NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62234461|ref|NP_060566|]
View 

notchless protein homolog 1 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 1.39e-104

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 1.39e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 181 LLWDPSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319 145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQ 339
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 340 gpeRLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319 260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62234461 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 1.02e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 1.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461    17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 1.39e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 1.39e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 181 LLWDPSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319 145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQ 339
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 340 gpeRLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319 260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62234461 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-484 6.99e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 278.45  E-value: 6.99e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDP 185
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 186 STGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 264
Cdd:cd00200  81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrgqgperl 344
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 345 vsgsddftlflwspaedkkpltrmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 424
Cdd:cd00200 185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 425 DSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 1.02e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 1.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461    17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 8.48e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 8.48e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 62234461    105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-142 1.87e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.87e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62234461   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-441 2.33e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  159 VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGR-------TLAGHSKwITGLSWEPLHANPecryVASSSKDGSVRIW 231
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNSYIKSQ----VASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  232 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVlcrtlqghghwvntmalstdyalrtga 305
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGV--------------------------- 609

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  306 fepaeasvnpqdlqgSLQELKERAlsryNLVRGQGP----ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFS 381
Cdd:PLN00181 610 ---------------SIGTIKTKA----NICCVQFPsesgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV 670

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461  382 pDSRIVASASFDKSIKLWD------GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-484 1.39e-104

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 1.39e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 181 LLWDPSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Cdd:COG2319 145 RLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkL 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQ 339
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 340 gpeRLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Cdd:COG2319 260 ---LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62234461 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
104-444 5.68e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 287.96  E-value: 5.68e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 104 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLW 183
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 184 DPSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYS 262
Cdd:COG2319 190 DLATGKLL-RTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLAS 263

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 263 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpe 342
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK--- 301

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 343 RLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 422
Cdd:COG2319 302 LLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                       330       340
                ....*....|....*....|..
gi 62234461 423 SADSRLLVSGSSDSTLKVWDVK 444
Cdd:COG2319 381 SPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
99-485 5.86e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 282.96  E-value: 5.86e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  99 RVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNG 178
Cdd:COG2319  21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 179 QILLWDPSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG 258
Cdd:COG2319 101 TVRLWDLATGLLL-RTLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 259 -LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvr 337
Cdd:COG2319 175 kLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--------------------------------------- 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 338 GQgpeRLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAV 417
Cdd:COG2319 216 GK---LLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62234461 418 YQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-484 6.99e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 278.45  E-value: 6.99e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDP 185
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 186 STGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 264
Cdd:cd00200  81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 265 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrgqgperl 344
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 345 vsgsddftlflwspaedkkpltrmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 424
Cdd:cd00200 185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 425 DSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
121-483 5.26e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 5.26e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVgRTLAGHSK 200
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 201 WITGLSWEPLHanpecRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVL 279
Cdd:COG2319  80 AVLSVAFSPDG-----RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 280 CRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLVSGSDDFTLFLWSpA 359
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-L 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Cdd:COG2319 192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 62234461 440 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:COG2319 272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-299 7.40e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 190.62  E-value: 7.40e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 185 PSTGKqVGRTLAGHSKWITGLSWEPlhanPECRYVASSSkDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:cd00200 164 LRTGK-CVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 62234461 264 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-273 1.79e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.07  E-value: 1.79e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 185 PSTGKQVGrTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:cd00200 206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279

                       170
                ....*....|
gi 62234461 264 SQDRTIKVWR 273
Cdd:cd00200 280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
105-276 2.44e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 2.44e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 185 PSTGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 263
Cdd:COG2319 317 LATGKLL-RTLTGHTGAVRSVAF-----SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASG 390

                       170
                ....*....|...
gi 62234461 264 SQDRTIKVWRAHD 276
Cdd:COG2319 391 SADGTVRLWDLAT 403
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 1.02e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 1.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461    17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 COG2319
WD40 repeat [General function prediction only];
379-484 4.78e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 4.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100
                ....*....|....*....|....*.
gi 62234461 459 VYAVDWSPDGQRVASGGKDKCLRIWR 484
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWD 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 8.48e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 8.48e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 62234461    105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 403-442 9.73e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 9.73e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 62234461    403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-142 1.87e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.87e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62234461   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-441 2.33e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  159 VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGR-------TLAGHSKwITGLSWEPLHANPecryVASSSKDGSVRIW 231
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNSYIKSQ----VASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  232 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVlcrtlqghghwvntmalstdyalrtga 305
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGV--------------------------- 609

