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heat shock protein HSP 90-alpha [Mus musculus]
Protein Classification
HSP90 family protein ( domain architecture ID 1903338 )
HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction
List of domain hits
Name
Accession
Description
Interval
E-value
HSP90 super family
cl46693 Hsp90 protein;
18-733
0e+00
Hsp90 protein;
PTZ00272 :Pssm-ID: 481033
Cd Length: 701
Bit Score: 940.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P S K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DE aeekeeke EE KE K EEK E SDDK P E 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D ED -------- EE DT K KAD E DGEE P K 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 258 I E D V gsd E E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWE EHL A V KHFSVEGQLE 337
Cdd:PTZ00272 235 V E E V --- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWE DPA A T KHFSVEGQLE 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 338 FR ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L 417
Cdd:PTZ00272 309 FR SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 418 VKKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IY F ITG 497
Cdd:PTZ00272 389 VKKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IY Y ITG 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 498 ET K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK 577
Cdd:PTZ00272 469 DS K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 578 DI L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K ND 657
Cdd:PTZ00272 549 EV L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E ND 628
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254 658 K S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD ptv DDTSA A VTE E MP P L E GDDD TS R ME E VD 733
Cdd:PTZ00272 629 K A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
18-733
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 940.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P S K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DE aeekeeke EE KE K EEK E SDDK P E 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D ED -------- EE DT K KAD E DGEE P K 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 258 I E D V gsd E E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWE EHL A V KHFSVEGQLE 337
Cdd:PTZ00272 235 V E E V --- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWE DPA A T KHFSVEGQLE 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 338 FR ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L 417
Cdd:PTZ00272 309 FR SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 418 VKKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IY F ITG 497
Cdd:PTZ00272 389 VKKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IY Y ITG 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 498 ET K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK 577
Cdd:PTZ00272 469 DS K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 578 DI L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K ND 657
Cdd:PTZ00272 549 EV L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E ND 628
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254 658 K S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD ptv DDTSA A VTE E MP P L E GDDD TS R ME E VD 733
Cdd:PTZ00272 629 K A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
196-721
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 825.27
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 196 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K EE K EEE kekeeke S DD K P EI E DVG sdeeeeek KDGD K 275
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E EE E EEE ------- E DD D P KV E EED -------- EEEE K 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 276 KK K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWE EH LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN 355
Cdd:pfam00183 66 KK T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWE DP LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 356 R KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N Y 435
Cdd:pfam00183 146 K KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D Y 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 436 KKF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIY F ITGE T K DQ V A NS A F V ERL R K H 515
Cdd:pfam00183 226 KKF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIY Y ITGE S K EE V E NS P F L ERL K K K 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 516 G L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L EK KVEKVVVSNRLV T 595
Cdd:pfam00183 306 G Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L GD KVEKVVVSNRLV D 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 596 SPC CI VTS T YGW T ANMERIMKAQALR - D N S TMG YM AA KK H LEINP D H S II ET L RQKA EADK N DK SV KDL VI LLYETALL S 674
Cdd:pfam00183 386 SPC VL VTS Q YGW S ANMERIMKAQALR k D S S MSS YM SS KK T LEINP R H P II KE L LKRV EADK D DK TA KDL AL LLYETALL R 465
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 6754254 675 SGFSLEDP QTH A N RIYRM I KLGLGIDED DPTVDD ---- TSAAVT EE M P PL E 721
Cdd:pfam00183 466 SGFSLEDP ASF A S RIYRM L KLGLGIDED EIVEEE deie EEEEEE EE E P EE E 516
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-698
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 728.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPS K QDR TLTI V D T G 95
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 96 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 171
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 172 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekeekeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W E EH L AVK H FS 331
Cdd:COG0326 219 ------------------------------------- E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F E DP L FWI H LN 261
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 332 VEG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK 411
Cdd:COG0326 262 VEG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK 340
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 412 V IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK 490
Cdd:COG0326 341 K IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK 419
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 491 H IY F ITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK e G LELPEDE EEKK KQ EE KKTK F E 570
Cdd:COG0326 420 K IY Y ITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS - G DLDLDKL EEKK ES EE EEEE F K 498
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 571 N L CKIM K DI L EK KV EK V V VS N RL VT SP C C I V TSTYGWTAN ME RIM KA qalrdnst MG -- YMA AK KH LEINP D H SIIET L R 648
Cdd:COG0326 499 P L LERF K EA L GD KV KD V R VS A RL TD SP A C L V ADEGDMSRR ME KML KA -------- MG qd MPE AK PI LEINP N H PLVKK L A 570
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 6754254 649 qkae A DKNDKSV KDL VI LLY ET ALL SS G FS LEDP QTHAN R IYRMIKLG LG 698
Cdd:COG0326 571 ---- A EEDEELF KDL AE LLY DQ ALL AE G GL LEDP AAFVK R LNKLLEKA LG 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214
3.32e-111
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 334.49
E-value: 3.32e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 28 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P S K QD RTLTI V DTGIGMTK AD LINNL 107
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 108 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 185
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 6754254 186 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 214
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191
6.40e-12
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 62.67
E-value: 6.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 40 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPSKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 119
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754254 120 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 191
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
18-733
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 940.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P S K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DE aeekeeke EE KE K EEK E SDDK P E 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D ED -------- EE DT K KAD E DGEE P K 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 258 I E D V gsd E E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWE EHL A V KHFSVEGQLE 337
Cdd:PTZ00272 235 V E E V --- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWE DPA A T KHFSVEGQLE 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 338 FR ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L 417
Cdd:PTZ00272 309 FR SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 418 VKKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IY F ITG 497
Cdd:PTZ00272 389 VKKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IY Y ITG 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 498 ET K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK 577
Cdd:PTZ00272 469 DS K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 578 DI L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K ND 657
