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Concise Results
Standard Results
Full Results
histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C]
Protein Classification
phosphatidylinositol kinase family protein ( domain architecture ID 11472127 )
phosphatidylinositol kinase family protein such as the serine/threonine-protein kinase tor2, which is an essential phosphatidylinositol kinase homolog required for G1 progression
List of domain hits
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
947-2612
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1369.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 947 RILGKLGGRNR Q FLK P P TD L TEKTEL D IDAIADFKIN G M P E D VP L SVT P GIQS A LNI L Q S YK S DI HYRK S A YKY L TCV L L 1026
Cdd:pfam20206 1 RILGKLGGRNR R FLK E P PK L EYRDAG D EASLTVELEF G A P S D QT L PLD P AVDL A KRT L R S ST S LP HYRK Q A FEL L KSA L A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1027 L MTK S S a EF P TNYTEL L KT A VNSIKLER I GI E K ----- N FDLEPTVN K RDYSN QE N LF LRL L ESV F Y A T SIKEL KDD A MD 1101
Cdd:pfam20206 81 L LLD S D - DS P DDLLAR L QA A IQPLLEVK I ES E A psdls N LNTDDSAA K AKAEE QE E LF KQA L KGL F F A A SIKEL RAE A LP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1102 L L NN LL D HF C LL QVNTTLLNKRNYNGT FN IDL knpnf M LD SSLIL DAI PFA LS YYIP E V R EV G VLAY K R I YEKSCLIY G E 1181
Cdd:pfam20206 160 F L KG LL R HF T LL ELAEEIGPFKESRRR FN LEG ----- P LD PLVFI DAI VES LS SESK E L R DA G ESVL K L I LDTLVTLL G S 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1182 --- ELA L SHSFIPE LA KQ F I HLCY D E TY Y N K R GG V LGI KV L IDNVKSSSVFLKKY Q YNLANG LLFVLKD TQS E A PS AIT D 1258
Cdd:pfam20206 235 kev VDQ L NEPLFHY LA SR F C HLCY E E AW Y R K L GG C LGI RI L LERLDLGLKWVLDH Q LEFVRA LLFVLKD MPP E V PS GNV D 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1259 S A EKL L IDL L ------- SI T FADVKEEDLGNKV L ENTLTDI V C ELS NA N PK VR NAC QK S L HTISN LTGIP IVK L MDHS K Q 1331
Cdd:pfam20206 315 D A KDT L LFI L kvcntpp KS T PKTTEGTAKQRSK L NTLVGLL V S ELS SS N EI VR ETA QK A L ELLAE LTGIP VTE L LEPV K E 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1332 F LL S PIF A KPLRALPF T MQIG NV DAITFCLSL PNTF L T FNEEL F RLL Q E SIV LADAED ES L stn IQKTTE Y STSE QL V QL 1411
Cdd:pfam20206 395 R LL Q PIF T KPLRALPF P MQIG HI DAITFCLSL RPPL L E FNEEL V RLL H E ALA LADAED AA L --- VGRNPQ Y KNLT QL I QL 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1412 R I ACI K LL AI A LKNEE F ATAQ Q G N I R I RI LA VFFK TMLKT SPE IINTTYEA LK GS LA ENS KLPK E LLQ N GL K P L LMNLSD 1491
Cdd:pfam20206 472 R V ACI R LL SA A MACPD F LAPK Q V N T R N RI IS VFFK SLYSR SPE VVDAAHDG LK QV LA QQQ KLPK D LLQ T GL R P I LMNLSD 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1492 H QK LTV P GL DA L SK LLELL IA YFKVEIG R KLLDHL TA W CRV E V L DTLFGQD L A E QMPT KI IVS I I NIFHLLPP Q A DM FL N 1571
Cdd:pfam20206 552 H KR LTV A GL EG L AR LLELL TN YFKVEIG E KLLDHL RK W ADP E M L QEASLKP L E E NEEV KI AAA I L NIFHLLPP A A SK FL E 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1572 DL LLK V ML LE RK LR LQLD SPFR T PLA R YLNR FHNPVT E Y F KKNMTLRQLVLFMCN I VQR P E A KE L AEDFEKELDNFYDF - 1650
Cdd:pfam20206 632 DL VKL V IQ LE AV LR RYVS SPFR E PLA K YLNR YPEEAV E F F LERLSDPRYSRLFRD I LKS P D A EP L RAEVSSKPSRVSLL n 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1651 YISNIPKNQVRVVSFF t NMVDLFN T M V IT N GD e WL KKKGNMILK L KDMLNLTLKTIK - E N SFYID H L Q LNQSIAKFQALY 1729
Cdd:pfam20206 712 IKLFLETADSKTALRY - QGLLIVR T L V KL N PN - WL PSNNDVLQA L LQLWRSLHRLQR l G N EDSLI H F Q QLRESKLLLKIL 789
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1730 L RFTELSER D QNP L -------- L LDFI DFSF sngikasys L KK F IFHNIIASSNK E - K QNNFINDATL F VLSDKCL D ARI 1800
Cdd:pfam20206 790 L QYLRQNPD D IDL L fdlleift L PTVT DFSF --------- L RD F LYEEVALKYSV E q K RAILLRFLEM F PDPTTSQ D LKV 860
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1801 FV L KNV IN ST L IYEVATSG S l K SY LV E dkk PKWLEL LH N KIWK NSNAILA y D VLDHH D LF R F ELLQLS AIFIKADP E I I A 1880
Cdd:pfam20206 861 KA L RHL IN PI L AASFERGE S - K EE LV D --- ADVIDQ LH A KIWK PLQLAGD - D ATFSD D GL R I ELLQLS TLLVEYAS E L I G 935
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1881 E IK KD I IKF C WNF I KL E D TLI KQ S AY LVTSY FI SK FD F P I K V V T QV F VALL RSSHV E A R Y LV K Q S LD V L T P V L HE R MNAA 1960
Cdd:pfam20206 936 E NR KD L IKF A WNF L KL D D PTV KQ A AY VLIAR FI EA FD T P P K I V L QV Y VALL KAHQP E G R A LV R Q A LD I L A P A L PK R LPEN 1015
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1961 GTPD TW IN W V KR VM VE -- N S SS Q NNIL YQ FLIS HPDLF FNS R D LF ISNIIHHMN K ITFMS N SNSDSHT LA I DLA S LI LY W 2038
Cdd:pfam20206 1016 PGYP TW VK W T KR IL VE eg H S IP Q LVHI YQ LIVR HPDLF YPN R E LF VPHMVTSLQ K LGLPP N ATTETRK LA V DLA E LI IR W 1095
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2039 E NKTL E ITN V NNTKTDSD G DVVMSDSKSDINPVEADTTAIIV ------- D ANN N S PI S L H LRE ACTA FLIR YV C A S NHRA 2111
Cdd:pfam20206 1096 E RRRS E SMD V SESSNEES G GDKQTVPLDSSSSPKSFASSSAS adptmga D DSS N Y PI P L S LRE TVVN FLIR FA C T S TEDS 1175
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2112 IETE L GL RA INI L SE L I S DKH W TN V NV KL VY FEK F L IFQDLDSEN I LYY C m NAL DV L YVFFKN K TKE WI ME NL PTI Q N LL 2191
Cdd:pfam20206 1176 SSKG L SA RA LEL L KD L L S PDL W PD V SI KL SF FEK V L AQTEVSENS I PQI C - NAL EI L NIVLEV K PNA WI IS NL SQL Q K LL 1254
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2192 EKC I KSD HHDV QEAL QKV L QV I MK A IKAQGVS vi I E EESPGKT F IQMLTSV IT QD L Q -- ETSSVTAGVT L AWVLFMNF PD 2269
Cdd:pfam20206 1255 EKC L KSD NPKI QEAL RPI L KR I LE A LPVSVEG -- S E DAEEVSS F YKFIETI IT EG L S sl TNTGLLGTLS L LSAWAKHR PD 1332
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2270 N I V P LLTP LMK TFS KL C K D HL --- S ISQPKDAMALEEARI T TK LL E K V L YI L S L K VS L LG DS RR P FLS TVAL LI DH S M D Q 2346
Cdd:pfam20206 1333 Y I D P FIPS LMK VLQ KL V K E HL aan S QDASSSSASPPPFES T AE LL I K T L EL L K L R VS H LG EQ RR W FLS ALVQ LI EK S N D V 1412
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2347 NF LR K I VN M S R S WI F - N TE I FPT V KEKA AI L T KM LA FE I RG EPS LS KL F YEIV L KLFDQEHFNNT E I TVR M E QP FL V G T R 2425
Cdd:pfam20206 1413 EL LR T I LD M V R E WI K e Q TE G FPT I KEKA GL L V KM MS FE F RG DAA LS AD F LDLI L DIYEDPALARS E L TVR L E PA FL M G L R 1492
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2426 VE D IG IRK R F MT I L DNSL E R DIK ERL Y Y VIRD QNWE FIA D YP W LN QAL Q LL Y GS FNREKE LSL KNIYCLS P P si L QEYLP 2505
Cdd:pfam20206 1493 SS D PK IRK K F FA I F DNSL S R SLA ERL L Y ILGV QNWE SLG D HY W IK QAL D LL L GS VDKDNP LSL SESSASI P S -- L TALEE 1570
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2506 ENA E MVT E VN D L EL SNFVK GH I A SMQG L CRIISS D FI D S L IEIFY QD PKAI H RA WV T LFP QVYKSIPKN E KYGFVRS I IT 2585
Cdd:pfam20206 1571 ADK E ESY E ME D D EL DKLLS GH R A FLDE L RSVTLG D LL D P L RQLLH QD SNLT H KL WV S LFP AAWSALSRR E QEDLTKA I VP 1650
1690 1700
....*....|....*....|....*..
