NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7106325|ref|NP_035951|]
View 

glypican-6 isoform 2 precursor [Mus musculus]

Protein Classification

glypican family protein( domain architecture ID 10471748)

glypican family protein is a cell surface proteoglycan that bears heparan sulfate, similar to human glypican-1 that binds alpha-4 (V) collagen and participates in Schwann cell myelination

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
23-522 0e+00

Glypican;


:

Pssm-ID: 460084  Cd Length: 554  Bit Score: 919.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325     23 ADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRH 102
Cdd:pfam01153  14 ASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    103 KKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHF 182
Cdd:pfam01153  94 RKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    183 SEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPT 262
Cdd:pfam01153 174 SDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    263 VRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCG 342
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    343 QPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDERVTAGTSNEE 420
Cdd:pfam01153 334 TPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNED 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    421 ECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSG 500
Cdd:pfam01153 413 KCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492

                         490       500
                  ....*....|....*....|....
gi 7106325    501 CMDDVCPTEFEFVT--TEAPAVDP 522
Cdd:pfam01153 493 CPSDLCKGDLPFVFelTDTPATPA 516
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
23-522 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 919.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325     23 ADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRH 102
Cdd:pfam01153  14 ASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    103 KKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHF 182
Cdd:pfam01153  94 RKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    183 SEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPT 262
Cdd:pfam01153 174 SDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    263 VRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCG 342
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    343 QPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDERVTAGTSNEE 420
Cdd:pfam01153 334 TPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNED 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    421 ECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSG 500
Cdd:pfam01153 413 KCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492

                         490       500
                  ....*....|....*....|....
gi 7106325    501 CMDDVCPTEFEFVT--TEAPAVDP 522
Cdd:pfam01153 493 CPSDLCKGDLPFVFelTDTPATPA 516
 
Name Accession Description Interval E-value
Glypican pfam01153
Glypican;
23-522 0e+00

Glypican;


Pssm-ID: 460084  Cd Length: 554  Bit Score: 919.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325     23 ADVKARSCSEVRQAYGAKGFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRH 102
Cdd:pfam01153  14 ASGKARSCSEVRQLYSAKGFSLNDVPQSEISGEHLRICPQGYTCCTSEMEEKLSNQSRREFEQLVHEASSSLQTTLTTNH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    103 KKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQYHF 182
Cdd:pfam01153  94 RKFDEFFRELLNISENSLNDMFVRTYGRLYTQNAELFKDLFTELRRYYRGSNVNLEEALNEFWARLLERLFKLVNPQYHF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    183 SEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPT 262
Cdd:pfam01153 174 SDDYLECLSKQTEQLKPFGDVPRKLKLQLTRAFIAARAFVQGLNLGREVVNKVSQVPLSPECTRALMKMLYCPHCRGLPS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    263 VRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCG 342
Cdd:pfam01153 254 VKPCYNYCLNVMRGCLANQADLDTEWRNFIDSLLLVAERLEGPFNIENVIDSIHVKISEAIMNMQENSMKLTAKVFQGCG 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    343 QPKPAPAlRSARSA-PENFNTR-FRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDERVTAGTSNEE 420
Cdd:pfam01153 334 TPKPTPY-RSTRSSsPEEKKKRgFRTYTPEERPTTAAGTRLDRLVTDVKEKLKEMKSFWSTLPDTLCSDEKMAADPTNED 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106325    421 ECWNGHSKARYLPEIMNDGLTNQINNPEVEVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSG 500
Cdd:pfam01153 413 KCWNGQTKGRYLPEVMGNGLANQINNPEVEVDITKPDMVIRQQIMKLKIMTNRLKNAYPGNDVDFQDDSDDSSGSGSGDG 492

                         490       500
                  ....*....|....*....|....
gi 7106325    501 CMDDVCPTEFEFVT--TEAPAVDP 522
Cdd:pfam01153 493 CPSDLCKGDLPFVFelTDTPATPA 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH