|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
127-1014 |
9.68e-171 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 518.73 E-value: 9.68e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 127 PRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEF 206
Cdd:COG4581 13 EALADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 207 --QDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSA 284
Cdd:COG4581 93 gaENVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 285 TIPNARQFAEWICHLHkQPCHVIYTDYRPTPL-QHYifpAGGDGLHLVVDENGDFrednfntamqvlrdagdlakgdqkg 363
Cdd:COG4581 173 TVGNAEEFAEWLTRVR-GETAVVVSEERPVPLeFHY---LVTPRLFPLFRVNPEL------------------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 364 rkggtKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAidclsDEDKKLPQVEH 443
Cdd:COG4581 224 -----LRPPSRHEVIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 444 VLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGR 523
Cdd:COG4581 294 LSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGR 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 524 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLR---VEEInpEYMLEKSFYQFQHYRAIPG 600
Cdd:COG4581 374 AGRRGIDTEGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNLLArpgLERA--RELLEDSFAQFQADRSVVG 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 601 VVEKVKNSEEQYNKIVI---PNEESVVIYYKIRQQLAKLgkeieeyihkpkyclpflqpgrlvkvknegddfgwgvvvnf 677
Cdd:COG4581 452 LARRARELERALAGVVErlaCDLGDLQEYFALRQPLSPL----------------------------------------- 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 678 skksnvkpnsgeldplyvvevllrcskeslknsatEAAKPAKPDEkgEMQVVpvlvhllsaisSVRLYIPKDLRPVdnrq 757
Cdd:COG4581 491 -----------------------------------EALERESPAY--ALDVV-----------SVPEATLEDPRPV---- 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 758 svlKSIQEVQKRFPDGIPLLDPIDDMgiqdqglkkviQKVEAFEHRMYSHPLHNDPnLETVYTLCEKKAQIAIDIksakr 837
Cdd:COG4581 519 ---LLAQDRRARGEAAAAMKAAIEYD-----------ERMERLEEVLRPHPLHECP-LERAFELYRETHPWVRDI----- 578
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 838 ELKKARTVLQMDELkcrKRVLRRLGFAtSSDVIEMKGRVACEISSAdelllTEMMFNGLFNDLSAEQATALLSCFVF--- 914
Cdd:COG4581 579 ELRPKSVARDFDRF---CELLREYGYL-DDLTLTSEGLLLRYLYDA-----AEALRQGVPDDLDPEELAALISWLVEevr 649
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 915 QENSSEMPKL-TEQLAGPLRQMQECAKRIAKVSAEAKLEideetylssfKPHLmDVVYTWATGATFAHICKMTDVFEGSI 993
Cdd:COG4581 650 RVDSSEWERLpSPANRRAFVLVNALFRRLELLERRHGLP----------ELDP-GLAGAWASGADLAEVLDATDLDAGDF 718
|
890 900
....*....|....*....|....*
gi 193211480 994 IRCMRRL----EELLRQMCQAAKAI 1014
Cdd:COG4581 719 VRWVRQVidpdPELRRTARAAVDLI 743
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
110-312 |
5.46e-157 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 462.30 E-value: 5.46e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 110 CTHEVALPAEEDYLPL--KPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIF 187
Cdd:cd18024 1 CTHEVALPPDYDYTPIsaHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 188 TSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWE 267
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 193211480 268 ETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYR 312
Cdd:cd18024 161 ETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
582-841 |
5.49e-109 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 339.64 E-value: 5.49e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 582 EYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVK 661
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 662 VK-NEGDDFGWGVVVNFSKKSNvKPNSGELDPLYVVEVLLRCSKES-------LKNSATEAAKPAKPDEKGEMQVVPVLV 733
Cdd:pfam13234 81 VKdNGDQDFGWGVVVNFKKRKK-NGKAEPPQESYIVDVLLVLALVSspedldkFNDVNPEGFRPAPPGEKGEMEVVPVPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 734 HLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDP 813
Cdd:pfam13234 160 SDIEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDGIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHKSP 239
|
250 260
....*....|....*....|....*...
gi 193211480 814 NLETVYTLCEKKAQIAIDIKSAKRELKK 841
Cdd:pfam13234 240 RLEELYALYHEKVELQEEIKELKKEISD 267
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
133-309 |
4.27e-85 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 272.22 E-value: 4.27e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 133 AKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLM 212
Cdd:cd18027 2 AFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 213 TGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQF 292
Cdd:cd18027 82 TGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVEF 161
|
170
....*....|....*..
gi 193211480 293 AEWICHLHKQPCHVIYT 309
Cdd:cd18027 162 ADWIGRIKKKNIYVIST 178
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
143-644 |
5.12e-80 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 271.00 E-value: 5.12e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 143 FQREAI-QCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREM---YEEFQ-DVGLMTGDVT 217
Cdd:COG1204 26 PQAEALeAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFkrdFEELGiKVGVSTGDYD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 218 INP----TASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL---PDNVHYVFLSATIPNAR 290
Cdd:COG1204 106 SDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEVLLARLrrlNPEAQIVALSATIGNAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 291 QFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPaggDGLHLVVDENGDFREDNFNTAMQVLRDAGdlakgdqkgrkggtkg 370
Cdd:COG1204 186 EIAEWL------DAELVKSDWRPVPLNEGVLY---DGVLRFDDGSRRSKDPTLALALDLLEEGG---------------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 371 psnvfkivkmimernfqPVIIFSFSKKDCEAYALQMTKL--DFNTDEEKKMVEEVFSNAIDC--LSDEDKKLPQvehvlp 446
Cdd:COG1204 241 -----------------QVLVFVSSRRDAESLAKKLADElkRRLTPEEREELEELAEELLEVseETHTNEKLAD------ 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 447 LLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDfrwISSGEYIQMSGRAGR 526
Cdd:COG1204 298 CLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMVP---IPVLEFKQMAGRAGR 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 527 RGMDDRGIVILMVDEKMSPT-IGKQLLKGSADPLNSAFHLTYNMVLNLLRV---------EEINpEYmLEKSFYQFQHYR 596
Cdd:COG1204 375 PGYDPYGEAILVAKSSDEADeLFERYILGEPEPIRSKLANESALRTHLLALiasgfansrEELL-DF-LENTFYAYQYDK 452
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 193211480 597 A-IPGVVEKVKNSEEQYNKIVIPNEesvviyykiRQQLAKLGKEI-EEYI 644
Cdd:COG1204 453 GdLEEVVDDALEFLLENGFIEEDGD---------RLRATKLGKLVsRLYI 493
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
653-778 |
2.59e-70 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 229.77 E-value: 2.59e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 653 FLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDP--LYVVEVLLRCSKESLKNSA-TEAAKPAKPDEKGEMQVV 729
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSENSPPqeSYVVDVLLNCSSGSSINNGsPSGIRPPGPGEKGEMEVV 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 193211480 730 PVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLD 778
Cdd:cd13154 81 PVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDGLPLLD 129
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
868-1035 |
3.06e-70 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 230.42 E-value: 3.06e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 868 DVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAkVSA 947
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSPELAEALRLLEEIAHRIA-VSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 948 EakleideetylssFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGI 1027
Cdd:pfam08148 80 F-------------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEAI 146
|
....*...
gi 193211480 1028 TKIKRDIV 1035
Cdd:pfam08148 147 ELIKRDIV 154
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
312-540 |
3.12e-64 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 213.95 E-value: 3.12e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 312 RPTPLQHYIFPAGGDGLHLVVDENGDFrednfntamqvlrdagdlakgdqkgrkggtkgPSNVFKIVKMIMERNFQPVII 391
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKF--------------------------------DSDIIVLLKIETVSEGKPVLV 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 392 FSFSKKDCEAYALQMtkldfntdeekkmveevfsnaidclsdedkklpqvehvlpllkRGIGIHHGGLLPILKETIEILF 471
Cdd:cd18795 49 FCSSRKECEKTAKDL-------------------------------------------AGIAFHHAGLTREDRELVEELF 85
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193211480 472 SEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD 540
Cdd:cd18795 86 REGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
140-296 |
1.16e-58 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 199.41 E-value: 1.16e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 140 LDAFQREAIQCVDN-NQSVLVSAHTSAGKTVCAEYAIALALRE-KQRVIFTSPIKALSNQKYREMYEEFQ----DVGLMT 213
Cdd:cd17921 2 LNPIQREALRALYLsGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFGplgkNVGLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 214 GDVTINPT----ASCLVMTTEILRSMLYRGSE-VMREVAWVIFDEIHYMRDSERGVVWEETIILLP---DNVHYVFLSAT 285
Cdd:cd17921 82 GDPSVNKLllaeADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKNARFVGLSAT 161
|
170
....*....|.
gi 193211480 286 IPNARQFAEWI 296
Cdd:cd17921 162 LPNAEDLAEWL 172
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
138-574 |
1.33e-39 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 157.35 E-value: 1.33e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 138 FILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMyEEFQDVGLMT---- 213
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEEL-SRLRSLGMRVkisi 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 214 GDVTINPT----ASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETI----ILLPDnVHYVFLSAT 285
Cdd:PRK01172 100 GDYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLssarYVNPD-ARILALSAT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 286 IPNARQFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPAggDGLHLVVDENGDFREDnfntamqvlrdagdlakgdqkgrk 365
Cdd:PRK01172 179 VSNANELAQWL------NASLIKSNFRPVPLKLGILYR--KRLILDGYERSQVDIN------------------------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 366 ggtkgpsnvfKIVKMIMERNFQpVIIFSFSKKDCEAYAlqmtkldfntdeekKMVEEVFS--NAIDCLSDEDKKLPqvEH 443
Cdd:PRK01172 227 ----------SLIKETVNDGGQ-VLVFVSSRKNAEDYA--------------EMLIQHFPefNDFKVSSENNNVYD--DS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 444 VLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGR 523
Cdd:PRK01172 280 LNEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGR 359
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 193211480 524 AGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLL 574
Cdd:PRK01172 360 AGRPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMGSQRKVRFNTL 410
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
144-538 |
2.32e-33 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 138.55 E-value: 2.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 144 QREAIQC-VDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREmYEEFQDVGLMTGDVTINP-- 220
Cdd:PRK02362 28 QAEAVEAgLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEE-FERFEELGVRVGISTGDYds 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 221 ------TASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL----PdNVHYVFLSATIPNAR 290
Cdd:PRK02362 107 rdewlgDNDIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKLrrlnP-DLQVVALSATIGNAD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 291 QFAEWIchlhkqPCHVIYTDYRPTPLQ---HYifpagGDGLHLvvdengdfrednfntamqvlrdagdlakgDQKGRKGG 367
Cdd:PRK02362 186 ELADWL------DAELVDSEWRPIDLRegvFY-----GGAIHF-----------------------------DDSQREVE 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 368 TKGPSNVFKIVKMIMERNFQpVIIFSFSKKDCEAYALQMTkldfntDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPL 447
Cdd:PRK02362 226 VPSKDDTLNLVLDTLEEGGQ-CLVFVSSRRNAEGFAKRAA------SALKKTLTAAERAELAELAEEIREVSDTETSKDL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 448 ---LKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKD-FRWISSGEYIQMSGR 523
Cdd:PRK02362 299 adcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAgMQPIPVLEYHQMAGR 378
|
410
....*....|....*
gi 193211480 524 AGRRGMDDRGIVILM 538
Cdd:PRK02362 379 AGRPGLDPYGEAVLL 393
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
121-593 |
3.12e-32 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 134.94 E-value: 3.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 121 DYLPLKPRVGKAAKE------YPFILDAFQREAIQcvdnNQSVLVSAHTSAGKTVCAEYAIA-LALREKQRVIFTSPIKA 193
Cdd:PRK00254 4 DELRVDERIKRVLKErgieelYPPQAEALKSGVLE----GKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 194 LSNQKYREmYEEFQDVGL----MTGDVtiNPTASCL------VMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERG 263
Cdd:PRK00254 80 LAEEKYRE-FKDWEKLGLrvamTTGDY--DSTDEWLgkydiiIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 264 VVWEETIILLPDNVHYVFLSATIPNARQFAEWIchlhkqPCHVIYTDYRPTPLQHYIFPAGgdglhLVVDENGdfREDNF 343
Cdd:PRK00254 157 ATLEMILTHMLGRAQILGLSATVGNAEELAEWL------NAELVVSDWRPVKLRKGVFYQG-----FLFWEDG--KIERF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 344 NTAMQVL-RDAGDLAKGdqkgrkggtkgpsnvfkivkmimernfqpVIIFSFSKKDCEAYALQMTKL--DFNTDEEKKMV 420
Cdd:PRK00254 224 PNSWESLvYDAVKKGKG-----------------------------ALVFVNTRRSAEKEALELAKKikRFLTKPELRAL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 421 EEvfsnaidcLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTN 500
Cdd:PRK00254 275 KE--------LADSLEENPTNEKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRD 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 501 ARKFdgKDFRW--ISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNM---VLNLL- 574
Cdd:PRK00254 347 TKRY--SNFGWedIPVLEIQQMMGRAGRPKYDEVGEAIIVATTEEPSKLMERYIFGKPEKLFSMLSNESAFrsqVLALIt 424
|
490 500
....*....|....*....|....
gi 193211480 575 -----RVEEINPeyMLEKSFYQFQ 593
Cdd:PRK00254 425 nfgvsNFKELVN--FLERTFYAHQ 446
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
141-296 |
7.50e-31 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 120.17 E-value: 7.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 141 DAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD---------V 209
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLREsdDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 210 GLMTGDVTINPTASCLVMTT--EILRSML---YRGSEVMReVAWVIFDEIHYMRDSERGVVWEETIILLPdnVHYVFLSA 284
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLlspHNASWVPR-IKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSA 159
|
170
....*....|..
gi 193211480 285 TIPNARQFAEWI 296
Cdd:cd18025 160 TIGNPQKFHEWL 171
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
137-315 |
6.20e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 117.98 E-value: 6.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 137 PFILDAFQREAIQCV-DNNQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQD----- 208
Cdd:smart00487 6 FEPLRPYQKEAIEALlSGLRDVILAAPTGSGKTLAALLPALEALKRgkGGRVLVLVPTRELAEQWAEELKKLGPSlglkv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 209 VGLMTGDVT-------INPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVF 281
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....
gi 193211480 282 LSATIPNarqFAEWICHLHKQPCHVIYTDYRPTP 315
Cdd:smart00487 166 LSATPPE---EIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
144-287 |
1.27e-28 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 112.72 E-value: 1.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ---RVIFTSPIKALSNQKYREMYEEFQDVGLM----TGDV 216
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLKvaslLGGD 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193211480 217 TINP------TASCLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIP 287
Cdd:pfam00270 84 SRKEqleklkGPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
144-296 |
6.75e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 111.27 E-value: 6.75e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 144 QREAIQC-VDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKyremYEEFQD-------VGLMTGD 215
Cdd:cd18028 6 QAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEK----YEEFKKleeiglkVGISTGD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 216 VTINPT----ASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETII---LLPDNVHYVFLSATIPN 288
Cdd:cd18028 82 YDEDDEwlgdYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVArlrRLNPNTQIIGLSATIGN 161
|
....*...
