvakmgITEYNnqcraivmry 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKI--GRDPED-----WTEYN---------- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1811715198 128 SAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRG 175
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
420-635 |
1.92e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.58 E-value: 1.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 420 PSWFVRVENMVDQLLRnndlcywVPELVReKRFGNWLKdardwtISRNRYWGTPIPL-WVSDDFeevvcIGSvaeleels 498
Cdd:cd00812 139 TEWKEKLLKDLEKLDG-------WPEEVR-AMQENWIG------CSRQRYWGTPIPWtDTMESL-----SDS-------- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 499 gakisdlhresvdhltipsrcgkgslhrisevfdCWFESGsmpYAQVHYPF--------ENKREFEDAFPADFIAEGIDQ 570
Cdd:cd00812 192 ----------------------------------TWYYAR---YTDAHNLEqpyegdleFDREEFEYWYPVDIYIGGKEH 234
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 571 -----TRGWFYTLLVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 635
Cdd:cd00812 235 apnhlLYSRFNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-190 |
3.48e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 66.54 E-value: 3.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEYEIDKtLGIrGPEDVakmgiteynnqcraiVM 125
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEK-EGI-TPEEL---------------VD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811715198 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLS 190
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
48-635 |
6.42e-11 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 66.68 E-value: 6.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIE--------LAA----EKEGITP-----QELVD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYrgvkvmpfstacntplsnfeshqnykdvqdps 205
Cdd:COG0143 71 RIHAEFKELFEKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIY-------------------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 206 vfvtfpleedetvslvawtttpwtlpsnlavcvnpemqyvkikdvargrllilmearlsalyklESDYEilerfpGAYlk 285
Cdd:COG0143 117 ----------------------------------------------------------------KGEYE------GWY-- 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 286 gkkyrplfdyflkpavlsfqCKENGAFtvLVDNYVkeeEGTgvvhqAPYFGAEDYRvcmdfniirKDSLPVCpvdasgcf 365
Cdd:COG0143 125 --------------------CPECERF--LPDRYV---EGT-----CPKCGAEDAY---------GDQCENC-------- 157
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 366 ttevtdfagqyvkdadksiirtlkeqGRLLVATTFTHsyPFCWRSDTPLIYKAVPSWFVRVENMVDQLL----RNNDlcy 441
Cdd:COG0143 158 --------------------------GATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLewieENPD--- 206
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 442 WVPELVREKRfgNWLKDA-RDWTISRNRYWGTPIPlwvsddfeevvcigsvaeleelsGAKisdlhresvDHltipsrcg 520
Cdd:COG0143 207 IQPEVRNEVL--SWLKEGlQDLSISRDFDWGIPVP-----------------------GDP---------GK-------- 244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 521 kgslhriseVFDCWFE------SGSMPYAQVHYPFENkreFEDAFPAD------FIaeGIDQTRgwFYTLL---VLATAl 585
Cdd:COG0143 245 ---------VFYVWFDaligyiSATKGYADDRGLPED---FEKYWPAPdtelvhFI--GKDIIR--FHAIIwpaMLMAA- 307
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 1811715198 586 fGQPPFKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 635
Cdd:COG0143 308 -GLPLPKKVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLL 355
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
384-635 |
5.58e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.08 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 384 IIRTLKEQGRLLVATtftHSYPFCWRSDTPL-IYKAVPSWFVRVENMVDQL---LRNNDLCYWvPELVReKRFGNWLKDA 459
Cdd:cd00814 104 FFKKLYENGYIYEGE---YEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLlewLEKNPDFIW-PENAR-NEVLSWLKEG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 460 -RDWTISR-NRYWGTPIPlwvsdDFEevvcigsvaeleelsgakisdlhresvDHltipsrcgkgslhriseVFDCWFE- 536
Cdd:cd00814 179 lKDLSITRdLFDWGIPVP-----LDP---------------------------GK-----------------VIYVWFDa 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 537 -----SGSMPYAQvhyPFENKREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVIVNGLVLAsDGQ 606
Cdd:cd00814 210 ligyiSATGYYNE---EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA--GLPLPTRIVAHGYLTV-EGK 279
|
250 260
....*....|....*....|....*....
