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Conserved domains on  [gi|6319998|ref|NP_010078|]
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Ack1p [Saccharomyces cerevisiae S288C]

Protein Classification

TPR and SEL1 domain-containing protein( domain architecture ID 12218275)

TPR and SEL1 domain-containing protein

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  16870393
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
394-608 4.75e-29

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 115.80  E-value: 4.75e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  394 AFQYYQHGAEVCSNSACmYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKGDsPQTLYELGKIYEFSVlppeiqnllfanG 473
Cdd:COG0790  50 AAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPK-DYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGL------------G 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  474 IRKDSQLAIKYYQQCAKDfEYPLAQWKLGNCYEFGDlGLPVVAKKSIYWYSKAAAAqpkGNPMAMLSLSGWYLTGapNIL 553
Cdd:COG0790 115 VPQDYAKALEWYEKAAEQ-GDADAQYNLGLLYLNGE-GVPKDPAKAAEWYRKAAEQ---GDADAQYNLGVLYENG--RGV 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6319998  554 KPNNKEAFNWALKSSKCSDgklARTEFALGFYYEKGVGCEVDLDLAKQYYQRAAR 608
Cdd:COG0790 188 PKDPAKALEWYRKAAEQGD---ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 318-361 9.17e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 9.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 6319998     318 PPAMYLMGTLYSHQpylpiknkNIVIKNDEKALEYYCKAAKLNN 361
Cdd:smart00671   1 AEAQYNLGQMYEYG--------LGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
394-608 4.75e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 115.80  E-value: 4.75e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  394 AFQYYQHGAEVCSNSACmYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKGDsPQTLYELGKIYEFSVlppeiqnllfanG 473
Cdd:COG0790  50 AAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPK-DYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGL------------G 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  474 IRKDSQLAIKYYQQCAKDfEYPLAQWKLGNCYEFGDlGLPVVAKKSIYWYSKAAAAqpkGNPMAMLSLSGWYLTGapNIL 553
Cdd:COG0790 115 VPQDYAKALEWYEKAAEQ-GDADAQYNLGLLYLNGE-GVPKDPAKAAEWYRKAAEQ---GDADAQYNLGVLYENG--RGV 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6319998  554 KPNNKEAFNWALKSSKCSDgklARTEFALGFYYEKGVGCEVDLDLAKQYYQRAAR 608
Cdd:COG0790 188 PKDPAKALEWYRKAAEQGD---ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 579-610 1.94e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.47  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 6319998     579 EFALGFYYEKGVGCEVDLDLAKQYYQRAARMG 610
Cdd:smart00671   4 QYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 495-529 2.99e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 2.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6319998    495 PLAQWKLGNCYEFGdLGLPVVAKKSIYWYSKAAAA 529
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 318-361 9.17e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 9.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 6319998     318 PPAMYLMGTLYSHQpylpiknkNIVIKNDEKALEYYCKAAKLNN 361
Cdd:smart00671   1 AEAQYNLGQMYEYG--------LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 318-360 3.84e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.19  E-value: 3.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 6319998    318 PPAMYLMGTLYSHQPYLPiknkniviKNDEKALEYYCKAAKLN 360
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVP--------KDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
394-608 4.75e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 115.80  E-value: 4.75e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  394 AFQYYQHGAEVCSNSACmYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKGDsPQTLYELGKIYEFSVlppeiqnllfanG 473
Cdd:COG0790  50 AAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPK-DYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGL------------G 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  474 IRKDSQLAIKYYQQCAKDfEYPLAQWKLGNCYEFGDlGLPVVAKKSIYWYSKAAAAqpkGNPMAMLSLSGWYLTGapNIL 553
Cdd:COG0790 115 VPQDYAKALEWYEKAAEQ-GDADAQYNLGLLYLNGE-GVPKDPAKAAEWYRKAAEQ---GDADAQYNLGVLYENG--RGV 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6319998  554 KPNNKEAFNWALKSSKCSDgklARTEFALGFYYEKGVGCEVDLDLAKQYYQRAAR 608
Cdd:COG0790 188 PKDPAKALEWYRKAAEQGD---ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
315-529 1.44e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 114.26  E-value: 1.44e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  315 LKWPPAMYLMGTLYSHQPYLPiknkniviKNDEKALEYYCKAAKLNNSDACYRAGVCFEYQRGTssldpsptkEQCIKKA 394
Cdd:COG0790  60 AGGAEAQYNLGLMYAEGRGVP--------KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGV---------PQDYAKA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  395 FQYYQHGAEvCSNSACMYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKGDsPQTLYELGKIYEfsvlppeiqnllFANGI 474
Cdd:COG0790 123 LEWYEKAAE-QGDADAQYNLGLLYLNGEGVPK-DPAKAAEWYRKAAEQGD-ADAQYNLGVLYE------------NGRGV 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6319998  475 RKDSQLAIKYYQQcAKDFEYPLAQWKLGNCYEFGDlGLPVVAKKSIYWYSKAAAA 529
Cdd:COG0790 188 PKDPAKALEWYRK-AAEQGDADAQYNLGRLYLNGE-GVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
412-621 6.03e-26

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 106.94  E-value: 6.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  412 YKLGMSHLYGLNMQKTDVLLAIKWFDKAAQKGDsPQTLYELGKIYEFsvlppeiqnllfANGIRKDSQLAIKYYQQCAKD 491
Cdd:COG0790  30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGG-AEAQYNLGLMYAE------------GRGVPKDYEKALEWFEKAAEQ 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  492 fEYPLAQWKLGNCYEFGdLGLPVVAKKSIYWYSKAAAAqpkGNPMAMLSLSGWYLTGapNILKPNNKEAFNWALKSSkcs 571
Cdd:COG0790  97 -GDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAAEQ---GDADAQYNLGLLYLNG--EGVPKDPAKAAEWYRKAA--- 166

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6319998  572 DGKLARTEFALGFYYEKGVGCEVDLDLAKQYYQRAARMGFRKAVDALRSL 621
Cdd:COG0790 167 EQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRL 216
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 579-610 1.94e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.47  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 6319998     579 EFALGFYYEKGVGCEVDLDLAKQYYQRAARMG 610
Cdd:smart00671   4 QYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 495-529 2.99e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 2.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6319998    495 PLAQWKLGNCYEFGdLGLPVVAKKSIYWYSKAAAA 529
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAEL 34
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 580-610 3.02e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 3.02e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 6319998    580 FALGFYYEKGVGCEVDLDLAKQYYQRAARMG 610
Cdd:pfam08238   5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 408-443 4.05e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.97  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6319998    408 SACMYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKG 443
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPK-DPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 495-528 4.09e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.92  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6319998     495 PLAQWKLGNCYEFGdLGLPVVAKKSIYWYSKAAA 528
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 411-444 8.90e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 8.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6319998     411 MYKLGMSHLYGLNMQKtDVLLAIKWFDKAAQKGD 444
Cdd:smart00671   4 QYNLGQMYEYGLGVPK-DLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 318-361 9.17e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 9.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 6319998     318 PPAMYLMGTLYSHQpylpiknkNIVIKNDEKALEYYCKAAKLNN 361
Cdd:smart00671   1 AEAQYNLGQMYEYG--------LGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 393-608 1.31e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  393 KAFQYYQHGAEVCSNSA-CMYKLGmsHLYglnMQKTDVLLAIKWFDKA-AQKGDSPQTLYELGKIYEFsvlppeiqnllf 470
Cdd:COG2956  26 KAIDLLEEALELDPETVeAHLALG--NLY---RRRGEYDRAIRIHQKLlERDPDRAEALLELAQDYLK------------ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  471 angiRKDSQLAIKYYQQCAK-DFEYPLAQWKLGNCYEF-GDLglpvvaKKSIYWYSKAAAAQPKgNPMAMLSLSGWYLtg 548
Cdd:COG2956  89 ----AGLLDRAEELLEKLLElDPDDAEALRLLAEIYEQeGDW------EKAIEVLERLLKLGPE-NAHAYCELAELYL-- 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319998  549 apniLKPNNKEAFNWALKSSKcSDGKLARTEFALG-FYYEKGvgcevDLDLAKQYYQRAAR 608
Cdd:COG2956 156 ----EQGDYDEAIEALEKALK-LDPDCARALLLLAeLYLEQG-----DYEEAIAALERALE 206
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 318-360 3.84e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.19  E-value: 3.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 6319998    318 PPAMYLMGTLYSHQPYLPiknkniviKNDEKALEYYCKAAKLN 360
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVP--------KDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
320-506 3.89e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 3.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  320 AMYLMGTLYSHQpylpiknkniviKNDEKALEYYCKAAKLN--NSDACYRAGVCFEYQrgtssldpsptkeQCIKKAFQY 397
Cdd:COG0457  10 AYNNLGLAYRRL------------GRYEEAIEDYEKALELDpdDAEALYNLGLAYLRL-------------GRYEEALAD 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319998  398 YQHGAEVCSNSA-CMYKLGMSHlygLNMQKTDvlLAIKWFDKA-AQKGDSPQTLYELGKIYEFsvlppeiqnllfangiR 475
Cdd:COG0457  65 YEQALELDPDDAeALNNLGLAL---QALGRYE--EALEDYDKAlELDPDDAEALYNLGLALLE----------------L 123

                       170       180       190
                ....*....|....*....|....*....|..
gi 6319998  476 KDSQLAIKYYQQC-AKDFEYPLAQWKLGNCYE 506
Cdd:COG0457 124 GRYDEAIEAYERAlELDPDDADALYNLGIALE 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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