|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
6-1046 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1612.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882 5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 86 DCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882 85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 166 LYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQY 244
Cdd:PLN02882 165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 245 VKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENgAFTVLVDN 311
Cdd:PLN02882 245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADD 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 312 YVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVAT 391
Cdd:PLN02882 324 YVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 392 TFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWV 471
Cdd:PLN02882 404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 472 SDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWFESGSMPYAQVHYPFENKREFE 549
Cdd:PLN02882 484 SDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFE 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 550 DAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLIN 629
Cdd:PLN02882 564 KNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 630 SPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRESPNITDRWILSFMQSLIGFFE 708
Cdd:PLN02882 644 SPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVR 723
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMDKDTL-------------- 774
Cdd:PLN02882 724 EEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPfftevlyqnlrkvl 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 775 -----SIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK-SLEKYIIEE 848
Cdd:PLN02882 804 pgseeSIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKLKEYVLEE 883
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 849 LNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQ 928
Cdd:PLN02882 884 LNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIKVVRDFKR 962
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 929 ATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYK--AKSEGTYLNSVIESHT 1005
Cdd:PLN02882 963 PEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDEVDESALSQVLKSQA 1042
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|...
gi 1811715232 1006 EFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1046
Cdd:PLN02882 1043 QYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-978 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1108.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00427 148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTF-------------PLEEDETV------------- 218
Cdd:PTZ00427 228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLlgekysvlynnkr 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 219 --------------------SLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYK-LESDYE--- 274
Cdd:PTZ00427 308 ensnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKeLKWNVEdlk 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 275 ILERFPGAYLKGKKYRPLFDYFLKcKEN---GAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDS-LPVC 350
Cdd:PTZ00427 388 IVNRFKGKELKGLRYKPLFTNFYE-KYNfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKnIFID 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 351 PVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNN 430
Cdd:PTZ00427 467 PLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 431 DLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAK-ISDLHRESVDHLTIP 509
Cdd:PTZ00427 547 ETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIEIK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 510 SRCGKG--SLHRISEVFDCWFESGSMPYAQVHYPFENKRE-FEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN 586
Cdd:PTZ00427 627 NPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 587 VIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQN 666
Cdd:PTZ00427 707 LICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQE 786
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 667 VLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGEN 746
Cdd:PTZ00427 787 VTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGSL 866
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 747 GMEDCVMALET------LFSVLLS-------------LCRLMDKDTL---------------------SIHYLMLPRVRE 786
Cdd:PTZ00427 867 GEENCLQSLCTtyrtlhLFTVLMApftpfiteyiyqqLRRVKSTNEHnennetgntkegdlnrgvihkSVHFIMLPQVDE 946
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 787 E-LIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNkyGI 865
Cdd:PTZ00427 947 KyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS--CL 1024
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 866 RLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDI--RLMYTF-DQATggtaqfEAHSDA 942
Cdd:PTZ00427 1025 DFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFqNDNT------DIISNN 1098
|
1050 1060 1070
....*....|....*....|....*....|....*.
gi 1811715232 943 QALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNL 978
Cdd:PTZ00427 1099 YVTILMDFTTDQQLENMASARELCNHIQKMRKNLSL 1134
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-972 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1002.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060 13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 86 DCHGLPVEYEIDKTLGIRGPeDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:COG0060 93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 166 LYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEED------ETVSLVAWTTTPWTLPSNLAVCVN 239
Cdd:COG0060 172 LYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 240 PEMQYVKIKdVARGRLLILMEARLSAL---YKLEsDYEILERFPGAYLKGKKYRPLFDYFLKckENGAFTVLVDNYVKEE 316
Cdd:COG0060 250 PDIDYVLVE-VTGGERLILAEALVEAVlkeLGIE-DYEVLATFKGAELEGLRYEHPFYYVVG--YDRAHPVILGDYVTTE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 317 EGTGVVHQAPYFGAEDYRVCMDFNiirkdsLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTH 395
Cdd:COG0060 326 DGTGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITH 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 396 SYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDF 475
Cdd:COG0060 400 SYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPE-WGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDC 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 476 EEVV----CIGSVAELEELSGAKIS---DLHRESVDHlTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVhypfENKREF 548
Cdd:COG0060 479 GELHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENREEL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 549 edAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:COG0060 554 --HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVA 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 629 NSPvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFLIQNVLrlqkeeeiEFLYNENTVR-ESPNITDRWILSFMQSLIGFF 707
Cdd:COG0060 632 SSD--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLANLD--------DFDPAEDAVPyEDLPELDRWILSRLNELIKEV 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 708 ETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGMEDCVMALETLFSVLLSLCRLM---------------- 769
Cdd:COG0060 701 TEAYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLapilpftaeeiwqnlp 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 770 DKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGR----VIRDRKTipIKYPLKEIVVIHQDPEALKDIKSLEKYI 845
Cdd:COG0060 781 GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEELAAALESLGDLL 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 846 IEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmtsikqlsseeLEQFQKTGTIVVEghelhdedirlmyt 925
Cdd:COG0060 859 AEELNVSEVELVDDAEDLG----------------KDALKA------------LDVEGISVTVEVE-------------- 896
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*..
gi 1811715232 926 fdQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 972
Cdd:COG0060 897 --KADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-639 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 971.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 17 KILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEI 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 97 DKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 177 KVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvaRGRLL 256
Cdd:pfam00133 161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 257 ILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVC 336
Cdd:pfam00133 234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 337 MDFNIirkdsLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF 416
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 417 VRVENMVDQLLRNNDLCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEEL---SGA 493
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 494 KISDLHRESVDHLtipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLV 573
Cdd:pfam00133 461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1811715232 574 LATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
5-839 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 957.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392 2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:TIGR00392 82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVFVTFPLEEDE-------TVSLVAWTTTPWTLPSNLA 235
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 236 VCVNPEMQYVKIKDVARGRLLILMEARLSALY-KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVK 314
Cdd:TIGR00392 242 IAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 315 EEEGTGVVHQAPYFGAEDYRVCmdfniiRKDSLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRT-------LKEQGR 386
Cdd:TIGR00392 322 TEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKGL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 387 LLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTP 466
Cdd:TIGR00392 396 LLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIP 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 467 IPLWVSDDFEEVVCIGSVAELEEL-----SGAKISDLHRESVDHLTIPSRCGkGSLHRISEVFDCWFESGSMPYAQVHYP 541
Cdd:TIGR00392 475 IPIWYCEDTGEPIVVGSIEELIELielkgIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYP 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 542 FENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGAD 621
Cdd:TIGR00392 554 FENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGAD 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 622 ALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQ--NVLRLQKEEEIEFLYNENTVrespnitDRWILSF 699
Cdd:TIGR00392 633 ILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVAVEKFPEE-------DRWILSR 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 700 MQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLM--------- 769
Cdd:TIGR00392 704 LNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLapflphtae 783
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715232 770 --------DKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK 839
Cdd:TIGR00392 784 eiyqnlpgGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-640 |
1.40e-157 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 473.64 E-value: 1.40e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNN 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 119 QCRAIVMRYSAEWKSTVSRLGRWIDFDNDyktlypqfmesvwwvfkqlydkglvyrgvkvmpfstacntplsnfeshqnY 198
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENP--------------------------------------------------Y 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 199 KdvqdpsvfvtfpleedetvslvawTTTPWTlpsnlavcvnpemqyvkikdvargrllilMEARLSALYKLesdyeiler 278
Cdd:cd00818 111 K------------------------TMDPEY-----------------------------MESVWWVFKQL--------- 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 279 fpgaYLKGKKYRplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaeDYRVCMdfniirkdslpvcpvdasgcf 358
Cdd:cd00818 129 ----HEKGLLYR-----------------------------------------GYKVVP--------------------- 142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 359 ttevtdfagqyvkdadksiirtlkeqgrllvattfthsypfcWrsdtPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPE 438
Cdd:cd00818 143 ------------------------------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPE 176
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 439 LVREkRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsvaeleelsgakisdlhresvdhltipsrcgkgslH 518
Cdd:cd00818 177 WVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-------------------------------------R 218
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 519 RISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDG 598
Cdd:cd00818 219 RVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDG 297
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 1811715232 599 QKMSKRKKNYPDPVSIIQKYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818 298 RKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
6-912 |
3.43e-119 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 390.57 E-value: 3.43e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 6 PENINFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:TIGR00422 2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 86 DCHGLPVEYEIDKTLGIRGPE--DVakmGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVF 163
Cdd:TIGR00422 80 DHAGIATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 164 KQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEmq 243
Cdd:TIGR00422 157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEV--EYKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 244 yvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKckengaftVLVDNYVKEEEGTGVV 322
Cdd:TIGR00422 233 ----------------------------D----ERY--KHLIGKKVIlPLTGRKIP--------IIADEYVDMEFGTGAV 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 323 HQAPyfgAEDYRvcmDFNIIRKDSLP-VCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCW 401
Cdd:TIGR00422 271 KVTP---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCW 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 402 RSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVV 479
Cdd:TIGR00422 345 RSGTVVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVY 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 480 cigsVAELEELSGAKISDlhresvdhltipsrCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAE 559
Cdd:TIGR00422 424 ----VAKEEPLPDDKTNT--------------GPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVT 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 560 GIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpVVRAENLR 639
Cdd:TIGR00422 485 GYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDIN 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 640 FKE---EGVRDVLKDVllpwYNAYRFLIQNVlrlqkEEEIEFLYNENTVRESpnitDRWILSFMQSLIGFFETEMAAYRL 716
Cdd:TIGR00422 564 FDWkrvESARNFLNKL----WNASRFVLMNL-----SDDLELSGGEEKLSLA----DRWILSKLNRTIKEVRKALDKYRF 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 717 YTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDcVMALETLFSVLLSLCRLM---------------DKDTLSIHYLM 780
Cdd:TIGR00422 631 AEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAEK-KAARDTLYYVLDKALRLLhpfmpfiteeiwqhfKEGADSIMLQS 709
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 781 LPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDK 860
Cdd:TIGR00422 710 YPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEK 788
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 1811715232 861 NKYGIRL-RAEPDHMVLG--KRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEG 912
Cdd:TIGR00422 789 PEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEG 843