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  306 fepaeasvnpqdlqgSLQELKERAlsryNLVRGQGP----ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFS 381
Cdd:PLN00181 610 ---------------SIGTIKTKA----NICCVQFPsesgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV 670

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461  382 pDSRIVASASFDKSIKLWD------GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-184 2.42e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.42e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 62234461    145 TETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 341-456 7.54e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  341 PERLVSGSDDFTLFLWS-PAEDKK-----PLTRMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 413
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 62234461  414 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 pfam00400
WD domain, G-beta repeat;
404-442 1.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62234461   404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-400 4.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 62234461    361 DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 96-276 5.26e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 5.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461   96 AIFRVRAVTRCTSS---LEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTCKGHRHWVLSISW 164
Cdd:PTZ00421  54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  165 SPDGRK-LASGCKNGQILLWDPSTGKqVGRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERILT 243
Cdd:PTZ00421 134 HPSAMNvLASAGADMVVNVWDVERGK-AVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 62234461  244 GH--TQSVTCLrWGGDGLL-----YSASQDRTIKVWRAHD 276
Cdd:PTZ00421 208 AHasAKSQRCL-WAKRKDLiitlgCSKSQQRQIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 447-483 6.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 62234461    447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 324-454 9.60e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 9.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  324 ELKERALSRYNL-VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTghQALINQVLFSPDS-RIVASASFDKSIKLWDG 401
Cdd:PLN00181 570 EMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgRSLAFGSADHKVYYYDL 647

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 62234461  402 RTGKY-LASLRGHVAAVYQIAWsADSRLLVSGSSDSTLKVWDvkaqkLAMDLPG 454
Cdd:PLN00181 648 RNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD-----LSMSISG 695
WD40 pfam00400
WD domain, G-beta repeat;
362-400 1.28e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62234461   362 KKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-272 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 62234461    236 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
447-483 2.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 62234461   447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 159-286 3.45e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  159 VLSISWSP-DGRKLASGCKNGQILLWD-PSTGKQVGRT-----LAGHSKWITGLSWEPLHANpecrYVASSSKDGSVRIW 231
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461  232 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
147-184 3.88e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 3.88e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62234461   147 TPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-232 4.17e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.17e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 62234461    187 TGKQVgRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWD 232
Cdd:smart00320   1 SGELL-KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 370-482 5.24e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.82  E-value: 5.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  370 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 440
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 62234461  441 WDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 482
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
236-272 5.25e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.25e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62234461   236 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 272
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
193-232 1.51e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 62234461   193 RTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWD 232
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 159-207 2.11e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.73  E-value: 2.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 62234461   159 VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVgRTLAGHSKWITGLSW 207
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 129-272 3.72e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP-DGRKLASGCKNGQILLWDPSTGKQVGRTlaghskwitglsw 207
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI------------- 614

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461  208 ePLHANPEC--------RYVASSSKDGSVRIWDTTAGR---CERIltGHTQSVTCLRWGGDGLLYSASQDRTIKVW 272
Cdd:PLN00181 615 -KTKANICCvqfpsesgRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 374-483 2.40e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  374 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 445
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 62234461  446 QKLAMDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 483
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
PTZ00420 PTZ00420
coronin; Provisional
 362-452 2.89e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  362 KKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 432
Cdd:PTZ00420  64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143

                         90       100
                 ....*....|....*....|.
gi 62234461  433 SS-DSTLKVWDVKAQKLAMDL 452
Cdd:PTZ00420 144 SGfDSFVNIWDIENEKRAFQI 164
PTZ00420 PTZ00420
coronin; Provisional
 110-304 4.16e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  110 LEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWdlstETPHftckgHRHWVLSISwspdgrklasgckngqillwDPSTg 188
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW----EIPH-----NDESVKEIK--------------------DPQC- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  189 kqvgrTLAGHSKWITGLSWEPLHANPECryvaSSSKDGSVRIWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QD 266
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVG 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 62234461  267 RTIKVWRAHDGVLCRTLQGHGH-------WVNTMALSTDYALRTG 304
Cdd:PTZ00420 189 KHMHIIDPRKQEIASSFHIHDGgkntkniWIDGLGGDDNYILSTG 233
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 387-443 5.12e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 5.12e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 62234461  387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDV 443
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsADPTLLASGSDDGSVKLWSI 605
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 128-274 7.51e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 43.12  E-value: 7.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 128 YLASGSGDTTVRFWDLSTETPH-FTckGHRHWVLSISWSPDGRKLA---SGCKNGQILLWDPSTGKQvgRTLAGHSKWIT 203
Cdd:COG0823   3 FTLSRDGNSDIYVVDLDGGEPRrLT--NSPGIDTSPAWSPDGRRIAftsDRGGGPQIYVVDADGGEP--RRLTFGGGYNA 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62234461 204 GLSWeplhaNPECRYVA-SSSKDGSVRIW--DTTAGRcERILTGHTQSVTclrWGGDG--LLYSASQDRTIKVWRA 274
Cdd:COG0823  79 SPSW-----SPDGKRLAfVSRSDGRFDIYvlDLDGGA-PRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYVV 145
PTZ00420 PTZ00420
coronin; Provisional
 342-400 1.46e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62234461  342 ERLVSGSDDFTLFLWS-PAED------KKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 400
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 162-255 3.49e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461   162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRIWDTTAGRCERI 241
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAW-----RPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|....
gi 62234461   242 LTGHTQSVTCLRWG 255
Cdd:pfam12894  76 FSAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 378-472 4.27e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.10  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  378 VLFSPDSRIVASASfDKSiklwdGRTGKYLASLRGHVAA----------VYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
Cdd:COG4946  348 PAWSPDGKSIAYFS-DAS-----GEYELYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLASGK 421

                         90       100
                 ....*....|....*....|....*.
gi 62234461  448 LA-MDLPGHADEVYAVDWSPDGQRVA 472
Cdd:COG4946  422 VRkVDTDGYGDGISDLAWSPDSKWLA 447
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-165 6.20e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 6.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62234461   107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 116-266 1.46e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  116 AVISVAFSPTGKYLA-----SGSgdttvrfWDL------STETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWD 184
Cdd:COG4946  344 RERLPAWSPDGKSIAyfsdaSGE-------YELyiapadGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  185 PSTGKqvgRTLAGHSKW---ITGLSWeplhaNPECRYVASSSKDGS----VRIWDTTAGRcERILTGHTQSVTCLRWGGD 257
Cdd:COG4946  417 LASGK---VRKVDTDGYgdgISDLAW-----SPDSKWLAYSKPGPNqlsqIFLYDVETGK-TVQLTDGRYDDGSPAFSPD 487

                        170
                 ....*....|.
gi 62234461  258 G--LLYSASQD 266
Cdd:COG4946  488 GkyLYFLSSRD 498
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 361-472 2.08e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 2.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461 361 DKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLW----DGRTGKYLASLRGHVAAvyqIAWSADSRLLV-SGSS 434
Cdd:COG0823  19 DGGEPRRLTNSPGIDTSPAWSPDgRRIAFTSDRGGGPQIYvvdaDGGEPRRLTFGGGYNAS---PSWSPDGKRLAfVSRS 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62234461 435 DSTLKVWdvkaqklAMDLPGHA-----DEVYAVDWSPDGQRVA 472
Cdd:COG0823  96 DGRFDIY-------VLDLDGGAprrltDGPGSPSWSPDGRRIV 131
PTZ00420 PTZ00420
coronin; Provisional
 410-483 4.54e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461  410 LRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDVKAQKLAMD--------LPGHADEVYAVDWSPDGQRV-ASGGKDKC 479
Cdd:PTZ00420  70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPMNYYImCSSGFDSF 149


                 ....
gi 62234461  480 LRIW 483
Cdd:PTZ00420 150 VNIW 153
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 105-227 5.32e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62234461   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPhfTCKGHRHWVLSISWspdgrklasgckNGQILLWD 184
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRS--SEKRSRNTQTEFPR------------KDHVIAET 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 62234461   185 PStgkqvgRTLAGHSKWITGlswepLHANPECRYVASSSKDGS 227
Cdd:pfam20426 181 PF------HILCGHDDIITC-----LYVSVELDIVISGSKDGT 212
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 391-443 5.86e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62234461   391 SFdKSIKLWDGRTgkyLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH