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Conserved domains on  [gi|6323831|ref|NP_013902|]
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Mmt1p [Saccharomyces cerevisiae S288C]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 11414568)

cation diffusion facilitator (CDF) family transporter facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
160-479 3.51e-50

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


:

Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 173.37  E-value: 3.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  160 GVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVST 239
Cdd:COG0053   1 GRRAALASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  240 ILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAhtysedIIedvtdinaawiaaasiaAKEWIFRATRKIAINTNSN 319
Cdd:COG0053  81 LILLAGLFILYEAIERLLHPEPVEPSGLGLAVLLIS------IV-----------------VNEALARYLRRVGKKTGSP 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  320 VLMANAWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRylEIETLV 399
Cdd:COG0053 138 ALKADALHDRSDALTSLGVLIGLLLALLTGWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVE--RIRAII 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  400 KDTLNKLisnnnsqkpyGLKELTLLSSGPNLRGHLTLEVPlqkwGNiLGVNEFEIVTHHLRNVLTNEVSNLRRLDIeYVE 479
Cdd:COG0053 216 LSVPGVI----------GVHDLRTRKSGPRIFVDLHIEVD----PD-LTVEEAHDIADRIEAALREEFPGVADVTI-HVE 279
 
Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
160-479 3.51e-50

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 173.37  E-value: 3.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  160 GVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVST 239
Cdd:COG0053   1 GRRAALASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  240 ILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAhtysedIIedvtdinaawiaaasiaAKEWIFRATRKIAINTNSN 319
Cdd:COG0053  81 LILLAGLFILYEAIERLLHPEPVEPSGLGLAVLLIS------IV-----------------VNEALARYLRRVGKKTGSP 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  320 VLMANAWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRylEIETLV 399
Cdd:COG0053 138 ALKADALHDRSDALTSLGVLIGLLLALLTGWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVE--RIRAII 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  400 KDTLNKLisnnnsqkpyGLKELTLLSSGPNLRGHLTLEVPlqkwGNiLGVNEFEIVTHHLRNVLTNEVSNLRRLDIeYVE 479
Cdd:COG0053 216 LSVPGVI----------GVHDLRTRKSGPRIFVDLHIEVD----PD-LTVEEAHDIADRIEAALREEFPGVADVTI-HVE 279
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
173-371 4.28e-34

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 127.00  E-value: 4.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    173 GIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSS 252
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    253 LCALVGPV----IPHTIIDTIGNLGhahtysediiedvtdinaawiaaasiaAKEWIFRATRKIAINTNSNVLMANAWHH 328
Cdd:pfam01545  81 IQRLLSPGeeidPGLALILALVSLL---------------------------VNLFLLLYLRRAARRIRSPALKADALHA 133
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 6323831    329 RVDSLTSLVALVAISTGYLVNIQS---LDTIGGLIVSGLIIKAGGE 371
Cdd:pfam01545 134 LSDVLASLGVLISALLIYLGPITGgllADPLASLLIGLLILYTALR 179
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
173-390 1.12e-26

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 108.85  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    173 GIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSS 252
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    253 LCALV-GPVIPHT---IIDTIGNLghahtysediiedvtdinaawiaaasiAAKEWIFRATRKIAINTNSNVLMANAWHH 328
Cdd:TIGR01297  81 IERLInPEPEIDGgtmLIVAIVGL---------------------------IVNLILALYLHRVGHRLGSLALRAAALHV 133
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323831    329 RVDSLTSLVALVAIStGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDP 390
Cdd:TIGR01297 134 LSDALSSVGVLIGAL-LIYFGWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDL 194
PRK03557 PRK03557
CDF family zinc transporter ZitB;
169-253 2.86e-03

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 39.73  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831   169 GVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISI 248
Cdd:PRK03557  26 GVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILI 105

                 ....*
gi 6323831   249 GWSSL 253
Cdd:PRK03557 106 VWEAI 110
 
Name Accession Description Interval E-value
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
160-479 3.51e-50