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-742 |
1.43e-101 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 345.22 E-value: 1.43e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 10 NFPAEEEKILEFWTEFNCFQECLKQSKHKPkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:PLN02843 4 NSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 90 LPVEYEIDKTLGirgPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDK 169
Cdd:PLN02843 83 LPIELKVLQSLD---QEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 170 GLVYRGVKVMPFSTACNTPLSnfESHQNYKDVQ-DPSVFVTFPL---------EEDE---TVSLVAWTTTPWTLPSNLAV 236
Cdd:PLN02843 160 GYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpGLSLAIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 237 CVNPEMQY--VKIKDVA---------------------RGRLLILMEARLSAL-YKLESDYEILERFPGAYLKGKKYR-P 291
Cdd:PLN02843 238 AVNDKLQYsvVEVQSFSedestsggnkkkrpgnvlkeqQKLFLIVATDLVPALeAKWGVKLVVLKTFPGSDLEGCRYIhP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 292 LFDYflKCKengafTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMdfniirKDSLP-VCPVDASGCFTTEVTDFAGQYV 370
Cdd:PLN02843 318 LYNR--ESP-----VVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlLSPVDDAGKFTEEAGQFSGLSV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 371 -KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWL 449
Cdd:PLN02843 385 lGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMV 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 450 KDARDWTISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSGA------KISDLHRESVDHLTipsrcgkGSLHR 519
Cdd:PLN02843 464 SGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGSdawwymDVEDLLPEKYRDKA-------SDYEK 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 520 ISEVFDCWFESGSmPYAQVhypfeNKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQ 599
Cdd:PLN02843 537 GTDTMDVWFDSGS-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGF 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 600 KMSKRKKNYPDPVSII-----QK----YGADALRLY----------LINSPVVR--AENLRfkeeGVRDVLkdvllpwyn 658
Cdd:PLN02843 611 KMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLWvasvdytgdvLIGPQILKqmSDIYR----KLRGTL--------- 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 659 ayRFLIQNVLRLQKEEEIEFlynentvrESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRM 737
Cdd:PLN02843 678 --RYLLGNLHDWKPDNAVPY--------EDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNFYLDV 747
|
....*
gi 1811715232 738 NRRRL 742
Cdd:PLN02843 748 AKDRL 752
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-860 |
7.37e-98 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 330.62 E-value: 7.37e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 1 MLQQVPENINFPAEEEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVD 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 81 RRFGWDCHGLPVEYEIDKTLGIRgPEDVAKmgiTEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTlypqfMESVW 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQT-----ISPEY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 161 WV-----FKQLYDKGLVYRGVKVMPFSTACNTPLSNFEshQNYKDVQDPSVFVTFPLEEDETVsLVAwTTTPWTLPSNLA 235
Cdd:PRK13208 151 RRisqksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVEDGEEI-EIA-TTRPELLPACVA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 236 VCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKckengaftVLVDNYVK 314
Cdd:PRK13208 227 VVVHPD------------------------------D----ERY--KHLVGKTAIvPLFGVEVP--------ILADPLVD 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 315 EEEGTGVVHqapyfgaedyrVC-----MDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLL 388
Cdd:PRK13208 263 PDFGTGAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLG 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 389 VATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKD-ARDWTISRNRYWGTPI 467
Cdd:PRK13208 332 KQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPI 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 468 PLWVSDDFEEVVcigsVAELEELSgakisdlhresVDhltiPSR----------CGKGSLHRISEVFDCWFESGSMPYAQ 537
Cdd:PRK13208 411 PVWYCKDCGHPI----LPDEEDLP-----------VD----PTKdeppgykcpqCGSPGFEGETDVMDTWATSSITPLIV 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 538 VHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQ 616
Cdd:PRK13208 472 TGWE-RDEDLFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 617 KYGADALRLYLINSPVvrAENLRFKEEGV----RDVLKdvLLpwyNAYRFliqnVLRLQKEEEIEFLYNENTVrespnit 692
Cdd:PRK13208 550 KYGADAVRYWAASARL--GSDTPFDEKQVkigrRLLTK--LW---NASRF----VLHFSADPEPDKAEVLEPL------- 611
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 693 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLM-- 769
Cdd:PRK13208 612 DRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLap 691
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 770 -----------DKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIhqDPEALKDI 838
Cdd:PRK13208 692 flpfiteevwsWLYGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVY--GPADLELL 769
|
890 900
....*....|....*....|..
gi 1811715232 839 KSLEKYIIEELNVRKVTLSTDK 860
Cdd:PRK13208 770 EAAEEDLKAAGNIEELELVEGD 791
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
640-808 |
1.87e-69 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 230.52 E-value: 1.87e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 640 FKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEieflyNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTV 719
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPG-----KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 720 VPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLM-------------------DKDTLSIHYLM 780
Cdd:cd07961 76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMapftpfiteeiyqnlrrelGDAPESVHLLD 155
|
170 180
....*....|....*....|....*...
gi 1811715232 781 LPRVREELIDKKTESAVSQMQSVIELGR 808
Cdd:cd07961 156 WPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
15-834 |
1.39e-62 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 232.96 E-value: 1.39e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 15 EEKILEFWTEFNCFQeCLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEY 94
Cdd:PRK14900 25 EARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 95 EIDKTLgiRGPEDVAK--MGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PRK14900 104 IVEKEL--KKTEKKSRhdLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 173 YRGVKVMPFSTACNTPLSNFE-SHQNYKDVQDPSVfvTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEmqyvkikdva 251
Cdd:PRK14900 182 YREKKLINWCPDCRTALSDLEvEHEEAHQGELWSF--AYPLA-DGSGEIVVATTRPETMLGDTAVAVHPL---------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 252 rgrllilmEARLSALYklesdyeilerfpgaylkGKKYR-PLFDYFLKCKengAFTVLVDnyvkEEEGTGVVHQAPyfgA 330
Cdd:PRK14900 249 --------DPRYMALH------------------GKKVRhPITGRTFPIV---ADAILVD----PKFGTGAVKVTP---A 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 331 EDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGrlLVATTFTHSYPF--CWRSDTPL 407
Cdd:PRK14900 293 HDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrCQRSATIL 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 408 IYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVREKRFGnWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsva 485
Cdd:PRK14900 368 EPLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA----- 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 486 eleelsgakisdlhRESVDHLtipSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTR 565
Cdd:PRK14900 442 --------------RETPEAC---STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIF 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 566 GWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLInSPVVRAENLRFKE--- 642
Cdd:PRK14900 504 FWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKLAKeri 582
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 643 EGVRDVLKDVllpwYNAYRFLIQNVLrlqkeeeiEFLYNENTVRESP-NITDRWILSFMQSLIGFFETEMAAYRLYTVVP 721
Cdd:PRK14900 583 EGYRAFANKL----WNASRFALMNLS--------GYQERGEDPARLArTPADRWILARLQRAVNETVEALEAFRFNDAAN 650
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 722 RLVKFV-DILTNWYVRMNRRRLKGEN-GMEDCVMALET--LFSVLLSLCRLMDKDTLSIHYLMLPRVREEL--------- 788
Cdd:PRK14900 651 AVYAFVwHELCDWYIELAKEALASEDpEARRSVQAVLVhcLQTSYRLLHPFMPFITEELWHVLRAQVGASAwadsvlaae 730
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*
gi 1811715232 789 ------IDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPL---KEIVVIHQDPEA 834
Cdd:PRK14900 731 yprkgeADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPAL 785
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
12-862 |
9.33e-60 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 221.90 E-value: 9.33e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 12 PAE-EEKILEFWTEFNCFQeclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDrrfgWdchgL 90
Cdd:PRK05729 11 PKEvEAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK--------STVSRLGR 140
Cdd:PRK05729 80 PgtdhagiatqmvVERQLAAE------------GKS-----------RHDLgrekflekvwEWKeesggtitNQLRRLGA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:PRK05729 137 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADGSDYLV 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKc 299
Cdd:PRK05729 215 VA-TTRPETMLGDTAVAVNPE------------------------------D----ERY--KHLIGKTVIlPLVGREIP- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 300 kengaftVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVTDFAGQYV 370
Cdd:PRK05729 257 -------IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPGEYQGLDR 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 371 KDADKSIIRTLKEQGrLLVAT-TFTHSYPFCWRSDT---PLIYKavpSWFVRVENMVDQLL---RNNDLCYwVPElvR-E 442
Cdd:PRK05729 316 FEARKAIVADLEELG-LLVKIePHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALeavENGEIKF-VPE--RwE 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 443 KRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsvAELEelsgakisdlhresvdhltiPSRCGKGSLHRISE 522
Cdd:PRK05729 389 KTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYV-----GREE--------------------PEAREKALLTQDED 443
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 523 VFDCWFESGSMPYAQVHYPfENKREFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQPPFK 585
Cdd:PRK05729 444 VLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGQVPFK 505
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 586 NVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---LkdvllpwY 657
Cdd:PRK05729 506 DVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRNFankL-------W 575
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 658 NAYRFLIQNVLRLQKEEEIEflynentvRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVR 736
Cdd:PRK05729 576 NASRFVLMNLEGADVGELPD--------PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLE 647
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 737 MNRRRLKGENGMEdcvmALETLFSVLLSLCRLMD--------------KDTLSIHYLML---PRVREELiDKKTESAVSQ 799
Cdd:PRK05729 648 LAKPVLQEAAKRA----TRATLAYVLEQILRLLHpfmpfiteelwqklAPLGIEESIMLapwPEADEAI-DEAAEAEFEW 722
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1811715232 800 MQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNK 862
Cdd:PRK05729 723 LKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-860 |
3.08e-58 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 217.61 E-value: 3.08e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 12 PAE-EEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrrfGWdchgL 90
Cdd:COG0525 9 PKEvEAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT----LW----Q 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK----STVS----RLGR 140
Cdd:COG0525 79 PgtdhagiatqavVERQLAEE------------GKS-----------RHDLgrekflervwEWKeesgGTITnqlrRLGA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:COG0525 136 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEEVKGHLWHIRYPLADGSGYIV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFdyflkc 299
Cdd:COG0525 214 VA-TTRPETMLGDTAVAVHPE------------------------------D----ERY--KHLIGKTVIlPLV------ 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 300 keNGAFTVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVTDFAGQYV 370
Cdd:COG0525 251 --GREIPIIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINIlDEDGTINENAGKYRGLDR 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 371 KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT---PLIykavpS--WFVRVENMVDQLL---RNNDLcYWVPElvR- 441
Cdd:COG0525 315 FEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIeavEDGEI-KFVPE--Rw 386
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 442 EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDfEEVVcigsVAELEElsgakisdlhresvdhlTIPSRCGKGSLHRIS 521
Cdd:COG0525 387 EKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVY----VARTEP-----------------EACAKAGSVNLTQDE 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 522 EVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQPPF 584
Cdd:COG0525 445 DVLDTWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGEVPF 506
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 585 KNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---LkdvllpW 656
Cdd:COG0525 507 KDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRNFankL------W 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 657 yNAYRFLIQNvlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 735
Cdd:COG0525 578 -NASRFVLMN--------LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYL 648
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 736 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLM-----------------DKDTLSIhylML---PRVREELIDKKTES 795
Cdd:COG0525 649 ELAKPRLYGGDEAAKRE-TRATLVYVLEQILRLLhpfmpfiteeiwqklppRKEGESI---MLapwPEADEELIDEEAEA 724
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811715232 796 AVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDK 860
Cdd:COG0525 725 EFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
47-630 |
1.66e-52 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 189.38 E-value: 1.66e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 47 PPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDvAKMGITEYNNQCRAIVMR 126
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 127 YSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVyrgvkvmpfstacntplsnfeshqnYKDVQdpsv 206
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLI-------------------------YRDNR---- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 207 fvtfpleedetvsLVAWTTTpwtlpsnlavCvnpemqyvkikdvargrllilmearLSALykleSDYEIlerfpgaylkg 286
Cdd:cd00817 139 -------------LVNWCPK----------L-------------------------RTAI----SDIEV----------- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 287 kkyrplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaedyrvcmdfniirkdslpvcpvdasgcfttevtdfa 366
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 367 gqyvkdadksiirtlkeqgrllvattfthsypfCWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKR 444
Cdd:cd00817 156 ---------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-EKR 201
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 445 FGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsVAELEELSGAKISDLHREsvdhltipsRCGKGSLHRISEVF 524
Cdd:cd00817 202 YENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWV----VAREEDEAIDKAAPEACV---------PCGGEELKQDEDVL 268
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 525 DCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSK 603
Cdd:cd00817 269 DTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSK 346
|
570 580
....*....|....*....|....*..
