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Conserved domains on  [gi|16445428|ref|NP_061139|]
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tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-300 2.01e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 2.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEKKSQeNKGEdapldqgSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSV- 98
Cdd:cd00200  21 GKLLATG---SGDGTIKVWDLETGELLRT-LKGH-------TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTl 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  99 RTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPhGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL-WDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 179 SIESFCLGHTEFVSRISVVPTQpGLLLSSSGDGTLRLWEYRSGRQLHCC--HLASLQELVdpqapqkFAASRiafwcqEN 256
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGVNSVA-------FSPDG------YL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 16445428 257 CVALLCDGTpvVYIFQLDARRQQLVYRqqlAFQHQVWDVAFEET 300
Cdd:cd00200 234 LASGSEDGT--IRVWDLRTGECVQTLS---GHTNSVTSLAWSPD 272
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-300 2.01e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 2.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEKKSQeNKGEdapldqgSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSV- 98
Cdd:cd00200  21 GKLLATG---SGDGTIKVWDLETGELLRT-LKGH-------TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTl 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  99 RTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPhGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL-WDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 179 SIESFCLGHTEFVSRISVVPTQpGLLLSSSGDGTLRLWEYRSGRQLHCC--HLASLQELVdpqapqkFAASRiafwcqEN 256
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGVNSVA-------FSPDG------YL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 16445428 257 CVALLCDGTpvVYIFQLDARRQQLVYRqqlAFQHQVWDVAFEET 300
Cdd:cd00200 234 LASGSEDGT--IRVWDLRTGECVQTLS---GHTNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
20-216 9.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 9.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEKKsqenkgedAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVR 99
Cdd:COG2319 216 GKLLASG---SADGTVRLWDLATGKLL--------RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 100 TV-ARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLElGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:COG2319 285 TGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL-WDLATG 362

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 16445428 179 SIESFCLGHTEFVSRISVVPTQPgLLLSSSGDGTLRLW 216
Cdd:COG2319 363 ELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-217 5.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 16445428    186 GHTEFVSRISVVPTQPgLLLSSSGDGTLRLWE 217
Cdd:smart00320  10 GHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
186-217 9.80e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.80e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16445428   186 GHTEFVSRISVVPTQPgLLLSSSGDGTLRLWE 217
Cdd:pfam00400   9 GHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-300 2.01e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 2.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEKKSQeNKGEdapldqgSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSV- 98
Cdd:cd00200  21 GKLLATG---SGDGTIKVWDLETGELLRT-LKGH-------TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTl 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  99 RTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPhGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL-WDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 179 SIESFCLGHTEFVSRISVVPTQpGLLLSSSGDGTLRLWEYRSGRQLHCC--HLASLQELVdpqapqkFAASRiafwcqEN 256
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGVNSVA-------FSPDG------YL 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 16445428 257 CVALLCDGTpvVYIFQLDARRQQLVYRqqlAFQHQVWDVAFEET 300
Cdd:cd00200 234 LASGSEDGT--IRVWDLRTGECVQTLS---GHTNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
20-216 9.14e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 9.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEKKsqenkgedAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVR 99
Cdd:COG2319 216 GKLLASG---SADGTVRLWDLATGKLL--------RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 100 TV-ARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLElGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:COG2319 285 TGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL-WDLATG 362

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 16445428 179 SIESFCLGHTEFVSRISVVPTQPgLLLSSSGDGTLRLW 216
Cdd:COG2319 363 ELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
20-225 6.16e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 6.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  20 SRFLATSiasSDDDSLFIYDCSAAEkksqenkgEDAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVR 99
Cdd:COG2319 174 GKLLASG---SDDGTVRLWDLATGK--------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 100 TVARRC-TALTFIASEEKVLVADKSGDVYSFSVlEPHGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPH 178
Cdd:COG2319 243 TGHSGSvRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL-WDLATG 320

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 16445428 179 SIESFCLGHTEFVSRISVVPtQPGLLLSSSGDGTLRLWEYRSGRQLH 225
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
21-225 1.58e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  21 RFLATSiasSDDDSLFIYDcsAAEKKSQenkgedAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCL-SVR 99
Cdd:COG2319 133 KTLASG---SADGTVRLWD--LATGKLL------RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrTLT 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 100 TVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLElGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPHS 179
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRL-WDLATGE 279

