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Conserved domains on  [gi|1820395186|ref|NP_001365730|]
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cytokine receptor-like factor 1 isoform 4 precursor [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 40-137 1.06e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 77.46  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  40 GALPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLA 111
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1820395186 112 LFTPYEIWVEATNRLGSARSDVLTLD 137
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-247 1.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 145 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 223
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                          90       100
                  ....*....|....*....|....
gi 1820395186 224 pfgiygsKKAGIWSEWSHPTAAST 247
Cdd:cd00063    77 -------VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 40-137 1.06e-17

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 77.46  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  40 GALPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLA 111
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1820395186 112 LFTPYEIWVEATNRLGSARSDVLTLD 137
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-247 1.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 145 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 223
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                          90       100
                  ....*....|....*....|....
gi 1820395186 224 pfgiygsKKAGIWSEWSHPTAAST 247
Cdd:cd00063    77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 145-227 7.89e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 7.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  145 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 223
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 1820395186  224 PFGI 227
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
145-240 1.39e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 145 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 222
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 1820395186 223 npfgiygSKKAGIWSEWS 240
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
108-270 2.96e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.93  E-value: 2.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 108 KDLALFTPYEIWVEATNRLG--SARSDVLTLdVLDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRY 185
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYR 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 186 RVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHP------TAASTPRSERPGPGGG 258
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEvsattaSAASGESLTASVDAVP 434

                         170
                  ....*....|..
gi 1820395186 259 VCEPRGGEPSSG 270
Cdd:COG3401   435 LTDVAGATAAAS 446
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 44-128 2.60e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.13  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186   44 PEKPFNISCWSRNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 123
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 1820395186  124 NRLGS 128
Cdd:smart00060  78 NGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 44-135 8.82e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.16  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  44 PEKPFNISCWSRNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 123
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                          90
                  ....*....|...
gi 1820395186 124 NRLG-SARSDVLT 135
Cdd:cd00063    78 NGGGeSPPSESVT 90
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 40-137 1.06e-17

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 77.46  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  40 GALPPEKPFNISCWSRNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLA 111
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1820395186 112 LFTPYEIWVEATNRLGSARSDVLTLD 137
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-247 1.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 145 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 223
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                          90       100
                  ....*....|....*....|....
gi 1820395186 224 pfgiygsKKAGIWSEWSHPTAAST 247
Cdd:cd00063    77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 145-227 7.89e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 7.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  145 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 223
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 1820395186  224 PFGI 227
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
145-240 1.39e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 145 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 222
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 1820395186 223 npfgiygSKKAGIWSEWS 240
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 147-241 1.16e-07

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 48.95  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 147 PPDVHVSrVGGLEDQLSVRWVSPPALKDflfqakYQIRYRVEDSVDWKVV-----------DDVSNQTSCRLAGLKPGTV 215
Cdd:pfam16656   1 PEQVHLS-LTGDSTSMTVSWVTPSAVTS------PVVQYGTSSSALTSTAtatsstyttgdGGTGYIHRATLTGLEPGTT 73

                          90       100
                  ....*....|....*....|....*.
gi 1820395186 216 YFVQVRCnpfgiygskKAGIWSEWSH 241
Cdd:pfam16656  74 YYYRVGD---------DNGGWSEVYS 90
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
108-270 2.96e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.93  E-value: 2.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 108 KDLALFTPYEIWVEATNRLG--SARSDVLTLdVLDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRY 185
Cdd:COG3401   290 TGLTNGTTYYYRVTAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYR 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 186 RVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHP------TAASTPRSERPGPGGG 258
Cdd:COG3401   363 STSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEvsattaSAASGESLTASVDAVP 434

                         170
                  ....*....|..
gi 1820395186 259 VCEPRGGEPSSG 270
Cdd:COG3401   435 LTDVAGATAAAS 446
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 49-131 1.59e-06

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 46.19  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  49 NISCWSR-NMKDLTCRWTPgahgeTFLHTNYSLKYKLRWYGQDNTCEEYHTVGP----------------HSCHIPKdLA 111
Cdd:pfam18589   3 NISCETNgDLDLMTCRWNT-----TKWSLLADSKVNLRYRRSELSCEDRSTSSLkggsmvkecdcqgpgfYECTIQP-LY 76

                          90       100
                  ....*....|....*....|
gi 1820395186 112 LFTPYEIWVEATNRLGSARS 131
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQS 96
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 147-239 1.45e-05

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 43.49  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 147 PPDVHVSRVGgleDQLSVRwVSPPA--------LKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFV 218
Cdd:pfam09294   5 PPEVELEVEG---GSLNVT-VKDPEtregknlsLRDLYGSLQYRVSYW-KNSSNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|.
gi 1820395186 219 QVRcnpFGIYGSKKAGIWSEW 239
Cdd:pfam09294  80 SVQ---AFSPLDNKSSQRSPP 97
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 44-128 2.60e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.13  E-value: 2.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186   44 PEKPFNISCWSRNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 123
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 1820395186  124 NRLGS 128
Cdd:smart00060  78 NGAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
116-229 3.07e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.62  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 116 YEIWVEATNRLGSARSDVLTLDVLDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPAlkdfLFQAKYQIRYRVEDsvDW-- 193
Cdd:COG4733   599 YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLGGITLSWSFPVD----ADTLRTEIRYSTTG--DWas 672

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1820395186 194 -KVVDDVSNQTSCRLAGLKPGTVYFVQVRC-NPFGIYG 229
Cdd:COG4733   673 aTVAQALYPGNTYTLAGLKAGQTYYYRARAvDRSGNVS 710
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
109-255 9.63e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 9.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186 109 DLALFTPYEIWVEATNRLG-SARSDVLTLDVldvVTTDPPPDVHVSRVGGLEDQLSVRWvSPPALKDFlfqAKYQIRYRV 187
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGeSAPSNEVSVTT---PTTPPSAPTGLTATADTPGSVTLSW-DPVTESDA---TGYRVYRSN 270

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395186 188 EDSVDWKVVDDVsNQTSCRLAGLKPGTVYFVQVRCnpfgiygSKKAGIWSEWShPTAASTPRSERPGP 255
Cdd:COG3401   271 SGDGPFTKVATV-TTTSYTDTGLTNGTTYYYRVTA-------VDAAGNESAPS-NVVSVTTDLTPPAA 329
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 44-135 8.82e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.16  E-value: 8.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395186  44 PEKPFNISCWSRNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 123
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                          90
                  ....*....|...
gi 1820395186 124 NRLG-SARSDVLT 135
Cdd:cd00063    78 NGGGeSPPSESVT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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