gi 6321891 2586 LLSK P YH TR Q ISS R T NVI NM LL DSISK 2612
Cdd:pfam20206 1651 LLSK D YH SK Q ADK R P NVI QT LL EGVAR 1677
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
290-935
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 736.36
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 290 A Y C DFI L AQ I K AT SFLAY V f I RG Y A p E F L QD Y VNFV P DLII RLLQDCP S E L SS A RKELL H ATRHILST NYKKL F L P KL D Y 369
Cdd:pfam20175 1 L Y G DFI A AQ V K TL SFLAY L - L RG F A - E Q L RP Y QDKL P EIVV RLLQDCP P E A SS T RKELL V ATRHILST EFRSG F V P HI D L 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 370 L F DE RI LIG N G F T MH ETLRPLAYS TV AD F IH NI R S EL QLSEIE K TIK IY TGY L L D ES L ALTV Q I MSAKLLLNLV ER I L K L 449
Cdd:pfam20175 79 L L DE KV LIG T G V T SY ETLRPLAYS ML AD L IH HV R A EL SIEQLS K VVS IY SKN L H D PT L PPSI Q T MSAKLLLNLV DS I V K K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 450 GKEN PQEA pra KK LL MI I IDSYMNRF K T LNR Q Y DTIM K YYGRYETH K K EK -- A EKLKNSIQDN D KESE E FM rk VL E PSDD 527
Cdd:pfam20175 159 DDKD PQEA --- RD LL VR I LETFVEKL K S LNR Y Y PPLL K QHRKKKSE K E EK ts A DVDADEDRPA D IDTV E YL -- AI E RAKP 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 528 DHLMPQ P KK edindspdvemtesdkvvkndvemfdiknyapilllpt PTN DP I KDA FY L YR TL MSF LKTII HD L KVFN P P 607
Cdd:pfam20175 234 IEGIQF P SP -------------------------------------- SPV DP L KDA RF L FK TL LHG LKTII WG L RNCQ P T 275
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 608 P N ey TVAN P KL W A SV S R VFSY EEV IV F KD LF H E CIIGLKFFK dhneklsp ETTKKHFDI S MP S LPVSAT K DAR E LMDYL A 687
Cdd:pfam20175 276 P P -- QQNA P SG W N SV A R GLPP EEV DI F IR LF K E GVKCFDLYS -------- INKDPPTTA S SS S ISRTSS K EEK E VLELF A 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 688 FM F MQM D N ATF N E IIEQEL PF VY ER M LE DSG LL HVA Q S FL TSEIT SP N FA G ILLRFL KGK L K DLG NV D FNT S N VL I RLFK 767
Cdd:pfam20175 346 SI F TIL D P ATF Q E VFTSRM PF LF ER I LE NPA LL AIP Q F FL SNDSV SP R FA S ILLRFL VDR L E DLG AA D KKK S S VL L RLFK 425
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 768 L S FM S V N LFP NI NE V VL L PHL ND LIL N SLK YSTT A E EPL V YF Y L I R T LFRSIGGGRFE N LY RSIK P I L Q VLL QS LN QMIL 847
Cdd:pfam20175 426 L A FM A V T LFP EE NE A VL Q PHL PK LIL T SLK LALK A K EPL N YF L L L R A LFRSIGGGRFE L LY KEVL P L L P VLL EG LN RLLS 505
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 848 T A RL P HE R E L Y VELC I TVPVRLSVL A PYL PF LMKPLV F AL QQY P D LVSQGLRTLELC I DNLT A E YF DPI IE PVIDD VSK A 927
Cdd:pfam20175 506 S A HR P SM R D L F VELC L TVPVRLSVL L PYL SL LMKPLV L AL NSS P E LVSQGLRTLELC V DNLT P E FL DPI MQ PVIDD LMQ A 585
....*...
gi 6321891 928 L FNL L Q P Q 935
Cdd:pfam20175 586 L WKH L R P L 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3371-3676
1.64e-114
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 364.15
E-value: 1.64e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3371 IARFLP T V DF VR GTHSS YRRL M IRGHDGS VHS F A VQ Y P AV RHSRREER MF QL Y RL F N KS L SKNV ETRRR SI QF NL PI AI P 3450
Cdd:cd05163 1 IARFLP R V EI VR RHGTC YRRL T IRGHDGS KYP F L VQ T P SA RHSRREER VM QL F RL L N RV L ERKK ETRRR NL QF HV PI VV P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3451 LSPQVR IMN D SV S FTT L HE I HN efckkkgfdpddiqdfmadklnaahddalpapdmtil K V EI F N S IQ TMF VP SNV L KDH 3530
Cdd:cd05163 81 LSPQVR LVE D DP S YIS L QD I YE ------------------------------------- K L EI L N E IQ SKM VP ETI L SNY 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3531 F TSLFTQFE D F WLFRKQF AS Q YSSFV FM S Y MMMIN NRTPH K I HVDKTS GNVF TLEM LP srfpyervkpllknhdl S LPPD 3610
Cdd:cd05163 124 F LRTMPSPS D L WLFRKQF TL Q LALSS FM T Y VLSLG NRTPH R I LISRST GNVF MTDF LP ----------------- S INSQ 186
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321891 3611 S P IFH NNEPVPFRLTPNIQ SL IG DSAL EG IFAVNLFT I S RAL I EP DNE L NT YL A LF I RDE I ISW FS 3676
Cdd:cd05163 187 G P LLD NNEPVPFRLTPNIQ HF IG PIGV EG LLTSSMMA I A RAL T EP EYD L EQ YL S LF V RDE L ISW HK 252
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2757-3106
6.85e-83
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 277.31
E-value: 6.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2757 D L LL E CG WR VAD W NSD R DA L eqsvk S V M DVPT P RRQM F KTF LAL Q nfaes R KGDQ E VRKLCDEGI QL SLIKWVS L PIRYT 2836
Cdd:pfam02259 2 P L AA E AA WR LGQ W DLM R EY L ----- S L M KKDS P DKAF F EAI LAL H ----- R NQFD E AERYIEKAR QL LDTELSA L SGESY 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2837 PAHKW LL HGF QQ YM E FL E AT Q IY anlhtttv Q N L DSKAQ E I K RI LQ A WR D RLP NTW DDV NM W N D LV T W R QHAFQV I NNA Y 2916
Cdd:pfam02259 72 NRAYP LL VRL QQ LA E LE E II Q YK -------- Q K L GQSSE E L K SL LQ T WR N RLP GCQ DDV EI W Q D IL T V R SLVLSP I EDV Y 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2917 L P lipalqqsnsnsninthayr GYH EIA W V in R FA HV ARK HNMPDVCISQ L ARI ------------------ Y TL P NI E I 2978
Cdd:pfam02259 144 L G -------------------- GYH AEM W L -- K FA NL ARK SGRFSLAEKA L LKL lgedpeewlpevvyayak Y LW P TG E Q 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2979 QEA F LKLRE QAK C HY Q NMN EL TT GL D VI SN TNL VY F GTVQ k A EFFT LKG MFLSK L RAY ------ EE AN QA FAT A V Q I D LN 3052
Cdd:pfam02259 202 QEA L LKLRE FLS C YL Q KNG EL LS GL E VI NP TNL EE F TELL - A RCYL LKG KWQAA L GQN waeeks EE IL QA YLL A T Q F D PS 280
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321891 3053 LA KAW AQ W GF FN DRR L SE E -------- P NNI S - FASN A ISC YL QAAG L Y k NSKIRELLC R I L W 3106
Cdd:pfam02259 281 WY KAW HT W AL FN FEV L RK E eqgkeeeg P EDL S r YVVP A VEG YL RSLS L S - SENSLQDTL R L L T 342
FATC super family
cl03505 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3713-3744
9.71e-03
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
pfam02260 :Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 36.21
E-value: 9.71e-03
10 20 30
....*....|....*....|....*....|..
gi 6321891 3713 P TVTTQFILDC I GS A VS P R NLA RTDVNFM PW F 3744
Cdd:pfam02260 1 P LSVEGQVDEL I QE A TD P E NLA QMYIGWC PW W 32
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
947-2612
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1369.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 947 RILGKLGGRNR Q FLK P P TD L TEKTEL D IDAIADFKIN G M P E D VP L SVT P GIQS A LNI L Q S YK S DI HYRK S A YKY L TCV L L 1026
Cdd:pfam20206 1 RILGKLGGRNR R FLK E P PK L EYRDAG D EASLTVELEF G A P S D QT L PLD P AVDL A KRT L R S ST S LP HYRK Q A FEL L KSA L A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1027 L MTK S S a EF P TNYTEL L KT A VNSIKLER I GI E K ----- N FDLEPTVN K RDYSN QE N LF LRL L ESV F Y A T SIKEL KDD A MD 1101
Cdd:pfam20206 81 L LLD S D - DS P DDLLAR L QA A IQPLLEVK I ES E A psdls N LNTDDSAA K AKAEE QE E LF KQA L KGL F F A A SIKEL RAE A LP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1102 L L NN LL D HF C LL QVNTTLLNKRNYNGT FN IDL knpnf M LD SSLIL DAI PFA LS YYIP E V R EV G VLAY K R I YEKSCLIY G E 1181
Cdd:pfam20206 160 F L KG LL R HF T LL ELAEEIGPFKESRRR FN LEG ----- P LD PLVFI DAI VES LS SESK E L R DA G ESVL K L I LDTLVTLL G S 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1182 --- ELA L SHSFIPE LA KQ F I HLCY D E TY Y N K R GG V LGI KV L IDNVKSSSVFLKKY Q YNLANG LLFVLKD TQS E A PS AIT D 1258
Cdd:pfam20206 235 kev VDQ L NEPLFHY LA SR F C HLCY E E AW Y R K L GG C LGI RI L LERLDLGLKWVLDH Q LEFVRA LLFVLKD MPP E V PS GNV D 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1259 S A EKL L IDL L ------- SI T FADVKEEDLGNKV L ENTLTDI V C ELS NA N PK VR NAC QK S L HTISN LTGIP IVK L MDHS K Q 1331
Cdd:pfam20206 315 D A KDT L LFI L kvcntpp KS T PKTTEGTAKQRSK L NTLVGLL V S ELS SS N EI VR ETA QK A L ELLAE LTGIP VTE L LEPV K E 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1332 F LL S PIF A KPLRALPF T MQIG NV DAITFCLSL PNTF L T FNEEL F RLL Q E SIV LADAED ES L stn IQKTTE Y STSE QL V QL 1411
Cdd:pfam20206 395 R LL Q PIF T KPLRALPF P MQIG HI DAITFCLSL RPPL L E FNEEL V RLL H E ALA LADAED AA L --- VGRNPQ Y KNLT QL I QL 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1412 R I ACI K LL AI A LKNEE F ATAQ Q G N I R I RI LA VFFK TMLKT SPE IINTTYEA LK GS LA ENS KLPK E LLQ N GL K P L LMNLSD 1491
Cdd:pfam20206 472 R V ACI R LL SA A MACPD F LAPK Q V N T R N RI IS VFFK SLYSR SPE VVDAAHDG LK QV LA QQQ KLPK D LLQ T GL R P I LMNLSD 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1492 H QK LTV P GL DA L SK LLELL IA YFKVEIG R KLLDHL TA W CRV E V L DTLFGQD L A E QMPT KI IVS I I NIFHLLPP Q A DM FL N 1571
Cdd:pfam20206 552 H KR LTV A GL EG L AR LLELL TN YFKVEIG E KLLDHL RK W ADP E M L QEASLKP L E E NEEV KI AAA I L NIFHLLPP A A SK FL E 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1572 DL LLK V ML LE RK LR LQLD SPFR T PLA R YLNR FHNPVT E Y F KKNMTLRQLVLFMCN I VQR P E A KE L AEDFEKELDNFYDF - 1650
Cdd:pfam20206 632 DL VKL V IQ LE AV LR RYVS SPFR E PLA K YLNR YPEEAV E F F LERLSDPRYSRLFRD I LKS P D A EP L RAEVSSKPSRVSLL n 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1651 YISNIPKNQVRVVSFF t NMVDLFN T M V IT N GD e WL KKKGNMILK L KDMLNLTLKTIK - E N SFYID H L Q LNQSIAKFQALY 1729
Cdd:pfam20206 712 IKLFLETADSKTALRY - QGLLIVR T L V KL N PN - WL PSNNDVLQA L LQLWRSLHRLQR l G N EDSLI H F Q QLRESKLLLKIL 789
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1730 L RFTELSER D QNP L -------- L LDFI DFSF sngikasys L KK F IFHNIIASSNK E - K QNNFINDATL F VLSDKCL D ARI 1800
Cdd:pfam20206 790 L QYLRQNPD D IDL L fdlleift L PTVT DFSF --------- L RD F LYEEVALKYSV E q K RAILLRFLEM F PDPTTSQ D LKV 860
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1801 FV L KNV IN ST L IYEVATSG S l K SY LV E dkk PKWLEL LH N KIWK NSNAILA y D VLDHH D LF R F ELLQLS AIFIKADP E I I A 1880
Cdd:pfam20206 861 KA L RHL IN PI L AASFERGE S - K EE LV D --- ADVIDQ LH A KIWK PLQLAGD - D ATFSD D GL R I ELLQLS TLLVEYAS E L I G 935
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1881 E IK KD I IKF C WNF I KL E D TLI KQ S AY LVTSY FI SK FD F P I K V V T QV F VALL RSSHV E A R Y LV K Q S LD V L T P V L HE R MNAA 1960
Cdd:pfam20206 936 E NR KD L IKF A WNF L KL D D PTV KQ A AY VLIAR FI EA FD T P P K I V L QV Y VALL KAHQP E G R A LV R Q A LD I L A P A L PK R LPEN 1015
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1961 GTPD TW IN W V KR VM VE -- N S SS Q NNIL YQ FLIS HPDLF FNS R D LF ISNIIHHMN K ITFMS N SNSDSHT LA I DLA S LI LY W 2038
Cdd:pfam20206 1016 PGYP TW VK W T KR IL VE eg H S IP Q LVHI YQ LIVR HPDLF YPN R E LF VPHMVTSLQ K LGLPP N ATTETRK LA V DLA E LI IR W 1095
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2039 E NKTL E ITN V NNTKTDSD G DVVMSDSKSDINPVEADTTAIIV ------- D ANN N S PI S L H LRE ACTA FLIR YV C A S NHRA 2111
Cdd:pfam20206 1096 E RRRS E SMD V SESSNEES G GDKQTVPLDSSSSPKSFASSSAS adptmga D DSS N Y PI P L S LRE TVVN FLIR FA C T S TEDS 1175
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2112 IETE L GL RA INI L SE L I S DKH W TN V NV KL VY FEK F L IFQDLDSEN I LYY C m NAL DV L YVFFKN K TKE WI ME NL PTI Q N LL 2191
Cdd:pfam20206 1176 SSKG L SA RA LEL L KD L L S PDL W PD V SI KL SF FEK V L AQTEVSENS I PQI C - NAL EI L NIVLEV K PNA WI IS NL SQL Q K LL 1254
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2192 EKC I KSD HHDV QEAL QKV L QV I MK A IKAQGVS vi I E EESPGKT F IQMLTSV IT QD L Q -- ETSSVTAGVT L AWVLFMNF PD 2269
Cdd:pfam20206 1255 EKC L KSD NPKI QEAL RPI L KR I LE A LPVSVEG -- S E DAEEVSS F YKFIETI IT EG L S sl TNTGLLGTLS L LSAWAKHR PD 1332
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2270 N I V P LLTP LMK TFS KL C K D HL --- S ISQPKDAMALEEARI T TK LL E K V L YI L S L K VS L LG DS RR P FLS TVAL LI DH S M D Q 2346
Cdd:pfam20206 1333 Y I D P FIPS LMK VLQ KL V K E HL aan S QDASSSSASPPPFES T AE LL I K T L EL L K L R VS H LG EQ RR W FLS ALVQ LI EK S N D V 1412
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2347 NF LR K I VN M S R S WI F - N TE I FPT V KEKA AI L T KM LA FE I RG EPS LS KL F YEIV L KLFDQEHFNNT E I TVR M E QP FL V G T R 2425
Cdd:pfam20206 1413 EL LR T I LD M V R E WI K e Q TE G FPT I KEKA GL L V KM MS FE F RG DAA LS AD F LDLI L DIYEDPALARS E L TVR L E PA FL M G L R 1492
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2426 VE D IG IRK R F MT I L DNSL E R DIK ERL Y Y VIRD QNWE FIA D YP W LN QAL Q LL Y GS FNREKE LSL KNIYCLS P P si L QEYLP 2505
Cdd:pfam20206 1493 SS D PK IRK K F FA I F DNSL S R SLA ERL L Y ILGV QNWE SLG D HY W IK QAL D LL L GS VDKDNP LSL SESSASI P S -- L TALEE 1570
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2506 ENA E MVT E VN D L EL SNFVK GH I A SMQG L CRIISS D FI D S L IEIFY QD PKAI H RA WV T LFP QVYKSIPKN E KYGFVRS I IT 2585
Cdd:pfam20206 1571 ADK E ESY E ME D D EL DKLLS GH R A FLDE L RSVTLG D LL D P L RQLLH QD SNLT H KL WV S LFP AAWSALSRR E QEDLTKA I VP 1650
1690 1700
....*....|....*....|....*..
gi 6321891 2586 LLSK P YH TR Q ISS R T NVI NM LL DSISK 2612
Cdd:pfam20206 1651 LLSK D YH SK Q ADK R P NVI QT LL EGVAR 1677
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
1232-3744
0e+00
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 1354.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1232 KYQYNLANG L LFV LKD TQS E APSAIT D s AEKL L I DLL SIT F A D V KE E D L gnkvlentltdivc E LSN A N PK VRN AC Q KS L 1311
Cdd:COG5032 1 DRLAQIIYA L PSL LKD CFT E ILLRKS D - VRSS L F DLL HVS F L D Y KE K D E -------------- R LSN V N DL VRN ST Q SL L 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1312 H TISNL tg I P IVK LMDHS K Q F L LSPIFAK p LRALP F T M q I GNVD A I T F CLSL PNTF L tfneelfrllqesivlad A E DES 1391
Cdd:COG5032 66 N TISNL -- I K IVK FVLPL K S F F LSPIFAK - LRALP M T K - I LCIS A D T Y CLSL SIKA L ------------------ A D DES 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1392 L S T NIQKTT E YSTS eqlv Q L RIACIKL L A I A L KNEE F AT AQ QGN iririlav FFK TM L KTSP EI INTT YEAL KGS L A EN S 1471
Cdd:COG5032 124 L T T ILKTIR E LLSK ---- F L LRLRLLF L F I G L LAQK F SE AQ SKL -------- FFK LL L SILK EI LSDA YEAL LND L L EN L 191
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1472 K LP KE L LQN G L K PLL M N L SD H qkltvpgldalskllelli A YFKVEIGRKLLDHL T A W crvevldtlf GQ D L AE Q MPT KI 1551
Cdd:COG5032 192 K SL KE T LQN R L L PLL F N I SD G ------------------- N YFKVEIGRKLLDHL N A L ---------- GQ I L DC Q KIA KI 242
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1552 IV S iini F HL LP PQADM FLN D LL L KV M llerklr LQ L D S P FR TP L AR YL NR F HNPVTEY F KKNM tlrq LV LF MCNIVQR P 1631
Cdd:COG5032 243 TK S ---- F RS LP VIIKK FLN L LL I KV S ------- YY L P S F FR LS L LS YL DH F ETDLFKT F LVTS ---- CF LF FVDEICK P 307
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1632 E AKE LAE DFEKE L DN F YD fy I SN I PKNQVRVV S FF t NMVDLFNTMVITNG D EWLKKK G NMIL K LKDMLN L T L kti KENSF 1711
Cdd:COG5032 308 E SEH LAE EVSEK L SK F LT -- I EI I DSFPEIRI S AL - SSLLVIFDYHLALP D AVRLLF G ESND K VFLISE L A L --- DSTGR 381
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1712 YIDH L QLNQSIAK F QA L YLRF T E L SE rdq NP L L L D F IDFSFS ngikasyslkkfi FH N I I A SSN KEKQNN fi NDATLFVL 1791
Cdd:COG5032 382 LLRV L PARVLPSL F EF L LSLL T V L KI --- SG L I L E F EISAQL ------------- LC N L I R SSN QLLTSL -- ISPYFLFI 443
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1792 SD KC L D AR ifvlknvi NS TLI Y E V ATS G S LK SY L VE D KKPKW le LLHNKIWKNSNAI L AYD V ldhhdlfrfellqlsaif 1871
Cdd:COG5032 444 LP KC I D SS -------- NS EIS Y R V ENL G E LK DI L GL D RITDY -- QALSLRLIIVSIQ L RSF V ------------------ 495
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1872 ik ADP E I I AE I K K DIIK fcw NF IK LEDT likqsaylvtsy FISKF D F PIK V VT Q V F VALLR s SHV E ARYL V KQ S L D vlt P 1951
Cdd:COG5032 496 -- FKR E A I NQ I F K QLAS --- IV IK PFLD ------------ YPKRL D L PIK I VT V V Y VALLR - RPT E KLSG V LG S I D --- K 554
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1952 VL H ERMNAAGTP D TW i NWVKR V MV ensss Q NNIL Y Q F LI S HP DL F F NSR D lfi SNI I HHMNKITFMSNSNSD sh TL AI D L 2031
Cdd:COG5032 555 YS H IESEEMSSS D FP - WTKNP V GL ----- Q LLAV Y G F IR S ID DL Y F TVS D --- PTL I EILKLPVLSIVHSAI -- IE AI M L 623
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2032 AS L I L YW E NKTL E IT N vnntkt D S DGDVVMSD S K SDI NPVEADTTAI IV D A NNNSPI S LHLREACTAF L IRYVCAS nhra 2111
Cdd:COG5032 624 IK L S L GS E SSQF E DL N ------ P S FLYIFSNN S I SDI LFYFQNFLEL IV I A FFPLIR S EIIGIVLISS L FSKTWIL ---- 693
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2112 iete L G L RA I NIL S E LIS D khw TNVNV K LVYFE kflifqd L DSENILYYCM n A LDV L Y VFFK nkt KEWIMEN L PTIQNL L 2191
Cdd:COG5032 694 ---- L K L LL I AFI S K LIS A --- LQGEL K MLAPT ------- L FTLFLVLVER - Y LDV E Y SSVS --- FKLLLVI L VYFGGN L 755
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2192 E K ciks DHHDVQE alqkvlqvimkaikaqgvsviieeespgkt F I Q ML TSVITQD LQE TSSVT ag VTLAWVL F M N FPD N I 2271
Cdd:COG5032 756 E S ---- LVLLILD ------------------------------ L I V ML VEYTELG LQE SIFIE -- RLSQFFK F K N LSE N A 799