Cdd:PTZ00272 549 EV L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E ND 628
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254 658 K S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD ptv DDTSA A VTE E MP P L E GDDD TS R ME E VD 733
Cdd:PTZ00272 629 K A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
196-721
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 825.27
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 196 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K EE K EEE kekeeke S DD K P EI E DVG sdeeeeek KDGD K 275
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E EE E EEE ------- E DD D P KV E EED -------- EEEE K 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 276 KK K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWE EH LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN 355
Cdd:pfam00183 66 KK T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWE DP LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 356 R KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N Y 435
Cdd:pfam00183 146 K KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D Y 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 436 KKF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIY F ITGE T K DQ V A NS A F V ERL R K H 515
Cdd:pfam00183 226 KKF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIY Y ITGE S K EE V E NS P F L ERL K K K 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 516 G L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L EK KVEKVVVSNRLV T 595
Cdd:pfam00183 306 G Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L GD KVEKVVVSNRLV D 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 596 SPC CI VTS T YGW T ANMERIMKAQALR - D N S TMG YM AA KK H LEINP D H S II ET L RQKA EADK N DK SV KDL VI LLYETALL S 674
Cdd:pfam00183 386 SPC VL VTS Q YGW S ANMERIMKAQALR k D S S MSS YM SS KK T LEINP R H P II KE L LKRV EADK D DK TA KDL AL LLYETALL R 465
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 6754254 675 SGFSLEDP QTH A N RIYRM I KLGLGIDED DPTVDD ---- TSAAVT EE M P PL E 721
Cdd:pfam00183 466 SGFSLEDP ASF A S RIYRM L KLGLGIDED EIVEEE deie EEEEEE EE E P EE E 516
PRK05218
PRK05218 heat shock protein 90; Provisional
16-698
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 748.86
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R Y E S LTDP SKLDSGKE L H I NLIPS K QD RTLTI V D T G 95
Cdd:PRK05218 2 AM ET GE FQAE VK QL LH L M I HSL YSNKEIFLRELISN A SDA I DK L R F E A LTDP ALYEGDGD L K I RISFD K EA RTLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 96 IGMT KADL I N NLGTIAKSGTK A F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KVTVIT KH -- NDD E QYA WES SAG G SF T 171
Cdd:PRK05218 82 IGMT REEV I E NLGTIAKSGTK E F L E K L K gd QKK D SQL IGQFGVGFYSA FM VA D KVTVIT RS ag PAA E AVR WES DGE G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 172 VRTDTG E P mg RGT KVI LHLKED QT E Y L E E R RI KE I V KK H S Q FI GY PI T L FV E K E rdkevsddeaeekeekeeekekeeke 251
Cdd:PRK05218 162 IEEIEK E E -- RGT EIT LHLKED ED E F L D E W RI RS I I KK Y S D FI PV PI K L EK E E E -------------------------- 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D WEEH L AVK H FS 331
Cdd:PRK05218 214 ------------------------------------- E TI N SASAL WTR SKSE IT D EEY K EFYK H L AH D FDDP L FWI H NN 256
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 332 VEG QL E FRA LL FV P RR APFDLF e NR KK K NNI KLYV R RVFIMD NC EEL I PEYL N F IR GV V DSEDLPLN I SRE M LQ QSKIL K 411
Cdd:PRK05218 257 VEG PF E YTG LL YI P KK APFDLF - NR DR K GGL KLYV K RVFIMD DA EEL L PEYL R F VK GV I DSEDLPLN V SRE I LQ EDRVV K 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 412 V IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K KL SE LLR YYTSAS G d EM VSL KD Y CT RMKE N QK 490
Cdd:PRK05218 336 K IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GPVL K E G LY ED FA NR E KL AK LLR FASTHE G - KY VSL AE Y VE RMKE G QK 414
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 491 H IY F ITG ETKDQVA NS AFV E RLR K H G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TKEG L E - LP EDEEEK KKQ EE KKTK F 569
Cdd:PRK05218 415 K IY Y ITG DSREAAK NS PHL E LFK K K G I EV LLLTD PIDE FWISY L E EF D GK PFK SV ARGD L D l GK EDEEEK EEK EE AEEE F 494
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 570 EN L CKIM K DI L EK KV EK V VV S N RL VT SP C C I V TSTYGWTAN ME RIM KA QA lrdnst MGYMAA K KH LEINP D H SIIET L RQ 649
Cdd:PRK05218 495 KP L LERL K EA L GD KV KD V RL S H RL TD SP A C L V ADEGDMSTQ ME KLL KA AG ------ QEVPES K PI LEINP N H PLVKK L AD 568
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 6754254 650 kaea DKNDKSV KDL VI LLY ET ALL SS G F SLEDP QTHAN R IYRMIKLG L G 698