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 16445428 180 IESFCLGHTEFVSRISVVPTqpG-LLLSSSGDGTLRLWEYRSGRQLH 225
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPD--GkLLASGSDDGTVRLWDLATGKLLR 324
WD40 COG2319
WD40 repeat [General function prediction only];
24-225 3.07e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 3.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  24 ATSIASSDDDSLFIYDCSAAEkksqenkgEDAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCL-SVRTVA 102
Cdd:COG2319  91 RLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTGHS 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 103 RRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLElGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPHSIES 182
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRL-WDLATGKLLR 240

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 16445428 183 FCLGHTEFVSRISVVPTqpG-LLLSSSGDGTLRLWEYRSGRQLH 225
Cdd:COG2319 241 TLTGHSGSVRSVAFSPD--GrLLASGSADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
52-225 7.43e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 7.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  52 GEDAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVRTVAR-RCTALTFIASEEKVLVADKSGDVYSFS 130
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTaAVLSVAFSPDGRLLASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 131 VlEPHGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVsW-AAAPHSIESFcLGHTEFVSRISVVPTqpG-LLLSSS 208
Cdd:COG2319 107 L-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-WdLATGKLLRTL-TGHSGAVTSVAFSPD--GkLLASGS 181

                       170
                ....*....|....*..
gi 16445428 209 GDGTLRLWEYRSGRQLH 225
Cdd:COG2319 182 DDGTVRLWDLATGKLLR 198
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-225 9.07e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 9.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 143 GHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPHSIESFCLGHTEFVSRISVVPTQPgLLLSSSGDGTLRLWEYRSGR 222
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGDGTIKV-WDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGE 84


                ...
gi 16445428 223 QLH 225
Cdd:cd00200  85 CVR 87
WD40 COG2319
WD40 repeat [General function prediction only];
69-225 1.34e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  69 FSKSGSYFALTDDSKRLILFRTKPWQCLSVRTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLELGHLSML 148
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16445428 149 LDVAVSPDDRFILTADRDEKIRVsWAAAPHSIESFCLGHTEFVSRISVVPTQpGLLLSSSGDGTLRLWEYRSGRQLH 225
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL-WDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLR 156
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-217 3.61e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 3.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428 106 TALTFIASEEKVLVAdkSGD----VYSFSVLEPHGCGRlelGHLSMLLDVAVSPDDRFILTADRDEKIRVsWAAAPHSIE 181
Cdd:cd00200 181 NSVAFSPDGEKLLSS--SSDgtikLWDLSTGKCLGTLR---GHENGVNSVAFSPDGYLLASGSEDGTIRV-WDLRTGECV 254

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16445428 182 SFCLGHTEFVSRISVVPTqPGLLLSSSGDGTLRLWE 217
Cdd:cd00200 255 QTLSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-174 2.37e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  13 TLVVRGGSRFLATSiasSDDDSLFIYDcSAAEKKSQENKGEDapldqgsGAILASTFSKSGSYFALTDDSKRLILFRTKP 92
Cdd:cd00200 140 SVAFSPDGTFVASS---SQDGTIKLWD-LRTGKCVATLTGHT-------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445428  93 WQCLSVRTVAR-RCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLElGHLSMLLDVAVSPDDRFILTADRDEKIRV 171
Cdd:cd00200 209 GKCLGTLRGHEnGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                ...
gi 16445428 172 sWA 174
Cdd:cd00200 288 -WD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-226 3.36e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 3.36e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 16445428 186 GHTEFVSRISVVPtQPGLLLSSSGDGTLRLWEYRSGRQLHC 226
Cdd:cd00200   7 GHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRT 46
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-217 5.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 16445428    186 GHTEFVSRISVVPTQPgLLLSSSGDGTLRLWE 217
Cdd:smart00320  10 GHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
186-217 9.80e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.80e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16445428   186 GHTEFVSRISVVPTQPgLLLSSSGDGTLRLWE 217
Cdd:pfam00400   9 GHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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