NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|5902024|ref|NP_008833|]
View 

paired mesoderm homeobox protein 1 isoform pmx-1a [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 2.99e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 2.99e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 5902024     99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 2.99e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 2.99e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 5902024     99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-153 6.68e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 84.60  E-value: 6.68e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 5902024   99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNE 153
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 99-150 4.78e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 4.78e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 5902024      99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFR 150
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
105-185 1.10e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902024  105 QLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR----NERAMLANKNASLLKSYS---GDVTAVEQ 177
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKIGSlstGQISIIET 141


                ....*...
gi 5902024  178 PIVPRPAP 185
Cdd:COG5576 142 LEFSRTSY 149
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-151 2.99e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 96.03  E-value: 2.99e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 5902024     99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR 151
Cdd:pfam00046   5 TTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-153 6.68e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 84.60  E-value: 6.68e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 5902024   99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNE 153
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 99-150 4.78e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 82.30  E-value: 4.78e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 5902024      99 TTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFR 150
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
105-185 1.10e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902024  105 QLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRR----NERAMLANKNASLLKSYS---GDVTAVEQ 177
Cdd:COG5576  62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKkrsgKVEQRPGEEEADLAKIGSlstGQISIIET 141


                ....*...
gi 5902024  178 PIVPRPAP 185
Cdd:COG5576 142 LEFSRTSY 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH