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Conserved domains on  [gi|1913184266|ref|NP_001374316|]
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dnaJ homolog subfamily A member 4 isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ_bact super family cl37091
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 7-114 8.81e-40

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


The actual alignment was detected with superfamily member TIGR02349:

Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 138.89  E-value: 8.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGG-------- 76
Cdd:TIGR02349   2 YYEILGVSKDASEEEIKKAYRKLAKKYHPDRNKDKEaeEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGggggggfn 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  77 -SGSPSFSSPMDIFDMFFGGGGRMARERRGEVIKHGDLR 114
Cdd:TIGR02349  82 gFDIGFFGDFGDIFGDFFGGGGGSGRRRRSGPRRGEDLR 120
DnaJ_C super family cl47019
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 106-144 1.93e-03

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


The actual alignment was detected with superfamily member cd10747:

Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 37.40  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1913184266 106 EVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFPEK 144
Cdd:cd10747   120 PGTQPGTVLRLKGKGMPRLR-GGGRGDLYVEVKVEFPKK 157
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 7-114 8.81e-40

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 138.89  E-value: 8.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGG-------- 76
Cdd:TIGR02349   2 YYEILGVSKDASEEEIKKAYRKLAKKYHPDRNKDKEaeEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGggggggfn 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  77 -SGSPSFSSPMDIFDMFFGGGGRMARERRGEVIKHGDLR 114
Cdd:TIGR02349  82 gFDIGFFGDFGDIFGDFFGGGGGSGRRRRSGPRRGEDLR 120
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 7-114 3.02e-34

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 124.87  E-value: 3.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSG--SPS 81
Cdd:PRK10767    6 YYEVLGVSRNASEDEIKKAYRKLAMKYHPDRNPGDKeaeEKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGGGggFGG 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  82 FSSPMDIF-DMF---FGG--GGRMARERRGEvikhgDLR 114
Cdd:PRK10767   86 GGGFGDIFgDIFgdiFGGgrGGGRQRARRGA-----DLR 119
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 7-65 2.17e-33

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 114.11  E-value: 2.17e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE---GEKFKLISQAYEVLSDPKKRDVYD 65
Cdd:pfam00226   2 YYEILGVSPDASDEEIKKAYRKLALKYHPDKNPGDpeaEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 7-74 2.07e-32

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 114.03  E-value: 2.07e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 74
Cdd:COG0484     2 YYEILGVSRDASAEEIKKAYRKLAKKYHPDRNPGDPeaeEKFKEINEAYEVLSDPEKRAAYDRFGHAAELL 72
DnaJ smart00271
DnaJ molecular chaperone homology domain;
5-60 2.49e-26

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 95.76  E-value: 2.49e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266    5 TQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE----GEKFKLISQAYEVLSDPKK 60
Cdd:smart00271   1 TDYYEILGVPRDASLDEIKKAYRKLALKYHPDKNPGDkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 7-57 4.72e-26

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 94.92  E-value: 4.72e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE---GEKFKLISQAYEVLSD 57
Cdd:cd06257     2 YYDILGVPPDASDEEIKKAYRKLALKYHPDKNPDDpeaEEKFKEINEAYEVLSD 55
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 106-144 1.93e-03

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 37.40  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1913184266 106 EVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFPEK 144
Cdd:cd10747   120 PGTQPGTVLRLKGKGMPRLR-GGGRGDLYVEVKVEFPKK 157
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 106-142 1.96e-03

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 38.00  E-value: 1.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1913184266 106 EVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFP 142
Cdd:pfam01556 178 AGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 7-114 8.81e-40

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 138.89  E-value: 8.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGG-------- 76
Cdd:TIGR02349   2 YYEILGVSKDASEEEIKKAYRKLAKKYHPDRNKDKEaeEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGggggggfn 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  77 -SGSPSFSSPMDIFDMFFGGGGRMARERRGEVIKHGDLR 114
Cdd:TIGR02349  82 gFDIGFFGDFGDIFGDFFGGGGGSGRRRRSGPRRGEDLR 120
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 7-114 3.02e-34

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 124.87  E-value: 3.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSG--SPS 81
Cdd:PRK10767    6 YYEVLGVSRNASEDEIKKAYRKLAMKYHPDRNPGDKeaeEKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGGGggFGG 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  82 FSSPMDIF-DMF---FGG--GGRMARERRGEvikhgDLR 114
Cdd:PRK10767   86 GGGFGDIFgDIFgdiFGGgrGGGRQRARRGA-----DLR 119
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 1-114 8.88e-34

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 123.81  E-value: 8.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   1 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKN--PDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAI-----K 73
Cdd:PRK14298    1 MATTRDYYEILGLSKDASVEDIKKAYRKLAMKYHPDKNkePDAEEKFKEISEAYAVLSDAEKRAQYDRFGHAGIdnqysA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1913184266  74 EGGSGSPSFSSPMDIFDMFFGGGGRMARE--RRGevikhGDLR 114
Cdd:PRK14298   81 EDIFRGADFGGFGDIFEMFFGGGGRRGRMgpRRG-----SDLR 118
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 7-65 2.17e-33

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 114.11  E-value: 2.17e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE---GEKFKLISQAYEVLSDPKKRDVYD 65
Cdd:pfam00226   2 YYEILGVSPDASDEEIKKAYRKLALKYHPDKNPGDpeaEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 7-74 2.07e-32

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 114.03  E-value: 2.07e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 74
Cdd:COG0484     2 YYEILGVSRDASAEEIKKAYRKLAKKYHPDRNPGDPeaeEKFKEINEAYEVLSDPEKRAAYDRFGHAAELL 72
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 5-107 2.59e-32

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 119.77  E-value: 2.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   5 TQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGG---EQAIKEGGSGS 79
Cdd:PRK14278    3 RDYYGLLGVSRNASDAEIKRAYRKLARELHPDVNPDEEaqEKFKEISVAYEVLSDPEKRRIVDLGGdplESAGGGGGGFG 82

                          90       100
                  ....*....|....*....|....*...
gi 1913184266  80 PSFSSPMDIFDMFFGGGGrMARERRGEV 107
Cdd:PRK14278   83 GGFGGLGDVFEAFFGGGA-ASRGPRGRV 109
PRK14293 PRK14293
molecular chaperone DnaJ;
7-114 3.43e-30

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 114.32  E-value: 3.43e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKegGSGSPSFSS 84
Cdd:PRK14293    5 YYEILGVSRDADKDELKRAYRRLARKYHPDVNKEPGaeDRFKEINRAYEVLSDPETRARYDQFGEAGVS--GAAGFPDMG 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1913184266  85 PM----DIFDMFFGG----GGRMARERRGEVIKHGDLR 114
Cdd:PRK14293   83 DMggfaDIFETFFSGfggaGGQGGRRRRRGPQRGDDLR 120
PRK14280 PRK14280
molecular chaperone DnaJ;
7-98 3.65e-30

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 114.05  E-value: 3.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSS 84
Cdd:PRK14280    6 YYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEEGadEKFKEISEAYEVLSDDQKRAQYDQFGHAGPNQGFGGGGFGGG 85

                          90       100
                  ....*....|....*....|.
gi 1913184266  85 PM-------DIFDMFFGGGGR 98
Cdd:PRK14280   86 DFgggfgfeDIFSSFFGGGGR 106
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 7-114 1.54e-29

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 112.17  E-value: 1.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNP---DEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFS 83
Cdd:PRK14294    6 YYEILGVTRDASEEEIKKSYRKLAMKYHPDRNPgdkEAEELFKEAAEAYEVLSDPKKRGIYDQYGHEGLSGTGFSGFSGF 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1913184266  84 SPM-----DIFDMFFGGGGRMARERRGEVIKHGDLR 114
Cdd:PRK14294   86 DDIfssfgDIFEDFFGFGGGRRGRSRTAVRAGADLR 121
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 2-108 4.09e-29

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 111.84  E-value: 4.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   2 VKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEgEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKeggsGSPS 81
Cdd:PTZ00037   25 VDNEKLYEVLNLSKDCTTSEIKKAYRKLAIKHHPDKGGDP-EKFKEISRAYEVLSDPEKRKIYDEYGEEGLE----GGEQ 99

                          90       100
                  ....*....|....*....|....*..
gi 1913184266  82 FSSPMDIFDMFFGGGGRMARERRGEVI 108
Cdd:PTZ00037  100 PADASDLFDLIFGGGRKPGGKKRGEDI 126
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 4-99 8.08e-29

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 110.56  E-value: 8.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   4 ETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQ----------GGEQA 71
Cdd:PRK14276    3 NTEYYDRLGVSKDASQDEIKKAYRKLSKKYHPDINKEPGaeEKYKEVQEAYETLSDPQKRAAYDQygaaganggfGGGAG 82

                          90       100
                  ....*....|....*....|....*...
gi 1913184266  72 IKEGGSGSPSFSSPMDIFDMFFGGGGRM 99
Cdd:PRK14276   83 GFGGFDGSGGFGGFEDIFSSFFGGGGAR 110
PRK14297 PRK14297
molecular chaperone DnaJ;
7-113 1.17e-28

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 110.26  E-value: 1.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQ---------GGEQAIKE 74
Cdd:PRK14297    6 YYEVLGLEKGASDDEIKKAFRKLAIKYHPDKNKGNKeaeEKFKEINEAYQVLSDPQKKAQYDQfgtadfngaGGFGSGGF 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  75 GGSGSPSFSSPMDIFDMFFGGGGRMARERRGEVIKHGDL 113
Cdd:PRK14297   86 GGFDFSDMGGFGDIFDSFFGGGFGSSSRRRNGPQRGADI 124
PRK14289 PRK14289
molecular chaperone DnaJ;
1-114 1.22e-27

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 107.61  E-value: 1.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   1 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNP---DEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGS 77
Cdd:PRK14289    1 MAEKRDYYEVLGVSKTATVDEIKKAYRKKAIQYHPDKNPgdkEAEEKFKEAAEAYDVLSDPDKRSRYDQFGHAGVGGAAG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1913184266  78 GSPSFSSPM---DIFDMF----------------FGGGGRMARERRGEvikhgDLR 114
Cdd:PRK14289   81 GGGFSGEGMsmeDIFSMFgdifgghgggfggfggFGGGGSQQRVFRGS-----DLR 131
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 7-122 6.95e-27

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 105.66  E-value: 6.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQ------GGEQAIKEGGS 77
Cdd:PRK14281    5 YYEVLGVSRSADKDEIKKAYRKLALKYHPDKNPDNKeaeEHFKEVNEAYEVLSNDDKRRRYDQfghagvGSSAASGGGPG 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1913184266  78 GSPSFSSPMDIF----DMFFGGGGRMARERRG--EVIKHGDLRCVRDEGMP 122
Cdd:PRK14281   85 YGGGGGDFNDIFsafnDMFGGGARRGGGSPFGfeDVFGGGGRRRRASAGIP 135
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 7-104 2.22e-26

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 104.08  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSS 84
Cdd:PRK14291    5 YYEILGVSRNATQEEIKKAYRRLARKYHPDFNKNPEaeEKFKEINEAYQVLSDPEKRKLYDQFGHAAFSGSGQQQQGQEG 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1913184266  85 PMDIFDM--------------FFGGGGRMA--RERR 104
Cdd:PRK14291   85 FSDFGGGniediledvfdifgFGDIFGRRRatRERR 120
DnaJ smart00271
DnaJ molecular chaperone homology domain;
5-60 2.49e-26

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 95.76  E-value: 2.49e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266    5 TQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE----GEKFKLISQAYEVLSDPKK 60
Cdd:smart00271   1 TDYYEILGVPRDASLDEIKKAYRKLALKYHPDKNPGDkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 7-57 4.72e-26

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 94.92  E-value: 4.72e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE---GEKFKLISQAYEVLSD 57
Cdd:cd06257     2 YYDILGVPPDASDEEIKKAYRKLALKYHPDKNPDDpeaEEKFKEINEAYEVLSD 55
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 5-97 6.28e-26

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 103.00  E-value: 6.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   5 TQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGE---KFKLISQAYEVLSDPKKRDVYDQGGEQA-IKEGGSGSP 80
Cdd:PRK14284    1 MDYYTILGVSKTASPEEIKKAYRKLAVKYHPDKNPGDAEaekRFKEVSEAYEVLSDAQKRESYDRYGKDGpFAGAGGFGG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1913184266  81 SFSSPMD-------------------IFDMFFGGGG 97
Cdd:PRK14284   81 AGMGNMEdalrtfmgafggefggggsFFEGLFGGLG 116
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 2-110 1.06e-25

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 101.99  E-value: 1.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   2 VKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKN---PDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSG 78
Cdd:PRK14286    1 MSERSYYDILGVSKSANDEEIKSAYRKLAIKYHPDKNkgnKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVNAGAGG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1913184266  79 SPSFSSP---------MDIFDMFFG-------GGGRMARERRGEVIKH 110
Cdd:PRK14286   81 FGQGAYTdfsdifgdfGDIFGDFFGggrgggsGGGRRSGPQRGSDLRY 128
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 1-108 1.76e-25