gi 1811715198 607 KMSKRKKNYPDPVSIIQKYGADALRLYLI 635
Cdd:cd00814 280 KMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
547-635 |
3.83e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 57.89 E-value: 3.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 547 YPFENKREFEDAFPADFIAEGIDQTRgwFYT------LLVLatalfGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVS 620
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
|
90
....*....|....*
gi 1811715198 621 IIQKYGADALRLYLI 635
Cdd:PRK12267 313 LVDRYGLDALRYYLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
664-780 |
1.12e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 51.74 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 664 YNAYRFLIQNVLrlqkeeeiefLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILtNWYVR 743
Cdd:cd07375 15 YRLLSFFRKALG----------GTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLD 83
|
90 100 110
....*....|....*....|....*....|....*..
gi 1811715198 744 MNRRRLKGENGMEDCVMALETLFSVLLslcRLMAPYT 780
Cdd:cd07375 84 ELKPALQTEELREAVLAVLRAALVVLT---KLLAPFT 117
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
405-638 |
1.42e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 55.37 E-value: 1.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 405 PFCWRSDTPLIYKAVPSWFVRVENMVDQLLRnndlcyWV-------PELVREKRFgNWLKDA-RDWTISRNRYWGTPIPl 476
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLRE------WIeennpewPENVKNMVL-EWLKEGlKDRAISRDLDWGIPVP- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 477 wvsddfeevvcigsvaeleelsGAKisdlhresvdhltipsrcGKgslhriseVFDCWFESgSMPY-AQVHYPFENKREF 555
Cdd:pfam09334 239 ----------------------GAE------------------GK--------VFYVWLDA-PIGYiSATKELSGNEEKW 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 556 EDAFPAD-------FIaeGIDQTRgwFYTLLVLATALFGQPPF-KNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGA 627
Cdd:pfam09334 270 KEWWPNDpdtelvhFI--GKDIIY--FHTIFWPAMLLGAGYRLpTTVFAHGYLTY-EGGKMSKSRGNVVWPSEALDRFPP 344
|
250
....*....|..
gi 1811715198 628 DALRLYLI-NSP 638
Cdd:pfam09334 345 DALRYYLArNRP 356
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
405-635 |
2.84e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.89 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 405 PFCWRSDTPLIYKAVPSWFVRVENMVDQLL---RNNdlcywvPELV----REKRFGNWLKD-ARDWTISRNRY-WGTPIP 475
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLelyEAN------PDFIqpasRRNEVISFVKSgLKDLSISRTNFdWGIPVP 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 476 lwvSDDfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgsLHRISEVFD--CWFESGSM-PYAQVhypfENK 552
Cdd:PRK11893 216 ---GDP------------------------------------------KHVIYVWFDalTNYLTALGyPDDEE----LLA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 553 REFEDAFPAD--FIaeGIDQTR----GWfytlLVLATALfGQPPFKNVIVNG-LVLasDGQKMSKRKKNYPDPVSIIQKY 625
Cdd:PRK11893 247 ELFNKYWPADvhLI--GKDILRfhavYW----PAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEY 317
|
250
....*....|
gi 1811715198 626 GADALRLYLI 635
Cdd:PRK11893 318 GVDAVRYFLL 327
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
700-835 |
2.12e-06 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 49.45 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 700 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV-----RM-------NRRRlkgengmedcvMALETLF 766
Cdd:cd07960 46 DRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLdiikdRLycdakdsLERR-----------SAQTVLY 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715198 767 SVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVqdkdtlsiHYLMLPRVREELIDKKTESAVSQMQSV 835
Cdd:cd07960 115 HILDALLKLLAPILPFTAEEVWEHLPGEKKEESV--------FLEDWPELPEEWKDEELEEKWEKLLAL 175
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
579-637 |
6.48e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 45.65 E-value: 6.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715198 579 LVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 637
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
675-791 |
1.38e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.58 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 675 LRLQKEEE-IEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDILT--NWYVRMnrrrlkG 751
Cdd:cd07959 11 LRLERFYElAEELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWYRER------G 82
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1811715198 752 ENGMEDCVmaletLFSVLLSLCRLMAPYTPFLTELMYQNL 791
Cdd:cd07959 83 GAGMNKDL-----LRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
48-174 |
3.00e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 45.14 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715198 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEV--LFvcADDAHGTPIM--------LKA----EKEGITP-----EELIA 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1811715198 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYR 174
Cdd:PRK00133 72 RYHAEHKRDFAGFG--ISFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
583-657 |
4.43e-04 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 43.90 E-value: 4.43e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715198 583 TALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 657
Cdd:pfam01406 230 EAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
|
|
| |
