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Conserved domains on  [gi|2130752971|ref|NP_001384291|]
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putative protein CRIPTO3 precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 10559578)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; wall-associated receptor kinase (WAK) is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component; lacks the galacturonan-binding domain typically associated with WAKs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 115-149 1.77e-14

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


:

Pssm-ID: 462800  Cd Length: 35  Bit Score: 64.22  E-value: 1.77e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2130752971 115 CGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGC 149
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
 
Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 115-149 1.77e-14

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


Pssm-ID: 462800  Cd Length: 35  Bit Score: 64.22  E-value: 1.77e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2130752971 115 CGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGC 149
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
 
Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 115-149 1.77e-14

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


Pssm-ID: 462800  Cd Length: 35  Bit Score: 64.22  E-value: 1.77e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2130752971 115 CGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGC 149
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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