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 101.44  E-value: 1.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   1 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGE--------- 69
Cdd:PRK14283    1 MAEKRDYYEVLGVDRNADKKEIKKAYRKLARKYHPDVSEEEGaeEKFKEISEAYAVLSDDEKRQRYDQFGHagmdgfsqe 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1913184266  70 ---QAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGEVI 108
Cdd:PRK14283   81 difNNINFEDIFQGFGFGIGNIFDMFGFGGGSRHGPQRGADI 122
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 7-105 1.88e-25

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 101.50  E-value: 1.88e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQ---AIKEGGSGSPS 81
Cdd:PRK14292    4 YYELLGVSRTASADEIKSAYRKLALKYHPDRNKEKGaaEKFAQINEAYAVLSDAEKRAHYDRFGTApgaGMPGGDPFGGM 83

                          90       100
                  ....*....|....*....|....*
gi 1913184266  82 FSSPMDIFDMFFGGGGRMA-RERRG 105
Cdd:PRK14292   84 GFDPMDIFEQLFGGAGFGGgRGRRG 108
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 1-71 1.49e-24

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 99.10  E-value: 1.49e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913184266   1 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGE---KFKLISQAYEVLSDPKKRDVYDQGGEQA 71
Cdd:PRK14277    1 MAAKKDYYEILGVDRNATEEEIKKAYRRLAKKYHPDLNPGDKEaeqKFKEINEAYEILSDPQKRAQYDQFGHAA 74
SEC63 COG5407
Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular ...
 7-61 2.62e-24

Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444165 [Multi-domain]  Cd Length: 61  Bit Score: 90.83  E-value: 2.62e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKR 61
Cdd:COG5407     2 PYEVLGVAKTASADEIKKAYRKLAKKYHPDRNKGDPkaeERFKEINEAYELLSDAEKR 59
PRK14295 PRK14295
molecular chaperone DnaJ;
4-109 2.93e-24

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 98.38  E-value: 2.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   4 ETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKN---PDEGEKFKLISQAYEVLSDPKKRDVYD--------------- 65
Cdd:PRK14295    8 EKDYYKVLGVPKDATEAEIKKAYRKLAREYHPDANkgdAKAEERFKEISEAYDVLSDEKKRKEYDearslfgnggfrpgp 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913184266  66 --------------------QGGEQAikeggsgsPSFSSPMDIFDMFFGGGGRMARERRGEVIK 109
Cdd:PRK14295   88 gggggggfnfdlgdlfgggaQGGGGA--------GGGGGLGDVFGGLFNRGGRRTQPRRGADVE 143
PRK14279 PRK14279
molecular chaperone DnaJ;
4-66 1.41e-23

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 96.34  E-value: 1.41e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913184266   4 ETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDE---GEKFKLISQAYEVLSDPKKRDVYDQ 66
Cdd:PRK14279    8 EKDFYKELGVSSDASAEEIKKAYRKLARELHPDANPGDpaaEERFKAVSEAHDVLSDPAKRKEYDE 73
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
1-71 2.19e-23

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 89.39  E-value: 2.19e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1913184266   1 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG----EKFKLISQAYEVLSDPKKRDVYDQGGEQA 71
Cdd:COG2214     1 MPDLKDHYAVLGVPPDASLEEIRQAYRRLAKLLHPDRGGELKalaeELFQRLNEAYEVLSDPERRAEYDRELGQS 75
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 7-104 6.84e-23

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 94.42  E-value: 6.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGE---KFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFS 83
Cdd:PRK14301    6 YYEVLGVSRDASEDEIKKAYRKLALQYHPDRNPDNPEaeqKFKEAAEAYEVLRDAEKRARYDRFGHAGVNGNGGFGGFSS 85

                          90       100
                  ....*....|....*....|....*...
gi 1913184266  84 SP------MDIFDMFFG-GGGRMARERR 104
Cdd:PRK14301   86 AEdifshfSDIFGDLFGfSGGGSRRGPR 113
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 7-97 1.06e-22

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 93.92  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPD--KNPDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKE--GGSGSPSF 82
Cdd:PRK14287    6 YYEVLGVDRNASVDEVKKAYRKLARKYHPDvnKAPDAEDKFKEVKEAYDTLSDPQKKAHYDQFGHTDPNQgfGGGGAGDF 85

