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Conserved domains on  [gi|48762926|ref|NP_005040|]
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periodic tryptophan protein 2 homolog [Homo sapiens]

Protein Classification

WD40 and Utp12 domain-containing protein; WD40 and Utp12 domain-containing protein; WD40 repeat domain-containing protein; WD40 repeat domain-containing protein; WD40 and Utp12 domain-containing protein; WD40 repeat domain-containing protein; WD40 repeat domain-containing protein( domain architecture ID 13235546)

WD40 and Utp12 domain-containing protein; WD40 and Utp12 domain-containing protein; WD40 repeat domain-containing protein similar to Chlamydomonas reinhardtii cilia- and flagella-associated protein 52 (CFAP52) that may play a role in cell growth and/or survival; WD40 repeat domain-containing protein similar to Chlamydomonas reinhardtii cilia- and flagella-associated protein 52 (CFAP52) that may play a role in cell growth and/or survival; WD40 repeat domain-containing protein similar to Chlamydomonas reinhardtii cilia- and flagella-associated protein 52 (CFAP52) that may play a role in cell growth and/or survival; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; WD40 repeat domain-containing protein with an N-terminal P-loop motif-containing domain; WD40 repeat domain-containing protein similar to mammalian WD repeat-containing protein 3 (WDR3) and Arabidopsis thaliana periodic tryptophan protein 2 that is involved in the nucleolar processing of pre-18S ribosomal RNA; WD40 repeat domain-containing protein similar to mammalian WD repeat-containing protein 3 (WDR3) and Arabidopsis thaliana periodic tryptophan protein 2 that is involved in the nucleolar processing of pre-18S ribosomal RNA; protein containing domains WD40, and Utp12; WD40 and Utp12 domain-containing protein; WD40 repeat domain-containing protein similar to mammalian WD repeat-containing protein 3 (WDR3) and Arabidopsis thaliana periodic tryptophan protein 2 that is involved in the nucleolar processing of pre-18S ribosomal RNA; WD40 repeat domain-containing protein similar to mammalian WD repeat-containing protein 3 (WDR3) and Arabidopsis thaliana periodic tryptophan protein 2 that is involved in the nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0005515

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-635 5.16e-54

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.20  E-value: 5.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQ 370
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-SADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 371 GHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNF 450
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 451 RTFTSPRPtQFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
Cdd:COG2319 240 RTLTGHSG-SVRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 531 fDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDlktgrkeldkitakhaakgkAFT 609
Cdd:COG2319 318 -ATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--------------------AVT 376

                       330       340
                ....*....|....*....|....*.
gi 48762926 610 ALCYSADGHSILAGGMSKFVCIYHVR 635
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 770-875 3.31e-25

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 100.70  E-value: 3.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926   770 NESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSF-EVSRHLEFYLLWTHKLLMLHGQKLKSRAgTLLPVIQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 48762926   849 QKSIQRHLDDLSKLCSWNHYNMQYALA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-443 2.56e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  96 KGSVHSVSFSPDGRKFVVTKGNiaqmyhapGKKREFNAF--VLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVfga 173
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGD--------GTIKVWDLEtgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 174 erWD---NLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWqcDTPPEGLRlkppagwkadllqreeeeeeeedqe 250
Cdd:cd00200  78 --WDletGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCL------------------------- 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 251 gdreTTIRGKATPAeeektgkvkysrlakyffnkegdfnnlTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISD 330
Cdd:cd00200 129 ----TTLRGHTDWV---------------------------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 331 QSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVT 410
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256

                       330       340       350
                ....*....|....*....|....*....|...
gi 48762926 411 FTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD 443
Cdd:cd00200 257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
25-114 2.09e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  25 DGNS--VISPVGNRVTVFDLKNNK-SDTLPLATryNVKCVGLSPDGRLAIIVDEGGDALLV-SLVCRSVLHHFHFKGSVH 100
Cdd:COG3391  78 DGRRlyVANSGSGRVSVIDLATGKvVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSViDTATGKVVATIPVGAGPH 155

                        90
                ....*....|....
gi 48762926 101 SVSFSPDGRKFVVT 114
Cdd:COG3391 156 GIAVDPDGKRLYVA 169
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-635 5.16e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.20  E-value: 5.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQ 370
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-SADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 371 GHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNF 450
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 451 RTFTSPRPtQFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
Cdd:COG2319 240 RTLTGHSG-SVRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 531 fDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDlktgrkeldkitakhaakgkAFT 609
Cdd:COG2319 318 -ATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--------------------AVT 376

                       330       340
                ....*....|....*....|....*.
gi 48762926 610 ALCYSADGHSILAGGMSKFVCIYHVR 635
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-629 1.97e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.76  E-value: 1.97e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 322 LIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATG-SGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 402 TLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSprPTQF-SCVAVDASGEIVSAGAQDS 480
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWvNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 481 FeIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMfDSWRTKETLALTSDAL-AVTFRPDGAELA 559
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGHENGVnSVAFSPDGYLLA 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 560 VATLNSQITFWDPENAVQTGSIEGrHDlktgrkeldkitakhaakgKAFTALCYSADGHSILAGGMSKFV 629
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG-HT-------------------NSVTSLAWSPDGKRLASGSADGTI 285
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 770-875 3.31e-25

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 100.70  E-value: 3.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926   770 NESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSF-EVSRHLEFYLLWTHKLLMLHGQKLKSRAgTLLPVIQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 48762926   849 QKSIQRHLDDLSKLCSWNHYNMQYALA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-443 2.56e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  96 KGSVHSVSFSPDGRKFVVTKGNiaqmyhapGKKREFNAF--VLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVfga 173
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGD--------GTIKVWDLEtgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 174 erWD---NLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWqcDTPPEGLRlkppagwkadllqreeeeeeeedqe 250
Cdd:cd00200  78 --WDletGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCL------------------------- 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 251 gdreTTIRGKATPAeeektgkvkysrlakyffnkegdfnnlTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISD 330
Cdd:cd00200 129 ----TTLRGHTDWV---------------------------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 331 QSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVT 410
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256

                       330       340       350
                ....*....|....*....|....*....|...
gi 48762926 411 FTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD 443
Cdd:cd00200 257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 490-529 4.85e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 4.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 48762926    490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
20-232 1.27e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  20 LNFTCDGNSVIS-PVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSL---VCRSVLHHFHf 95
Cdd:COG2319 168 VAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLatgKLLRTLTGHS- 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  96 kGSVHSVSFSPDGRKFVVT-KGNIAQMYHAPGKKrefnafvLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAE 174
Cdd:COG2319 247 -GSVRSVAFSPDGRLLASGsADGTVRLWDLATGE-------LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 48762926 175 RWDNLiyYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGW 232
Cdd:COG2319 319 TGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 pfam00400
WD domain, G-beta repeat;
491-529 8.66e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 8.66e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48762926   491 GRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
25-114 2.09e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  25 DGNS--VISPVGNRVTVFDLKNNK-SDTLPLATryNVKCVGLSPDGRLAIIVDEGGDALLV-SLVCRSVLHHFHFKGSVH 100
Cdd:COG3391  78 DGRRlyVANSGSGRVSVIDLATGKvVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSViDTATGKVVATIPVGAGPH 155

                        90
                ....*....|....
gi 48762926 101 SVSFSPDGRKFVVT 114
Cdd:COG3391 156 GIAVDPDGKRLYVA 169
PTZ00421 PTZ00421
coronin; Provisional
 468-529 1.01e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762926  468 ASGEIVSAGAqDSFeIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:PTZ00421 137 AMNVLASAGA-DMV-VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-635 5.16e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.20  E-value: 5.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQ 370
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-SADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 371 GHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNF 450
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 451 RTFTSPRPtQFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
Cdd:COG2319 240 RTLTGHSG-SVRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 531 fDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDlktgrkeldkitakhaakgkAFT 609
Cdd:COG2319 318 -ATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--------------------AVT 376

                       330       340
                ....*....|....*....|....*.
gi 48762926 610 ALCYSADGHSILAGGMSKFVCIYHVR 635
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
285-574 1.62e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.05  E-value: 1.62e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 285 EGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGlGQLLVWEWQSES 364
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD-GTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 365 YVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDL 444
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 445 HRYRNFRTFTSPRPTQFScVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKT 524
Cdd:COG2319 276 ATGELLRTLTGHSGGVNS-VAFSPDGKLLASGSDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 48762926 525 VRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPEN 574
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
322-644 8.43e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 8.43e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 322 LIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASA-SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 402 TLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTqFSCVAVDASGEIVSAGAQDSf 481
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG- 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 482 EIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMfDSWRTKETLALTSDA-LAVTFRPDGAELAV 560
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGvNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 561 ATLNSQITFWDPENAVQTGSIEGRHDlktgrkeldkitakhaakgkAFTALCYSADGHSILAGGMSKFVCIYHVREQILM 640
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTGHTG--------------------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365


