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Conserved domains on  [gi|2170487658|ref|NP_001385806|]
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guanine nucleotide-binding protein subunit beta-like protein 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-322 6.21e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 6.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFcpapgAAENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:COG2319   113 LRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGRNTVM---DSVQLDSVGFCKSsilvrGQLcwmLAVpgkGSD--EVQILEMPSKTSVCTLKPEADAkpgmPMC 166
Cdd:COG2319   187 RLWDLATGKLLRTltgHTGAVRSVAFSPD-----GKL---LAS---GSAdgTVRLWDLATGKLLRTLTGHSGS----VRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 167 LGLwqtnSSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDF--DSQKAkgVSGSAGKVLAVWSLDDQQSLQV 244
Cdd:COG2319   252 VAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRT 325

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170487658 245 KKTHeliNPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:COG2319   326 LTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-322 6.21e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 6.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFcpapgAAENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:COG2319   113 LRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGRNTVM---DSVQLDSVGFCKSsilvrGQLcwmLAVpgkGSD--EVQILEMPSKTSVCTLKPEADAkpgmPMC 166
Cdd:COG2319   187 RLWDLATGKLLRTltgHTGAVRSVAFSPD-----GKL---LAS---GSAdgTVRLWDLATGKLLRTLTGHSGS----VRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 167 LGLwqtnSSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDF--DSQKAkgVSGSAGKVLAVWSLDDQQSLQV 244
Cdd:COG2319   252 VAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRT 325

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170487658 245 KKTHeliNPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:COG2319   326 LTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-321 3.44e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 3.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFCPapgaaENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-----DGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGR---------NTVMdSVQLDSvgfcKSSILVrgqlcwmlavpGKGSD-EVQILEMPSKTSVCTLKpeadAKP 161
Cdd:cd00200    76 RLWDLETGEcvrtltghtSYVS-SVAFSP----DGRILS-----------SSSRDkTIKVWDVETGKCLTTLR----GHT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 162 GMPMCLGLWQTNSslrpLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGVSGSAGKVLAVWSLDDQQS 241
Cdd:cd00200   136 DWVNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 242 LQVKKTHElinPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVW 320
Cdd:cd00200   212 LGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288


                  .
gi 2170487658 321 S 321
Cdd:cd00200   289 D 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 6.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 173 NSSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGV-SGSAGKVLAVWSLDDQQSLQVKKTheli 251
Cdd:PLN00181  541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT---- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2170487658 252 NPGIAEVTLRPDH-RLFATAGWDHRIRVFHWRTIK-PLAVLAFHSAPVHCVAFAADGLLAAGSKDQRISVWSL 322
Cdd:PLN00181  617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 1.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2170487658  283 TIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-321 6.82e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2170487658 285 KPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWS 321
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-322 6.21e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 6.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFcpapgAAENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:COG2319   113 LRTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGRNTVM---DSVQLDSVGFCKSsilvrGQLcwmLAVpgkGSD--EVQILEMPSKTSVCTLKPEADAkpgmPMC 166
Cdd:COG2319   187 RLWDLATGKLLRTltgHTGAVRSVAFSPD-----GKL---LAS---GSAdgTVRLWDLATGKLLRTLTGHSGS----VRS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 167 LGLwqtnSSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDF--DSQKAkgVSGSAGKVLAVWSLDDQQSLQV 244
Cdd:COG2319   252 VAF----SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRT 325

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170487658 245 KKTHeliNPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:COG2319   326 LTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-321 3.44e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 3.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFCPapgaaENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-----DGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGR---------NTVMdSVQLDSvgfcKSSILVrgqlcwmlavpGKGSD-EVQILEMPSKTSVCTLKpeadAKP 161
Cdd:cd00200    76 RLWDLETGEcvrtltghtSYVS-SVAFSP----DGRILS-----------SSSRDkTIKVWDVETGKCLTTLR----GHT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 162 GMPMCLGLWQTNSslrpLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGVSGSAGKVLAVWSLDDQQS 241
Cdd:cd00200   136 DWVNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 242 LQVKKTHElinPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVW 320
Cdd:cd00200   212 LGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288


                  .
gi 2170487658 321 S 321
Cdd:cd00200   289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
12-322 8.57e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 8.57e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  12 RFVLRGTQSAVNTLHFCPAPGaaenpLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRL 91
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGR-----LLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  92 CLWDLAEGR--NTVMD-SVQLDSVGFCKSsilvrGQLcwmLAVpGKGSDEVQILEMPSKTSVCTLKPEADakpgmpmclg 168
Cdd:COG2319   145 RLWDLATGKllRTLTGhSGAVTSVAFSPD-----GKL---LAS-GSDDGTVRLWDLATGKLLRTLTGHTG---------- 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 169 lWQTNSSLRP---LLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDF--DSQKAkgVSGSAGKVLAVWSLDDQQSLQ 243
Cdd:COG2319   206 -AVRSVAFSPdgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLL--ASGSADGTVRLWDLATGELLR 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 244 VKKTHeliNPGIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:COG2319   283 TLTGH---SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
33-322 2.10e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 2.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  33 AAENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGQgVTWLKTLPQGQQLLSQGRDPRLCLWDLAEGRNTVMDSVQLDSV 112
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAA-VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 113 GFCKSSILVRgqlcwmLAVPGKGSDEVQILEMPSKTSVCTLKPEADAkpgmPMCLGLwqtnSSLRPLLLAGYEDGSVTLW 192
Cdd:COG2319    82 LSVAFSPDGR------LLASASADGTVRLWDLATGLLLRTLTGHTGA----VRSVAF----SPDGKTLASGSADGTVRLW 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 193 DVSERKVCSQITCHEEPVMGLDF--DSQKAkgVSGSAGKVLAVWSLDDQQSLQVKKTHeliNPGIAEVTLRPDHRLFATA 270
Cdd:COG2319   148 DLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKLLASG 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2170487658 271 GWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:COG2319   223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
14-283 6.94e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 6.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  14 VLRGTQSAVNTLHFCPapgaaENPLLFSGSQNGLVHIWSLQTRRIVATLNGHGGqGVTWLKTLPQGQQLLSQGRDPRLCL 93
Cdd:COG2319   199 TLTGHTGAVRSVAFSP-----DGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRL 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658  94 WDLAEGRntvmdsvqldsvgfckssilvrgqlcwMLAVPGKGSDEVqilempskTSVCTLkpeADAKpgmpmclglwqtn 173
Cdd:COG2319   273 WDLATGE---------------------------LLRTLTGHSGGV--------NSVAFS---PDGK------------- 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 174 sslrpLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGVSGSAGKVLAVWSLDDQQSLQVKKTHElinP 253
Cdd:COG2319   302 -----LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT---G 373

                         250       260       270
                  ....*....|....*....|....*....|
gi 2170487658 254 GIAEVTLRPDHRLFATAGWDHRIRVFHWRT 283
Cdd:COG2319   374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-322 2.09e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 174 SSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGVSGSAGKVLAVWSLDDQQSLQVKKTHElinP 253
Cdd:cd00200    18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 254 GIAEVTLRPDHRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWSL 322
Cdd:cd00200    95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 6.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 173 NSSLRPLLLAGYEDGSVTLWDVSERKVCSQITCHEEPVMGLDFDSQKAKGV-SGSAGKVLAVWSLDDQQSLQVKKTheli 251
Cdd:PLN00181  541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKT---- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2170487658 252 NPGIAEVTLRPDH-RLFATAGWDHRIRVFHWRTIK-PLAVLAFHSAPVHCVAFAADGLLAAGSKDQRISVWSL 322
Cdd:PLN00181  617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 1.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2170487658  283 TIKPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-321 6.82e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2170487658 285 KPLAVLAFHSAPVHCVAFAADG-LLAAGSKDQRISVWS 321
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
223-319 1.84e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170487658 223 VSGSAGKVLAVWsldDQQSLQVKKTHELiNPGIAEVTLRPD-HRLFATAGWDHRIRVFHWRTIKPLAVLAFHSAPvHCVA 301
Cdd:COG3391    84 VANSGSGRVSVI---DLATGKVVATIPV-GGGPRGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIA 158

                          90       100
                  ....*....|....*....|
gi 2170487658 302 FAADG--LLAAGSKDQRISV 319
Cdd:COG3391   159 VDPDGkrLYVANSGSNTVSV 178
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-325 5.76e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.08  E-value: 5.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2170487658 293 HSAPVHCVAFAADG-LLAAGSKDQRISVWSLYPC 325
Cdd:cd00200     8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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