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2272 VP LL T PLM KTF SK L ckd H LSISQPK D AMALEEARIT T kl LEKVLY I L s LKV S L LGDSRR P FLS TV A L L I D H S MDQNF L RK 2351
Cdd:COG5032 800 SR LL P PLM DNL SK S --- H ELRCVSE D DVSALLIQLL T -- DRVICF I P - VIN S S LGDSRR I FLS LL A Q L L D D S LKEES L PY 873
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2352 IV N MS R SWIF n T E I F P TVK E KA AI L TKMLAFEIRGEPSLS kl FYEIV LK L F D QE HFN N TEITVRM E Q P flvgtrvedigi 2431
Cdd:COG5032 874 NL N VD R GTDL - R E F F Q TVK S KA EV L SMLPFVQSILFEAWN -- RVDFL LK D F W QE ELD N LLVALLK E L P ------------ 938
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2432 rkr FM TIL D N S LER D I kerl Y YVIRDQN W EFIADYP WL NQAL qllyg S FN R EKEL SLK NIYC L SPPS IL QEYLPENAEMV 2511
Cdd:COG5032 939 --- FM ALR D C S ILS D L ---- Y FMLGREL W NSVSFEC WL ELMN ----- S YK R LLIK SLK SKLH L PTIP IL ILQMLLDSKNL 1006
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2512 TE VNDLE L S N FV kghias MQG L CRI issd F ID SL IEIFY qdp K AI H RAWVTL FP Q vyksipkneky G FV R S II TLLS KP Y 2591
Cdd:COG5032 1007 TE FTEHQ L K N LP ------ LPS L SIG ---- F YE SL CSFLA --- K LL H DEELYF FP L ----------- L FV S S LE TLLS VN Y 1062
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2592 H TR Q ISS R T N v I NMLLD S ISKI esl E L P PHLVKYL AIS Y N A WYQSINI L ESIQSNTS I DN TK IIEANEDAL LELY VN L Q E 2671
Cdd:COG5032 1063 H IN Q LDL R P N - I LKHFG S FVRF --- Q L K PHLVKYL QRW Y E A LNRYFEL L SKGDRLFA I SF TK LRNVDALGK LELY SS L A E 1138
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2672 E DMF YG L W RRR a K YT ET NIGLS YEQ I G L W D KAQQLYEVAQ V KARS GAL P Y S q SE Y AL W ED N W I Q CA E KLQ H wd VL T EL AK 2751
Cdd:COG5032 1139 I DMF LS L H RRR - K LL ET LVATA YEQ V G E W Y KAQQLYEVAQ R KARS KEF P F S - LQ Y LY W HI N D I D CA D KLQ S -- VL A EL SL 1214
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2752 HE G FTD LLLE CG WR V A DWNSDR D A LE QSVKSVM D VPTPRRQM F KTFLA L QNF AE SRKGDQ E V R KL C DEG I Q LSL IK W VS L 2831
Cdd:COG5032 1215 VT G ISE LLLE ES WR R A LFSNIK D S LE SELEEII D GMYKSNED F GALML L SLS AE LWDKIL E G R SS C SKS I K LSL NI W LD L 1294
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2832 P I RYT P AHKW ll HG F QQYM E FL EA TQ I YAN L HTTTV Q N L DS K AQ EIK RI L QAW RDRLP NT W DDVNMWND L V TWRQ H AF QV 2911
Cdd:COG5032 1295 S I VVS P KDEP -- EL F IKFV E LC EA SS I RSK L LEKNI Q E L LE K LE EIK SP L GTL RDRLP PP W ALLDLKRL L A TWRQ N AF LR 1372
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2912 IN NAY LPL IPA L QQSN S N S NINTHAY RG YH E I A WV IN R FA H VARKH NM PD vci S QL AR IY T L P NI E I Q EAFL K LR EQAK C 2991
Cdd:COG5032 1373 IN PEL LPL LSS L LNLQ S S S LSKQLVS RG SS E S A IS IN S FA S VARKH FL PD --- N QL KK IY Q L S NI L I S EAFL L LR YLLL C 1449
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2992 HYQNM n EL TT GL D V ISN TNL VY F GTV Q KA EFF T lkgmflsklrayeeanqafatavqidlnlakawaq WG FFNDRRLSEE 3071
Cdd:COG5032 1450 RLGRR - EL KA GL N V WNL TNL EL F SDI Q ES EFF E ----------------------------------- WG KNLKLLSIIP 1493
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3072 P NNIS F A SNA I SCYLQ AAG L Y K NSKIR ELL CRI L wli S ID DA S G MLTNA F DS F RG EI P V wyw I T FIPQLL T SLS HKEA N M 3151
Cdd:COG5032 1494 P IEEI F L SNA L SCYLQ VKD L L K KLNLF ELL GSL L --- S AK DA A G SYYKN F HI F DL EI S V --- I P FIPQLL S SLS LLDL N S 1567
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3152 VRHI L IR I A K SY PQAL H F Q LR TTK E DF A VIQRQTMAVMGD K PD T N D RNGRRQPW E YLQ E LNN I lkt AYPLL A L SL E SLV A 3231
Cdd:COG5032 1568 AQSL L SK I G K EH PQAL V F T LR SAI E ST A LSKESVALSLEN K SR T H D PSLVKEAL E LSD E NIR I --- AYPLL H L LF E PIL A 1644
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3232 Q IND R FK S TTDE dlfr LINV LLID GT L NYN R LP FP RKNP k L PENTEKN L VKFSTTLL a PY IR P KF NA D FIDNKPDYET YI 3311
Cdd:COG5032 1645 Q LLS R LS S ENNK ---- ISVA LLID KP L HEE R EN FP SGLS - L SSFQSSF L KELIKKSP - RK IR K KF KI D ISLLNLSRKL YI 1718
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3312 KR LR YW R R RL ENK L DRAS KK enlev LC P H L SN FH H qk F ED I EI PGQYLL N K D nnvh F IK I A RF L P T V DF V RGTHSSY RRL 3391
Cdd:COG5032 1719 SV LR SI R K RL KRL L ELRL KK ----- VS P K L LL FH A -- F LE I KL PGQYLL D K P ---- F VL I E RF E P E V SV V KSHLQRP RRL 1787
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3392 M IRG H DG SVH SF A V QY pa VRHS R RE E RMF QL Y RL F NK S L S K NV ETRRR SIQFNLPIA IPLSP QVR I MNDSVSFT TLH E I H 3471
Cdd:COG5032 1788 T IRG S DG KLY SF I V KG -- GDDL R QD E LAL QL I RL M NK I L K K DK ETRRR DLWIRPYKV IPLSP GSG I IEWVPNSD TLH S I L 1865
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3472 N E FC K K K GFDP D DIQDFM A DK lnaahddalp APDMTI LK V E I F N s IQ T MFV P S n VL K D H F TSL F TQF ED FWLF R KQ FA SQ 3551
Cdd:COG5032 1866 R E YH K R K NISI D QEKKLA A RL ---------- DNLKLL LK D E F F T - KA T LKS P P - VL Y D W F SES F PNP ED WLTA R TN FA RS 1933
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3552 YSSFVFMS Y MMMINN R T P HK I HV D KT SG N V FTLEML psrfpyervk PL L K N HDLSL P P dspifhn N E P VPFRLT P NI QSL 3631
Cdd:COG5032 1934 LAVYSVIG Y ILGLGD R H P GN I LI D RS SG H V IHIDFG ---------- FI L F N APGRF P F ------- P E K VPFRLT R NI VEA 1996
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3632 I G D S AL EG I F AVNLF T IS RAL IEPDNE L NTY L A LF I RD EI I S W F snl HR P IIENP Q LR E M V QTN v DLIIR K VAQLGHLNS 3711
Cdd:COG5032 1997 M G V S GV EG S F RELCE T AF RAL RKNADS L MNV L E LF V RD PL I E W R --- RL P CFREI Q NN E I V NVL - ERFRL K LSEKDAEKF 2072
2490 2500 2510
....*....|....*....|....*....|...
gi 6321891 3712 TPTVTTQFILDC I GS A VS P RN LA RTDVNF MP WF 3744
Cdd:COG5032 2073 VDLLINKSVESL I TQ A TD P FQ LA TMYIGW MP FW 2105
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
290-935
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 736.36
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 290 A Y C DFI L AQ I K AT SFLAY V f I RG Y A p E F L QD Y VNFV P DLII RLLQDCP S E L SS A RKELL H ATRHILST NYKKL F L P KL D Y 369
Cdd:pfam20175 1 L Y G DFI A AQ V K TL SFLAY L - L RG F A - E Q L RP Y QDKL P EIVV RLLQDCP P E A SS T RKELL V ATRHILST EFRSG F V P HI D L 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 370 L F DE RI LIG N G F T MH ETLRPLAYS TV AD F IH NI R S EL QLSEIE K TIK IY TGY L L D ES L ALTV Q I MSAKLLLNLV ER I L K L 449
Cdd:pfam20175 79 L L DE KV LIG T G V T SY ETLRPLAYS ML AD L IH HV R A EL SIEQLS K VVS IY SKN L H D PT L PPSI Q T MSAKLLLNLV DS I V K K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 450 GKEN PQEA pra KK LL MI I IDSYMNRF K T LNR Q Y DTIM K YYGRYETH K K EK -- A EKLKNSIQDN D KESE E FM rk VL E PSDD 527
Cdd:pfam20175 159 DDKD PQEA --- RD LL VR I LETFVEKL K S LNR Y Y PPLL K QHRKKKSE K E EK ts A DVDADEDRPA D IDTV E YL -- AI E RAKP 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 528 DHLMPQ P KK edindspdvemtesdkvvkndvemfdiknyapilllpt PTN DP I KDA FY L YR TL MSF LKTII HD L KVFN P P 607
Cdd:pfam20175 234 IEGIQF P SP -------------------------------------- SPV DP L KDA RF L FK TL LHG LKTII WG L RNCQ P T 275
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 608 P N ey TVAN P KL W A SV S R VFSY EEV IV F KD LF H E CIIGLKFFK dhneklsp ETTKKHFDI S MP S LPVSAT K DAR E LMDYL A 687
Cdd:pfam20175 276 P P -- QQNA P SG W N SV A R GLPP EEV DI F IR LF K E GVKCFDLYS -------- INKDPPTTA S SS S ISRTSS K EEK E VLELF A 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 688 FM F MQM D N ATF N E IIEQEL PF VY ER M LE DSG LL HVA Q S FL TSEIT SP N FA G ILLRFL KGK L K DLG NV D FNT S N VL I RLFK 767
Cdd:pfam20175 346 SI F TIL D P ATF Q E VFTSRM PF LF ER I LE NPA LL AIP Q F FL SNDSV SP R FA S ILLRFL VDR L E DLG AA D KKK S S VL L RLFK 425
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 768 L S FM S V N LFP NI NE V VL L PHL ND LIL N SLK YSTT A E EPL V YF Y L I R T LFRSIGGGRFE N LY RSIK P I L Q VLL QS LN QMIL 847
Cdd:pfam20175 426 L A FM A V T LFP EE NE A VL Q PHL PK LIL T SLK LALK A K EPL N YF L L L R A LFRSIGGGRFE L LY KEVL P L L P VLL EG LN RLLS 505
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 848 T A RL P HE R E L Y VELC I TVPVRLSVL A PYL PF LMKPLV F AL QQY P D LVSQGLRTLELC I DNLT A E YF DPI IE PVIDD VSK A 927
Cdd:pfam20175 506 S A HR P SM R D L F VELC L TVPVRLSVL L PYL SL LMKPLV L AL NSS P E LVSQGLRTLELC V DNLT P E FL DPI MQ PVIDD LMQ A 585
....*...
gi 6321891 928 L FNL L Q P Q 935
Cdd:pfam20175 586 L WKH L R P L 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3371-3676
1.64e-114
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 364.15
E-value: 1.64e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3371 IARFLP T V DF VR GTHSS YRRL M IRGHDGS VHS F A VQ Y P AV RHSRREER MF QL Y RL F N KS L SKNV ETRRR SI QF NL PI AI P 3450
Cdd:cd05163 1 IARFLP R V EI VR RHGTC YRRL T IRGHDGS KYP F L VQ T P SA RHSRREER VM QL F RL L N RV L ERKK ETRRR NL QF HV PI VV P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3451 LSPQVR IMN D SV S FTT L HE I HN efckkkgfdpddiqdfmadklnaahddalpapdmtil K V EI F N S IQ TMF VP SNV L KDH 3530
Cdd:cd05163 81 LSPQVR LVE D DP S YIS L QD I YE ------------------------------------- K L EI L N E IQ SKM VP ETI L SNY 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3531 F TSLFTQFE D F WLFRKQF AS Q YSSFV FM S Y MMMIN NRTPH K I HVDKTS GNVF TLEM LP srfpyervkpllknhdl S LPPD 3610
Cdd:cd05163 124 F LRTMPSPS D L WLFRKQF TL Q LALSS FM T Y VLSLG NRTPH R I LISRST GNVF MTDF LP ----------------- S INSQ 186
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321891 3611 S P IFH NNEPVPFRLTPNIQ SL IG DSAL EG IFAVNLFT I S RAL I EP DNE L NT YL A LF I RDE I ISW FS 3676
Cdd:cd05163 187 G P LLD NNEPVPFRLTPNIQ HF IG PIGV EG LLTSSMMA I A RAL T EP EYD L EQ YL S LF V RDE L ISW HK 252
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2757-3106
6.85e-83
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 277.31
E-value: 6.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2757 D L LL E CG WR VAD W NSD R DA L eqsvk S V M DVPT P RRQM F KTF LAL Q nfaes R KGDQ E VRKLCDEGI QL SLIKWVS L PIRYT 2836
Cdd:pfam02259 2 P L AA E AA WR LGQ W DLM R EY L ----- S L M KKDS P DKAF F EAI LAL H ----- R NQFD E AERYIEKAR QL LDTELSA L SGESY 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2837 PAHKW LL HGF QQ YM E FL E AT Q IY anlhtttv Q N L DSKAQ E I K RI LQ A WR D RLP NTW DDV NM W N D LV T W R QHAFQV I NNA Y 2916
Cdd:pfam02259 72 NRAYP LL VRL QQ LA E LE E II Q YK -------- Q K L GQSSE E L K SL LQ T WR N RLP GCQ DDV EI W Q D IL T V R SLVLSP I EDV Y 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2917 L P lipalqqsnsnsninthayr GYH EIA W V in R FA HV ARK HNMPDVCISQ L ARI ------------------ Y TL P NI E I 2978
Cdd:pfam02259 144 L G -------------------- GYH AEM W L -- K FA NL ARK SGRFSLAEKA L LKL lgedpeewlpevvyayak Y LW P TG E Q 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2979 QEA F LKLRE QAK C HY Q NMN EL TT GL D VI SN TNL VY F GTVQ k A EFFT LKG MFLSK L RAY ------ EE AN QA FAT A V Q I D LN 3052
Cdd:pfam02259 202 QEA L LKLRE FLS C YL Q KNG EL LS GL E VI NP TNL EE F TELL - A RCYL LKG KWQAA L GQN waeeks EE IL QA YLL A T Q F D PS 280
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321891 3053 LA KAW AQ W GF FN DRR L SE E -------- P NNI S - FASN A ISC YL QAAG L Y k NSKIRELLC R I L W 3106
Cdd:pfam02259 281 WY KAW HT W AL FN FEV L RK E eqgkeeeg P EDL S r YVVP A VEG YL RSLS L S - SENSLQDTL R L L T 342
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3405-3677
1.89e-63
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 217.17
E-value: 1.89e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3405 V QYPAVRHS R RE ER MF QL Y RL F NK S L S K NV ETRRR SIQFNLPIA IP LS P QVRIMNDSVSF TTLHEI HN E FC K K KG FDP D d 3484
Cdd:smart00146 1 V IFKGGDDL R QD ER VL QL L RL M NK L L Q K DK ETRRR DLHLRPYKV IP TG P KSGLIEVVPNS TTLHEI LK E YR K Q KG KVL D - 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3485 iqdfmadklnaahdda L PAPDM T I LK VEIFNSIQ T MFV P SN VL K D H FT SL F TQ - F ED FWLF RK Q F ASQYSSFVFMS Y MMM 3563
Cdd:smart00146 80 ---------------- L RSQTA T R LK KLELFLEA T GKF P DP VL Y D W FT KK F PD p S ED YFEA RK N F TRSCAGYSVIT Y ILG 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3564 INN R TPHK I HV DKT s G NV F TLEMLPSRFPYERV kpllknhdlslppdspi F HNN E P VPFRLTP NIQSLI GDS ALE G I F AV 3643
Cdd:smart00146 144 LGD R HNDN I ML DKT - G HL F HIDFGFILGNGPKL ----------------- F GFP E R VPFRLTP EMVDVM GDS GYF G L F RS 205
250 260 270
....*....|....*....|....*....|....
gi 6321891 3644 NLFTIS RAL IEPD N ELNTY L A L FIR D EIIS W F S N 3677
Cdd:smart00146 206 LCERAL RAL RKNS N LIMSL L E L MLY D GLPD W R S G 239
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3402-3676
1.02e-61
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 212.57
E-value: 1.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3402 SFAVQ Y PAVRHS R RE E RMF Q LYR L FNKS LSK NVETR RR siq FNLPIA IPL S P QVR I MNDSVSFT TL HE I HN E FCKK k G FD 3481
Cdd:pfam00454 1 GYGGI Y KVGDDL R QD E LIL Q VFK L MDEE LSK DNLDL RR --- LKPYSV IPL G P KCG I IEWVPNSE TL AY I LD E YGEN - G VP 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3482 P DDIQDFMA dklnaahddal P A PDMTI LK V E if NSIQTMFV P SNV L KDH F TSLFTQF E DFWLF RK Q F ASQYSSFVFMS Y M 3561
Cdd:pfam00454 77 P TAMVKILH ----------- S A LNYPK LK L E -- FESRISLP P KVG L LQW F VKKSPDA E EWGEA RK N F VRSCAGYSVLD Y I 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3562 MMINN R TPHK I H VDKT S G NV F TLE mlpsrfpyervkpllkn HD L S LP PDSPIFHNN E P VPFRLT PNIQSLI G D S AL EG I F 3641
Cdd:pfam00454 144 LGNGD R HLDN I L VDKT T G KL F HID ----------------- FG L C LP DAGKDLPFP E K VPFRLT REMVYAM G P S GD EG L F 206
250 260 270
....*....|....*....|....*....|....*
gi 6321891 3642 AVNLF T ISR AL IEPD N E L NTY L A L FIR D EIIS W FS 3676
Cdd:pfam00454 207 RELCE T AYE AL RRNL N L L TNL L K L MVA D GLPD W SI 241
FATC
pfam02260 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3713-3744
9.71e-03
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 36.21
E-value: 9.71e-03
10 20 30
....*....|....*....|....*....|..
gi 6321891 3713 P TVTTQFILDC I GS A VS P R NLA RTDVNFM PW F 3744
Cdd:pfam02260 1 P LSVEGQVDEL I QE A TD P E NLA QMYIGWC PW W 32
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
947-2612
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1369.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 947 RILGKLGGRNR Q FLK P P TD L TEKTEL D IDAIADFKIN G M P E D VP L SVT P GIQS A LNI L Q S YK S DI HYRK S A YKY L TCV L L 1026
Cdd:pfam20206 1 RILGKLGGRNR R FLK E P PK L EYRDAG D EASLTVELEF G A P S D QT L PLD P AVDL A KRT L R S ST S LP HYRK Q A FEL L KSA L A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1027 L MTK S S a EF P TNYTEL L KT A VNSIKLER I GI E K ----- N FDLEPTVN K RDYSN QE N LF LRL L ESV F Y A T SIKEL KDD A MD 1101
Cdd:pfam20206 81 L LLD S D - DS P DDLLAR L QA A IQPLLEVK I ES E A psdls N LNTDDSAA K AKAEE QE E LF KQA L KGL F F A A SIKEL RAE A LP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1102 L L NN LL D HF C LL QVNTTLLNKRNYNGT FN IDL knpnf M LD SSLIL DAI PFA LS YYIP E V R EV G VLAY K R I YEKSCLIY G E 1181
Cdd:pfam20206 160 F L KG LL R HF T LL ELAEEIGPFKESRRR FN LEG ----- P LD PLVFI DAI VES LS SESK E L R DA G ESVL K L I LDTLVTLL G S 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1182 --- ELA L SHSFIPE LA KQ F I HLCY D E TY Y N K R GG V LGI KV L IDNVKSSSVFLKKY Q YNLANG LLFVLKD TQS E A PS AIT D 1258
Cdd:pfam20206 235 kev VDQ L NEPLFHY LA SR F C HLCY E E AW Y R K L GG C LGI RI L LERLDLGLKWVLDH Q LEFVRA LLFVLKD MPP E V PS GNV D 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1259 S A EKL L IDL L ------- SI T FADVKEEDLGNKV L ENTLTDI V C ELS NA N PK VR NAC QK S L HTISN LTGIP IVK L MDHS K Q 1331
Cdd:pfam20206 315 D A KDT L LFI L kvcntpp KS T PKTTEGTAKQRSK L NTLVGLL V S ELS SS N EI VR ETA QK A L ELLAE LTGIP VTE L LEPV K E 394
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1332 F LL S PIF A KPLRALPF T MQIG NV DAITFCLSL PNTF L T FNEEL F RLL Q E SIV LADAED ES L stn IQKTTE Y STSE QL V QL 1411
Cdd:pfam20206 395 R LL Q PIF T KPLRALPF P MQIG HI DAITFCLSL RPPL L E FNEEL V RLL H E ALA LADAED AA L --- VGRNPQ Y KNLT QL I QL 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1412 R I ACI K LL AI A LKNEE F ATAQ Q G N I R I RI LA VFFK TMLKT SPE IINTTYEA LK GS LA ENS KLPK E LLQ N GL K P L LMNLSD 1491
Cdd:pfam20206 472 R V ACI R LL SA A MACPD F LAPK Q V N T R N RI IS VFFK SLYSR SPE VVDAAHDG LK QV LA QQQ KLPK D LLQ T GL R P I LMNLSD 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1492 H QK LTV P GL DA L SK LLELL IA YFKVEIG R KLLDHL TA W CRV E V L DTLFGQD L A E QMPT KI IVS I I NIFHLLPP Q A DM FL N 1571
