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Conserved domains on  [gi|20149598|ref|NP_036272|]
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mitochondrial dicarboxylate carrier isoform 2 [Homo sapiens]

Protein Classification

solute carrier family 25 protein( domain architecture ID 10445172)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
198-284 1.28e-18

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 78.85  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   198 NIFTHFVASFIAGGCATFLCQPLDVLKTRLMN----SKGEYQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFV 272
Cdd:pfam00153   4 SFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVqggsGKSKGRGILDCFKKIYKEeGIRGLYKGLLPNLLRVAPAAAIYFG 83
                          90
                  ....*....|..
gi 20149598   273 FLEQLRKNFGIK 284
Cdd:pfam00153  84 TYETLKRLLLKK 95
Mito_carr pfam00153
Mitochondrial carrier protein;
95-190 2.38e-17

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 75.39  E-value: 2.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    95 GPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNyahALDGLYRVAREEGLRRLFSGATMASSRGALV 174
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPA 77
                          90
                  ....*....|....*.
gi 20149598   175 TVGQLSCYDQAKQLVL 190
Cdd:pfam00153  78 AAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
13-93 3.18e-15

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 69.61  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMAL----RVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDR 88
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILdcfkKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETLKRL 91

                  ....*
gi 20149598    89 VAKGS 93
Cdd:pfam00153  92 LLKKL 96
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
198-284 1.28e-18

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 78.85  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   198 NIFTHFVASFIAGGCATFLCQPLDVLKTRLMN----SKGEYQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFV 272
Cdd:pfam00153   4 SFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVqggsGKSKGRGILDCFKKIYKEeGIRGLYKGLLPNLLRVAPAAAIYFG 83
                          90
                  ....*....|..
gi 20149598   273 FLEQLRKNFGIK 284
Cdd:pfam00153  84 TYETLKRLLLKK 95
Mito_carr pfam00153
Mitochondrial carrier protein;
95-190 2.38e-17

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 75.39  E-value: 2.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    95 GPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNyahALDGLYRVAREEGLRRLFSGATMASSRGALV 174
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPA 77
                          90
                  ....*....|....*.
gi 20149598   175 TVGQLSCYDQAKQLVL 190
Cdd:pfam00153  78 AAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
13-93 3.18e-15

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 69.61  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMAL----RVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDR 88
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILdcfkKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETLKRL 91

                  ....*
gi 20149598    89 VAKGS 93
Cdd:pfam00153  92 LLKKL 96
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
13-279 2.47e-11

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 62.86  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   13 GGLASCGAACCTHPLDLLKVHLQTQQ---EVK----LRMTGMA---LRVVRTDGILALYSGLSASLCRQMTYSLTRFAIY 82
Cdd:PTZ00169  14 GGISAAISKTAVAPIERVKMLIQTQDsipEIKsgkvPRYSGIVncfRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFAFK 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   83 ETVRD---RVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKlpQGQRRNYAHALDGLYRVAREEGLRR 159
Cdd:PTZ00169  94 DYFKNmfpKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIG--KGGDREFTGLFDCLMKISKQTGFLS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598  160 LFSGaTMASSRGALVTVGQ-LSCYDQAKQLVLSTGYLSDNIFTHFVASFIAgGCATFLCQPLDVLKTRLMNSKGE----- 233
Cdd:PTZ00169 172 LYQG-FGVSVQGIIVYRGAyFGLYDSAKALLFGNDKNTNILYKWAVAQTVT-ILAGLISYPFDTVRRRMMMMSGRkakse 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 20149598  234 --YQGVFHCAVET-AKLGPLAFYKGLVPAGIRLIpHTVLTFVFLEQLRK 279
Cdd:PTZ00169 250 iqYTGTLDCWKKIlKNEGLGGFFKGAWANVLRGA-GGALVLVFYDELQK 297
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
13-189 3.43e-10