                          90
                  ....*....|....*
gi 1913184266  83 SSPMDIFDMFFGGGG 97
Cdd:PRK14287   86 GGFSDIFDMFFGGGG 100
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 1-68 3.82e-22

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 92.30  E-value: 3.82e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1913184266   1 MVKEtqYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG----EKFKLISQAYEVLSDPKKRDVYDQGG 68
Cdd:PRK14290    1 MAKD--YYKILGVDRNASQEDIKKAFRELAKKWHPDLHPGNKaeaeEKFKEISEAYEVLSDPQKRRQYDQTG 70
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 7-109 2.15e-21

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 90.24  E-value: 2.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG----EKFKLISQAYEVLSDPKKRDVYDQG---GEQAIK------ 73
Cdd:PRK14282    6 YYEILGVSRNATQEEIKRAYKRLVKEWHPDRHPENRkeaeQKFKEIQEAYEVLSDPQKRAMYDRFgyvGEQPPYqetesg 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1913184266  74 ----EGGSGSPSFSSPMDIFDMFFGGGG----RMARERRGEVIK 109
Cdd:PRK14282   86 ggffEDIFKDFENIFNRDIFDIFFGERRtqeeQREYARRGEDIR 129
PRK10266 PRK10266
curved DNA-binding protein;
7-105 2.43e-21

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 89.11  E-value: 2.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPD--KNPDEGEKFKLISQAYEVLSDPKKRDVYDQ--------GGEQAIKEGG 76
Cdd:PRK10266    6 YYAIMGVKPTDDLKTIKTAYRRLARKYHPDvsKEPDAEARFKEVAEAWEVLSDEQRRAEYDQlwqhrndpQFNRQFQHGD 85

                          90       100
                  ....*....|....*....|....*....
gi 1913184266  77 SGSPSFSSPMDIFDMFFGGGGRMARERRG 105
Cdd:PRK10266   86 GQSFNAEDFDDIFSSIFGQHARQSRQRPA 114
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 7-71 7.64e-21

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 87.69  E-value: 7.64e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG--EKFKLISQAYEVLSDPKKRDVYDQGGEQA 71
Cdd:PRK14299    6 YYAILGVPKNASQDEIKKAFKKLARKYHPDVNKSPGaeEKFKEINEAYTVLSDPEKRRIYDTYGTTA 72
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 7-106 3.67e-19

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 84.27  E-value: 3.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEK---FKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFS 83
Cdd:PRK14285    5 YYEILGLSKGASKDEIKKAYRKIAIKYHPDKNKGNKEAesiFKEATEAYEVLIDDNKRAQYDRFGHTAFEGGGGFEGFSG 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1913184266  84 SPM----------DIFDMFFGGGGRMARERRGE 106
Cdd:PRK14285   85 GFSgfsdifedfgDIFDSFFTGNRGQDKNRKHE 117
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 7-114 7.41e-17

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 77.75  E-value: 7.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDKNP--DEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGS---PS 81
Cdd:PRK14300    5 YYQILGVSKTASQADLKKAYLKLAKQYHPDTTDakDAEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFQNQQSRGgggNH 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  82 FSSPMDIFDMF------FGGGGRMARERRGEViKHGDLR 114
Cdd:PRK14300   85 GGFHPDINDIFgdffsdFMGGSRRSRPTSSKV-RGSDLK 122
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 2-103 2.94e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 76.14  E-value: 2.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1913184266   2 VKETQYYDILGVKPSASPEEIKKAYRKLALKYHPD--KNPDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIK------ 73
Cdd:PRK14296    1 MKKKDYYEVLGVSKTASEQEIRQAYRKLAKQYHPDlnKSPDAHDKMVEINEAADVLLDKDKRKQYDQFGHAAFDgssgfs 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1913184266  74 ------EGGSGSPSFSSPM---DIFDMFFgGGGRMARER 103
Cdd:PRK14296   81 snfgdfEDLFSNMGSSGFSsftNIFSDFF-GSNKSDYQR 118
PRK14288 PRK14288
molecular chaperone DnaJ;
4-74 3.96e-16

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 75.50  E-value: 3.96e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913184266   4 ETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEG---EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 74
Cdd:PRK14288    2 ELSYYEILEVEKHSNQETIKKSYRKLALKYHPDRNAGDKeaeEKFKLINEAYGVLSDEKKRALYDRYGKKGLNQ 75
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
7-63 2.06e-13