Cdd:pfam20206 552 H KR LTV A GL EG L AR LLELL TN YFKVEIG E KLLDHL RK W ADP E M L QEASLKP L E E NEEV KI AAA I L NIFHLLPP A A SK FL E 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1572 DL LLK V ML LE RK LR LQLD SPFR T PLA R YLNR FHNPVT E Y F KKNMTLRQLVLFMCN I VQR P E A KE L AEDFEKELDNFYDF - 1650
Cdd:pfam20206 632 DL VKL V IQ LE AV LR RYVS SPFR E PLA K YLNR YPEEAV E F F LERLSDPRYSRLFRD I LKS P D A EP L RAEVSSKPSRVSLL n 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1651 YISNIPKNQVRVVSFF t NMVDLFN T M V IT N GD e WL KKKGNMILK L KDMLNLTLKTIK - E N SFYID H L Q LNQSIAKFQALY 1729
Cdd:pfam20206 712 IKLFLETADSKTALRY - QGLLIVR T L V KL N PN - WL PSNNDVLQA L LQLWRSLHRLQR l G N EDSLI H F Q QLRESKLLLKIL 789
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1730 L RFTELSER D QNP L -------- L LDFI DFSF sngikasys L KK F IFHNIIASSNK E - K QNNFINDATL F VLSDKCL D ARI 1800
Cdd:pfam20206 790 L QYLRQNPD D IDL L fdlleift L PTVT DFSF --------- L RD F LYEEVALKYSV E q K RAILLRFLEM F PDPTTSQ D LKV 860
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1801 FV L KNV IN ST L IYEVATSG S l K SY LV E dkk PKWLEL LH N KIWK NSNAILA y D VLDHH D LF R F ELLQLS AIFIKADP E I I A 1880
Cdd:pfam20206 861 KA L RHL IN PI L AASFERGE S - K EE LV D --- ADVIDQ LH A KIWK PLQLAGD - D ATFSD D GL R I ELLQLS TLLVEYAS E L I G 935
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1881 E IK KD I IKF C WNF I KL E D TLI KQ S AY LVTSY FI SK FD F P I K V V T QV F VALL RSSHV E A R Y LV K Q S LD V L T P V L HE R MNAA 1960
Cdd:pfam20206 936 E NR KD L IKF A WNF L KL D D PTV KQ A AY VLIAR FI EA FD T P P K I V L QV Y VALL KAHQP E G R A LV R Q A LD I L A P A L PK R LPEN 1015
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1961 GTPD TW IN W V KR VM VE -- N S SS Q NNIL YQ FLIS HPDLF FNS R D LF ISNIIHHMN K ITFMS N SNSDSHT LA I DLA S LI LY W 2038
Cdd:pfam20206 1016 PGYP TW VK W T KR IL VE eg H S IP Q LVHI YQ LIVR HPDLF YPN R E LF VPHMVTSLQ K LGLPP N ATTETRK LA V DLA E LI IR W 1095
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2039 E NKTL E ITN V NNTKTDSD G DVVMSDSKSDINPVEADTTAIIV ------- D ANN N S PI S L H LRE ACTA FLIR YV C A S NHRA 2111
Cdd:pfam20206 1096 E RRRS E SMD V SESSNEES G GDKQTVPLDSSSSPKSFASSSAS adptmga D DSS N Y PI P L S LRE TVVN FLIR FA C T S TEDS 1175
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2112 IETE L GL RA INI L SE L I S DKH W TN V NV KL VY FEK F L IFQDLDSEN I LYY C m NAL DV L YVFFKN K TKE WI ME NL PTI Q N LL 2191
Cdd:pfam20206 1176 SSKG L SA RA LEL L KD L L S PDL W PD V SI KL SF FEK V L AQTEVSENS I PQI C - NAL EI L NIVLEV K PNA WI IS NL SQL Q K LL 1254
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2192 EKC I KSD HHDV QEAL QKV L QV I MK A IKAQGVS vi I E EESPGKT F IQMLTSV IT QD L Q -- ETSSVTAGVT L AWVLFMNF PD 2269
Cdd:pfam20206 1255 EKC L KSD NPKI QEAL RPI L KR I LE A LPVSVEG -- S E DAEEVSS F YKFIETI IT EG L S sl TNTGLLGTLS L LSAWAKHR PD 1332
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2270 N I V P LLTP LMK TFS KL C K D HL --- S ISQPKDAMALEEARI T TK LL E K V L YI L S L K VS L LG DS RR P FLS TVAL LI DH S M D Q 2346
Cdd:pfam20206 1333 Y I D P FIPS LMK VLQ KL V K E HL aan S QDASSSSASPPPFES T AE LL I K T L EL L K L R VS H LG EQ RR W FLS ALVQ LI EK S N D V 1412
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2347 NF LR K I VN M S R S WI F - N TE I FPT V KEKA AI L T KM LA FE I RG EPS LS KL F YEIV L KLFDQEHFNNT E I TVR M E QP FL V G T R 2425
Cdd:pfam20206 1413 EL LR T I LD M V R E WI K e Q TE G FPT I KEKA GL L V KM MS FE F RG DAA LS AD F LDLI L DIYEDPALARS E L TVR L E PA FL M G L R 1492
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2426 VE D IG IRK R F MT I L DNSL E R DIK ERL Y Y VIRD QNWE FIA D YP W LN QAL Q LL Y GS FNREKE LSL KNIYCLS P P si L QEYLP 2505
Cdd:pfam20206 1493 SS D PK IRK K F FA I F DNSL S R SLA ERL L Y ILGV QNWE SLG D HY W IK QAL D LL L GS VDKDNP LSL SESSASI P S -- L TALEE 1570
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2506 ENA E MVT E VN D L EL SNFVK GH I A SMQG L CRIISS D FI D S L IEIFY QD PKAI H RA WV T LFP QVYKSIPKN E KYGFVRS I IT 2585
Cdd:pfam20206 1571 ADK E ESY E ME D D EL DKLLS GH R A FLDE L RSVTLG D LL D P L RQLLH QD SNLT H KL WV S LFP AAWSALSRR E QEDLTKA I VP 1650
1690 1700
....*....|....*....|....*..
gi 6321891 2586 LLSK P YH TR Q ISS R T NVI NM LL DSISK 2612
Cdd:pfam20206 1651 LLSK D YH SK Q ADK R P NVI QT LL EGVAR 1677
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
1232-3744
0e+00
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 1354.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1232 KYQYNLANG L LFV LKD TQS E APSAIT D s AEKL L I DLL SIT F A D V KE E D L gnkvlentltdivc E LSN A N PK VRN AC Q KS L 1311
Cdd:COG5032 1 DRLAQIIYA L PSL LKD CFT E ILLRKS D - VRSS L F DLL HVS F L D Y KE K D E -------------- R LSN V N DL VRN ST Q SL L 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1312 H TISNL tg I P IVK LMDHS K Q F L LSPIFAK p LRALP F T M q I GNVD A I T F CLSL PNTF L tfneelfrllqesivlad A E DES 1391
Cdd:COG5032 66 N TISNL -- I K IVK FVLPL K S F F LSPIFAK - LRALP M T K - I LCIS A D T Y CLSL SIKA L ------------------ A D DES 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1392 L S T NIQKTT E YSTS eqlv Q L RIACIKL L A I A L KNEE F AT AQ QGN iririlav FFK TM L KTSP EI INTT YEAL KGS L A EN S 1471
Cdd:COG5032 124 L T T ILKTIR E LLSK ---- F L LRLRLLF L F I G L LAQK F SE AQ SKL -------- FFK LL L SILK EI LSDA YEAL LND L L EN L 191
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1472 K LP KE L LQN G L K PLL M N L SD H qkltvpgldalskllelli A YFKVEIGRKLLDHL T A W crvevldtlf GQ D L AE Q MPT KI 1551
Cdd:COG5032 192 K SL KE T LQN R L L PLL F N I SD G ------------------- N YFKVEIGRKLLDHL N A L ---------- GQ I L DC Q KIA KI 242
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1552 IV S iini F HL LP PQADM FLN D LL L KV M llerklr LQ L D S P FR TP L AR YL NR F HNPVTEY F KKNM tlrq LV LF MCNIVQR P 1631
Cdd:COG5032 243 TK S ---- F RS LP VIIKK FLN L LL I KV S ------- YY L P S F FR LS L LS YL DH F ETDLFKT F LVTS ---- CF LF FVDEICK P 307
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1632 E AKE LAE DFEKE L DN F YD fy I SN I PKNQVRVV S FF t NMVDLFNTMVITNG D EWLKKK G NMIL K LKDMLN L T L kti KENSF 1711
Cdd:COG5032 308 E SEH LAE EVSEK L SK F LT -- I EI I DSFPEIRI S AL - SSLLVIFDYHLALP D AVRLLF G ESND K VFLISE L A L --- DSTGR 381
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1712 YIDH L QLNQSIAK F QA L YLRF T E L SE rdq NP L L L D F IDFSFS ngikasyslkkfi FH N I I A SSN KEKQNN fi NDATLFVL 1791
Cdd:COG5032 382 LLRV L PARVLPSL F EF L LSLL T V L KI --- SG L I L E F EISAQL ------------- LC N L I R SSN QLLTSL -- ISPYFLFI 443
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1792 SD KC L D AR ifvlknvi NS TLI Y E V ATS G S LK SY L VE D KKPKW le LLHNKIWKNSNAI L AYD V ldhhdlfrfellqlsaif 1871
Cdd:COG5032 444 LP KC I D SS -------- NS EIS Y R V ENL G E LK DI L GL D RITDY -- QALSLRLIIVSIQ L RSF V ------------------ 495
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1872 ik ADP E I I AE I K K DIIK fcw NF IK LEDT likqsaylvtsy FISKF D F PIK V VT Q V F VALLR s SHV E ARYL V KQ S L D vlt P 1951
Cdd:COG5032 496 -- FKR E A I NQ I F K QLAS --- IV IK PFLD ------------ YPKRL D L PIK I VT V V Y VALLR - RPT E KLSG V LG S I D --- K 554
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 1952 VL H ERMNAAGTP D TW i NWVKR V MV ensss Q NNIL Y Q F LI S HP DL F F NSR D lfi SNI I HHMNKITFMSNSNSD sh TL AI D L 2031
Cdd:COG5032 555 YS H IESEEMSSS D FP - WTKNP V GL ----- Q LLAV Y G F IR S ID DL Y F TVS D --- PTL I EILKLPVLSIVHSAI -- IE AI M L 623
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2032 AS L I L YW E NKTL E IT N vnntkt D S DGDVVMSD S K SDI NPVEADTTAI IV D A NNNSPI S LHLREACTAF L IRYVCAS nhra 2111
Cdd:COG5032 624 IK L S L GS E SSQF E DL N ------ P S FLYIFSNN S I SDI LFYFQNFLEL IV I A FFPLIR S EIIGIVLISS L FSKTWIL ---- 693
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2112 iete L G L RA I NIL S E LIS D khw TNVNV K LVYFE kflifqd L DSENILYYCM n A LDV L Y VFFK nkt KEWIMEN L PTIQNL L 2191
Cdd:COG5032 694 ---- L K L LL I AFI S K LIS A --- LQGEL K MLAPT ------- L FTLFLVLVER - Y LDV E Y SSVS --- FKLLLVI L VYFGGN L 755
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2192 E K ciks DHHDVQE alqkvlqvimkaikaqgvsviieeespgkt F I Q ML TSVITQD LQE TSSVT ag VTLAWVL F M N FPD N I 2271
Cdd:COG5032 756 E S ---- LVLLILD ------------------------------ L I V ML VEYTELG LQE SIFIE -- RLSQFFK F K N LSE N A 799