Cdd:PRK05218 569 ---- EADEAKF KDL AE LLY DQ ALL AE G G SLEDP AAFVK R LNELLLKL L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-698
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 728.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPS K QDR TLTI V D T G 95
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 96 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 171
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 172 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekeekeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W E EH L AVK H FS 331
Cdd:COG0326 219 ------------------------------------- E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F E DP L FWI H LN 261
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 332 VEG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK 411
Cdd:COG0326 262 VEG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK 340
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 412 V IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK 490
Cdd:COG0326 341 K IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK 419
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 491 H IY F ITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK e G LELPEDE EEKK KQ EE KKTK F E 570
Cdd:COG0326 420 K IY Y ITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS - G DLDLDKL EEKK ES EE EEEE F K 498
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 571 N L CKIM K DI L EK KV EK V V VS N RL VT SP C C I V TSTYGWTAN ME RIM KA qalrdnst MG -- YMA AK KH LEINP D H SIIET L R 648
Cdd:COG0326 499 P L LERF K EA L GD KV KD V R VS A RL TD SP A C L V ADEGDMSRR ME KML KA -------- MG qd MPE AK PI LEINP N H PLVKK L A 570
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 6754254 649 qkae A DKNDKSV KDL VI LLY ET ALL SS G FS LEDP QTHAN R IYRMIKLG LG 698
Cdd:COG0326 571 ---- A EEDEELF KDL AE LLY DQ ALL AE G GL LEDP AAFVK R LNKLLEKA LG 616
PTZ00130
PTZ00130 heat shock protein 90; Provisional
3-731
1.79e-164
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 494.56
E-value: 1.79e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 3 E E TQTQDQ P MEE ee V E TFAF Q A E IAQ LM SL I I N TF Y SN KE I FLRELISN SS DAL D KIR YE SL T D P S K L DSG K E L H I NLIP 82
Cdd:PTZ00130 53 P E IEDGEK P TSG -- I E QHQY Q T E VTR LM DI I V N SL Y TQ KE V FLRELISN AA DAL E KIR FL SL S D E S V L GEE K K L E I RISA 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 83 S K QDRT L T I V DTGIGMTK A DLINNLGTIAKSGT KA F M EA L - QA G A D I S M IGQFGVGFYSA Y LVA E KV T V I TK H N D DEQY A 161
Cdd:PTZ00130 131 N K EKNI L S I T DTGIGMTK E DLINNLGTIAKSGT SN F L EA I s KS G G D M S L IGQFGVGFYSA F LVA D KV I V Y TK N N N DEQY I 210
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 162 WES S A GGS FT VRT D T - G EPMG RGT KVI LHLKED Q T EYLEERRIKEIVK K H SQFI G YPI T L FV E KERDK EV SD D E A E E K E E 240
Cdd:PTZ00130 211 WES T A DAK FT IYK D P r G STLK RGT RIS LHLKED A T NLMNDKKLVDLIS K Y SQFI Q YPI Y L LH E NVYTE EV LA D I A K E M E N 290
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 241 KEEEKEKEEK E S DD K peiedvgsdeeeeekkdgd K KK KKKIKE K YIDQEEL N KT KPIW T R N P DDI T N E E Y GE F YKS L TND 320
Cdd:PTZ00130 291 DPNYDSVKVE E T DD P ------------------- N KK TRTVEK K VKKWKLM N EQ KPIW L R P P KEL T D E D Y KK F FSV L SGF 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 321 WE E H L AVK HF SV EG QL EF RA L LFV P R RAP FDLFENRK K K N N IKLYVRRV FIM D NCE E LI P E Y LN F IR GVVDS E DLPLN I S 400
Cdd:PTZ00130 352 ND E P L YHI HF FA EG EI EF KC L IYI P S RAP SINDHLFT K Q N S IKLYVRRV LVA D EFV E FL P R Y MS F VK GVVDS D DLPLN V S 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 401 RE M LQQ S KILK VIR K NL V K K C L E ---- L FT E LAED KE N -------------------------- YK KF Y EQFS K NI K L G I 450
Cdd:PTZ00130 432 RE Q LQQ N KILK AVS K RI V R K I L D tfrt L YK E GKKN KE T lraelaketdeekkkeiqkkinepst YK LI Y KEYR K YL K T G C 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 451 H ED SQ NR K K LSE LL RYY T SAS g DEMV SL KD Y CTR MK EN QK H IY FIT G ETKDQVANSAFVERLR K HGLE V IYMI E PI DE Y C 530
Cdd:PTZ00130 512 Y ED DI NR N K IVK LL LFK T MLH - PKSI SL DT Y IEN MK PD QK F IY YAS G DSYEYLSKIPQLQIFK K KNID V VFLT E SV DE S C 590
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 531 VQ QLK E FE GK TLV S VT K EGLELPED E E EKKK Q E EK K TKFEN L CKIMK D I L EKKVE KV VV S N RLV TS PC CI V TSTY G WTAN 610
Cdd:PTZ00130 591 VQ RVQ E YD GK KFK S IQ K GEITFELT E D EKKK E E KV K KMYKA L IDVIS D T L RNQIF KV EI S R RLV DA PC AV V STEW G LSGQ 670
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 611 ME RI MK AQ a LRDNSTMGY M AAK K H LEINPDH S I IET L RQKAEADKN D KSVKDLVILL Y ET A L L S SGF S LED PQTH A NRI Y 690
Cdd:PTZ00130 671 ME KL MK IN - VNNSDQIKA M SGQ K I LEINPDH P I MID L LKRSVSNPK D SQLTESIKII Y QS A K L A SGF D LED TADL A QIV Y 749
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 6754254 691 RM I KLG LG I D ED ------ DP TVDD T SAAVT E EM P plegdd D TSRME E 731
Cdd:PTZ00130 750 DH I NQK LG V D NN lkiddl DP AIFE T KKIEQ E DS P ------ D GQKFH E 790
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214
3.32e-111
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 334.49
E-value: 3.32e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 28 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P S K QD RTLTI V DTGIGMTK AD LINNL 107
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 108 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 185
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 6754254 186 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 214
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
21-417
4.82e-31
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 128.91
E-value: 4.82e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 21 A FQ AEIAQLMS L IINTF YS NKEIFL REL IS N SS DA ldk I RYESLT DP S kl DS G K e LH I N L i PSKQDR TL TIV D T GIG M T K 100
Cdd:PRK14083 4 R FQ VDLRGVID L LSRHL YS SPRVYV REL LQ N AV DA --- I TARRAL DP T -- AP G R - IR I E L - TDAGGG TL IVE D N GIG L T E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 101 ADLINN L G TI AK S GTKA fm E A L QAGAD i SMI GQFG V G FY S AY LVA EKVT V ITKHND D EQ - YA W ESS A G G SFT VR TDTG E P 179
Cdd:PRK14083 77 EEVHEF L A TI GR S SKRD -- E N L GFARN - DFL GQFG I G LL S CF LVA DEIV V VSRSAK D GP a VE W RGK A D G TYS VR KLET E R 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 180 MGR GT K V I L HLKE D QT E Y LE ERRIK E IV KK HSQFIGY PI TLFV EK ER dkevsddeaeekeekeeekekeekesddkpeie 259
Cdd:PRK14083 154 AEP GT T V Y L RPRP D AE E W LE RETVE E LA KK YGSLLPV PI RVEG EK GG --------------------------------- 200
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 260 dvgsdeeeeekkdgdkkkkkkikekyidqee L N K T K P I WTR NPD D ITNE ----- E YGE fy KS L TNDWEEH -- L A V KHFSV 332
Cdd:PRK14083 201 ------------------------------- V N E T P P P WTR DYP D PETR reall A YGE -- EL L GFTPLDV ip L D V PSGGL 247
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 333 EG qlefra LLF V - P RRAPF dlfe NRKK K N ni KL Y VR R VFIMDNC E E L I P EYLN F I R G VV DSED L PLNI SRE M L QQSKI L K 411
Cdd:PRK14083 248 EG ------ VAY V l P YAVSP ---- AARR K H -- RV Y LK R MLLSEEA E N L L P DWAF F V R C VV NTDE L RPTA SRE A L YEDDA L A 315
....*.
gi 6754254 412 VI R KN L 417
Cdd:PRK14083 316 AV R EE L 321
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191
6.40e-12
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 62.67
E-value: 6.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 40 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPSKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 119
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754254 120 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 191
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
42-159
5.18e-08
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 52.33
E-value: 5.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 42 E IF L R ELI S NS S DA ldkiryesltdpskld SGKELH I NLIPSKQDR T - LT I V D T G I GM TKAD LIN N L G t I A K S GTK afme 120
Cdd:pfam13589 2 E GA L A ELI D NS I DA ---------------- DATNIK I EVNKNRGGG T e IV I E D D G H GM SPEE LIN A L R - L A T S AKE ---- 60
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6754254 121 alq A GADISMI G QF G V G FYS A Y L V - AE K V TV IT K HNDDEQ 159
Cdd:pfam13589 61 --- A KRGSTDL G RY G I G LKL A S L S l GA K L TV TS K KEGKSS 97
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
40-194
1.01e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 45.05
E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254 40 NK E IF LR ELI SN SS D ALD K IRYE sltdpsklds GK E LHIN L IP s KQDR TLT IV D T GIG MTKA DL innlgti AKSGTK a F M 119
Cdd:pfam02518 1 GD E LR LR QVL SN LL D NAL K HAAK ---------- AG E ITVT L SE - GGEL TLT VE D N GIG IPPE DL ------- PRIFEP - F S 61
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754254 120 E alqag AD ISMI G QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SF TV RTDT gepm G R GT K V I L H L KED Q 194
Cdd:pfam02518 62 T ----- AD KRGG G GT G L G LSIVRKLV E LL ------------------ GG TI TV ESEP ---- G G GT T V T L T L PLA Q 109
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