gi 193211480 289 ARQFAEWI 296
Cdd:cd18028 162 PDELAEWL 169
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
153-560 |
7.14e-23 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 105.36 E-value: 7.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 153 NNQSVlVSAhTSAGKTVCAEYA-IALALREKQRVIFTSPIKALSNQKYREM---YEEFQDVGLMTGDVTIN-------PT 221
Cdd:COG1202 226 KDQLV-VSA-TATGKTLIGELAgIKNALEGKGKMLFLVPLVALANQKYEDFkdrYGDGLDVSIRVGASRIRddgtrfdPN 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 222 ASCLVMTTEILRSMLyRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILL----PDnVHYVFLSATIPNARQFAEwic 297
Cdd:COG1202 304 ADIIVGTYEGIDHAL-RTGRDLGDIGTVVIDEVHMLEDPERGHRLDGLIARLkyycPG-AQWIYLSATVGNPEELAK--- 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 298 HLHKQPchVIYtDYRPTPLQ-HYIFPAGGDGL----HLVVDEngdfrednFNTAmqvlrdagdlakgDQKGRKGGTkgps 372
Cdd:COG1202 379 KLGAKL--VEY-EERPVPLErHLTFADGREKIriinKLVKRE--------FDTK-------------SSKGYRGQT---- 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 373 nvfkivkmimernfqpvIIFSFSKKDCeayalqmtkldfntdeekkmveEVFSNAIDCLSDEdkklpqvehvlpllkrgi 452
Cdd:COG1202 431 -----------------IIFTNSRRRC----------------------HEIARALGYKAAP------------------ 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 453 giHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLF-TNARkfdGKDfrWISSGEYIQMSGRAGRRGMDD 531
Cdd:COG1202 454 --YHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFdSLAM---GIE--WLSVQEFHQMLGRAGRPDYHD 526
|
410 420 430
....*....|....*....|....*....|....*...
gi 193211480 532 RGIVILMV------DEKMSPT---IGKQLLKGSADPLN 560
Cdd:COG1202 527 RGKVYLLVepgksyHRSMEMTedeVAFKLLKGEMEDVA 564
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
144-313 |
9.89e-23 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 97.43 E-value: 9.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 144 QREAIQ-CVDNNQSVLVSAHTSAGKTVCAEYAIALALRE-------KQRVIFTSPIKALSNQKYREMYEEFQDVGL---- 211
Cdd:cd18023 6 QSEVFPdLLYSDKNFVVSAPTGSGKTVLFELAILRLLKErnplpwgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscae 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 212 MTGDVTINPT---ASC-LVMTT-EILRSMLYRGSE---VMREVAWVIFDEIHYMRDsERGVVWE-------------ETI 270
Cdd:cd18023 86 LTGDTEMDDTfeiQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEvvvsrmktlssssELR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 193211480 271 ILLPDNVHYVFLSATIPNARQFAEWichLHKQP--CHVIYTDYRP 313
Cdd:cd18023 165 GSTVRPMRFVAVSATIPNIEDLAEW---LGDNPagCFSFGESFRP 206
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
111-537 |
6.25e-17 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 86.04 E-value: 6.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 111 THEVALPAEE-DYLP----LKPRVGKA-AKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ- 183
Cdd:COG1205 22 VHVRTIPAREaRYAPwpdwLPPELRAAlKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 184 -RVIFTSPIKALSNQKYREMYEEFQDVGL------MTGDVT------INPTASCLVMTTEIL-RSMLYRG---SEVMREV 246
Cdd:COG1205 102 aTALYLYPTKALARDQLRRLRELAEALGLgvrvatYDGDTPpeerrwIREHPDIVLTNPDMLhYGLLPHHtrwARFFRNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 247 AWVIFDEIH-YmrdseRGVvweetiilLPDNVHYVF------------------LSATIPNARQFAEwicHLHKQPCHVI 307
Cdd:COG1205 182 RYVVIDEAHtY-----RGV--------FGSHVANVLrrlrricrhygsdpqfilASATIGNPAEHAE---RLTGRPVTVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 308 YTDYRPTPLQHYIF---PAGGDGLhlvvdengdfREDNFNTAMQVLRDAgdlakgdqkgrkggtkgpsnvfkivkmiMER 384
Cdd:COG1205 246 DEDGSPRGERTFVLwnpPLVDDGI----------RRSALAEAARLLADL----------------------------VRE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 385 NFQpVIIFSFSkkdceayalqmtkldfntdeeKKMVEEVFSNAIDCLSDedkklpqvehvlPLLKRGIGIHHGGLLPILK 464
Cdd:COG1205 288 GLR-TLVFTRS---------------------RRGAELLARYARRALRE------------PDLADRVAAYRAGYLPEER 333
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193211480 465 ETIEILFSEGLIKALFATETFAMGINMP---ArTVLftnarkfDGkdfrW---ISSgeYIQMSGRAGRRGmdDRGIVIL 537
Cdd:COG1205 334 REIERGLRSGELLGVVSTNALELGIDIGgldA-VVL-------AG----YpgtRAS--FWQQAGRAGRRG--QDSLVVL 396
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
154-296 |
3.93e-16 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 76.85 E-value: 3.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 154 NQSVLVSAHTSAGKTVCAEYAIALALREKQ----RVIFTSPIKALSNQKYR---EMYEEFQ---DVGLMTGDVT------ 217
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPekgvQVLYISPLKALINDQERrleEPLDEIDleiPVAVRHGDTSqsekak 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 218 -INPTASCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVH----YVFLSATIPNAR 290
Cdd:cd17922 81 qLKNPPGILITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKLTGrplrRIGLSATLGNLE 160
|
....*.