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2272 VP LL T PLM KTF SK L ckd H LSISQPK D AMALEEARIT T kl LEKVLY I L s LKV S L LGDSRR P FLS TV A L L I D H S MDQNF L RK 2351
Cdd:COG5032 800 SR LL P PLM DNL SK S --- H ELRCVSE D DVSALLIQLL T -- DRVICF I P - VIN S S LGDSRR I FLS LL A Q L L D D S LKEES L PY 873
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2352 IV N MS R SWIF n T E I F P TVK E KA AI L TKMLAFEIRGEPSLS kl FYEIV LK L F D QE HFN N TEITVRM E Q P flvgtrvedigi 2431
Cdd:COG5032 874 NL N VD R GTDL - R E F F Q TVK S KA EV L SMLPFVQSILFEAWN -- RVDFL LK D F W QE ELD N LLVALLK E L P ------------ 938
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2432 rkr FM TIL D N S LER D I kerl Y YVIRDQN W EFIADYP WL NQAL qllyg S FN R EKEL SLK NIYC L SPPS IL QEYLPENAEMV 2511
Cdd:COG5032 939 --- FM ALR D C S ILS D L ---- Y FMLGREL W NSVSFEC WL ELMN ----- S YK R LLIK SLK SKLH L PTIP IL ILQMLLDSKNL 1006
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2512 TE VNDLE L S N FV kghias MQG L CRI issd F ID SL IEIFY qdp K AI H RAWVTL FP Q vyksipkneky G FV R S II TLLS KP Y 2591
Cdd:COG5032 1007 TE FTEHQ L K N LP ------ LPS L SIG ---- F YE SL CSFLA --- K LL H DEELYF FP L ----------- L FV S S LE TLLS VN Y 1062
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2592 H TR Q ISS R T N v I NMLLD S ISKI esl E L P PHLVKYL AIS Y N A WYQSINI L ESIQSNTS I DN TK IIEANEDAL LELY VN L Q E 2671
Cdd:COG5032 1063 H IN Q LDL R P N - I LKHFG S FVRF --- Q L K PHLVKYL QRW Y E A LNRYFEL L SKGDRLFA I SF TK LRNVDALGK LELY SS L A E 1138
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2672 E DMF YG L W RRR a K YT ET NIGLS YEQ I G L W D KAQQLYEVAQ V KARS GAL P Y S q SE Y AL W ED N W I Q CA E KLQ H wd VL T EL AK 2751
Cdd:COG5032 1139 I DMF LS L H RRR - K LL ET LVATA YEQ V G E W Y KAQQLYEVAQ R KARS KEF P F S - LQ Y LY W HI N D I D CA D KLQ S -- VL A EL SL 1214
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2752 HE G FTD LLLE CG WR V A DWNSDR D A LE QSVKSVM D VPTPRRQM F KTFLA L QNF AE SRKGDQ E V R KL C DEG I Q LSL IK W VS L 2831
Cdd:COG5032 1215 VT G ISE LLLE ES WR R A LFSNIK D S LE SELEEII D GMYKSNED F GALML L SLS AE LWDKIL E G R SS C SKS I K LSL NI W LD L 1294
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2832 P I RYT P AHKW ll HG F QQYM E FL EA TQ I YAN L HTTTV Q N L DS K AQ EIK RI L QAW RDRLP NT W DDVNMWND L V TWRQ H AF QV 2911
Cdd:COG5032 1295 S I VVS P KDEP -- EL F IKFV E LC EA SS I RSK L LEKNI Q E L LE K LE EIK SP L GTL RDRLP PP W ALLDLKRL L A TWRQ N AF LR 1372
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2912 IN NAY LPL IPA L QQSN S N S NINTHAY RG YH E I A WV IN R FA H VARKH NM PD vci S QL AR IY T L P NI E I Q EAFL K LR EQAK C 2991
Cdd:COG5032 1373 IN PEL LPL LSS L LNLQ S S S LSKQLVS RG SS E S A IS IN S FA S VARKH FL PD --- N QL KK IY Q L S NI L I S EAFL L LR YLLL C 1449
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2992 HYQNM n EL TT GL D V ISN TNL VY F GTV Q KA EFF T lkgmflsklrayeeanqafatavqidlnlakawaq WG FFNDRRLSEE 3071
Cdd:COG5032 1450 RLGRR - EL KA GL N V WNL TNL EL F SDI Q ES EFF E ----------------------------------- WG KNLKLLSIIP 1493
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3072 P NNIS F A SNA I SCYLQ AAG L Y K NSKIR ELL CRI L wli S ID DA S G MLTNA F DS F RG EI P V wyw I T FIPQLL T SLS HKEA N M 3151
Cdd:COG5032 1494 P IEEI F L SNA L SCYLQ VKD L L K KLNLF ELL GSL L --- S AK DA A G SYYKN F HI F DL EI S V --- I P FIPQLL S SLS LLDL N S 1567
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3152 VRHI L IR I A K SY PQAL H F Q LR TTK E DF A VIQRQTMAVMGD K PD T N D RNGRRQPW E YLQ E LNN I lkt AYPLL A L SL E SLV A 3231
Cdd:COG5032 1568 AQSL L SK I G K EH PQAL V F T LR SAI E ST A LSKESVALSLEN K SR T H D PSLVKEAL E LSD E NIR I --- AYPLL H L LF E PIL A 1644
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3232 Q IND R FK S TTDE dlfr LINV LLID GT L NYN R LP FP RKNP k L PENTEKN L VKFSTTLL a PY IR P KF NA D FIDNKPDYET YI 3311
Cdd:COG5032 1645 Q LLS R LS S ENNK ---- ISVA LLID KP L HEE R EN FP SGLS - L SSFQSSF L KELIKKSP - RK IR K KF KI D ISLLNLSRKL YI 1718
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3312 KR LR YW R R RL ENK L DRAS KK enlev LC P H L SN FH H qk F ED I EI PGQYLL N K D nnvh F IK I A RF L P T V DF V RGTHSSY RRL 3391
Cdd:COG5032 1719 SV LR SI R K RL KRL L ELRL KK ----- VS P K L LL FH A -- F LE I KL PGQYLL D K P ---- F VL I E RF E P E V SV V KSHLQRP RRL 1787
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3392 M IRG H DG SVH SF A V QY pa VRHS R RE E RMF QL Y RL F NK S L S K NV ETRRR SIQFNLPIA IPLSP QVR I MNDSVSFT TLH E I H 3471
Cdd:COG5032 1788 T IRG S DG KLY SF I V KG -- GDDL R QD E LAL QL I RL M NK I L K K DK ETRRR DLWIRPYKV IPLSP GSG I IEWVPNSD TLH S I L 1865
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3472 N E FC K K K GFDP D DIQDFM A DK lnaahddalp APDMTI LK V E I F N s IQ T MFV P S n VL K D H F TSL F TQF ED FWLF R KQ FA SQ 3551
Cdd:COG5032 1866 R E YH K R K NISI D QEKKLA A RL ---------- DNLKLL LK D E F F T - KA T LKS P P - VL Y D W F SES F PNP ED WLTA R TN FA RS 1933
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3552 YSSFVFMS Y MMMINN R T P HK I HV D KT SG N V FTLEML psrfpyervk PL L K N HDLSL P P dspifhn N E P VPFRLT P NI QSL 3631
Cdd:COG5032 1934 LAVYSVIG Y ILGLGD R H P GN I LI D RS SG H V IHIDFG ---------- FI L F N APGRF P F ------- P E K VPFRLT R NI VEA 1996
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3632 I G D S AL EG I F AVNLF T IS RAL IEPDNE L NTY L A LF I RD EI I S W F snl HR P IIENP Q LR E M V QTN v DLIIR K VAQLGHLNS 3711
Cdd:COG5032 1997 M G V S GV EG S F RELCE T AF RAL RKNADS L MNV L E LF V RD PL I E W R --- RL P CFREI Q NN E I V NVL - ERFRL K LSEKDAEKF 2072
2490 2500 2510
....*....|....*....|....*....|...
gi 6321891 3712 TPTVTTQFILDC I GS A VS P RN LA RTDVNF MP WF 3744
Cdd:COG5032 2073 VDLLINKSVESL I TQ A TD P FQ LA TMYIGW MP FW 2105
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
290-935
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 736.36
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 290 A Y C DFI L AQ I K AT SFLAY V f I RG Y A p E F L QD Y VNFV P DLII RLLQDCP S E L SS A RKELL H ATRHILST NYKKL F L P KL D Y 369
Cdd:pfam20175 1 L Y G DFI A AQ V K TL SFLAY L - L RG F A - E Q L RP Y QDKL P EIVV RLLQDCP P E A SS T RKELL V ATRHILST EFRSG F V P HI D L 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 370 L F DE RI LIG N G F T MH ETLRPLAYS TV AD F IH NI R S EL QLSEIE K TIK IY TGY L L D ES L ALTV Q I MSAKLLLNLV ER I L K L 449
Cdd:pfam20175 79 L L DE KV LIG T G V T SY ETLRPLAYS ML AD L IH HV R A EL SIEQLS K VVS IY SKN L H D PT L PPSI Q T MSAKLLLNLV DS I V K K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 450 GKEN PQEA pra KK LL MI I IDSYMNRF K T LNR Q Y DTIM K YYGRYETH K K EK -- A EKLKNSIQDN D KESE E FM rk VL E PSDD 527
Cdd:pfam20175 159 DDKD PQEA --- RD LL VR I LETFVEKL K S LNR Y Y PPLL K QHRKKKSE K E EK ts A DVDADEDRPA D IDTV E YL -- AI E RAKP 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 528 DHLMPQ P KK edindspdvemtesdkvvkndvemfdiknyapilllpt PTN DP I KDA FY L YR TL MSF LKTII HD L KVFN P P 607
Cdd:pfam20175 234 IEGIQF P SP -------------------------------------- SPV DP L KDA RF L FK TL LHG LKTII WG L RNCQ P T 275
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 608 P N ey TVAN P KL W A SV S R VFSY EEV IV F KD LF H E CIIGLKFFK dhneklsp ETTKKHFDI S MP S LPVSAT K DAR E LMDYL A 687
Cdd:pfam20175 276 P P -- QQNA P SG W N SV A R GLPP EEV DI F IR LF K E GVKCFDLYS -------- INKDPPTTA S SS S ISRTSS K EEK E VLELF A 345
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 688 FM F MQM D N ATF N E IIEQEL PF VY ER M LE DSG LL HVA Q S FL TSEIT SP N FA G ILLRFL KGK L K DLG NV D FNT S N VL I RLFK 767
Cdd:pfam20175 346 SI F TIL D P ATF Q E VFTSRM PF LF ER I LE NPA LL AIP Q F FL SNDSV SP R FA S ILLRFL VDR L E DLG AA D KKK S S VL L RLFK 425
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 768 L S FM S V N LFP NI NE V VL L PHL ND LIL N SLK YSTT A E EPL V YF Y L I R T LFRSIGGGRFE N LY RSIK P I L Q VLL QS LN QMIL 847
Cdd:pfam20175 426 L A FM A V T LFP EE NE A VL Q PHL PK LIL T SLK LALK A K EPL N YF L L L R A LFRSIGGGRFE L LY KEVL P L L P VLL EG LN RLLS 505
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 848 T A RL P HE R E L Y VELC I TVPVRLSVL A PYL PF LMKPLV F AL QQY P D LVSQGLRTLELC I DNLT A E YF DPI IE PVIDD VSK A 927
Cdd:pfam20175 506 S A HR P SM R D L F VELC L TVPVRLSVL L PYL SL LMKPLV L AL NSS P E LVSQGLRTLELC V DNLT P E FL DPI MQ PVIDD LMQ A 585
....*...
