MORC family CW-type zinc finger protein 1 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
17-134 | 1.39e-66 | ||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. : Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 218.43 E-value: 1.39e-66
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Morc6_S5 super family | cl39387 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
236-437 | 5.41e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. The actual alignment was detected with superfamily member pfam17942: Pssm-ID: 465579 Cd Length: 139 Bit Score: 64.10 E-value: 5.41e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
482-527 | 8.24e-12 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. : Pssm-ID: 462181 Cd Length: 46 Bit Score: 60.79 E-value: 8.24e-12
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Name | Accession | Description | Interval | E-value | ||||
HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
17-134 | 1.39e-66 | ||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 218.43 E-value: 1.39e-66
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
28-160 | 2.90e-29 | ||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 113.58 E-value: 2.90e-29
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Morc6_S5 | pfam17942 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
236-437 | 5.41e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. Pssm-ID: 465579 Cd Length: 139 Bit Score: 64.10 E-value: 5.41e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
482-527 | 8.24e-12 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. Pssm-ID: 462181 Cd Length: 46 Bit Score: 60.79 E-value: 8.24e-12
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mutl | TIGR00585 | DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
31-77 | 7.46e-04 | ||||
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 42.63 E-value: 7.46e-04
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MutL | COG0323 | DNA mismatch repair ATPase MutL [Replication, recombination and repair]; |
34-77 | 1.33e-03 | ||||
DNA mismatch repair ATPase MutL [Replication, recombination and repair]; Pssm-ID: 440092 [Multi-domain] Cd Length: 515 Bit Score: 42.34 E-value: 1.33e-03
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KpsE | COG3524 | Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
292-351 | 4.05e-03 | ||||
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 40.60 E-value: 4.05e-03
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HATPase_c | smart00387 | Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
31-103 | 5.76e-03 | ||||
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 37.63 E-value: 5.76e-03
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mutL | PRK00095 | DNA mismatch repair endonuclease MutL; |
34-77 | 8.32e-03 | ||||
DNA mismatch repair endonuclease MutL; Pssm-ID: 234630 [Multi-domain] Cd Length: 617 Bit Score: 39.81 E-value: 8.32e-03
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Name | Accession | Description | Interval | E-value | ||||
HATPase_MORC-like | cd16931 | Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ... |
17-134 | 1.39e-66 | ||||
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker. Pssm-ID: 340408 [Multi-domain] Cd Length: 118 Bit Score: 218.43 E-value: 1.39e-66
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HATPase_c_3 | pfam13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ... |
28-160 | 2.90e-29 | ||||
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 113.58 E-value: 2.90e-29
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Morc6_S5 | pfam17942 | Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ... |
236-437 | 5.41e-12 | ||||
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway. Pssm-ID: 465579 Cd Length: 139 Bit Score: 64.10 E-value: 5.41e-12
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zf-CW | pfam07496 | CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ... |
482-527 | 8.24e-12 | ||||
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found. Pssm-ID: 462181 Cd Length: 46 Bit Score: 60.79 E-value: 8.24e-12
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mutl | TIGR00585 | DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
31-77 | 7.46e-04 | ||||
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 42.63 E-value: 7.46e-04
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HATPase_MutL-MLH-PMS-like | cd16926 | Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
34-77 | 1.15e-03 | ||||
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease. Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 41.27 E-value: 1.15e-03
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MutL | COG0323 | DNA mismatch repair ATPase MutL [Replication, recombination and repair]; |
34-77 | 1.33e-03 | ||||
DNA mismatch repair ATPase MutL [Replication, recombination and repair]; Pssm-ID: 440092 [Multi-domain] Cd Length: 515 Bit Score: 42.34 E-value: 1.33e-03
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KpsE | COG3524 | Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; |
292-351 | 4.05e-03 | ||||
Capsule polysaccharide export protein KpsE/RkpR [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442746 [Multi-domain] Cd Length: 370 Bit Score: 40.60 E-value: 4.05e-03
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HATPase_c | smart00387 | Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
31-103 | 5.76e-03 | ||||
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 37.63 E-value: 5.76e-03
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mutL | PRK00095 | DNA mismatch repair endonuclease MutL; |
34-77 | 8.32e-03 | ||||
DNA mismatch repair endonuclease MutL; Pssm-ID: 234630 [Multi-domain] Cd Length: 617 Bit Score: 39.81 E-value: 8.32e-03
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Blast search parameters | ||||
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