NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|10092639|ref|NP_057525|]
View 

cysteine-rich motor neuron 1 protein precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 907-1036 1.11e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092639    907 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 985
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 10092639    986 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1036
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 4.97e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.32  E-value: 4.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 10092639     39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 683-734 3.25e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.11  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    683 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 734
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 819-873 1.22e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.57  E-value: 1.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    819 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 873
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
403-456 4.04e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     403 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 456
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
336-390 1.19e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.19e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 390
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 567-592 3.07e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.07e-04
                           10        20
                   ....*....|....*....|....*.
gi 10092639    567 CPELSCSKICPLGFQQDSHGCLICKC 592
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
758-808 4.68e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 4.68e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 10092639     758 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 808
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 612-662 1.86e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 1.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    612 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 662
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 907-1036 1.11e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092639    907 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 985
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 10092639    986 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1036
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 4.97e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.32  E-value: 4.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 10092639     39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 683-734 3.25e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    683 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 734
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 819-873 1.22e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    819 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 873
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
403-456 4.04e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     403 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 456
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
683-734 1.01e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.01e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 10092639     683 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 734
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
336-390 1.19e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.19e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 390
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 336-390 2.78e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.78e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 390
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 567-592 3.07e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.07e-04
                           10        20
                   ....*....|....*....|....*.
gi 10092639    567 CPELSCSKICPLGFQQDSHGCLICKC 592
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
819-873 3.22e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 3.22e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     819 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 873
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
758-808 4.68e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 4.68e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 10092639     758 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 808
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 758-808 4.98e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 4.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 10092639    758 GDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRK--GQCCPYC 808
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 8.94e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 38.99  E-value: 8.94e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092639      37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFgiyGTCDRGLRCVIRPP 95
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYT---PRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 612-662 1.86e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    612 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 662
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 403-456 4.47e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    403 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 456
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 907-1036 1.11e-76

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 247.46  E-value: 1.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092639    907 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 985
Cdd:pfam19442    1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 10092639    986 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 1036
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 4.97e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.32  E-value: 4.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 10092639     39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 683-734 3.25e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    683 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 734
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 819-873 1.22e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.22e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    819 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 873
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
403-456 4.04e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.04e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     403 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 456
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
683-734 1.01e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.01e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 10092639     683 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 734
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
336-390 1.19e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.19e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 390
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 336-390 2.78e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.78e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    336 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 390
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 567-592 3.07e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 3.07e-04
                           10        20
                   ....*....|....*....|....*.
gi 10092639    567 CPELSCSKICPLGFQQDSHGCLICKC 592
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
819-873 3.22e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 3.22e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 10092639     819 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 873
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
758-808 4.68e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 4.68e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 10092639     758 GDIFLAAESWKPDVCTSCICIDS-VISCFSESCPSV-SCERPVLRK--GQCCPYC 808
Cdd:smart00214    5 GRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 758-808 4.98e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.94  E-value: 4.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 10092639    758 GDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLRK--GQCCPYC 808
Cdd:pfam00093    5 GVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 8.94e-04

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 38.99  E-value: 8.94e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10092639      37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFgiyGTCDRGLRCVIRPP 95
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYT---PRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 612-662 1.86e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 10092639    612 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 662
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 827-873 3.15e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.22  E-value: 3.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 10092639    827 ADEERWDLDSCTH---CYC---LQGQTLCSTVS--CPPLPCVEPINVEGSCCPMC 873
Cdd:pfam14828  181 AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 403-456 4.47e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10092639    403 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 456
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 420-456 7.13e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 7.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 10092639    420 DCTFCQC---VNGERHC--VATVCGQ-TCTNPVKVPGECCPVC 456
Cdd:pfam14828  193 DPSGCGCgndENLERICanVLQRCPPpHCLSPLRPEGHCCDVC 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH