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Conserved domains on  [gi|1833563291|ref|NP_001368925|]
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zinc finger protein 106 isoform 10 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 648-879 6.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 135.16  E-value: 6.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNN 722
Cdd:cd00200    46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 723 KRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVH 800
Cdd:cd00200   126 KCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 801 AHNIHTGELVRIYKGHNHAVT--VVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYD 876
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSAD 282


                  ...
gi 1833563291 877 GSI 879
Cdd:cd00200   283 GTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 648-879 6.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.16  E-value: 6.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNN 722
Cdd:cd00200    46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 723 KRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVH 800
Cdd:cd00200   126 KCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 801 AHNIHTGELVRIYKGHNHAVT--VVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYD 876
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSAD 282


                  ...
gi 1833563291 877 GSI 879
Cdd:cd00200   283 GTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
648-880 2.80e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 2.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIK 720
Cdd:COG2319   157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 721 NNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQS 798
Cdd:COG2319   235 TGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGT 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 799 VHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGC 874
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGS 391


                  ....*.
gi 1833563291 875 YDGSIQ 880
Cdd:COG2319   392 ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 648-679 6.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.89e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1833563291  648 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 679
Cdd:smart00320   7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
647-679 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1833563291 647 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 679
Cdd:pfam00400   5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 648-879 6.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.16  E-value: 6.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLHSRW--RILYAGLANGTVVTFNIKNN 722
Cdd:cd00200    46 TLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTLTGhTSYVSSVAFSPdgRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 723 KRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVH 800
Cdd:cd00200   126 KCLTTLRGH-TDWVNSVAFSPDG--TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 801 AHNIHTGELVRIYKGHNHAVT--VVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYD 876
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNsvAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSAD 282


                  ...
gi 1833563291 877 GSI 879
Cdd:cd00200   283 GTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 647-879 1.12e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 647 GSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRECVEQLQLE----DRVLCLHSRWRILYAGLaNGTVVTFNIK 720
Cdd:cd00200     3 RTLKGHTGGVTCVAFSpdGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpvRDVAASADGTYLASGSS-DKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 721 NNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKV--VNDLVFSGSSDQS 798
Cdd:cd00200    82 TGECVRTLTGH-TSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 799 VHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHKS--MIYTGC 874
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDgyLLASGS 238


                  ....*
gi 1833563291 875 YDGSI 879
Cdd:cd00200   239 EDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
648-880 2.80e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 2.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNIK 720
Cdd:COG2319   157 TLTGHSGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSV--AFspdgKLLASGSADGTVRLWDLA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 721 NNKRLEIFECHGPRaVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQS 798
Cdd:COG2319   235 TGKLLRTLTGHSGS-VRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGT 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 799 VHAHNIHTGELVRIYKGHNHAVTVVNI--LGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGC 874
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGS 391


                  ....*.
gi 1833563291 875 YDGSIQ 880
Cdd:COG2319   392 ADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
640-880 7.88e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 7.88e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 640 DDDEPTEGSFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYNLVSRECVEQLQ-LEDRVLCLhsRW----RILYAGLANG 712
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSV--AFspdgKTLASGSADG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 713 TVVTFNIKNNKRLEIFECHgPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LV 790
Cdd:COG2319   143 TVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 791 FSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK- 867
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPd 299

                         250
                  ....*....|....
gi 1833563291 868 -SMIYTGCYDGSIQ 880
Cdd:COG2319   300 gKLLASGSDDGTVR 313
WD40 COG2319
WD40 repeat [General function prediction only];
648-846 1.75e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 648 SFEGHQAAVNAIQiF---GNLLYTCSADKTVRVYNLVSRECVEQLQL-EDRVLCLhsRW----RILYAGLANGTVVTFNI 719
Cdd:COG2319   199 TLTGHTGAVRSVA-FspdGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSV--AFspdgRLLASGSADGTVRLWDL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 720 KNNKRLEIFEcHGPRAVSCLATAQEGarKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQ 797
Cdd:COG2319   276 ATGELLRTLT-GHSGGVNSVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDG 352

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1833563291 798 SVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQS 846
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 769-879 1.64e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 1.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 769 LLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYEL 844
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1833563291 845 QSHDRLQVYGGHKDMIMCMTIHKS--MIYTGCYDGSI 879
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKTI 117
WD40 COG2319
WD40 repeat [General function prediction only];
731-880 5.01e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 5.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 731 HGPRAVSCLATAQEGARklLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGE 808
Cdd:COG2319    34 GLAAAVASLAASPDGAR--LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1833563291 809 LVRIYKGHNHAVTVVNIL--GKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 880
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 648-679 6.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.89e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1833563291  648 SFEGHQAAVNAIQIF--GNLLYTCSADKTVRVYN 679
Cdd:smart00320   7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
647-679 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1833563291 647 GSFEGHQAAVNAIQI--FGNLLYTCSADKTVRVYN 679
Cdd:pfam00400   5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 736-811 3.82e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.44  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833563291 736 VSCLATAQEGArkLLVVGSYDCTISV-------------RDARNGLL----------LRTLEGHSKTILCMKVVN--DLV 790
Cdd:pfam20426 127 VSCVAVTSDGS--ILATGSYDTTVMVwevlrgrssekrsRNTQTEFPrkdhviaetpFHILCGHDDIITCLYVSVelDIV 204

                          90       100
                  ....*....|....*....|.
gi 1833563291 791 FSGSSDQSVHAHNIHTGELVR 811
Cdd:pfam20426 205 ISGSKDGTCIFHTLREGRYVR 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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