gi 1811715232 604 RKKNYPDPVSIIQKYGADALRLYLINS 630
Cdd:cd00817 347 SLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-788 |
7.55e-50 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 192.46 E-value: 7.55e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 13 AEEEKILEFWTEFNCFQECLKQSKHKpkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PLN02943 64 TSEERIYNWWESQGYFKPNFDRGGDP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 93 EYEIDKTLGIRGPEDVaKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PLN02943 142 QLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 173 YRGVKVMPFSTACNTPLSNFESHqnYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPE----MQYVkik 248
Cdd:PLN02943 221 YQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPEddrySKYI--- 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 249 dvarGRLLILmearlsalyklesdyeilerfPgayLKGKKYRPlfdyflkckengaftVLVDNYVKEEEGTGVVHQAPYF 328
Cdd:PLN02943 296 ----GKMAIV---------------------P---MTYGRHVP---------------IIADRYVDKDFGTGVLKISPGH 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 329 GAEDYRvcmdfnIIRKDSLPVCPV---DASgcftteVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT 405
Cdd:PLN02943 333 DHNDYL------LARKLGLPILNVmnkDGT------LNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 406 ---PLIYKavpSWFVRVENMVDQLLR---NNDLCYwVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLW--VSDDFEE 477
Cdd:PLN02943 401 viePLVSK---QWFVTMEPLAEKALKaveNGELTI-IPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 478 VVCigsVAELEELSGAKISDLHRESVDhltipsrcgkgsLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFI 557
Cdd:PLN02943 476 DYI---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVL 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 558 AEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAEN 637
Cdd:PLN02943 541 ETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLN 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 638 LRFKEEGVRDVLKDVLlpwYNAYRFLIQNVLRLQKEEEIEFLYN-----ENTVRESPnITDRWILSFMQSLIGFFETEMA 712
Cdd:PLN02943 621 LSTERLTSNKAFTNKL---WNAGKFVLQNLPSQSDTSAWEHILAckfdkEESLLSLP-LPECWVVSKLHELIDSVTTSYD 696
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1811715232 713 AYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMdkdtlsiHYLMlPRVREEL 788
Cdd:PLN02943 697 KYFFGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLL-------HPFM-PFVTEEL 765
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
390-628 |
2.97e-49 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 177.61 E-value: 2.97e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 390 ATTFTHSYPFCWRS-----DTPLIYK------AVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKDARDWTIS 458
Cdd:cd00668 106 ITTEPEYSKAVELIfsrlyEKGLIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAIS 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 459 RNRYWGTPIPLWVsddfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgslhrisevFDCWFESGSMPYAQV 538
Cdd:cd00668 185 RQRYWGTPLPEDV----------------------------------------------------FDVWFDSGIGPLGSL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 539 HYPFENkREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKY 618
Cdd:cd00668 213 GYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKY 291
|
250
....*....|
gi 1811715232 619 GADALRLYLI 628
Cdd:cd00668 292 GADALRYYLT 301
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-862 |
2.48e-46 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 181.36 E-value: 2.48e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 15 EEKILEFWTEFNCFQ--ECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLP- 91
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAt 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 92 ---VEYEIDKTLG-IR---GPEDVAKMgITEYNNQcraivmrYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00419 114 qvvVEKKLMKEENkTRhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVF----------------VTFPLEEDETVSLVAWTTTPW 228
Cdd:PTZ00419 186 RLYEDGLIYRDTRLVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 229 TLPSNLAVCVNPemqyvkiKDvargrllilmearlsalyklesdyeilERFpgAYLKGKkyrplfdyFLKC---KENGAF 305
Cdd:PTZ00419 264 TMLGDVAVAVHP-------KD---------------------------ERY--KKLHGK--------ELIHpfiPDRKIP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 306 TVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQ 384
Cdd:PTZ00419 300 IIADDELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEEELKEM 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 385 GRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQ---LLRNNDLCYWVPELVREkrFGNWLKDARDWTISRNR 461
Cdd:PTZ00419 374 GLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRaveAVRNGELKIIPSSHENV--WYHWLENIQDWCISRQL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 462 YWGTPIP-----------------LWV-SDDFEEvvCIGSVAELEELSGAKISdlhresvdhltipsrcgkgsLHRISEV 523
Cdd:PTZ00419 452 WWGHRIPayrviskgpetdpsdeePWVvARSEEE--ALEKAKKKFGLSEEDFE--------------------LEQDEDV 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 524 FDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSK 603
Cdd:PTZ00419 510 LDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSK 588
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 604 RKKNYPDPVSIIQKYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV----- 652
Cdd:PTZ00419 589 SKGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrvvg 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 653 -------LlpWyNAYRFLIQNVLRLQKeeEIEFLYNENTVRESPNITDRWILSFMQSLIG----------FFETEMAAYR 715
Cdd:PTZ00419 669 yrhfcnkL--W-NAVKFALMKLLKDFN--LPNSTLFKPNNVESLPWEDKWILHRLNVAIKevtegfkeydFSEATQATYN 743
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 716 LYtvvprLVKFVDIltnwYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMdkdtlsiHYLMlPRVREEL------- 788
Cdd:PTZ00419 744 FW-----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLL-------HPMM-PFITEELyqrlpny 806
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 789 -------------------IDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPeaLKDIKSLEKYIIEEL 849
Cdd:PTZ00419 807 lrksesisiakypqpnpgwNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAE--LIELIESAENLISTL 884
|
970
....*....|....
