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Conserved domains on  [gi|116292186|ref|NP_034279|]
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erythropoietin receptor isoform 1 precursor [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 37-139 1.14e-33

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 122.91  E-value: 1.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186   37 SKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSF 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 116292186  117 VPLELQVTEA-SGSPRYHRIIHIN 139
Cdd:pfam09067  81 VPLHITVVATnTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-243 1.32e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186 145 DAPAGLLARRAEEGShVVLRWLPPPGaPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARma 224
Cdd:cd00063    2 SPPTNLRVTDVTSTS-VTLSWTPPED-DGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                         90
                 ....*....|....*....
gi 116292186 225 epsFSGFWSAWSEPASLLT 243
Cdd:cd00063   78 ---NGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 37-139 1.14e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 122.91  E-value: 1.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186   37 SKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSF 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 116292186  117 VPLELQVTEA-SGSPRYHRIIHIN 139
Cdd:pfam09067  81 VPLHITVVATnTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-243 1.32e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186 145 DAPAGLLARRAEEGShVVLRWLPPPGaPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARma 224
Cdd:cd00063    2 SPPTNLRVTDVTSTS-VTLSWTPPED-DGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                         90
                 ....*....|....*....
gi 116292186 225 epsFSGFWSAWSEPASLLT 243
Cdd:cd00063   78 ---NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 145-222 7.33e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.33e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116292186   145 DAPAGLLARRAEEGShVVLRWLPPPGAPMTTHI-RYEVDVSAGNraGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRAR 222
Cdd:smart00060   2 SPPSNLRVTDVTSTS-VTLSWEPPPDDGITGYIvGYRVEYREEG--SEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
145-222 1.25e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186  145 DAPAGLLARRAEEGShVVLRWLPPP--GAPMTthiRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRAR 222
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPdgNGPIT---GYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
140-298 9.38e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186 140 EVVLLDAPAGLLARRAEEGShVVLRWLPPPGAPMTTHIRYevdvSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAV 219
Cdd:COG3401  323 DLTPPAAPSGLTATAVGSSS-ITLSWTASSDADVTGYNVY----RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKV 397

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116292186 220 RARMAepsfSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPESEFEGLFTT 298
Cdd:COG3401  398 TAVDA----AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 37-139 1.14e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 122.91  E-value: 1.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186   37 SKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSF 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 116292186  117 VPLELQVTEA-SGSPRYHRIIHIN 139
Cdd:pfam09067  81 VPLHITVVATnTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 145-243 1.32e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186 145 DAPAGLLARRAEEGShVVLRWLPPPGaPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARma 224
Cdd:cd00063    2 SPPTNLRVTDVTSTS-VTLSWTPPED-DGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                         90
                 ....*....|....*....
gi 116292186 225 epsFSGFWSAWSEPASLLT 243
Cdd:cd00063   78 ---NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 145-222 7.33e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.33e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116292186   145 DAPAGLLARRAEEGShVVLRWLPPPGAPMTTHI-RYEVDVSAGNraGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRAR 222
Cdd:smart00060   2 SPPSNLRVTDVTSTS-VTLSWEPPPDDGITGYIvGYRVEYREEG--SEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
145-222 1.25e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186  145 DAPAGLLARRAEEGShVVLRWLPPP--GAPMTthiRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRAR 222
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPdgNGPIT---GYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
140-298 9.38e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116292186 140 EVVLLDAPAGLLARRAEEGShVVLRWLPPPGAPMTTHIRYevdvSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAV 219
Cdd:COG3401  323 DLTPPAAPSGLTATAVGSSS-ITLSWTASSDADVTGYNVY----RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKV 397

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116292186 220 RARMAepsfSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPESEFEGLFTT 298
Cdd:COG3401  398 TAVDA----AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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