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 62.89  E-value: 2.06e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913184266   7 YYDILGVKPSASPEEIKKAYRKLALKYHPDK----NPDE-----GEKFKLISQAYEVLSDPKKRDV 63
Cdd:COG1076     6 AFELLGLPPDADDAELKRAYRKLQREHHPDRlaagLPEEeqrlaLQKAAAINEAYETLKDPRGIDL 71
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 2-74 6.24e-12

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 64.04  E-value: 6.24e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1913184266    2 VKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDK-NPDEG-EKFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 74
Cdd:PTZ00341   570 IPDTLFYDILGVGVNADMKEISERYFKLAENYYPPKrSGNEGfHKFKKINEAYQILGDIDKKKMYNKFGYDGIKG 644
ZUO1 COG5269
Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / ...
 3-65 1.58e-09

Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227594 [Multi-domain]  Cd Length: 379  Bit Score: 56.58  E-value: 1.58e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1913184266   3 KETQYYDILGV---KPSASPEEIKKAYRKLALKYHPDKNPDEGEK-----FKLISQAYEVLSDPKKRDVYD 65
Cdd:COG5269    41 KKVDLYALLGLskyRTKAIPPQILKAHKKKVYKYHPDKTAAGGNKgcdefFKLIQKAREVLGDRKLRLQYD 111
djlA PRK09430
co-chaperone DjlA;
8-55 1.82e-08

co-chaperone DjlA;


Pssm-ID: 236512 [Multi-domain]  Cd Length: 267  Bit Score: 52.89  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1913184266   8 YDILGVKPSASPEEIKKAYRKLALKYHPDK-----NPDE-----GEKFKLISQAYEVL 55
Cdd:PRK09430  203 YKVLGVSESDDDQEIKRAYRKLMSEHHPDKlvakgLPPEmmemaKEKAQEIQAAYELI 260
PHA03102 PHA03102
Small T antigen; Reviewed
 9-70 2.70e-05

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 42.74  E-value: 2.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1913184266   9 DILGVKPSA--SPEEIKKAYRKLALKYHPDKNPDEgEKFKLISQAYEVLSDPKKRDVYDQGGEQ 70
Cdd:PHA03102    9 DLLGLPRSAwgNLPLMRKAYLRKCLEFHPDKGGDE-EKMKELNTLYKKFRESVKSLRDLDGEED 71
PHA02624 PHA02624
large T antigen; Provisional
 9-61 5.88e-05

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 43.05  E-value: 5.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1913184266   9 DILGVKPSA--SPEEIKKAYRKLALKYHPDKNPDEgEKFKLISQAYEVLSDPKKR 61
Cdd:PHA02624   15 DLLGLPMAAwgNLPLMRKAYLRKCKEYHPDKGGDE-EKMKRLNSLYKKLQEGVKS 68
PTZ00100 PTZ00100
DnaJ chaperone protein; Provisional
 5-36 3.63e-04

DnaJ chaperone protein; Provisional


Pssm-ID: 240265  Cd Length: 116  Bit Score: 38.68  E-value: 3.63e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1913184266   5 TQYYDILGVKPSASPEEIKKAYRKLALKYHPD 36
Cdd:PTZ00100   65 SEAYKILNISPTASKERIREAHKQLMLRNHPD 96
hscB PRK01356
co-chaperone HscB; Provisional
 7-64 1.28e-03

co-chaperone HscB; Provisional


Pssm-ID: 167217 [Multi-domain]  Cd Length: 166  Bit Score: 37.93  E-value: 1.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1913184266   7 YYDILGVKP--SASPEEIKKAYRKLALKYHPD--KNPDEGEKFKLIS----QAYEVLSDPKKRDVY 64
Cdd:PRK01356    4 YFQLLGLPQeyNIDLKILEKQYFAMQVKYHPDkaKTLQEKEQNLIIAselnNAYSTLKDALKRAEY 69
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 106-144 1.93e-03

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 37.40  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1913184266 106 EVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFPEK 144
Cdd:cd10747   120 PGTQPGTVLRLKGKGMPRLR-GGGRGDLYVEVKVEFPKK 157
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 106-142 1.96e-03

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 38.00  E-value: 1.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1913184266 106 EVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFP 142
Cdd:pfam01556 178 AGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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