gi 1811715232 850 -NVRKVTLSTDKNK 862
Cdd:PTZ00419 885 aKIGSVSVIPPIEE 898
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-178 |
1.34e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 141.02 E-value: 1.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 40 KFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGpedvaKMGITEYNNQ 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKK-----KTIWIEEFRE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 120 -CRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKV 178
Cdd:cd00668 76 dPKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
10-673 |
3.34e-35 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 145.28 E-value: 3.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 10 NFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 90 LPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAivmrysaewkstvsrLGRWIDFDNDYKTLYPQFMESVWWVFKQLYD 168
Cdd:TIGR00396 80 LPAEnAAIKR--GIH-PAKWTYENIANMKKQLQA---------------LGFSYDWDREIATCDPEYYKWTQWIFLELFE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 169 KGLVYRgvKVMPF--------------------STACNTP--------------------LSNFES----HQNYKDVQ-- 202
Cdd:TIGR00396 142 KGLAYV--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPvekkelkqwflkitayaeelLNDLEEldhwPESVKEMQrn 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 203 ----DPSVFVTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvargrLLILMEARLSALYKLESDYEILER 278
Cdd:TIGR00396 220 wigkSEGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVE--------KAAENNPKVAAFIKKILNKTVAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 279 FP------GAYLKGKKYRPLfdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV 352
Cdd:TIGR00396 291 TKatkekkGVDTGIKAIHPL--------TGEKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKPV 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 353 dasgcfttevTDFAGQyvkdaDKSIIRTLKEQGRLLVATTFTHSypfcwrsDTPLIYKAVPSWFVrvENMVDQLLRNNDL 432
Cdd:TIGR00396 357 ----------IDPAEK-----DLSLTAAYTEDGVLVNSGEFNGL-------NSSEARNAIIDMLE--KEGKGKRKVNYRL 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 433 cywvpelvrekrfgnwlkdaRDWTISRNRYWGTPIPLWVSDDFEEVVCIGS-----VAELEELSGAKISDLHR-ESVDHL 506
Cdd:TIGR00396 413 --------------------RDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPEDVVYDGDGGSPLSRiPEWVNV 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 507 TIPSrCGKGSLhRISEVFDCWFESG--SMPYAQVHYP--FENKREFEDAFPADFIAEGIDQT-------RgWFYTLLVLA 575
Cdd:TIGR00396 473 TCPS-CGKPAL-RETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaR-FFHKFLRDI 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 576 TALFGQPPFKNVIVNGLVLA-------------------------------SDGQKMSKRKKNYPDPVSIIQKYGADALR 624
Cdd:TIGR00396 550 GYVNTKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADALR 629
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|
gi 1811715232 625 LYLI-NSPVvrAENLRFKEEGVRdvlkdvllpwyNAYRFLiQNVLRLQKE 673
Cdd:TIGR00396 630 LFIMfMGPI--AASLEWNESGLE-----------GARRFL-DRVWNLVYE 665
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-925 |
1.42e-34 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 143.47 E-value: 1.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 54 PHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVeyeidktLGI-----RGPEDVakmgITEYNNQCR------- 121
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-------LGIaeriaRGDPET----IELYKSLYGipeeele 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 122 ------AIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLsnfESH 195
Cdd:PRK12300 70 kfkdpeYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV---GDH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 196 qNYKDVQDPSV--FVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKdvARGRLLILMEArlsALYKL---E 270
Cdd:PRK12300 147 -DLLDGEEPEIveYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE---AAEKLsfqD 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 271 SDYEILERFPGAYLKGKKYR-PLFDyflkcKEngaFTVLVDNYVKEEEGTGVV-----HqAPYfgaeDYRVCMDFNIIRK 344
Cdd:PRK12300 221 RDVEIIEEIKGSELIGKKVKnPVTG-----KE---VPILPADFVDPDNGTGVVmsvpaH-APY----DYVALRDLKKNKE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 345 DS-----LPVCPVDASGCF----------------------TTEV--------------TDFAGQYVKDADKSIIRTLKE 383
Cdd:PRK12300 288 LLdviepIPLIEVEGYGEFpakevveklgiksqedpeleeaTKEVyraefhkgvlkentGEYAGKPVREAREKITKDLIE 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 384 QGRLLVATTFTHSYPFCwRSDTPLIYKAVP-SWFV---------RVENMVDQLlrnnDLcywVPELVReKRFGN---WLK 450
Cdd:PRK12300 368 KGIADIMYEFSNRPVYC-RCGTECVVKVVKdQWFIdysdpewkeLAHKALDNM----EI---IPEEYR-KEFENtidWLK 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 451 darDWTISRNRYWGTPIPlWvsdDFEEVVcigsvaelEELS------------------GAKISDLHRESVDHLTIpsrc 512
Cdd:PRK12300 439 ---DRACARRRGLGTRLP-W---DEEWII--------ESLSdstiymayytiahkireyGIKPEQLTPEFFDYVFL---- 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 513 GKGSLHRISEvfdcwfESGsMPYAQVHypfENKREFEDAFPADFIAEGIDqtrgwfytlLV---LA------TALFGQ-- 581
Cdd:PRK12300 500 GKGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAIFPEek 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 582 -PpfKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVLKDvll 654
Cdd:PRK12300 561 wP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQLER--- 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 655 pWYNayrfLIQNVLRLQKEEEIEFLynentvrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDILT--N 732
Cdd:PRK12300 631 -FYE----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYELLNdlR 690
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 733 WYvrmnRRRLKGENGmedcvMALETLFSV---LLS-----LC----RLMDKDTLsIHYLMLPRVREELIDKKTESAVSQM 800
Cdd:PRK12300 691 WY----LRRVGEANN-----KVLREVLEIwirLLApftphLAeelwHKLGGEGF-VSLEKWPEPDESKIDEEAELAEEYV 760
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 801 QSVIElgrvirdrktipikyplkeivvihqdpealkDIKSLEKYIieELNVRKVTLST-DKNKYGIrLRAEPDHMVLGKR 879
Cdd:PRK12300 761 KRLIE-------------------------------DIREILKVA--KIKPKKVYIYVaPDWKYEV-LEIAAENGDVKEA 806
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*.
gi 1811715232 880 LKGAFKAVmtSIKQLSSEELEQFQKtgtIVVEGHELHDEDIRLMYT 925
Cdd:PRK12300 807 IKELMKDE--ELRKHGKEVAKLAQK---IVKEVLKLDKEVRKLILK 847
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-623 |
2.00e-29 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 127.32 E-value: 2.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 4 QVPENINFPAEEEKILEFWTEFNCFQECLKQSKhkPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRF 83
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 84 GWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQcraiVMRYSAEWKSTV----SRLGRWIDFDNDYKTLYPQFMESV 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSE----VWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 160 WWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPS--------------VFVTF--PLEEDETVSLVAw 223
Cdd:PLN02381 249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEV--DYIDIKERTllkvpgydkpvefgVLTSFayPLEGGLGEIVVA- 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 224 TTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmEARLSALYKlesdyeileRFPGAYLKGKKYRPLFDyflkckeng 303
Cdd:PLN02381 326 TTRIETMLGDTAIAIHPD------------------DERYKHLHG---------KFAVHPFNGRKLPIICD--------- 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 304 afTVLVD-NYvkeeeGTGVVHQAPYFGAEDYRV----CMDF-NIIRKDSlpvcPVDASGCfttevTDFAGQYVKDADKSI 377
Cdd:PLN02381 370 --AILVDpNF-----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNGG-----SEFAGMPRFAAREAV 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 378 IRTLKEQGRLLVATTFTHSYPFCWRSD---TPLIYkavPSWFVRVENMVDQLL------RNNDLCYWVPELVREKRfgNW 448
Cdd:PLN02381 434 IEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALdaaidgENKKLEFIPKQYLAEWK--RW 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 449 LKDARDWTISRNRYWGTPIPLW---VSDDFEEVVCIGS----VAELEELSGAKISdlhresvdhLTIPSRcgKGSLHRIS 521
Cdd:PLN02381 509 LENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNESDALLEAS---------QKFPGK--KFELSQDP 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 522 EVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKM 601
Cdd:PLN02381 578 DVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKM 656
|
650 660
....*....|....*....|..
gi 1811715232 602 SKRKKNYPDPVSIIQKYGADAL 623
Cdd:PLN02381 657 SKSLGNVIDPLEVINGISLEGL 678
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-626 |
1.50e-19 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 95.28 E-value: 1.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 3 QQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHVDR 81
Cdd:PLN02563 74 PAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 82 RFGWDCHGLPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAIVMRYsaewkstvsrlgrwiDFDNDYKTLYPQFMESVW 160
Cdd:PLN02563 154 PMGWDAFGLPAEqYAIET--GTH-PKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEPEYYKWTQ 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 161 WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFE---------SH-------------------------------QNYKD 200
Cdd:PLN02563 216 WIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergGHpvirkpmrqwmlkitayadrlledlddldwpESIKE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 201 VQ------------DPSVFVTFPLEEDETVSLvaWTTTPWTLPSNLAVCVNPEMQYVkikdvarGRLLILMEARLSALYK 268
Cdd:PLN02563 296 MQrnwigrsegaelDFSVLDGEGKERDEKITV--YTTRPDTLFGATYLVVAPEHPLL-------SSLTTAEQKEAVEEYV 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 269 -LESDYEILER----------FPGAYLKgkkyRPLfdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcm 337
Cdd:PLN02563 367 dAASRKSDLERtelqkektgvFTGSYAI----NPA--------TGEAIPIWVADYVLGSYGTGAIMAVP---AHDTR--- 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 338 DFNIIRKDSLPVCPV---------DASGCFTTEVT---------DFAGQYVKDADKSIIRtlkeqgrllvattfthsypf 399
Cdd:PLN02563 429 DFEFAQKFDLPIKWVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIE-------------------- 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 400 cwrsdtpliykavpswfvrvenmvdqllrnndlcyWVPELVREKRFGNWlkDARDWTISRNRYWGTPIPLWVSDDFEEVV 479
Cdd:PLN02563 489 -----------------------------------WLEETGNGKKKVNY--KLRDWLFARQRYWGEPIPVVFLEDSGEPV 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 480 CIgSVAELEelsgakisdLHRESVDHLTiPSRCGKGSLHRISE---VFDC----WF--ESGSMP--------YAQVHYP- 541
Cdd:PLN02563 532 PV-PESDLP---------LTLPELDDFT-PTGTGEPPLAKAVSwvnTVDPssgkPArrETNTMPqwagscwyYLRFMDPk 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 542 -----FENKREfEDAFPADFIAEGIDQ-------TRGW---FYTLLVLATalfgQPPFKNVIVNGLVLA---------SD 597
Cdd:PLN02563 601 nsnalVDKEKE-KYWMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSD 675
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1811715232 598 GQ---------------------------------------------KMSKRKKNYPDPVSIIQKYGADALRLY 626
Cdd:PLN02563 676 GEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY 749
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
845-1008 |
2.98e-19 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 87.14 E-value: 2.98e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 845 IIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGT--IVVEGH--ELHDEDI 920
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 921 RLmytfdQATGgTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEgtyLNSV 1000
Cdd:pfam19302 83 LV-----TRQG-KEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEM---LEAA 153
|
....*...
gi 1811715232 1001 IESHTEFI 1008
Cdd:pfam19302 154 IEKFEDYI 161
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
693-826 |
8.34e-15 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 72.82 E-value: 8.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 693 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEdcvMALETLFSVLLSLCRLM-- 769
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLap 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811715232 770 ------DK--DTLSIHYLMLPrVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 826
Cdd:pfam08264 78 fmpfitEElwQKESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-175 |
1.81e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 75.75 E-value: 1.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTlgIRGPEDvakmgITEYNnqcraivmry 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKI--GRDPED-----WTEYN---------- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1811715232 128 SAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRG 175
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
413-628 |
2.31e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.58 E-value: 2.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 413 PSWFVRVENMVDQLLRnndlcywVPELVReKRFGNWLKdardwtISRNRYWGTPIPL-WVSDDFeevvcIGSvaeleels 491
Cdd:cd00812 139 TEWKEKLLKDLEKLDG-------WPEEVR-AMQENWIG------CSRQRYWGTPIPWtDTMESL-----SDS-------- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 492 gakisdlhresvdhltipsrcgkgslhrisevfdCWFESGsmpYAQVHYPF--------ENKREFEDAFPADFIAEGIDQ 563
Cdd:cd00812 192 ----------------------------------TWYYAR---YTDAHNLEqpyegdleFDREEFEYWYPVDIYIGGKEH 234
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 564 -----TRGWFYTLLVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:cd00812 235 apnhlLYSRFNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
48-628 |
1.29e-11 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 68.60 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIE--------LAA----EKEGITP-----QELVD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYrgvkvmpfstacntplsnfeshqnykdvqdps 205
Cdd:COG0143 71 RIHAEFKELFEKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIY-------------------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 206 vfvtfpleedetvslvawtttpwtlpsnlavcvnpemqyvkikdvargrllilmearlsalyklESDYEilerfpGAYlk 285
Cdd:COG0143 117 ----------------------------------------------------------------KGEYE------GWY-- 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 286 gkkyrplfdyflkCKENGAFtvLVDNYVkeeEGTgvvhqAPYFGAEDYRvcmdfniirKDSLPVCpvdasgcfttevtdf 365
Cdd:COG0143 125 -------------CPECERF--LPDRYV---EGT-----CPKCGAEDAY---------GDQCENC--------------- 157
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 366 agqyvkdadksiirtlkeqGRLLVATTFTHsyPFCWRSDTPLIYKAVPSWFVRVENMVDQLL----RNNDlcyWVPELVR 441
Cdd:COG0143 158 -------------------GATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLewieENPD---IQPEVRN 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 442 EKRfgNWLKDA-RDWTISRNRYWGTPIPlwvsddfeevvcigsvaeleelsGAKisdlhresvDHltipsrcgkgslhri 520
Cdd:COG0143 214 EVL--SWLKEGlQDLSISRDFDWGIPVP-----------------------GDP---------GK--------------- 244