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 173.37  E-value: 3.51e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  160 GVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVST 239
Cdd:COG0053   1 GRRAALASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIVAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  240 ILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAhtysedIIedvtdinaawiaaasiaAKEWIFRATRKIAINTNSN 319
Cdd:COG0053  81 LILLAGLFILYEAIERLLHPEPVEPSGLGLAVLLIS------IV-----------------VNEALARYLRRVGKKTGSP 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  320 VLMANAWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRylEIETLV 399
Cdd:COG0053 138 ALKADALHDRSDALTSLGVLIGLLLALLTGWPWLDPIAAILIGLLILKVAYKLARESLSLLMDEALDEELVE--RIRAII 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  400 KDTLNKLisnnnsqkpyGLKELTLLSSGPNLRGHLTLEVPlqkwGNiLGVNEFEIVTHHLRNVLTNEVSNLRRLDIeYVE 479
Cdd:COG0053 216 LSVPGVI----------GVHDLRTRKSGPRIFVDLHIEVD----PD-LTVEEAHDIADRIEAALREEFPGVADVTI-HVE 279
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
173-371 4.28e-34

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 127.00  E-value: 4.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    173 GIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSS 252
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    253 LCALVGPV----IPHTIIDTIGNLGhahtysediiedvtdinaawiaaasiaAKEWIFRATRKIAINTNSNVLMANAWHH 328
Cdd:pfam01545  81 IQRLLSPGeeidPGLALILALVSLL---------------------------VNLFLLLYLRRAARRIRSPALKADALHA 133
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 6323831    329 RVDSLTSLVALVAISTGYLVNIQS---LDTIGGLIVSGLIIKAGGE 371
Cdd:pfam01545 134 LSDVLASLGVLISALLIYLGPITGgllADPLASLLIGLLILYTALR 179
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
173-390 1.12e-26

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 108.85  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    173 GIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSS 252
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    253 LCALV-GPVIPHT---IIDTIGNLghahtysediiedvtdinaawiaaasiAAKEWIFRATRKIAINTNSNVLMANAWHH 328
Cdd:TIGR01297  81 IERLInPEPEIDGgtmLIVAIVGL---------------------------IVNLILALYLHRVGHRLGSLALRAAALHV 133
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323831    329 RVDSLTSLVALVAIStGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDP 390
Cdd:TIGR01297 134 LSDALSSVGVLIGAL-LIYFGWHWADPIAALLISLLILYTAFRLLKESINVLLDAAPDEEDL 194
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
162-369 4.12e-19

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 87.48  E-value: 4.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  162 RITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTIL 241
Cdd:COG1230  18 RRLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANALLL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  242 AMAGISIGWSSLCALVGPVIPHT----IIDTIG---NLGHAhtysediiedvtdinaawiaaasiaakeWIFRATRKiai 314
Cdd:COG1230  98 LVVAGYILYEAIQRLFNPPPVAGggmlVVAVIGlvvNLVSA----------------------------WLLHRGSK--- 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6323831  315 nTNSNVLMANaWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAG 369
Cdd:COG1230 147 -HDLNLRGAY-LHVLADALGSVAVIVAALVILFTGWTWLDPLLSLLIALLILRSA 199
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
158-269 4.02e-06

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 48.37  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    158 NAGVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAAnkptadypYGYGKIETVGSLAV 237
Cdd:TIGR01297  94 GTMLIVAIVGLIVNLILALYLHRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIY--------FGWHWADPIAALLI 165
                          90       100       110
                  ....*....|....*....|....*....|..
gi 6323831    238 STILAMAGISIGWSSLCALVGPVIPHTIIDTI 269
Cdd:TIGR01297 166 SLLILYTAFRLLKESINVLLDAAPDEEDLEEI 197
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
150-261 4.79e-06

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 48.29  E-value: 4.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831  150 LSTEQirknagvRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKI 229
Cdd:COG3965   1 SRTEQ-------RLLKLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGYWHL 73
                        90       100       110
                ....*....|....*....|....*....|..
gi 6323831  230 EtvgslavSTILAMAGISIGWSSLCALVGPVI 261
Cdd:COG3965  74 E-------PLVLAIKGLILLLLCLYALVNAVG 98
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
166-257 3.05e-04

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 41.87  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831    166 VGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPtadyPYGYGKIETVGSLAVSTILAMAG 245
Cdd:pfam01545 102 VSLLVNLFLLLYLRRAARRIRSPALKADALHALSDVLASLGVLISALLIYLGP----ITGGLLADPLASLLIGLLILYTA 177
                          90
                  ....*....|..
gi 6323831    246 ISIGWSSLCALV 257
Cdd:pfam01545 178 LRLLKESLSILL 189
PRK03557 PRK03557
CDF family zinc transporter ZitB;
169-253 2.86e-03

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 39.73  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323831   169 GVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISI 248
Cdd:PRK03557  26 GVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILI 105

                 ....*
gi 6323831   249 GWSSL 253
Cdd:PRK03557 106 VWEAI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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