gi 193211480 291 QFAEWI 296
Cdd:cd17922 161 EAAAFL 166
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
440-528 |
4.27e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 74.17 E-value: 4.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 440 QVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMP-ARTVLFTNArkfdgkdfrWISSGEYI 518
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYI 72
|
90
....*....|
gi 193211480 519 QMSGRAGRRG 528
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
154-296 |
7.80e-15 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 73.95 E-value: 7.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 154 NQSVLVSAHTSAGKTVCAEYAIALALRE--KQRVIFTSPIKALSNQKYREMYEEFQDV-GL----MTGDVTINPT----A 222
Cdd:cd18022 17 DNNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGDVTPDMKaladA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 223 SCLVMTTE----ILRSMLYRgsEVMREVAWVIFDEIHyMRDSERGVVWEetIILLPDN---------VHYVFLSATIPNA 289
Cdd:cd18022 97 DIIITTPEkwdgISRSWQTR--EYVQQVSLIIIDEIH-LLGSDRGPVLE--VIVSRMNyissqtekpVRLVGLSTALANA 171
|
....*..
gi 193211480 290 RQFAEWI 296
Cdd:cd18022 172 GDLANWL 178
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
142-296 |
1.32e-13 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 70.36 E-value: 1.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 142 AFQREAIQCV-DNNQSVLVSAHTSAGKTVCAEYAIALALR--EKQRVIFTSPIKALSNQKYREMYEEFQDVG-----LMT 213
Cdd:cd18021 6 PIQTQVFNSLyNTDDNVFVGAPTGSGKTVCAELALLRHWRqnPKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvKLT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 214 GDVTINP---TASCLVMTT----EILrSMLYRGSEVMREVAWVIFDEIHyMRDSERGVVWEetIIL---------LPDNV 277
Cdd:cd18021 86 GETSTDLkllAKSDVILATpeqwDVL-SRRWKQRKNVQSVELFIADELH-LIGGENGPVYE--VVVsrmryissqLEKPI 161
|
170
....*....|....*....
gi 193211480 278 HYVFLSATIPNARQFAEWI 296
Cdd:cd18021 162 RIVGLSSSLANARDVGEWL 180
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
157-285 |
1.96e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 68.58 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 157 VLVSAHTSAGKTVCAEYAIALALREKQ-RVIFTSPIKALSNQKYREMYEEFQ---DVGLMTGDVT-------INPTASCL 225
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGkKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSaeereknKLGDADII 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193211480 226 VMTTE-ILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETII--LLPDNVHYVFLSAT 285
Cdd:cd00046 84 IATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
142-313 |
2.31e-13 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 69.94 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 142 AFQREAIQ--CVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQR-VIFTSPIKALSNQKYREMYEEFQDVGL----MTG 214
Cdd:cd18026 19 DWQKECLSlpGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKkALFVLPYVSIVQEKVDALSPLFEELGFrvegYAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 215 DVTINPTA-----SCLVMTTEILRSMLYRGSEVMR--EVAWVIFDEIHYMRDSERGVVWEETIILL----PDNVHYVFLS 283
Cdd:cd18026 99 NKGRSPPKrrkslSVAVCTIEKANSLVNSLIEEGRldELGLVVVDELHMLGDGHRGALLELLLTKLlyaaQKNIQIVGMS 178
|
170 180 190
....*....|....*....|....*....|
gi 193211480 284 ATIPNARQFAEWichLHKQpchVIYTDYRP 313
Cdd:cd18026 179 ATLPNLEELASW---LRAE---LYTTNFRP 202
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
142-334 |
5.28e-11 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 67.05 E-value: 5.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 142 AFQREAIQCVDNNQSVLVSAHTSAGKTV---------CAEYAIALALREKQRVIFTSPIKALSNQKYR-------EMYEE 205
Cdd:COG1201 27 PPQREAWPAIAAGESTLLIAPTGSGKTLaaflpaldeLARRPRPGELPDGLRVLYISPLKALANDIERnlrapleEIGEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 206 FQD------VGLMTGDvTinpTAS-----------CLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGVVW 266
Cdd:COG1201 107 AGLplpeirVGVRTGD-T---PASerqrqrrrpphILITTPESLALLLTspDARELLRGVRTVIVDEIHALAGSKRGVHL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 267 EETI----ILLPDNVHYVFLSATIPNARQFAEWIC-HLHKQPCHVIYTDYR----------PTPLQHYIFPAGGDGLHL- 330
Cdd:COG1201 183 ALSLerlrALAPRPLQRIGLSATVGPLEEVARFLVgYEDPRPVTIVDAGAGkkpdlevlvpVEDLIERFPWAGHLWPHLy 262
|
....*.
gi 193211480 331 --VVDE 334
Cdd:COG1201 263 prVLDL 268
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
142-294 |
3.69e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 60.29 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 142 AFQREAIQCVDNNQSVLVSAHTSAGKTVCaeY---AIALALREKQ-RVIFTSPIKALSN---QKYREMYEEFQ---DVGL 211
Cdd:cd17923 3 SHQAEAIEAARAGRSVVVTTGTASGKSLC--YqlpILEALLRDPGsRALYLYPTKALAQdqlRSLRELLEQLGlgiRVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 212 MTGD--------VTINPtASCLVMTTEILRSMLYRGSE----VMREVAWVIFDEIHYMrdseRGVVWEETIILL------ 273
Cdd:cd17923 81 YDGDtpreerraIIRNP-PRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLrrlrrl 155
|
170 180
....*....|....*....|....*
gi 193211480 274 --PDNVHYVFL--SATIPNARQFAE 294
Cdd:cd17923 156 crRYGADPQFIltSATIGNPAEHAR 180
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
144-264 |
4.07e-10 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 64.14 E-value: 4.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 144 QREAIQCVDNNQSVLVSAHTSAGKTVCAEYAI-----ALA----LREKQRVIFTSPIKALSN--------------QKYR 200
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIidelfRLGregeLEDKVYCLYVSPLRALNNdihrnleeplteirEIAK 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193211480 201 EMYEEFQD--VGLMTGDVT-------INPTASCLVMTTEILRSMLY--RGSEVMREVAWVIFDEIHYMRDSERGV 264
Cdd:PRK13767 117 ERGEELPEirVAIRTGDTSsyekqkmLKKPPHILITTPESLAILLNspKFREKLRTVKWVIVDEIHSLAENKRGV 191
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
130-642 |
1.19e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 62.35 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 130 GKAAKEYPFILDAFQREAIQ-----CVDNNQSVLVSAHTSAGKTVCAEYAIAlALREKQRVIFTSPIKALSNQkYREMYE 204
Cdd:COG1061 71 GDEASGTSFELRPYQQEALEallaaLERGGGRGLVVAPTGTGKTVLALALAA-ELLRGKRVLVLVPRRELLEQ-WAEELR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 205 EFQDVGLMTGDvTINPTASCLVMTTEILRSMLYRgSEVMREVAWVIFDEIHYMRDSergvVWEETIILLPDNvhYVF-LS 283
Cdd:COG1061 149 RFLGDPLAGGG-KKDSDAPITVATYQSLARRAHL-DELGDRFGLVIIDEAHHAGAP----SYRRILEAFPAA--YRLgLT 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 284 ATiPNaRQFAEWIchLHKQPCHVIYtDYRPTPL--QHYIFPAggdgLHLVVDENGDFREDNFNTAMQVLRDAgdLAKGDQ 361
Cdd:COG1061 221 AT-PF-RSDGREI--LLFLFDGIVY-EYSLKEAieDGYLAPP----EYYGIRVDLTDERAEYDALSERLREA--LAADAE 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 362 kgrkggtkgpsNVFKIVKMIMER--NFQPVIIFSFSKKDCEAYAlqmtkldfntdeekKMVEEVFSNAIDCLSDEDKKlp 439
Cdd:COG1061 290 -----------RKDKILRELLREhpDDRKTLVFCSSVDHAEALA--------------ELLNEAGIRAAVVTGDTPKK-- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 440 qvehvlpllKRgigihhggllpilKETIEiLFSEGLIKALFATETFAMGINMP-ARTVLFTNARKfdgkdfrwiSSGEYI 518
Cdd:COG1061 343 ---------ER-------------EEILE-AFRDGELRILVTVDVLNEGVDVPrLDVAILLRPTG---------SPREFI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 519 QMSGRAGRRGMD-DRGIVILMVDEKMSptigkqLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRA 597
Cdd:COG1061 391 QRLGRGLRPAPGkEDALVYDFVGNDVP------VLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEE 464
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 193211480 598 IPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEE 642
Cdd:COG1061 465 LLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEE 509
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
133-287 |
2.63e-09 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 57.81 E-value: 2.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 133 AKEYPFILDAFQREAIQCV--DNNQSV----LVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEF 206
Cdd:cd17918 9 CKSLPFSLTKDQAQAIKDIekDLHSPEpmdrLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 207 QD--VGLMTGDVT--INPTASCLVMTTEILRSmlyrgSEVMREVAWVIFDEIHYMrdserGVVWEETIILLpDNVHYVFL 282
Cdd:cd17918 89 PFinVELVTGGTKaqILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GATHFLEA 157
|
....*.
gi 193211480 283 SAT-IP 287
Cdd:cd17918 158 TATpIP 163
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
477-538 |
1.69e-08 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 54.10 E-value: 1.69e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193211480 477 KALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMD-DRGIVILM 538
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHfPEGEVTTL 134
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
423-528 |
1.86e-08 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 53.37 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 423 VFSNAIDCLsdedkklpQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMP-ARTVLFTNA 501
Cdd:pfam00271 20 IFSQTKKTL--------EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVINYDL 91
|
90 100
....*....|....*....|....*..
gi 193211480 502 rkfdgkdfrWISSGEYIQMSGRAGRRG 528
Cdd:pfam00271 92 ---------PWNPASYIQRIGRAGRAG 109
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
159-296 |
4.93e-08 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 57.63 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 159 VSAHTSAGKTVCA-EYAIALALREK------------QRVIFTSPIKALSNQKYREMYEEFQ----------------DV 209
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLQIPLKgiaderrrrgetevnlRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 210 GLMTGDVTINPTA-------SCLVMTTEILRSMLY-RGSEVMREVAWVIFDEIHYMRDSERG----VVWEETIILLPDNV 277
Cdd:PRK09751 81 GIRTGDTPAQERSkltrnppDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170
....*....|....*....
gi 193211480 278 HYVFLSATIPNARQFAEWI 296
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFL 179
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
140-285 |
4.74e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.38 E-value: 4.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 140 LDAFQREAIQCVD---NNQSVLVSAHTSAGKTVCAEYAIALALreKQRVIFTSPIKALSNQkyreMYEEFQD------VG 210
Cdd:cd17926 1 LRPYQEEALEAWLahkNNRRGILVLPTGSGKTLTALALIAYLK--ELRTLIVVPTDALLDQ----WKERFEDflgdssIG 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193211480 211 LMTGDVTINPTASCLVMTT-EILRSMLYRGSEVMREVAWVIFDEIHymRDSERGvvWEEtiILLPDNVHYVF-LSAT 285
Cdd:cd17926 75 LIGGGKKKDFDDANVVVATyQSLSNLAEEEKDLFDQFGLLIVDEAH--HLPAKT--FSE--ILKELNAKYRLgLTAT 145
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
154-293 |
4.33e-06 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 48.91 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 154 NQSVLVSAHTSAGKTVCAEYAIalaLREKQR--------------VIFTSPIKALsnqkYREMYEEFQD--------VGL 211
Cdd:cd18019 33 DENLLLCAPTGAGKTNVALLTI---LREIGKhrnpdgtinldafkIVYIAPMKAL----VQEMVGNFSKrlapygitVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 212 MTGDVT-----INPTaSCLVMTTEILRSMLYRGSE--VMREVAWVIFDEIHYMRDsERGVVWE-------ETIILLPDNV 277
Cdd:cd18019 106 LTGDQQltkeqISET-QIIVTTPEKWDIITRKSGDrtYTQLVRLIIIDEIHLLHD-DRGPVLEsivartiRQIEQTQEYV 183
|
170
....*....|....*.
gi 193211480 278 HYVFLSATIPNARQFA 293
Cdd:cd18019 184 RLVGLSATLPNYEDVA 199
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
142-286 |
4.78e-06 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 49.06 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 142 AFQREAIQCVDNNQSVLVSAHTSAGKTV-CAEYAIALALREKQ----RVIFTSP--IKALSNQKyREMYEEFQDVGLMTG 214
Cdd:cd17972 63 KFREEILEAISNNPVVIIRGATGCGKTTqVPQYILDDFIQNDRaaecNIVVTQPrrISAVSVAE-RVAFERGEEVGKSCG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 215 ------DVTINPTASCLVMTTEILRSMLYRGsevMREVAWVIFDEIHyMRDSERG---VVWEETIILLPDnVHYVFLSAT 285
Cdd:cd17972 142 ysvrfeSVLPRPHASILFCTVGVLLRKLEAG---IRGISHVIVDEIH-ERDINTDfllVVLRDVVQAYPD-LRVILMSAT 216
|
.