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 59.40  E-value: 3.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGM---ALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRD 87
Cdd:PTZ00169 120 GGLAGASSLLIVYPLDFARTRLASDigKGGDREFTGLfdcLMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKA 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   88 RVAKGSQGPLPFHEKVLLGSVSGLAgGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMA 167
Cdd:PTZ00169 200 LLFGNDKNTNILYKWAVAQTVTILA-GLISYPFDTVRRRMMMMSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWAN 278
                        170       180
                 ....*....|....*....|....*
gi 20149598  168 SSR---GALVTVgqlsCYDQAKQLV 189
Cdd:PTZ00169 279 VLRgagGALVLV----FYDELQKLL 299
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
198-284 1.28e-18

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 78.85  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   198 NIFTHFVASFIAGGCATFLCQPLDVLKTRLMN----SKGEYQGVFHCAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFV 272
Cdd:pfam00153   4 SFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVqggsGKSKGRGILDCFKKIYKEeGIRGLYKGLLPNLLRVAPAAAIYFG 83
                          90
                  ....*....|..
gi 20149598   273 FLEQLRKNFGIK 284
Cdd:pfam00153  84 TYETLKRLLLKK 95
Mito_carr pfam00153
Mitochondrial carrier protein;
95-190 2.38e-17

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 75.39  E-value: 2.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    95 GPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNyahALDGLYRVAREEGLRRLFSGATMASSRGALV 174
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPA 77
                          90
                  ....*....|....*.
gi 20149598   175 TVGQLSCYDQAKQLVL 190
Cdd:pfam00153  78 AAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
13-93 3.18e-15

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 69.61  E-value: 3.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598    13 GGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMAL----RVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDR 88
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILdcfkKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETLKRL 91

                  ....*
gi 20149598    89 VAKGS 93
Cdd:pfam00153  92 LLKKL 96
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
13-279 2.47e-11

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 62.86  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   13 GGLASCGAACCTHPLDLLKVHLQTQQ---EVK----LRMTGMA---LRVVRTDGILALYSGLSASLCRQMTYSLTRFAIY 82
Cdd:PTZ00169  14 GGISAAISKTAVAPIERVKMLIQTQDsipEIKsgkvPRYSGIVncfRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFAFK 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   83 ETVRD---RVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKlpQGQRRNYAHALDGLYRVAREEGLRR 159
Cdd:PTZ00169  94 DYFKNmfpKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIG--KGGDREFTGLFDCLMKISKQTGFLS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598  160 LFSGaTMASSRGALVTVGQ-LSCYDQAKQLVLSTGYLSDNIFTHFVASFIAgGCATFLCQPLDVLKTRLMNSKGE----- 233
Cdd:PTZ00169 172 LYQG-FGVSVQGIIVYRGAyFGLYDSAKALLFGNDKNTNILYKWAVAQTVT-ILAGLISYPFDTVRRRMMMMSGRkakse 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 20149598  234 --YQGVFHCAVET-AKLGPLAFYKGLVPAGIRLIpHTVLTFVFLEQLRK 279
Cdd:PTZ00169 250 iqYTGTLDCWKKIlKNEGLGGFFKGAWANVLRGA-GGALVLVFYDELQK 297
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
13-189 3.43e-10

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 59.40  E-value: 3.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   13 GGLASCGAACCTHPLDLLKVHLQTQ--QEVKLRMTGM---ALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRD 87
Cdd:PTZ00169 120 GGLAGASSLLIVYPLDFARTRLASDigKGGDREFTGLfdcLMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKA 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20149598   88 RVAKGSQGPLPFHEKVLLGSVSGLAgGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMA 167
Cdd:PTZ00169 200 LLFGNDKNTNILYKWAVAQTVTILA-GLISYPFDTVRRRMMMMSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWAN 278
                        170       180
                 ....*....|....*....|....*
gi 20149598  168 SSR---GALVTVgqlsCYDQAKQLV 189
Cdd:PTZ00169 279 VLRgagGALVLV----FYDELQKLL 299
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
208-255 5.19e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 37.60  E-value: 5.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 20149598  208 IAGGCATFLCQPLDVLKTRLMNSKGEYqgvFHCAVETAKLGPLAFYKG 255
Cdd:PTZ00168 188 LAGGIAGFLTTPVDVIKSRQIIYGKSY---IETVTEIAEEGYLTFYKG 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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