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Conserved domains on  [gi|31377806|ref|NP_002635|]
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polymeric immunoglobulin receptor precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 4.36e-34

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 125.59  E-value: 4.36e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 464 LKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDE--GPSKAFVNCDENSRLVSLTLNLVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGvvPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 31377806 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 353-457 1.63e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 118.27  E-value: 1.63e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 353 PRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWegaQNGRCPLLVDSEGWVKaqyEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                        90       100
                ....*....|....*....|....*
gi 31377806 433 SRDAGFYWCLTNGDTLWRTTVEIKI 457
Cdd:cd05716  75 KEDAGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 1.67e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.49  E-value: 1.67e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaRGGCITLISSEGYVSSkyaGRANLTNFPENGTFVVNIAQLSQD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 31377806 104 DSGRYKCGLGINS-RGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDGdRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 2.22e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 95.16  E-value: 2.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 239 KPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSgENCDVVVNTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-226 2.75e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 134 LNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPnytGRIRLDIQGTGqLLFSVVINQLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 214 DAGQYLCQAGDDS 226
Cdd:cd05716  77 DAGWYWCGVGDDG 89
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 4.36e-34

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 125.59  E-value: 4.36e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 464 LKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDE--GPSKAFVNCDENSRLVSLTLNLVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGvvPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 31377806 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 353-457 1.63e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 118.27  E-value: 1.63e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 353 PRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWegaQNGRCPLLVDSEGWVKaqyEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                        90       100
                ....*....|....*....|....*
gi 31377806 433 SRDAGFYWCLTNGDTLWRTTVEIKI 457
Cdd:cd05716  75 KEDAGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 1.67e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.49  E-value: 1.67e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaRGGCITLISSEGYVSSkyaGRANLTNFPENGTFVVNIAQLSQD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 31377806 104 DSGRYKCGLGINS-RGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDGdRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 2.22e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 95.16  E-value: 2.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 239 KPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSgENCDVVVNTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-226 2.75e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 134 LNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPnytGRIRLDIQGTGqLLFSVVINQLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 214 DAGQYLCQAGDDS 226
Cdd:cd05716  77 DAGWYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-127 1.98e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    24 GPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQ--GARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLS 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 31377806   102 QDDSGRYKCGLGINSRG-LSFDVSLEV 127
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 355-446 2.19e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   355 SPTVVKGVAGGSVAVLCPYNRKESKSI--KYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|....
gi 31377806   433 SRDAGFYWCLTNGD 446
Cdd:pfam07686  82 LSDSGTYTCAVIPS 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-560 5.83e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 5.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    467 PGNVTAVLGETLKvpchFPCKFSSYEKYWCKWNNTGCQALPSQDEgpskafVNCDENSRLVSLTLNLVTRADEGWYWCGV 546
Cdd:smart00410   1 PPSVTVKEGESVT----LSCEASGSPPPEVTWYKQGGKLLAESGR------FSVSRSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 31377806    547 KQGHFYGE-TAAVYV 560
Cdd:smart00410  71 TNSSGSASsGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 138-237 1.92e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    138 KVYTVDLGRTVTINCPFkTENAQKRKSLYKQiglypvlvidssGYVNPNYTGRIRLDIQGTGqllFSVVINQLRLSDAGQ 217
Cdd:smart00410   2 PSVTVKEGESVTLSCEA-SGSPPPEVTWYKQ------------GGKLLAESGRFSVSRSGST---STLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 31377806    218 YLCQAGDDSNSNKKNADLQV 237
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 466-546 2.22e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.46  E-value: 2.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   466 VPGNVTAVLGETLKVPCHFPCKFS--SYEKYWCKWNNTGCQALP-------SQDEGPSKAF-VNCDENSRLVSLTLNLVT 535
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLiayysngSEEGVKKGRFsGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 31377806   536 RADEGWYWCGV 546
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 8.23e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 8.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806     25 PEEVNSVEGNSVSITCYYpptSVNRHTRKYWCRQGARggciTLISSEGYVSSKYAGRANLTnfpengtfvvnIAQLSQDD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA---SGSPPPEVTWYKQGGK----LLAESGRFSVSRSGSTSTLT-----------ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 31377806    105 SGRYKCGLGINSRGLSFDVSLEV 127
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 251-340 1.22e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.76  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   251 GSVTFHC--ALGPEVANVAKFLCRQSSGENCDVVV----NTLGKraPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYL 324
Cdd:pfam07686  12 GSVTLPCtySSSMSEASTSVYWYRQPPGKGPTFLIayysNGSEE--GVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYT 89

                          90
                  ....*....|....*.
gi 31377806   325 CGAHSDGQLQEGSPIQ 340
Cdd:pfam07686  90 CAVIPSGEGVFGKGTR 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-238 1.76e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   141 TVDLGRTVTINCPFKT--ENAQKRKSLYKQ---IGLYPVLVIDSSGYVNPNYTGRIRLdIQGTGQLLFSVVINQLRLSDA 215
Cdd:pfam07686   7 TVALGGSVTLPCTYSSsmSEASTSVYWYRQppgKGPTFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 31377806   216 GQYLCQ-AGDDSNSNKKNADLQVL 238
Cdd:pfam07686  86 GTYTCAvIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 356-457 2.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    356 PTVVKGVAGGSVAVLCPYNRKESKSIkYWcLWEGAQngrcpllvdsegWVKaqYEGRLSLLEEPGNGTFTviLNQLTSRD 435
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TW-YKQGGK------------LLA--ESGRFSVSRSGSTSTLT--ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 31377806    436 AGFYWC-LTNGDTLWRTTVEIKI 457
Cdd:smart00410  63 SGTYTCaATNSSGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-337 3.92e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 3.92e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31377806    267 AKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDkdGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGS 337
Cdd:smart00410  12 VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 464-560 4.36e-34

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 125.59  E-value: 4.36e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 464 LKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDE--GPSKAFVNCDENSRLVSLTLNLVTRADEGW 541
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGvvPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90
                ....*....|....*....
gi 31377806 542 YWCGVKQGHFYGETAAVYV 560
Cdd:cd05716  81 YWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 353-457 1.63e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 118.27  E-value: 1.63e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 353 PRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWegaQNGRCPLLVDSEGWVKaqyEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKW---GSEGCQTLVSSEGVVP---GGRISLTDDPDNGVFTVTLNQLR 74

                        90       100
                ....*....|....*....|....*
gi 31377806 433 SRDAGFYWCLTNGDTLWRTTVEIKI 457
Cdd:cd05716  75 KEDAGWYWCGVGDDGDRGLTVQVKL 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-126 1.67e-29

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.49  E-value: 1.67e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806  24 GPEEVNSVEGNSVSITCYYPPTsvNRHTRKYWCRQGaRGGCITLISSEGYVSSkyaGRANLTNFPENGTFVVNIAQLSQD 103
Cdd:cd05716   3 GPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWG-SEGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....
gi 31377806 104 DSGRYKCGLGINS-RGLSFDVSLE 126
Cdd:cd05716  77 DAGWYWCGVGDDGdRGLTVQVKLV 100
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 239-331 2.22e-23

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 95.16  E-value: 2.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 239 KPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSgENCDVVVNTLGKRAPafeGRILLNPQDKDGSFSVVITGLRKE 318
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 319 DAGRYLCGAHSDG 331
Cdd:cd05716  77 DAGWYWCGVGDDG 89
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 134-226 2.75e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 92.08  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 134 LNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPnytGRIRLDIQGTGqLLFSVVINQLRLS 213
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEGCQTLVSSEGVVPG---GRISLTDDPDN-GVFTVTLNQLRKE 76

