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Conserved domains on  [gi|77695917|ref|NP_002598|]
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platelet-derived growth factor subunit A isoform 1 preproprotein [Homo sapiens]

Protein Classification

PDGF_N and PDGF domain-containing protein( domain architecture ID 11152297)

PDGF_N and PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-95 1.62e-33

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


:

Pssm-ID: 461394  Cd Length: 78  Bit Score: 114.84  E-value: 1.62e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77695917    21 EEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD--TSLRAHGVHATKHVPEK-RPLPIRRKRSIEEAVPAV 95
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKrRQLHSRRKRSIEEAVPAV 78
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 94-181 3.40e-29

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 104.04  E-value: 3.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917     94 AVCKTRTVIYEIPRSQVDPTsaNFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHrsVKVAKVEYVRKKPKlKEVQVRLEE 173
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 77695917    174 HLECACAT 181
Cdd:smart00141  76 HTKCECRP 83
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-95 1.62e-33

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 114.84  E-value: 1.62e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77695917    21 EEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD--TSLRAHGVHATKHVPEK-RPLPIRRKRSIEEAVPAV 95
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKrRQLHSRRKRSIEEAVPAV 78
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 94-181 3.40e-29

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 104.04  E-value: 3.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917     94 AVCKTRTVIYEIPRSQVDPTsaNFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHrsVKVAKVEYVRKKPKlKEVQVRLEE 173
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 77695917    174 HLECACAT 181
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 94-181 1.67e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 97.05  E-value: 1.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917  94 AVCKTRTVIYEIPRSQVDPTsaNFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRkKPKLKEVQVRLEE 173
Cdd:cd00135   1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 77695917 174 HLECACAT 181
Cdd:cd00135  78 HTECECRP 85
PDGF pfam00341
PDGF/VEGF domain;
96-179 6.55e-26

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 95.43  E-value: 6.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917    96 CKTRTVIYEIPRSQVDPTSANFLiwPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHL 175
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 77695917   176 ECAC 179
Cdd:pfam00341  79 QCEC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 112-191 1.62e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 46.15  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917  112 PTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQV-RLEEHLECAC--ATTSLNPDY 188
Cdd:PHA02661  62 PGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEHTKCKCefKTTPPPTTT 141


                 ...
gi 77695917  189 REE 191
Cdd:PHA02661 142 TRE 144
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-95 1.62e-33

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 114.84  E-value: 1.62e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77695917    21 EEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD--TSLRAHGVHATKHVPEK-RPLPIRRKRSIEEAVPAV 95
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEveTKHRAHSDHSSSSVDLKrRQLHSRRKRSIEEAVPAV 78
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 94-181 3.40e-29

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 104.04  E-value: 3.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917     94 AVCKTRTVIYEIPRSQVDPTsaNFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHrsVKVAKVEYVRKKPKlKEVQVRLEE 173
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 77695917    174 HLECACAT 181
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 94-181 1.67e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 97.05  E-value: 1.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917  94 AVCKTRTVIYEIPRSQVDPTsaNFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRkKPKLKEVQVRLEE 173
Cdd:cd00135   1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 77695917 174 HLECACAT 181
Cdd:cd00135  78 HTECECRP 85
PDGF pfam00341
PDGF/VEGF domain;
96-179 6.55e-26

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 95.43  E-value: 6.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917    96 CKTRTVIYEIPRSQVDPTSANFLiwPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHL 175
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 77695917   176 ECAC 179
Cdd:pfam00341  79 QCEC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 112-191 1.62e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 46.15  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77695917  112 PTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQV-RLEEHLECAC--ATTSLNPDY 188
Cdd:PHA02661  62 PGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEHTKCKCefKTTPPPTTT 141


                 ...
gi 77695917  189 REE 191
Cdd:PHA02661 142 TRE 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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