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Conserved domains on  [gi|120407033|ref|NP_032825|]
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programmed cell death protein 2 isoform 1 [Mus musculus]

Protein Classification

zf-MYND and PDCD2_C domain-containing protein( domain architecture ID 10484607)

zf-MYND and PDCD2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDCD2_C pfam04194
Programmed cell death protein 2, C-terminal putative domain;
237-338 2.04e-47

Programmed cell death protein 2, C-terminal putative domain;


:

Pssm-ID: 461221  Cd Length: 111  Bit Score: 155.84  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120407033  237 DHIFQKFKSKIALEPEQILRYGRGIKPIWISGENIPQ-EKDIPDCP-CGAKRIFEFQVMPQLLNHLKADR-LGRSIDWGV 313
Cdd:pfam04194   1 DKTFQKFQKRIAANPEQVLRYSFGGKPLWYSSEGRPSlASDIPNCEnCGGPRVFEFQLMPQLINYLEVDDeSDDGMDWGT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 120407033  314 LAVFTCAESCSLGS------GYTEEFVWKQD 338
Cdd:pfam04194  81 IIVYTCSKSCDPPEwdegdvGYVEEFVWVQW 111
zf-MYND pfam01753
MYND finger;
134-171 8.36e-10

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.58  E-value: 8.36e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 120407033  134 CRVCGC--LAPMTCSRCKQAHYCSKEHQTLDWrLGHKQAC 171
Cdd:pfam01753   1 CAVCGKeaLKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
 
Name Accession Description Interval E-value
PDCD2_C pfam04194
Programmed cell death protein 2, C-terminal putative domain;
237-338 2.04e-47

Programmed cell death protein 2, C-terminal putative domain;


Pssm-ID: 461221  Cd Length: 111  Bit Score: 155.84  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120407033  237 DHIFQKFKSKIALEPEQILRYGRGIKPIWISGENIPQ-EKDIPDCP-CGAKRIFEFQVMPQLLNHLKADR-LGRSIDWGV 313
Cdd:pfam04194   1 DKTFQKFQKRIAANPEQVLRYSFGGKPLWYSSEGRPSlASDIPNCEnCGGPRVFEFQLMPQLINYLEVDDeSDDGMDWGT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 120407033  314 LAVFTCAESCSLGS------GYTEEFVWKQD 338
Cdd:pfam04194  81 IIVYTCSKSCDPPEwdegdvGYVEEFVWVQW 111
zf-MYND pfam01753
MYND finger;
134-171 8.36e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.58  E-value: 8.36e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 120407033  134 CRVCGC--LAPMTCSRCKQAHYCSKEHQTLDWrLGHKQAC 171
Cdd:pfam01753   1 CAVCGKeaLKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
 132-157 2.13e-03

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 35.67  E-value: 2.13e-03
                         10        20
                 ....*....|....*....|....*.
gi 120407033 132 HLCRVCGCLAPMTCSRCkQAHYCSKE 157
Cdd:cd21437    8 KFCSVCGYWGKYTCVRC-GARYCSLK 32
 
Name Accession Description Interval E-value
PDCD2_C pfam04194
Programmed cell death protein 2, C-terminal putative domain;
237-338 2.04e-47

Programmed cell death protein 2, C-terminal putative domain;


Pssm-ID: 461221  Cd Length: 111  Bit Score: 155.84  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120407033  237 DHIFQKFKSKIALEPEQILRYGRGIKPIWISGENIPQ-EKDIPDCP-CGAKRIFEFQVMPQLLNHLKADR-LGRSIDWGV 313
Cdd:pfam04194   1 DKTFQKFQKRIAANPEQVLRYSFGGKPLWYSSEGRPSlASDIPNCEnCGGPRVFEFQLMPQLINYLEVDDeSDDGMDWGT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 120407033  314 LAVFTCAESCSLGS------GYTEEFVWKQD 338
Cdd:pfam04194  81 IIVYTCSKSCDPPEwdegdvGYVEEFVWVQW 111
zf-MYND pfam01753
MYND finger;
134-171 8.36e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.58  E-value: 8.36e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 120407033  134 CRVCGC--LAPMTCSRCKQAHYCSKEHQTLDWrLGHKQAC 171
Cdd:pfam01753   1 CAVCGKeaLKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
 132-157 2.13e-03

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 35.67  E-value: 2.13e-03
                         10        20
                 ....*....|....*....|....*.
gi 120407033 132 HLCRVCGCLAPMTCSRCkQAHYCSKE 157
Cdd:cd21437    8 KFCSVCGYWGKYTCVRC-GARYCSLK 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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