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Conserved domains on  [gi|1833563338|ref|NP_001368924|]
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zinc finger protein 106 isoform 9 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 759-1036 9.21e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 9.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  759 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 836
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  837 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 913
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  914 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 989
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1833563338  990 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1036
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 759-1036 9.21e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 9.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  759 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 836
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  837 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 913
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  914 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 989
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1833563338  990 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1036
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
761-1037 1.91e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 1.91e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  761 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 838
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  839 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 913
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  914 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 989
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1833563338  990 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1037
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 794-836 5.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 5.20e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1833563338   794 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 836
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
759-791 3.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.73e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1833563338  759 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 791
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 759-1036 9.21e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 9.21e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  759 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 836
Cdd:cd00200      3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY---LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  837 VKSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYD 913
Cdd:cd00200     80 LETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  914 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVT--VVNILGKVMVT 989
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLAS 236

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1833563338  990 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 1036
Cdd:cd00200    237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
761-1037 1.91e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 1.91e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  761 FEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYNVK 838
Cdd:COG2319    116 LTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDGKLLASGSDDGTVRLWDLA 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  839 SRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYD 913
Cdd:COG2319    193 TGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSAD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  914 CTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVT 989
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLAS 347

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1833563338  990 ACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1037
Cdd:COG2319    348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
752-1037 1.98e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 1.98e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  752 DDDEPTEGSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKnaALYTGSSD 829
Cdd:COG2319     65 AAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGK--TLASGSAD 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  830 HTIRCYNVKSRECVeqlqledRVLCLHSRW----------RILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATA 899
Cdd:COG2319    142 GTVRLWDLATGKLL-------RTLTGHSGAvtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFS 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  900 QEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAV 977
Cdd:COG2319    214 PDG--KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1833563338  978 TVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIH--KSMIYTGCYDGSIQ 1037
Cdd:COG2319    292 NSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 760-1000 7.33e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.33e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  760 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGknaALYTGSSDHTIRCYNV 837
Cdd:cd00200     46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  838 KSRECVEQLQL-EDRVLCL--HSRWRILYAGLANGTVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGARklLVVGSYDC 914
Cdd:cd00200    123 ETGKCLTTLRGhTDWVNSVafSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEK--LLSSSSDG 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  915 TISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVTA 990
Cdd:cd00200    200 TIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASG 279

                          250
                   ....*....|
gi 1833563338  991 CLDKFVRVYE 1000
Cdd:cd00200    280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
760-1003 1.36e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.21  E-value: 1.36e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  760 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRKCIGVFEGHTSKVNCLLVTQtSGKNAAlyTGSSDHTIRCYNV 837
Cdd:COG2319    157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLA--SGSADGTVRLWDL 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  838 KSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIKNNKRLEIFEcHGPRAVSCLATAQEGarKLLVVGSY 912
Cdd:COG2319    234 ATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSD 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  913 DCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMV 988
Cdd:COG2319    309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLA 388

                          250
                   ....*....|....*
gi 1833563338  989 TACLDKFVRVYELQS 1003
Cdd:COG2319    389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 797-1036 4.21e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 4.21e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  797 CIGVFEGHTSKVNCLlvtQTSGKNAALYTGSSDHTIRCYNVKSRECVEQLQLE----DRVLCLHSRWRILYAGLaNGTVV 872
Cdd:cd00200      1 LRRTLKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADGTYLASGSS-DKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  873 TFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSG 950
Cdd:cd00200     77 LWDLETGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  951 SSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--M 1026
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyL 233

                          250
                   ....*....|
gi 1833563338 1027 IYTGCYDGSI 1036
Cdd:cd00200    234 LASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
888-1037 6.08e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 6.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  888 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGE 965
Cdd:COG2319     34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1833563338  966 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1037
Cdd:COG2319    112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 794-836 5.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 5.20e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1833563338   794 SRKCIGVFEGHTSKVNCLLVTQTSGKnaaLYTGSSDHTIRCYN 836
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKY---LASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-791 9.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 9.57e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1833563338   760 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 791
Cdd:smart00320    7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
759-791 3.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.73e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1833563338  759 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 791
Cdd:pfam00400    5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
795-836 5.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1833563338  795 RKCIGVFEGHTSKVNCLLVtqtSGKNAALYTGSSDHTIRCYN 836
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAF---SPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 893-968 6.07e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.06  E-value: 6.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563338  893 VSCLATAQEGArkLLVVGSYDCTISV-------------RDARNGLL----------LRTLEGHSKTILCMKVVN--DLV 947
Cdd:pfam20426  127 VSCVAVTSDGS--ILATGSYDTTVMVwevlrgrssekrsRNTQTEFPrkdhviaetpFHILCGHDDIITCLYVSVelDIV 204

                           90       100
                   ....*....|....*....|.
gi 1833563338  948 FSGSSDQSVHAHNIHTGELVR 968
Cdd:pfam20426  205 ISGSKDGTCIFHTLREGRYVR 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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