cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDSFCGCS 123
Cdd:cd20526    1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                         90
                 ....*....|....*....
gi 227116332 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526   81 VAEVLRMERIILDKLHWDL 99

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDSFCGCS 123
Cdd:cd20526    1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                         90
                 ....*....|....*....
gi 227116332 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526   81 VAEVLRMERIILDKLHWDL 99

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332    50 QWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDsfcgCSSSEILR 129
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILR 76

                   ....*..
gi 227116332   130 MERIILD 136
Cdd:smart00385  77 MERLLLE 83

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332 146 TPLDFLHIFHAIAVSArpqllFSLPKLSPSQHLAVLTKQLLH--------CMACNQLLQFKGSMLALAMV--SLEMEKLI 215
Cdd:cd20529    2 TPAHFLEYYLSQGVLF-----VDDHDGLPSELLEKVKEYVRKyadffldlSLQDYAFLNYKPSLLAAACIaaARKALGLS 76

                 ...
gi 227116332 216 PDW 218
Cdd:cd20529   77 PTW 79

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDSFCGCS 123
Cdd:cd20526    1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                         90
                 ....*....|....*....
gi 227116332 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526   81 VAEVLRMERIILDKLHWDL 99

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDSFCGCSS 124
Cdd:cd20584    2 RDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCTV 81

                         90
                 ....*....|....*
gi 227116332 125 SEILRMERIILDKLN 139
Cdd:cd20584   82 SDLKRMEKIISEKLH 96

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332   39 NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKtVEEDEkIPVLKVLARDS 118
Cdd:pfam00134  25 DINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAK-YEEIY-PPTVEDLVYIT 102

                          90       100
                  ....*....|....*....|....
gi 227116332  119 FCGCSSSEILRMERIILDKLNWDL 142
Cdd:pfam00134 103 DNAYTREEILRMERLILETLNFDL 126

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332    50 QWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARDsfcgCSSSEILR 129
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILR 76

                   ....*..
gi 227116332   130 MERIILD 136
Cdd:smart00385  77 MERLLLE 83

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  47 EVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTVEEDEKIPVLKVLARdsFCGCSSSE 126
Cdd:cd20559    1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSK--MCCNSYGE 78

                         90
                 ....*....|....*..
gi 227116332 127 --ILRMERIILDKLNWD 141
Cdd:cd20559   79 elFIQMEMHILNTLNWD 95

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  39 NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKY-LNCIAISCFFLAAKtVEEdekI--PVLKVLA 115
Cdd:cd20519   31 SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAK-LEE---IypPKLSEFA 106

                         90       100
                 ....*....|....*....|....*
gi 227116332 116 RDSFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20519  107 YVTDGACTEDEILTMELIILKALNW 131

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  42 PSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTveEDEKIPVLKVLARDSFCG 121
Cdd:cd20568   38 WKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKNFAYMTDGA 115

                         90
                 ....*....|....*....
gi 227116332 122 CSSSEILRMERIILDKLNW 140
Cdd:cd20568  116 YTVEDILRAERYMLNTLEF 134

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  47 EVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKtveEDEKIPVLKVLARdsFCGCSSSE 126
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACK---LEELPRTLKEIAK--VSGVSEKE 75

                 ....*..
gi 227116332 127 ILRMERI 133
Cdd:cd00043   76 LRKAEKE 82

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  42 PSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVK-AHPKYLNCIAISCFFLAAKTveEDEKIPVLKVLARDSFC 120
Cdd:cd20580   40 PKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDG 117

                         90       100
                 ....*....|....*....|
gi 227116332 121 GCSSSEILRMERIILDKLNW 140
Cdd:cd20580  118 ACSEDDILDMELIILKALKW 137

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAH---PKYLNCIAISCFFLAAKtVEEDEKIPVLKVLARDSFCG 121
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkdkPWMLQLLAVACLSLAAK-MEETDVPLLVDLQVEEPKYV 80

                         90
                 ....*....|....*....
gi 227116332 122 CSSSEILRMERIILDKLNW 140
Cdd:cd20543   81 FEAKTIQRMELLVLSTLEW 99

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  36 TNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTveedEKIPVLKVla 115
Cdd:cd20562   33 IQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKY----EEICAPQV-- 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227116332 116 rDSFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20562  107 -EEFCyitdnTYTKQEVLEMEIDVLNALQFE 136

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKtVEEDEKIPVlkvlarD 117
Cdd:cd20504   28 PDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAK-YEEIYPPEV------E 100

                         90       100
                 ....*....|....*....|....*..
gi 227116332 118 SFC-----GCSSSEILRMERIILDKLN 139
Cdd:cd20504  101 EFVyitddTYTKKQVLRMEHLVLKVLS 127

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTveeDEKIPvlkvLARD 117
Cdd:cd20573   48 KEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKM---KETIP----LTAE 120

                         90       100
                 ....*....|....*....|....*....
gi 227116332 118 SFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20573  121 KLCiytdnSIRPEELLQMELLVLNKLKWD 149

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  10 QRLSSLLERAISREAQMWKVNvpkiptnQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNC 89
Cdd:cd20575   28 QNLLRLEERYVPRVSYFQCVQ-------REIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQL 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 227116332  90 IAISCFFLAAKTveeDEKIPvlkvLARDSFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20575  101 LGAVCMLLASKL---RETTP----LTIEKLCiytdnSISPRQLLDWEILVLGKLKWD 150

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  58 QFNLYPETFALASSLLDRFlatvkahpkYLNC---------IAISCFFLAAKTVEEDEKIpvlkvlarDSFCG------C 122
Cdd:cd20524   68 AFKLPDSVLATALTYFKRF---------YLKNsvmeyhpkeIMLTCLYLACKVEEFNISI--------DQFVGnikeseK 130

                         90       100
                 ....*....|....*....|
gi 227116332 123 SSSEILRMERIILDKLNWDL 142
Cdd:cd20524  131 TAEIILEYELLLLQGLNFHL 150

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKtVEEDEKIPV--LKVLARDSFcgc 122
Cdd:cd20517    6 RKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASK-IRTVKPITVskLTYLSCDCF--- 81

                         90
                 ....*....|....*...
gi 227116332 123 SSSEILRMERIILDKLNW 140
Cdd:cd20517   82 TNLELINQEKDILEALKW 99

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  60 NLYPETFALASSLLDRFLA--TVKAHPKYLncIAISCFFLAAKtVEEDEK-----IPVLKVLARD----SFCGCSSSEIL 128
Cdd:cd20530   26 GLPYDTIATGIVYFHRFYMfhSFKDFDRYV--TAACCLFLAGK-VEETPKkckdiIKTARSLLNDkqfaQFGDDPKEEVM 102

                         90
                 ....*....|...
gi 227116332 129 RMERIILDKLNWD 141
Cdd:cd20530  103 VLERILLQTIKFD 115

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116332  50 QWLAKLKYQFNLYPETFALASSLLDRFlatVKAHPKYLNCIAIS-------CFFLAAKTVEEDEkiPVLKVLARdsFCGC 122
Cdd:cd20557    4 SFIARLLRRTRLSPSVVLLALVYLERL---RRRLPEALLGQEGSpyrlflvALMLASKYLDDES--YSNKSWAE--ISGL 76

                         90
                 ....*....|....*...
gi 227116332 123 SSSEILRMERIILDKLNW 140
Cdd:cd20557   77 PVRELNAMEREFLEALDW 94