gi 193211480 286 I 286
Cdd:cd17972 217 I 217
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
163-266 |
7.17e-06 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 46.78 E-value: 7.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 163 TSAGKTvcaeYAiAL-ALREKQRVIFTSPIKALSnqkyREMYEEFQDVG----LMTGD-VTINPTASCLVMTTEilrsML 236
Cdd:cd17913 10 TNSGKT----YH-ALqRLKSAKSGVYCGPLRLLA----WEVYERLNAEGvpcdLVTGQeRREVEGATHVSCTVE----MA 76
|
90 100 110
....*....|....*....|....*....|
gi 193211480 237 YRGSEVmrEVAwVIfDEIHYMRDSERGVVW 266
Cdd:cd17913 77 SISEPY--DVA-VI-DEIQMIGDPQRGWAW 102
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
464-537 |
8.75e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 44.62 E-value: 8.75e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193211480 464 KETIEILFSEglIKALFATETFAMGINMP-ARTVLFTNarkfdgkdfRWISSGEYIQMSGRAGrRGMDDRGIVIL 537
Cdd:cd18785 13 IEHAEEIASS--LEILVATNVLGEGIDVPsLDTVIFFD---------PPSSAASYIQRVGRAG-RGGKDEGEVIL 75
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
154-296 |
8.06e-05 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 44.73 E-value: 8.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 154 NQSVLVSAHTSAGKTVCAEYAIALALREKQR-----------VIFTSPIKALSNqkyrEMYEEFQD--------VGLMTG 214
Cdd:cd18020 17 NENMLICAPTGAGKTNIAMLTILHEIRQHVNqggvikkddfkIVYIAPMKALAA----EMVEKFSKrlaplgikVKELTG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 215 DVTINPT---ASCLVMTTEILRSMLYRGS----EVMREVAWVIFDEIHYMRDsERGVVWEETIILLPDNVH-------YV 280
Cdd:cd18020 93 DMQLTKKeiaETQIIVTTPEKWDVVTRKSsgdvALSQLVRLLIIDEVHLLHD-DRGPVIESLVARTLRQVEstqsmirIV 171
|
170
....*....|....*.
gi 193211480 281 FLSATIPNARQFAEWI 296
Cdd:cd18020 172 GLSATLPNYLDVADFL 187
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
407-529 |
4.13e-04 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 41.43 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 407 TKLDFNTDEEKKMVEEVFSNA--IDCLSDEDkklpqVEHVLPLLKRgIGIH----HGGLLPILKETIEILFSEGLIKALF 480
Cdd:cd18794 12 DKKDEKLDLLKRIKVEHLGGSgiIYCLSRKE-----CEQVAARLQS-KGISaaayHAGLEPSDRRDVQRKWLRDKIQVIV 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 193211480 481 ATETFAMGINMP-ARTVLFTNARKfdgkdfrwiSSGEYIQMSGRAGRRGM 529
Cdd:cd18794 86 ATVAFGMGIDKPdVRFVIHYSLPK---------SMESYYQESGRAGRDGL 126
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
137-290 |
1.00e-03 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 41.16 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 137 PFILDAFQReaiqcvdNNQSVLVsAHTSAGKTVCAEYAIALAL-REKQRVIFTSPIKALSNQKYREMYEEF-----QDVG 210
Cdd:cd17990 8 PALRAALDA-------GGQVVLE-APPGAGKTTRVPLALLAELwIAGGKIIVLEPRRVAARAAARRLATLLgeapgETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 211 L-MTGDVTINPTASCLVMTTEILRSMLYRGSEvMREVAWVIFDEIHymrdsERGV--------VWEETIILLPDnVHYVF 281
Cdd:cd17990 80 YrVRGESRVGRRTRVEVVTEGVLLRRLQRDPE-LSGVGAVILDEFH-----ERSLdadlalalLLEVQQLLRDD-LRLLA 152
|
....*....
gi 193211480 282 LSATIPNAR 290
Cdd:cd17990 153 MSATLDGDG 161
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
143-295 |
1.39e-03 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 40.98 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 143 FQREAIQCVDNNQSVLVSAHTSAGKT-----VCAEYAIALALREKQRVIFTSP--IKALSNQKyREMYEEFQDVGLmtGD 215
Cdd:cd17981 6 MKQEIINMIDNNQVTVISGETGCGKTtqvtqFILDDAIERGKGSSCRIVCTQPrrISAISVAE-RVAAERAESCGL--GN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 216 VT----------INPTASCLVMTTEILRSMLyRGSEVMREVAWVIFDEIHyMRDSERGVVWEETIILLP--DNVHYVFLS 283
Cdd:cd17981 83 STgyqirlesrkPRKQGSILYCTTGIVLQWL-QSDPHLSNVSHLVLDEIH-ERNLQSDVLMGIVKDLLPfrSDLKVILMS 160
|
170
....*....|..
gi 193211480 284 ATIpNARQFAEW 295
Cdd:cd17981 161 ATL-NAEKFSDY 171
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
157-290 |
1.63e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 40.74 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 157 VLVSAHTSAGKTvcaEYAIALALR-----EKQRVIFTSPIKALSNQ---KYREMYEEFQD---VGLMTGDVTINPT---- 221
Cdd:cd17930 4 VILEAPTGSGKT---EAALLWALKlaargGKRRIIYALPTRATINQmyeRIREILGRLDDedkVLLLHSKAALELLesde 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193211480 222 --------------------ASCLVMTT--EILRSML-YRGSEVM-----REVawVIFDEIHyMRDSErgvVWEETIILL 273
Cdd:cd17930 81 epdddpveavdwalllkrswLAPIVVTTidQLLESLLkYKHFERRlhglaNSV--VVLDEVQ-AYDPE---YMALLLKAL 154
|
170 180
....*....|....*....|..
gi 193211480 274 PD-----NVHYVFLSATIPNAR 290
Cdd:cd17930 155 LEllgelGGPVVLMTATLPALL 176
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