gi 6321891 928 L FNL L Q P Q 935
Cdd:pfam20175 586 L WKH L R P L 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3371-3676
1.64e-114
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 364.15
E-value: 1.64e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3371 IARFLP T V DF VR GTHSS YRRL M IRGHDGS VHS F A VQ Y P AV RHSRREER MF QL Y RL F N KS L SKNV ETRRR SI QF NL PI AI P 3450
Cdd:cd05163 1 IARFLP R V EI VR RHGTC YRRL T IRGHDGS KYP F L VQ T P SA RHSRREER VM QL F RL L N RV L ERKK ETRRR NL QF HV PI VV P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3451 LSPQVR IMN D SV S FTT L HE I HN efckkkgfdpddiqdfmadklnaahddalpapdmtil K V EI F N S IQ TMF VP SNV L KDH 3530
Cdd:cd05163 81 LSPQVR LVE D DP S YIS L QD I YE ------------------------------------- K L EI L N E IQ SKM VP ETI L SNY 123
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3531 F TSLFTQFE D F WLFRKQF AS Q YSSFV FM S Y MMMIN NRTPH K I HVDKTS GNVF TLEM LP srfpyervkpllknhdl S LPPD 3610
Cdd:cd05163 124 F LRTMPSPS D L WLFRKQF TL Q LALSS FM T Y VLSLG NRTPH R I LISRST GNVF MTDF LP ----------------- S INSQ 186
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321891 3611 S P IFH NNEPVPFRLTPNIQ SL IG DSAL EG IFAVNLFT I S RAL I EP DNE L NT YL A LF I RDE I ISW FS 3676
Cdd:cd05163 187 G P LLD NNEPVPFRLTPNIQ HF IG PIGV EG LLTSSMMA I A RAL T EP EYD L EQ YL S LF V RDE L ISW HK 252
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2757-3106
6.85e-83
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 277.31
E-value: 6.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2757 D L LL E CG WR VAD W NSD R DA L eqsvk S V M DVPT P RRQM F KTF LAL Q nfaes R KGDQ E VRKLCDEGI QL SLIKWVS L PIRYT 2836
Cdd:pfam02259 2 P L AA E AA WR LGQ W DLM R EY L ----- S L M KKDS P DKAF F EAI LAL H ----- R NQFD E AERYIEKAR QL LDTELSA L SGESY 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2837 PAHKW LL HGF QQ YM E FL E AT Q IY anlhtttv Q N L DSKAQ E I K RI LQ A WR D RLP NTW DDV NM W N D LV T W R QHAFQV I NNA Y 2916
Cdd:pfam02259 72 NRAYP LL VRL QQ LA E LE E II Q YK -------- Q K L GQSSE E L K SL LQ T WR N RLP GCQ DDV EI W Q D IL T V R SLVLSP I EDV Y 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2917 L P lipalqqsnsnsninthayr GYH EIA W V in R FA HV ARK HNMPDVCISQ L ARI ------------------ Y TL P NI E I 2978
Cdd:pfam02259 144 L G -------------------- GYH AEM W L -- K FA NL ARK SGRFSLAEKA L LKL lgedpeewlpevvyayak Y LW P TG E Q 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 2979 QEA F LKLRE QAK C HY Q NMN EL TT GL D VI SN TNL VY F GTVQ k A EFFT LKG MFLSK L RAY ------ EE AN QA FAT A V Q I D LN 3052
Cdd:pfam02259 202 QEA L LKLRE FLS C YL Q KNG EL LS GL E VI NP TNL EE F TELL - A RCYL LKG KWQAA L GQN waeeks EE IL QA YLL A T Q F D PS 280
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321891 3053 LA KAW AQ W GF FN DRR L SE E -------- P NNI S - FASN A ISC YL QAAG L Y k NSKIRELLC R I L W 3106
Cdd:pfam02259 281 WY KAW HT W AL FN FEV L RK E eqgkeeeg P EDL S r YVVP A VEG YL RSLS L S - SENSLQDTL R L L T 342
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3405-3677
1.89e-63
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 217.17
E-value: 1.89e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3405 V QYPAVRHS R RE ER MF QL Y RL F NK S L S K NV ETRRR SIQFNLPIA IP LS P QVRIMNDSVSF TTLHEI HN E FC K K KG FDP D d 3484
Cdd:smart00146 1 V IFKGGDDL R QD ER VL QL L RL M NK L L Q K DK ETRRR DLHLRPYKV IP TG P KSGLIEVVPNS TTLHEI LK E YR K Q KG KVL D - 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3485 iqdfmadklnaahdda L PAPDM T I LK VEIFNSIQ T MFV P SN VL K D H FT SL F TQ - F ED FWLF RK Q F ASQYSSFVFMS Y MMM 3563
Cdd:smart00146 80 ---------------- L RSQTA T R LK KLELFLEA T GKF P DP VL Y D W FT KK F PD p S ED YFEA RK N F TRSCAGYSVIT Y ILG 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3564 INN R TPHK I HV DKT s G NV F TLEMLPSRFPYERV kpllknhdlslppdspi F HNN E P VPFRLTP NIQSLI GDS ALE G I F AV 3643
Cdd:smart00146 144 LGD R HNDN I ML DKT - G HL F HIDFGFILGNGPKL ----------------- F GFP E R VPFRLTP EMVDVM GDS GYF G L F RS 205
250 260 270
....*....|....*....|....*....|....
gi 6321891 3644 NLFTIS RAL IEPD N ELNTY L A L FIR D EIIS W F S N 3677
Cdd:smart00146 206 LCERAL RAL RKNS N LIMSL L E L MLY D GLPD W R S G 239
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3402-3676
1.02e-61
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 212.57
E-value: 1.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3402 SFAVQ Y PAVRHS R RE E RMF Q LYR L FNKS LSK NVETR RR siq FNLPIA IPL S P QVR I MNDSVSFT TL HE I HN E FCKK k G FD 3481
Cdd:pfam00454 1 GYGGI Y KVGDDL R QD E LIL Q VFK L MDEE LSK DNLDL RR --- LKPYSV IPL G P KCG I IEWVPNSE TL AY I LD E YGEN - G VP 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3482 P DDIQDFMA dklnaahddal P A PDMTI LK V E if NSIQTMFV P SNV L KDH F TSLFTQF E DFWLF RK Q F ASQYSSFVFMS Y M 3561
Cdd:pfam00454 77 P TAMVKILH ----------- S A LNYPK LK L E -- FESRISLP P KVG L LQW F VKKSPDA E EWGEA RK N F VRSCAGYSVLD Y I 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3562 MMINN R TPHK I H VDKT S G NV F TLE mlpsrfpyervkpllkn HD L S LP PDSPIFHNN E P VPFRLT PNIQSLI G D S AL EG I F 3641
Cdd:pfam00454 144 LGNGD R HLDN I L VDKT T G KL F HID ----------------- FG L C LP DAGKDLPFP E K VPFRLT REMVYAM G P S GD EG L F 206
250 260 270
....*....|....*....|....*....|....*
gi 6321891 3642 AVNLF T ISR AL IEPD N E L NTY L A L FIR D EIIS W FS 3676
Cdd:pfam00454 207 RELCE T AYE AL RRNL N L L TNL L K L MVA D GLPD W SI 241
PIKKc
cd05164 Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members ...
3371-3669
1.90e-19
Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members include ATM (Ataxia telangiectasia mutated), ATR (Ataxia telangiectasia and Rad3-related), TOR (Target of rapamycin), SMG-1 (Suppressor of morphogenetic effect on genitalia-1), and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP, ATM and TRRAP, C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints, genome surveillance, mRNA surveillance, and translation control. The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270708 [Multi-domain]
Cd Length: 222
Bit Score: 90.02
E-value: 1.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3371 IA R F L P T V D f VRGTHSSYRRLM I R G H DG SVHS F A V Q yp AVRHS R RE ER MF QL YR L F N KS L S K NV ETR R R SIQFNLPIAI P 3450
Cdd:cd05164 1 IA S F D P R V R - ILASLQKPKKIT I L G S DG KEYP F L V K -- GDDDL R KD ER VM QL FQ L L N TL L E K DK ETR K R NLTIRTYSVV P 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3451 LS P Q VRIMNDSVSF TTL H eihnefckkkgfdpddiqdfmadklnaahddalpapdmtilkveifnsiqtmfvps N VLK DH 3530
Cdd:cd05164 78 LS S Q SGLIEWVDNT TTL K -------------------------------------------------------- P VLK KW 101
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321891 3531 F TSL F TQFEDFWLF R KQFASQYSSFVFMS Y MMMINN R TPHK I HV D KTS G N V FTLEM lps RFPYERV K P L LKN hdlslppd 3610
Cdd:cd05164 102 F NET F PDPTQWYEA R SNYTKSTAVMSMVG Y IIGLGD R HLEN I LI D TKT G E V VHIDF --- GMIFNKG K T L PVP -------- 170
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 6321891 3611 spifhnn E P VPFRLT P NI QSLI G DSAL EG I F AVNLFTIS R ALIEPDNE L N T Y L AL F IR D 3669
Cdd:cd05164 171 ------- E I VPFRLT R NI INGM G PTGV EG L F RKSCEQVL R VFRKHKDK L I T F L DT F LY D 222
PIKKc_SMG1
cd05170 Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1; SMG-1 plays a critical ...
3618-3674
3.50e-04
Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1; SMG-1 plays a critical role in the mRNA surveillance mechanism known as non-sense mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) generated by genome mutations and by errors during transcription and splicing. SMG-1 phosphorylates Upf1, another central component of NMD, at the C-terminus upon recognition of PTCs. The phosphorylation/dephosphorylation cycle of Upf1 is essential for promoting NMD. In addition to its catalytic domain, SMG-1 contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain at the C-terminus. SMG-1 is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The SMG-1 catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270714
Cd Length: 304
Bit Score: 45.71
E-value: 3.50e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 6321891 3618 E P VPFRLT P NI QSLI G DSAL EG I F AVNLFTISRA L IEPDNE L N T Y L AL F IR D EIIS W 3674
Cdd:cd05170 246 E K VPFRLT Q NI EHAL G PTGV EG T F RLSCEQVLKI L RKGRET L L T L L EA F VY D PLVD W 302
FATC
pfam02260 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3713-3744
9.71e-03
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 36.21
E-value: 9.71e-03
10 20 30
....*....|....*....|....*....|..
gi 6321891 3713 P TVTTQFILDC I GS A VS P R NLA RTDVNFM PW F 3744
Cdd:pfam02260 1 P LSVEGQVDEL I QE A TD P E NLA QMYIGWC PW W 32
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