                        90
                ....*....|...
gi 31377806 214 DAGQYLCQAGDDS 226
Cdd:cd05716  77 DAGWYWCGVGDDG 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-127 1.98e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 69.79  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    24 GPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQ--GARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLS 101
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 31377806   102 QDDSGRYKCGLGINSRG-LSFDVSLEV 127
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGvFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 355-446 2.19e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.54  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   355 SPTVVKGVAGGSVAVLCPYNRKESKSI--KYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLT 432
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|....
gi 31377806   433 SRDAGFYWCLTNGD 446
Cdd:pfam07686  82 LSDSGTYTCAVIPS 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 467-560 5.83e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 53.66  E-value: 5.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    467 PGNVTAVLGETLKvpchFPCKFSSYEKYWCKWNNTGCQALPSQDEgpskafVNCDENSRLVSLTLNLVTRADEGWYWCGV 546
Cdd:smart00410   1 PPSVTVKEGESVT----LSCEASGSPPPEVTWYKQGGKLLAESGR------FSVSRSGSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|....*
gi 31377806    547 KQGHFYGE-TAAVYV 560
Cdd:smart00410  71 TNSSGSASsGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 138-237 1.92e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.12  E-value: 1.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    138 KVYTVDLGRTVTINCPFkTENAQKRKSLYKQiglypvlvidssGYVNPNYTGRIRLDIQGTGqllFSVVINQLRLSDAGQ 217
Cdd:smart00410   2 PSVTVKEGESVTLSCEA-SGSPPPEVTWYKQ------------GGKLLAESGRFSVSRSGST---STLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 31377806    218 YLCQAGDDSNSNKKNADLQV 237
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 466-546 2.22e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.46  E-value: 2.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   466 VPGNVTAVLGETLKVPCHFPCKFS--SYEKYWCKWNNTGCQALP-------SQDEGPSKAF-VNCDENSRLVSLTLNLVT 535
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLiayysngSEEGVKKGRFsGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 31377806   536 RADEGWYWCGV 546
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 8.23e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 8.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806     25 PEEVNSVEGNSVSITCYYpptSVNRHTRKYWCRQGARggciTLISSEGYVSSKYAGRANLTnfpengtfvvnIAQLSQDD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA---SGSPPPEVTWYKQGGK----LLAESGRFSVSRSGSTSTLT-----------ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 31377806    105 SGRYKCGLGINSRGLSFDVSLEV 127
Cdd:smart00410  63 SGTYTCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 251-340 1.22e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.76  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   251 GSVTFHC--ALGPEVANVAKFLCRQSSGENCDVVV----NTLGKraPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYL 324
Cdd:pfam07686  12 GSVTLPCtySSSMSEASTSVYWYRQPPGKGPTFLIayysNGSEE--GVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYT 89

                          90
                  ....*....|....*.
gi 31377806   325 CGAHSDGQLQEGSPIQ 340
Cdd:pfam07686  90 CAVIPSGEGVFGKGTR 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 141-238 1.76e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 44.37  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806   141 TVDLGRTVTINCPFKT--ENAQKRKSLYKQ---IGLYPVLVIDSSGYVNPNYTGRIRLdIQGTGQLLFSVVINQLRLSDA 215
Cdd:pfam07686   7 TVALGGSVTLPCTYSSsmSEASTSVYWYRQppgKGPTFLIAYYSNGSEEGVKKGRFSG-RGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 31377806   216 GQYLCQ-AGDDSNSNKKNADLQVL 238
Cdd:pfam07686  86 GTYTCAvIPSGEGVFGKGTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 141-231 1.06e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 42.32  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 141 TVDLGRTVTINCPFKTENAQKRKSLYKQI-GLYPVLVI---DSSGYVNPNYTGRIRLDIQGTGQllFSVVINQLRLSDAG 216
Cdd:cd00099   9 SVQEGESVTLSCEVSSSFSSTYIYWYRQKpGQGPEFLIylsSSKGKTKGGVPGRFSGSRDGTSS--FSLTISNLQPEDSG 86

                        90
                ....*....|....*
gi 31377806 217 QYLCQAGDDSNSNKK 231
Cdd:cd00099  87 TYYCAVSESGGTDKL 101
IgV_PD1 cd16088
Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are ...
 20-111 5.36e-04

Immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1); The members here are composed of the immunoglobulin (Ig)-like domain of Programmed Cell Death 1 (PD1; also known as CD279/cluster of differentiation 279). PD1 is a cell surface receptor that is expressed on T cells and pro-B cells. The protein's structure includes an extracellular IgV domain followed by a transmembrane region and an intracellular tail. Activation of CD4+ T cells, CD8+ T cells, NKT cells, B cells, and monocytes induces PD-1 expression, immediately after which it binds two distinct ligands, PD-L1 (also known as B7-H1 or CD274/cluster of differentiation 274) and PD-L2, also known as B7-DC. PD-1 plays an important role in down regulating the immune system by preventing the activation of T-cells, reducing autoimmunity and promoting self-tolerance. The inhibitory effect of PD-1 is accomplished by promoting apoptosis in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells. A class of drugs that target PD-1, known as the PD-1 inhibitors, activate the immune system to attack tumors and treat cancer. Comparisons between the mouse PD-1 (mPD-1) and human PD-1 (hPD-1) reveals that unlike the mPD-1 which has a conventional IgSF V-set domain, hPD-1 lacks a C" strand, and instead the C' and D strands are connected by a long and flexible loop. In addition, the BC loop is not stabilized by disulfide bonding to the F strand of the ligand binding beta sheet. These differences result in different binding affinities of human and mouse PD-1 for their ligands.