                ....
gi 48762926 641 KRFE 644
Cdd:COG2319 366 RTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 322-629 1.97e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.76  E-value: 1.97e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 322 LIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATG-SGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 402 TLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSprPTQF-SCVAVDASGEIVSAGAQDS 480
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWvNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 481 FeIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMfDSWRTKETLALTSDAL-AVTFRPDGAELA 559
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGHENGVnSVAFSPDGYLLA 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 560 VATLNSQITFWDPENAVQTGSIEGrHDlktgrkeldkitakhaakgKAFTALCYSADGHSILAGGMSKFV 629
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG-HT-------------------NSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
295-644 1.67e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.67e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 295 AFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGcSGLGQLLVWEWQSESYVLKQQGHFN 374
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAG-AGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 375 SMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 455 SPRPTqFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMfDSW 534
Cdd:COG2319 160 GHSGA-VTSVAFSPDGKLLASGSDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-ATG 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 535 RTKETLALTSDA-LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDlktgrkeldkitakhaakgkAFTALCY 613
Cdd:COG2319 237 KLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--------------------GVNSVAF 296

                       330       340       350
                ....*....|....*....|....*....|.
gi 48762926 614 SADGHSILAGGMSKFVCIYHVREQILMKRFE 644
Cdd:COG2319 297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 292-571 9.31e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.36  E-value: 9.31e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 292 TAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQG 371
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSD-KTIRLWDLETGECVRTLTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 372 HFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDL---HRYR 448
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLrtgKCVA 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 449 NFRTFTSPrptqFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
Cdd:cd00200 172 TLTGHTGE----VNSVAFSPDGEKLLSSSSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 48762926 529 DMfDSWRTKETL-ALTSDALAVTFRPDGAELAVATLNSQITFWD 571
Cdd:cd00200 247 DL-RTGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 370-714 4.38e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 4.38e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRN 449
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 450 FRTFTSPRPTqFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:cd00200  86 VRTLTGHTSY-VSSVAFSPDGRILSSSSRDK-TIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 530 MfDSWRTKETLAL-TSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGrHDlktgrkeldkitakhaakgKAF 608
Cdd:cd00200 164 L-RTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HE-------------------NGV 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 609 TALCYSADGHSILAGGMSKFVCIYHVREQILMKRFEiscnlsldameeflnrrkmtefgnlalidqdagqedgvaiplpg 688
Cdd:cd00200 223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-------------------------------------------- 258

                       330       340
                ....*....|....*....|....*.
gi 48762926 689 vrkgdmssrhfKPEIRVTSLRFSPTG 714
Cdd:cd00200 259 -----------GHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 291-529 3.70e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 3.70e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAfGCSGLGQLLVWEWQSESYVLKQQ 370
Cdd:cd00200  54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLR 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 371 GHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNF 450
Cdd:cd00200 133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48762926 451 RTFTSpRPTQFSCVAVDASGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:cd00200 213 GTLRG-HENGVNSVAFSPDGYLLASGSEDG-TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 770-875 3.31e-25

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 100.70  E-value: 3.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926   770 NESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSF-EVSRHLEFYLLWTHKLLMLHGQKLKSRAgTLLPVIQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 48762926   849 QKSIQRHLDDLSKLCSWNHYNMQYALA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-443 2.56e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  96 KGSVHSVSFSPDGRKFVVTKGNiaqmyhapGKKREFNAF--VLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVfga 173
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGD--------GTIKVWDLEtgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 174 erWD---NLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWqcDTPPEGLRlkppagwkadllqreeeeeeeedqe 250
Cdd:cd00200  78 --WDletGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCL------------------------- 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 251 gdreTTIRGKATPAeeektgkvkysrlakyffnkegdfnnlTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISD 330
Cdd:cd00200 129 ----TTLRGHTDWV---------------------------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 331 QSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVT 410
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256

                       330       340       350
                ....*....|....*....|....*....|...
gi 48762926 411 FTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD 443
Cdd:cd00200 257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-401 2.91e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 2.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  58 VKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHF--HfKGSVHSVSFSPDGRKFVVT-KGNIAQMYhapgkkrEFNAF 134
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgH-TGPVRDVAASADGTYLASGsSDKTIRLW-------DLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 135 VLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVfgaerWDNLIY---YALGGHKDAIVACFFESNSLDLYSLSQDGV 211
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV-----WDVETGkclTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 212 LCMWqcdtppeglrlkppagwkaDLlqreeeeeeeedqegdrettirgkatpaeeeKTGKVKYSRLAKYffnkegdfNNL 291
Cdd:cd00200 159 IKLW-------------------DL-------------------------------RTGKCVATLTGHT--------GEV 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 292 TAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAfGCSGLGQLLVWEWQSESYVLKQQG 371
Cdd:cd00200 181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA-SGSEDGTIRVWDLRTGECVQTLSG 259

                       330       340       350
                ....*....|....*....|....*....|
gi 48762926 372 HFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200 260 HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 490-529 4.85e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 4.85e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 48762926    490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
20-232 1.27e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  20 LNFTCDGNSVIS-PVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSL---VCRSVLHHFHf 95
Cdd:COG2319 168 VAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLatgKLLRTLTGHS- 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  96 kGSVHSVSFSPDGRKFVVT-KGNIAQMYHAPGKKrefnafvLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAE 174
Cdd:COG2319 247 -GSVRSVAFSPDGRLLASGsADGTVRLWDLATGE-------LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 48762926 175 RWDNLiyYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGW 232
Cdd:COG2319 319 TGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
25-219 1.34e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 1.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  25 DGNSVIS-PVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHF-HFKGSVHSV 102
Cdd:COG2319 215 DGKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSV 294

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 103 SFSPDGRKFVVT-KGNIAQMYHAPGKKrefnafvLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAErwDNLIY 181
Cdd:COG2319 295 AFSPDGKLLASGsDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA--TGELL 365

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 48762926 182 YALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDT 219
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
491-529 8.66e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 8.66e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48762926   491 GRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-216 9.52e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 9.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  35 NRVTVFDLKNNK-SDTLPLATRYnVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFH-FKGSVHSVSFSPDGRKFV 112
Cdd:cd00200 115 KTIKVWDVETGKcLTTLRGHTDW-VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 113 VTKG-NIAQMYhapgkkrEFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLiyYALGGHKDAI 191
Cdd:cd00200 194 SSSSdGTIKLW-------DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV--QTLSGHTNSV 264

                       170       180
                ....*....|....*....|....*
gi 48762926 192 VACFFESNSLDLYSLSQDGVLCMWQ 216
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-216 8.44e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 8.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  22 FTCDGNSVISpVG--NRVTVFDLKNNKS-DTLPLATRYnVKCVGLSPDGRLA--------IIVDEggdalLVSLVCRSVL 90
Cdd:cd00200  59 ASADGTYLAS-GSsdKTIRLWDLETGECvRTLTGHTSY-VSSVAFSPDGRILssssrdktIKVWD-----VETGKCLTTL 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  91 HHfHfKGSVHSVSFSPDGrKFVVTKG--NIAQMYhapgkkrEFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMST 168
Cdd:cd00200 132 RG-H-TDWVNSVAFSPDG-TFVASSSqdGTIKLW-------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 48762926 169 WVFGAERWDNLiyYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQ 216
Cdd:cd00200 202 KLWDLSTGKCL--GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
377-574 1.22e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 377 VALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTA--TGYVVVTSSMDGTVRAFDLHRYRNFRTFT 454
Cdd:COG3391  28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGadGRRLYVANSGSGRVSVIDLATGKVVATIP 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 455 S-PRPTQfscVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPiSGLCFNPMKSVLASASWD-----KTVRLW 528
Cdd:COG3391 108 VgGGPRG---LAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGKRLYVANSGsntvsVIVSVI 183

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 48762926 529 DMfDSWRTKETLALTSDALAVTFRPDGAELAVA--------TLNSQITFWDPEN 574
Cdd:COG3391 184 DT-ATGKVVATIPVGGGPVGVAVSPDGRRLYVAnrgsntsnGGSNTVSVIDLAT 236
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 362-401 1.38e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 48762926    362 SESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
370-401 2.07e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.07e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 48762926   370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
25-114 2.09e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  25 DGNS--VISPVGNRVTVFDLKNNK-SDTLPLATryNVKCVGLSPDGRLAIIVDEGGDALLV-SLVCRSVLHHFHFKGSVH 100
Cdd:COG3391  78 DGRRlyVANSGSGRVSVIDLATGKvVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSViDTATGKVVATIPVGAGPH 155

                        90
                ....*....|....
gi 48762926 101 SVSFSPDGRKFVVT 114
Cdd:COG3391 156 GIAVDPDGKRLYVA 169
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 370-473 4.10e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 46.50  E-value: 4.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 370 QGHFNSMVALAYSPDGQYIVTggDDGK--VKVWNtLSGFCFVTFTEhsSGV--------TGVTFTATGYVVVTSSMDGTV 439
Cdd:cd14961   7 PGTLNNPTGVAVTPTGRVVVA--DDGNkrIQVFD-SDGNCLQQFGP--KGDagqdirypLDVAVTPDGHIVVTDAGDRSV 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 48762926 440 RAFDLHRYRNF---RTFTSPRPtqfscVAVDASGEIV 473
Cdd:cd14961  82 KVFSFDGRLKLfvrKSFSLPWG-----VAVNPSGEIL 113
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-443 6.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.53e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 48762926    404 SGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD 443
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
405-443 1.03e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 48762926   405 GFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD 443
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 379-500 1.58e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.50  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 379 LAYSPDGQYI-VTGGDDGKVKVWNTLSGFCFvTFTEHSSG------VTGVTFTATGYVVVTSSMDGTVRAFDLH-RYRnf 450
Cdd:cd14962 105 IAVDPAGKRLyVVDTLAHKVKVFDLDGRLLF-DIGKRGSGpgefnlPTDLAVDRDGNLYVTDTMNFRVQIFDADgKFL-- 181

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 48762926 451 RTFTS--PRPTQFS---CVAVDASGEI-VSAGAQDSFEIFvwsMQTGRLLDVLSGH 500
Cdd:cd14962 182 RSFGErgDGPGSFArpkGIAVDSEGNIyVVDAAFDNVQIF---NPEGELLLTVGGP 234
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
22-114 1.58e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926  22 FTCDGNS--VISPVGNRVTVFDLKNNKSDTlPLATRYNVKCVGLSPDGRLAIIVDEGGDAL--LVSLVC---RSVLHHFH 94
Cdd:COG3391 117 VDPDGGRlyVADSGNGRVSVIDTATGKVVA-TIPVGAGPHGIAVDPDGKRLYVANSGSNTVsvIVSVIDtatGKVVATIP 195

                        90       100
                ....*....|....*....|
gi 48762926  95 FKGSVHSVSFSPDGRKFVVT 114
Cdd:COG3391 196 VGGGPVGVAVSPDGRRLYVA 215
PTZ00421 PTZ00421
coronin; Provisional
 468-529 1.01e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762926  468 ASGEIVSAGAqDSFeIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
Cdd:PTZ00421 137 AMNVLASAGA-DMV-VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
378-582 1.40e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.54  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 378 ALAYSPDGQYIVTGGDDGKVKVWNTLSGfcfvTFTEHS----SGVTGVTFTATGYVVVTSSMDGTVRAFDLHRyRNFRTF 453
Cdd:COG4257  21 DVAVDPDGAVWFTDQGGGRIGRLDPATG----EFTEYPlgggSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKT-GEITTF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762926 454 TSPRPT-QFSCVAVDASGEIVSAgAQDSFEIFVWSMQTGRLL--DVLSGHEGPiSGLCFNPMKSVLASASWDKTVRlwdM 530
Cdd:COG4257  96 ALPGGGsNPHGIAFDPDGNLWFT-DQGGNRIGRLDPATGEVTefPLPTGGAGP-YGIAVDPDGNLWVTDFGANAIG---R 170

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 48762926 531 FD----SWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPEnavqTGSIE 582
Cdd:COG4257 171 IDpdtgTLTEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPK----TGTVT 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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