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Conserved domains on  [gi|28559037|ref|NP_032402|]
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GTPase IMAP family member 1 [Mus musculus]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 27-229 1.07e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 298.68  E-value: 1.07e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  27 LRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPrTDPGCVETARCFVL 106
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 107 SAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDnRALRDLVAECGGRVCA 186
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 28559037 187 LNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQD 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
MIT_CorA-like super family cl00459
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 217-294 5.87e-03

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


The actual alignment was detected with superfamily member cd12821:

Pssm-ID: 469776 [Multi-domain]  Cd Length: 285  Bit Score: 37.68  E-value: 5.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 217 AHYSNEVYELVQdtrcadpQDQVakvaeIVAERMQRRTRLL-------------AGLWG--WRKFYWKGWRRGFSVFLG- 280
Cdd:cd12821 201 EEYEQELDTLQD-------IEEV-----VSSHRGNEIMKTLtvvttvflpltliGGLWGmnFKNMPELEWKYGYLFVLGl 268

                        90
                ....*....|....*..
gi 28559037 281 ---VAILIYLLFYRKGF 294
Cdd:cd12821 269 iilSTAGLYLYLRRKGW 285
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 27-229 1.07e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 298.68  E-value: 1.07e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  27 LRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPrTDPGCVETARCFVL 106
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 107 SAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDnRALRDLVAECGGRVCA 186
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 28559037 187 LNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQD 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 27-232 1.60e-99

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 290.28  E-value: 1.60e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037    27 LRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPrTDPGCVETARCFVL 106
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS-NDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037   107 SAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDNRALRDLVAEcggrvca 186
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 28559037   187 lnnrATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQDTRC 232
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGE 194
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 27-151 1.60e-06

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 48.74  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037    27 LRLILVGRTGTGKSATGNSILGQkcflsRLGAVPVTRS----CTLASRMWAGWQVEVVDTPDIFssEIPRTDPGCVETAR 102
Cdd:TIGR00991  39 LTILVMGKGGVGKSSTVNSIIGE-----RIATVSAFQSeglrPMMVSRTRAGFTLNIIDTPGLI--EGGYINDQAVNIIK 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28559037   103 CFVLSAPgPHALLLVTQLGRFTMQ--DSQALAAVKRLFGKQVMARTVVVFT 151
Cdd:TIGR00991 112 RFLLGKT-IDVLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLT 161
YeeP COG3596
Predicted GTPase [General function prediction only];
17-179 6.34e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 43.99  E-value: 6.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  17 EDSRAPQMPQLRLILVGRTGTGKSATGNSILGQKcfLSRLGAV-PVTRSCTLASRMWAGWQ-VEVVDTPDIfsSEIPRTD 94
Cdd:COG3596  30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAE--VAEVGVGrPCTREIQRYRLESDGLPgLVLLDTPGL--GEVNERD 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  95 PGCVETARCfvlsAPGPHALLLVTQLGRFTMQ-DSQALAAVKRLFGKqvmARTVVVFTrQEDLA-----GDSLQDYVHCT 168
Cdd:COG3596 106 REYRELREL----LPEADLILWVVKADDRALAtDEEFLQALRAQYPD---PPVLVVLT-QVDRLepereWDPPYNWPSPP 177

                       170
                ....*....|.
gi 28559037 169 DNRALRDLVAE 179
Cdd:COG3596 178 KEQNIRRALEA 188
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 217-294 5.87e-03

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 37.68  E-value: 5.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 217 AHYSNEVYELVQdtrcadpQDQVakvaeIVAERMQRRTRLL-------------AGLWG--WRKFYWKGWRRGFSVFLG- 280
Cdd:cd12821 201 EEYEQELDTLQD-------IEEV-----VSSHRGNEIMKTLtvvttvflpltliGGLWGmnFKNMPELEWKYGYLFVLGl 268

                        90
                ....*....|....*..
gi 28559037 281 ---VAILIYLLFYRKGF 294
Cdd:cd12821 269 iilSTAGLYLYLRRKGW 285
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 27-229 1.07e-102

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 298.68  E-value: 1.07e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  27 LRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPrTDPGCVETARCFVL 106
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 107 SAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDnRALRDLVAECGGRVCA 186
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSC-EALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 28559037 187 LNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQD 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 27-232 1.60e-99

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 290.28  E-value: 1.60e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037    27 LRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPrTDPGCVETARCFVL 106
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS-NDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037   107 SAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDNRALRDLVAEcggrvca 186
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 28559037   187 lnnrATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQDTRC 232
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGE 194
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 27-151 7.01e-15

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 72.74  E-value: 7.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  27 LRLILVGRTGTGKSATGNSILG-QKCFLSRLGavPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPRTDPGCVETARCFV 105
Cdd:cd01853  32 LTILVLGKTGVGKSSTINSIFGeRKVSVSAFQ--SETLRPREVSRTVDGFKLNIIDTPGLLESQDQRVNRKILSIIKRFL 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 28559037 106 LSAPgPHALLLVTQLG--RFTMQDSQALAAVKRLFGKQVMARTVVVFT 151
Cdd:cd01853 110 KKKT-IDVVLYVDRLDmyRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 27-151 1.60e-06

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 48.74  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037    27 LRLILVGRTGTGKSATGNSILGQkcflsRLGAVPVTRS----CTLASRMWAGWQVEVVDTPDIFssEIPRTDPGCVETAR 102
Cdd:TIGR00991  39 LTILVMGKGGVGKSSTVNSIIGE-----RIATVSAFQSeglrPMMVSRTRAGFTLNIIDTPGLI--EGGYINDQAVNIIK 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28559037   103 CFVLSAPgPHALLLVTQLGRFTMQ--DSQALAAVKRLFGKQVMARTVVVFT 151
Cdd:TIGR00991 112 RFLLGKT-IDVLLYVDRLDAYRVDtlDGQVIRAITDSFGKDIWRKSLVVLT 161
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 31-174 1.70e-06

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 47.07  E-value: 1.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  31 LVGRTGTGKSATGNSILGQKcflsrLGAVPVTRSCTLASRMWAGW------QVEVVDTPDIFSSEIPRtdpgcveTARCF 104
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGGE-----VGEVSDVPGTTRDPDVYVKEldkgkvKLVLVDTPGLDEFGGLG-------REELA 69

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 105 VLSAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVmaRTVVVFTRQeDLAGDSLQDYVHCTDNRALR 174
Cdd:cd00882  70 RLLLRGADLILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGNKI-DLLEEREVEELLRLEELAKI 136
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 27-151 3.36e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 48.41  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037    27 LRLILVGRTGTGKSATGNSILG-QKCFLSRLGavPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPR-TDPGCVETARCF 104
Cdd:TIGR00993 119 LNILVLGKSGVGKSATINSIFGeVKFSTDAFG--MGTTSVQEIEGLVQGVKIRVIDTPGLKSSASDQsKNEKILSSVKKF 196

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 28559037   105 VLSAPgPHALLLVTQLGRFT--MQDSQALAAVKRLFGKQVMARTVVVFT 151
Cdd:TIGR00993 197 IKKNP-PDIVLYVDRLDMQTrdSNDLPLLRTITDVLGPSIWFNAIVTLT 244
YeeP COG3596
Predicted GTPase [General function prediction only];
17-179 6.34e-05

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 43.99  E-value: 6.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  17 EDSRAPQMPQLRLILVGRTGTGKSATGNSILGQKcfLSRLGAV-PVTRSCTLASRMWAGWQ-VEVVDTPDIfsSEIPRTD 94
Cdd:COG3596  30 LERLLVELPPPVIALVGKTGAGKSSLINALFGAE--VAEVGVGrPCTREIQRYRLESDGLPgLVLLDTPGL--GEVNERD 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037  95 PGCVETARCfvlsAPGPHALLLVTQLGRFTMQ-DSQALAAVKRLFGKqvmARTVVVFTrQEDLA-----GDSLQDYVHCT 168
Cdd:COG3596 106 REYRELREL----LPEADLILWVVKADDRALAtDEEFLQALRAQYPD---PPVLVVLT-QVDRLepereWDPPYNWPSPP 177

                       170
                ....*....|.
gi 28559037 169 DNRALRDLVAE 179
Cdd:COG3596 178 KEQNIRRALEA 188
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 28-83 1.04e-03

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 37.98  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28559037    28 RLILVGRTGTGKSATGNSILGQKcflSRLGAVP-VTRSCTLASRMWAGWQVEVVDTP 83
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAK---AIVSDYPgTTRDPNEGRLELKGKQIILVDTP 54
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 217-294 5.87e-03

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 37.68  E-value: 5.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28559037 217 AHYSNEVYELVQdtrcadpQDQVakvaeIVAERMQRRTRLL-------------AGLWG--WRKFYWKGWRRGFSVFLG- 280
Cdd:cd12821 201 EEYEQELDTLQD-------IEEV-----VSSHRGNEIMKTLtvvttvflpltliGGLWGmnFKNMPELEWKYGYLFVLGl 268

                        90
                ....*....|....*..
gi 28559037 281 ---VAILIYLLFYRKGF 294
Cdd:cd12821 269 iilSTAGLYLYLRRKGW 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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