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 521 seVFDCWFE------SGSMPYAQVHYPFENKREF---EDAFPADFIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVI 588
Cdd:COG0143 245 --VFYVWFDaligyiSATKGYADDRGLPEDFEKYwpaPDTELVHFI--GKDIIR--FHAIIwpaMLMAA--GLPLPKKVF 316
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 1811715232 589 VNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:COG0143 317 AHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLL 355
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
453-627 |
1.64e-11 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 68.92 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 453 RDWTISRNRYWGTPIPLWVSDDfeevvCiGSVA-----------ELEELSGAKISDL--HRESVdHLTIPsRCGKgSLHR 519
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLarAPEWV-NVTCP-KCGG-PARR 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 520 ISEVFDCWFESgS---MPYAQVHYpfenkrefeDAFPADFIAE----GIDQ--------------TRgwFYTLLVLATAL 578
Cdd:COG0495 491 ETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTKVLRDLGL 558
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1811715232 579 FGQP-PFKNVIVNGLV--LASDG------QKMSKRKKNYPDPVSIIQKYGADALRLYL 627
Cdd:COG0495 559 VSFDePFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFE 616
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-190 |
4.23e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 66.16 E-value: 4.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEYEIDKtLGIrGPEDVakmgiteynnqcraiVM 125
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEK-EGI-TPEEL---------------VD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1811715232 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLS 190
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
657-788 |
2.49e-09 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 56.80 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 657 YNAYRFLIQNvlrlqkeeeIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 735
Cdd:cd07962 17 WNAARFVLMN---------LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1811715232 736 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMdkdtlsiHYLMlPRVREEL 788
Cdd:cd07962 88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLL-------HPFM-PFITEEL 131
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
377-628 |
6.77e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 58.70 E-value: 6.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 377 IIRTLKEQGRLLVATtftHSYPFCWRSDTPL-IYKAVPSWFVRVENMVDQL---LRNNDLCYWvPELVReKRFGNWLKDA 452
Cdd:cd00814 104 FFKKLYENGYIYEGE---YEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLlewLEKNPDFIW-PENAR-NEVLSWLKEG 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 453 -RDWTISR-NRYWGTPIPlwvsdDFEevvcigsvaeleelsgakisdlhresvDHltipsrcgkgslhriseVFDCWFE- 529
Cdd:cd00814 179 lKDLSITRdLFDWGIPVP-----LDP---------------------------GK-----------------VIYVWFDa 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 530 -----SGSMPYAQvhyPFENKREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVIVNGLVLAsDGQ 599
Cdd:cd00814 210 ligyiSATGYYNE---EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA--GLPLPTRIVAHGYLTV-EGK 279
|
250 260
....*....|....*....|....*....
gi 1811715232 600 KMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:cd00814 280 KMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
540-628 |
3.96e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 57.50 E-value: 3.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 540 YPFENKREFEDAFPADFIAEGIDQTRgwFYT------LLVLatalfGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVS 613
Cdd:PRK12267 241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
|
90
....*....|....*
gi 1811715232 614 IIQKYGADALRLYLI 628
Cdd:PRK12267 313 LVDRYGLDALRYYLL 327
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
398-628 |
3.08e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 54.50 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 398 PFCWRSDTPLIYKAVPSWFVRVENMVDQLL---RNNdlcywvPELVR-EKRFG---NWLKD-ARDWTISRNRY-WGTPIP 468
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLelyEAN------PDFIQpASRRNeviSFVKSgLKDLSISRTNFdWGIPVP 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 469 lwvSDDfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgsLHRISEVFD--CWFESGSM-PYAQVhypfENK 545
Cdd:PRK11893 216 ---GDP------------------------------------------KHVIYVWFDalTNYLTALGyPDDEE----LLA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 546 REFEDAFPAD--FIaeGIDQTR----GWfytlLVLATALfGQPPFKNVIVNG-LVLasDGQKMSKRKKNYPDPVSIIQKY 618
Cdd:PRK11893 247 ELFNKYWPADvhLI--GKDILRfhavYW----PAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEY 317
|
250
....*....|
gi 1811715232 619 GADALRLYLI 628
Cdd:PRK11893 318 GVDAVRYFLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
657-769 |
7.77e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 49.04 E-value: 7.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 657 YNAYRFLIQNVLrlqkeeeiefLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILtNWYVR 736
Cdd:cd07375 15 YRLLSFFRKALG----------GTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLD 83
|
90 100 110
....*....|....*....|....*....|...
gi 1811715232 737 MNRRRLKGENGMEDCVMALETLFSVLLSLCRLM 769
Cdd:cd07375 84 ELKPALQTEELREAVLAVLRAALVVLTKLLAPF 116
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
572-630 |
6.54e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 45.65 E-value: 6.54e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715232 572 LVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 630
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
48-174 |
3.20e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 45.14 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811715232 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEV--LFvcADDAHGTPIM--------LKA----EKEGITP-----EELIA 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1811715232 126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYR 174
Cdd:PRK00133 72 RYHAEHKRDFAGFG--ISFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
576-650 |
4.22e-04 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 43.90 E-value: 4.22e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1811715232 576 TALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 650
Cdd:pfam01406 230 EAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
|
|
| |