Pssm-ID: 409509  Cd Length: 112  Bit Score: 40.18  E-value: 5.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806  20 SPIFGPEEVNSVEGNSVSITCYYPPTSvnRHTRKYWCRQGARGGCITLIS-SEGYVSSKYAGRANLTNFPENGTFVVNIA 98
Cdd:cd16088   1 PPTFSPALLVVTEGANATFTCSFSNTS--ESFVLNWYRLSPSNQTDKLAAfPEDRSQPGQDWRFRVTQLPNGRDFHMSVV 78

                        90
                ....*....|...
gi 31377806  99 QLSQDDSGRYKCG 111
Cdd:cd16088  79 RARRNDSGTYLCG 91
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 127-230 5.87e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 39.95  E-value: 5.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 127 VSQGPGLLndtkvyTVDLGRTVTINCPFKTENAQkrkSL--YKQI-GLYPVLVIDSSGYVNPNYTGRIRLDIQgTGQLLF 203
Cdd:cd04983   1 VTQSPQSL------SVQEGENVTLNCNYSTSTFY---YLfwYRQYpGQGPQFLIYISSDSGNKKKGRFSATLD-KSRKSS 70

                        90       100
                ....*....|....*....|....*..
gi 31377806 204 SVVINQLRLSDAGQYLCQAGDDSNSNK 230
Cdd:cd04983  71 SLHISAAQLSDSAVYFCALSESGGTGK 97
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 25-110 9.53e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 39.35  E-value: 9.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806  25 PEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGY---VSSKYAGRANLTNFP---ENGTfvVNIA 98
Cdd:cd05718   6 PTEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAGSSQNVAVFHPQYgpsVPNPYAERVEFLAARlglRNAT--LRIR 83

                        90
                ....*....|..
gi 31377806  99 QLSQDDSGRYKC 110
Cdd:cd05718  84 NLRVEDEGNYIC 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 356-457 2.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806    356 PTVVKGVAGGSVAVLCPYNRKESKSIkYWcLWEGAQngrcpllvdsegWVKaqYEGRLSLLEEPGNGTFTviLNQLTSRD 435
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TW-YKQGGK------------LLA--ESGRFSVSRSGSTSTLT--ISNVTPED 62

                           90       100
                   ....*....|....*....|...
gi 31377806    436 AGFYWC-LTNGDTLWRTTVEIKI 457
Cdd:smart00410  63 SGTYTCaATNSSGSASSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
35-110 3.04e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.36  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806     35 SVSITCYYPPTSVNRHTRkYWCRQGARGGCITLIS----SEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKC 110
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYV-SWVRQPPGKGLEWLGYigsnGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 365-441 3.29e-03

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 38.28  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377806 365 GSVAVLC-------PYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQ--YEGRLSLLEEPGN-GTFTVILNQLTSR 434
Cdd:cd05902  13 SSVLLPCvftlppsASSPPEGPRIKWTKLSTSGGQQQRPVLVARDNVVRVAkaFQGRVSLPGYPKNrYNASLVLSRLRYS 92


                ....*..
gi 31377806 435 DAGFYWC 441
Cdd:cd05902  93 DSGTYRC 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 267-337 3.92e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 3.92e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31377806    267 AKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDkdGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGS 337
Cdd:smart00410  12 VTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNSSGSASSG 80
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 280-325 5.53e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.30  E-value: 5.53e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 31377806 280 DVVVnTLGKRAPAF---EGRILLNpQDKDGSFSVVITGLRKEDAGRYLC 325
Cdd:cd05877  49 DVLV-AIGTRHKSYgsyQGRVFLR-RADDLDASLVITDLRLEDYGRYRC 95
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 187-254 6.03e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.30  E-value: 6.03e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31377806 187 YTGRIRLdiQGTGQLLFSVVINQLRLSDAGQYLCQAGDDsnsnkknadlqvLKPEPELVYEDLRGSVT 254
Cdd:cd05877  64 YQGRVFL--RRADDLDASLVITDLRLEDYGRYRCEVIDG------------LEDESVVVALRLRGVVF 117
IgV_CD80 cd16086
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here ...
 161-220 9.30e-03

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 80). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as cluster of differentiation 152/CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 319335  Cd Length: 105  Bit Score: 36.66  E-value: 9.30e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31377806 161 KRKSLYKQIGLYPVLVIdSSGYVN--PNYTGRIRLDIQGTgqllFSVVINQLRLSDAGQYLC 220
Cdd:cd16086  26 AQVRIYWQKDDKMVLTI-ISGDVKvwPEYKNRTLFDITNN----LSIVILALRLSDRGTYTC 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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