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Conserved domains on  [gi|7656934|ref|NP_055021|]
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transmembrane protein 258 [Homo sapiens]

Protein Classification

OST5 family protein( domain architecture ID 10526105)

OST5 family protein such as transmembrane protein 258 (TMEM258) that is a component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains

Gene Ontology:  GO:0006487|GO:0008250

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ost5 pfam05251
Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, ...
 7-79 2.39e-26

Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, where the enzyme oligosaccharyltransferase (OTase) transfers donor glycans from a dolichol pyrophosphate (DolP) carrier (Lipid-linked oligosaccharide; LLO) to polypeptides. The yeast OTase is a hetero-oligomeric complex composed of essential (Ost1, Ost2, Wbp1, Stt3, and Swp1) and nonessential (Ost3, Ost4, Ost5, and Ost6) subunits. This domain family is found in Ost5. The precise function of this subunit is not known, however Ost5 appears to form a sub-complex with Ost1, and this sub-complex associates with the catalytic Stt3 subunit of OTase. Down regulation of Ost5 resulted in a limited effect on glycosylation and no effect on the stability of Ost1 or Stt3 subunits.


:

Pssm-ID: 461602  Cd Length: 73  Bit Score: 91.48  E-value: 2.39e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7656934     7 SRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV 79
Cdd:pfam05251  1 PPFSPPVPPSLQPTLAFVLLLIGLLLTAYFFIYEVTSTKPKRSLVKELLLALVASLFLGFGVVFLFLAVGVYV 73
 
Name Accession Description Interval E-value
Ost5 pfam05251
Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, ...
 7-79 2.39e-26

Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, where the enzyme oligosaccharyltransferase (OTase) transfers donor glycans from a dolichol pyrophosphate (DolP) carrier (Lipid-linked oligosaccharide; LLO) to polypeptides. The yeast OTase is a hetero-oligomeric complex composed of essential (Ost1, Ost2, Wbp1, Stt3, and Swp1) and nonessential (Ost3, Ost4, Ost5, and Ost6) subunits. This domain family is found in Ost5. The precise function of this subunit is not known, however Ost5 appears to form a sub-complex with Ost1, and this sub-complex associates with the catalytic Stt3 subunit of OTase. Down regulation of Ost5 resulted in a limited effect on glycosylation and no effect on the stability of Ost1 or Stt3 subunits.


Pssm-ID: 461602  Cd Length: 73  Bit Score: 91.48  E-value: 2.39e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7656934     7 SRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV 79
Cdd:pfam05251  1 PPFSPPVPPSLQPTLAFVLLLIGLLLTAYFFIYEVTSTKPKRSLVKELLLALVASLFLGFGVVFLFLAVGVYV 73
 
Name Accession Description Interval E-value
Ost5 pfam05251
Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, ...
 7-79 2.39e-26

Oligosaccharyltransferase subunit 5; Eukaryotic N-glycosylation is catalyzed in the ER lumen, where the enzyme oligosaccharyltransferase (OTase) transfers donor glycans from a dolichol pyrophosphate (DolP) carrier (Lipid-linked oligosaccharide; LLO) to polypeptides. The yeast OTase is a hetero-oligomeric complex composed of essential (Ost1, Ost2, Wbp1, Stt3, and Swp1) and nonessential (Ost3, Ost4, Ost5, and Ost6) subunits. This domain family is found in Ost5. The precise function of this subunit is not known, however Ost5 appears to form a sub-complex with Ost1, and this sub-complex associates with the catalytic Stt3 subunit of OTase. Down regulation of Ost5 resulted in a limited effect on glycosylation and no effect on the stability of Ost1 or Stt3 subunits.


Pssm-ID: 461602  Cd Length: 73  Bit Score: 91.48  E-value: 2.39e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7656934     7 SRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV 79
Cdd:pfam05251  1 PPFSPPVPPSLQPTLAFVLLLIGLLLTAYFFIYEVTSTKPKRSLVKELLLALVASLFLGFGVVFLFLAVGVYV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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