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Conserved domains on  [gi|186972114|ref|NP_062016|]
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fibronectin precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 3.30e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.98  E-value: 3.30e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.25e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.25e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1539-1620 1.82e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.77  E-value: 1.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1539 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 186972114  1616 DSPAS 1620
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1633-1713 5.15e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.62  E-value: 5.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.03e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGNq 1072
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1073 qsPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGeAPREVTSDSGSIVVSGLTPGVEYTYTI 1152
Cdd:COG3401   133 --GGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT-TSLTVTSTTLVDGGGDIEPGTTYYYRV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1153 QVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaDQS 1229
Cdd:COG3401   210 AATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---TTT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1230 SCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------IPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRITVV 1302
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVYRS 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1303 AAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTWAP 1379
Cdd:COG3401   364 TSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTDVA 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1380 PPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDV 1459
Cdd:COG3401   440 GATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490
                  ....*....|.
gi 186972114 1460 TANSFTVHWVA 1470
Cdd:COG3401   520 VGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 1.30e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1449 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.34e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 1.19e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.19e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186972114   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.46e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1813 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 3.83e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 3.83e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
698-1033 8.69e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 8.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 186972114 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
fn1 pfam00039
Fibronectin type I domain;
232-271 8.87e-15

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 8.87e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2341-2382 1.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 186972114   2341 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2382
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2296-2340 1.22e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.22e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114   2296 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2340
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.70e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.70e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.47e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.47e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1905-1984 5.68e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 5.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.77e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.61  E-value: 1.77e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 4.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 4.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2384-2423 7.01e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114 2384 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2423
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.25e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.25e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 186972114    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
619-688 1.38e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.38e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186972114   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.45e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.65  E-value: 4.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 186972114   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1810 1.07e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1800 ESQPLIGVQST 1810
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2210-2268 8.11e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186972114  2210 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2268
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 9.98e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.57  E-value: 9.98e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 3.30e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.98  E-value: 3.30e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.25e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.25e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.39e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.39e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 186972114  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 1.68e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.68e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 186972114  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.27e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.85  E-value: 1.27e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 186972114   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1539-1620 1.82e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.77  E-value: 1.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1539 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 186972114  1616 DSPAS 1620
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 2.88e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.00  E-value: 2.88e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 186972114   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 5.15e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.62  E-value: 5.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.03e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGNq 1072
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1073 qsPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGeAPREVTSDSGSIVVSGLTPGVEYTYTI 1152
Cdd:COG3401   133 --GGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT-TSLTVTSTTLVDGGGDIEPGTTYYYRV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1153 QVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaDQS 1229
Cdd:COG3401   210 AATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---TTT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1230 SCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------IPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRITVV 1302
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVYRS 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1303 AAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTWAP 1379
Cdd:COG3401   364 TSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTDVA 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1380 PPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDV 1459
Cdd:COG3401   440 GATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490
                  ....*....|.
gi 186972114 1460 TANSFTVHWVA 1470
Cdd:COG3401   520 VGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 1.30e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1449 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.34e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 1.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.19e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186972114   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.46e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1813 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1358-1439 2.39e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1994-2074 2.80e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 2.80e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1994 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  2071 KSEP 2074
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 3.63e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 3.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 186972114  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 3.83e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 3.83e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1033 8.69e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 8.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 186972114 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
fn1 pfam00039
Fibronectin type I domain;
232-271 8.87e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 8.87e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2341-2382 1.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 186972114   2341 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2382
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2296-2340 1.22e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.22e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114   2296 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2340
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-274 2.01e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.01e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 186972114    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH 274
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 2.40e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.60  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1449 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 1526 ESPP 1529
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.70e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.70e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.47e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.47e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1905-1984 5.68e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 5.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1539-1621 5.83e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1539 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 186972114 1616 DSPASS 1621
Cdd:cd00063    82 ESPPSE 87
fn1 pfam00039
Fibronectin type I domain;
561-599 8.96e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 8.96e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1720 1.56e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1710 ESQPLVQTAVT 1720
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2296-2335 1.63e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2296 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRC 2335
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.77e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.61  E-value: 1.77e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1695-2065 2.25e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1695 TVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS-PEDGIHELFPAPDGD 1773
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVaAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1774 EDTAELHGLRPGSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTG 1853
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1854 PMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET- 1930
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESd 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1931 ITGFQVDAIPANGQTPVQRTiSPDVRSYTITGLQPGTDYKIHLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLTTT 2005
Cdd:COG3401   261 ATGYRVYRSNSGDGPFTKVA-TVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVG 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186972114 2006 PNSLLVSWQAPR-ARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 2065
Cdd:COG3401   340 SSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
470-508 2.65e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.65e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
907-987 7.82e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 7.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLpGEHGQRLPVNRNTF-AEVTGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 186972114   983 RESKP 987
Cdd:pfam00041   80 GEGPP 84
fn1 pfam00039
Fibronectin type I domain;
187-226 8.46e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 8.46e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 2.29e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.29e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 186972114    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 2.50e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1436 ES 1437
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 2.83e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 63.12  E-value: 2.83e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 4.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 4.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2384-2423 7.01e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114 2384 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2423
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 7.47e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.95  E-value: 7.47e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1994-2072 1.12e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 1.12e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1994 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   2071 KS 2072
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.25e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.25e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 186972114    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 1436 ESIP 1439
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
619-688 1.38e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.38e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186972114   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.49e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.49e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.53e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.53e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTAPKNGlgPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 186972114   1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 2.62e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.62e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1449 DSPTGFDSSDVTANSFTVHWVAPRAP-ITGYIIRHHAEHSAGRPRQDRV--PPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1526 ES 1527
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 3.06e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114  984 ESKPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 4.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 4.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1616 DS 1617
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.45e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.65  E-value: 4.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 186972114   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2341-2378 5.59e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 59.25  E-value: 5.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2341 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2378
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2294-2338 5.90e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114 2294 DSCFDPYTVSHYAVGEEWERLSDsGFKLTCQCLGfGSGHFRCDSS 2338
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1900 6.55e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1813 PAPTNLKFTQVSPTTLTAQWTAPS---VKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1890 TSRPAQGVVTT 1900
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1810 1.07e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1800 ESQPLIGVQST 1810
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.28e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 1.28e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.79e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 1.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1723 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGDEDTAELHGLRPGSEYTVSVVALHGG 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 186972114  1799 MESQP 1803
Cdd:pfam00041   80 GEGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2385-2425 1.81e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 58.13  E-value: 1.81e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114   2385 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2425
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 3.28e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.28e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 186972114   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 3.97e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.96  E-value: 3.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 6.13e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 6.13e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 186972114   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.17e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 1.17e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1905-1985 1.48e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1905 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 186972114 1981 RSSPV 1985
Cdd:cd00063    82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 1.62e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.43  E-value: 1.62e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2340-2381 2.27e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.27e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114 2340 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2381
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1884 6.03e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 6.03e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186972114   1813 PAPTNLKFTQVSPTTLTAQWTAPSVK-LTGYRV--RVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYA 1884
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.22e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2385-2420 4.20e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 51.16  E-value: 4.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2385 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2420
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 6.20e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.79  E-value: 6.20e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
53-88 1.38e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.62  E-value: 1.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1905-1979 2.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1905 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRTISPDVRSYTITGLQPGTDYKIHLYTLNDN 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 5.35e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 5.35e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114    907 PAPKDLQFVEVTDVKVTIMWTPPNSAV-TGYRVDVLPVNLPGEHGQR--LPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114    984 ES 985
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
2210-2268 8.11e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186972114  2210 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2268
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1725-1801 5.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 5.54e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1725 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELfpAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1799
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1800 ES 1801
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 1.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.10e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186972114    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRPK--TSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEyrEEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 9.98e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.57  E-value: 9.98e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 1.01e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 1.47e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 41.16  E-value: 1.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114  307 HCVTDS-GVVYSVGMQWLKSQGDKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 3.30e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.98  E-value: 3.30e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.25e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.25e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 186972114    413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.39e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.39e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 186972114  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 1.68e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.68e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 186972114  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 1.27e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.85  E-value: 1.27e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 186972114   360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1539-1620 1.82e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.77  E-value: 1.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1539 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 186972114  1616 DSPAS 1620
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 2.88e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.00  E-value: 2.88e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 186972114   420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 5.15e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.62  E-value: 5.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 7.03e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 90.06  E-value: 7.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGNq 1072
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1073 qsPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGeAPREVTSDSGSIVVSGLTPGVEYTYTI 1152
Cdd:COG3401   133 --GGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVAT-TSLTVTSTTLVDGGGDIEPGTTYYYRV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1153 QVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEVvhaDQS 1229
Cdd:COG3401   210 AATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---TTT 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1230 SCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------IPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRITVV 1302
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVYRS 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1303 AAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTWAP 1379
Cdd:COG3401   364 TSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTDVA 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1380 PPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDV 1459
Cdd:COG3401   440 GATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAA 519

                         490
                  ....*....|.
gi 186972114 1460 TANSFTVHWVA 1470
Cdd:COG3401   520 VGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 1.30e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.68  E-value: 1.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1449 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1994-2074 1.34e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1994 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 2071 KSEP 2074
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 1.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.19e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186972114   811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1813-1893 1.46e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.60  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1813 PAPTNLKFTQVSPTTLTAQWTAP---SVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1890 TSRP 1893
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1358-1439 2.39e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.39e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1994-2074 2.80e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 2.80e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1994 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  2071 KSEP 2074
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 3.63e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 3.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 186972114  886 QESTPVFIQQETT 898
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 3.83e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 3.83e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1033 8.69e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 8.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  698 TTSASTPVTSNTVTGETAPFSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401   290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWT 927
Cdd:COG3401   370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  928 PPNSAVTGYRVDVLPVNLPgehgqrlPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401   450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                         330       340
                  ....*....|....*....|....*.
gi 186972114 1008 TDRTVLVTWTPPRARIAGYRLTVGLT 1033
Cdd:COG3401   523 APDGTPNVTGASPVTVGASTGDVLIT 548
fn1 pfam00039
Fibronectin type I domain;
232-271 8.87e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 8.87e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2341-2382 1.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.15e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 186972114   2341 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2382
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2296-2340 1.22e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.22e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114   2296 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRCDSSKW 2340
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1240-1667 1.98e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1240 LEYNVSVYTVKDDKESAPISDTVIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1319
Cdd:COG3401    22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1320 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIE-LTNLLVRYSPVKNE 1398
Cdd:COG3401   102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1399 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDVTANSFTVHWVAPRAP 1474
Cdd:COG3401   180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTES 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1475 -ITGYIIrHHAEHSAGRPRQdRVPPSRNSITLTNLNPGTEYIVTIIAVNGR-EESPPligqqSTVSDV---------PRD 1543
Cdd:COG3401   260 dATGYRV-YRSNSGDGPFTK-VATVTTTSYTDTGLTNGTTYYYRVTAVDAAgNESAP-----SNVVSVttdltppaaPSG 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1544 LEVIASTPTSLLISWEPPA-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSK 1622
Cdd:COG3401   333 LTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSE 411

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 186972114 1623 PVSINYQTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTA 1667
Cdd:COG3401   412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAA 456
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-274 2.01e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.01e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 186972114    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH 274
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 2.40e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.60  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1449 DSPTGFDSSDVTANSFTVHWVAPR---APITGYIIRHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 1526 ESPP 1529
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.70e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.70e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 3.47e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.47e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1905-1984 5.68e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 5.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1905 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 186972114  1981 RSSP 1984
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1539-1621 5.83e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1539 DVPRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 186972114 1616 DSPASS 1621
Cdd:cd00063    82 ESPPSE 87
fn1 pfam00039
Fibronectin type I domain;
561-599 8.96e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 8.96e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1720 1.56e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1710 ESQPLVQTAVT 1720
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
2296-2335 1.63e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2296 CFDPYTVSHYAVGEEWERLSDSGFKLTCQCLGFGSGHFRC 2335
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 1.77e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.61  E-value: 1.77e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1695-2065 2.25e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1695 TVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS-PEDGIHELFPAPDGD 1773
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVaAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1774 EDTAELHGLRPGSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTG 1853
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1854 PMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET- 1930
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESd 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1931 ITGFQVDAIPANGQTPVQRTiSPDVRSYTITGLQPGTDYKIHLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLTTT 2005
Cdd:COG3401   261 ATGYRVYRSNSGDGPFTKVA-TVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAVG 339

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186972114 2006 PNSLLVSWQAPR-ARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 2065
Cdd:COG3401   340 SSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
1267-1349 2.45e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 2.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1267 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1344
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 186972114  1345 ESAPT 1349
Cdd:pfam00041   81 EGPPS 85
fn1 pfam00039
Fibronectin type I domain;
470-508 2.65e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.65e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
807-1297 3.34e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 3.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  807 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQ 886
Cdd:COG3401    54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  887 ESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWTPPNSAVTGYRVDVLPVNLPGEHGqrlpvnrntfaevtGL 966
Cdd:COG3401   134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  967 SPGVTYLFKVFAVHQGRESKP----LTAQQTTKLDAPTNLQFVNETDRTVLVTWTP-PRARIAGYRLTVGLTRGGQPKQY 1041
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKV 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1042 NVGPMASkYPLRNLQPGSEYTVTLMAVKGN-QQSPKATGVFTTLQPLRSIPPYN---TEVTETTIVITWTPAP---RIGF 1114
Cdd:COG3401   280 ATVTTTS-YTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTPPAAPSGltaTAVGSSSITLSWTASSdadVTGY 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1115 KLGVRPSQGGEAPREVTSDSG-SIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA-------NPD 1186
Cdd:COG3401   359 NVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAsvdavplTDV 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1187 TGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGTALEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAP 1257
Cdd:COG3401   439 AGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 186972114 1258 ISDTVIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGY 1297
Cdd:COG3401   519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
fn3 pfam00041
Fibronectin type III domain;
907-987 7.82e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 7.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLpGEHGQRLPVNRNTF-AEVTGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 186972114   983 RESKP 987
Cdd:pfam00041   80 GEGPP 84
fn1 pfam00039
Fibronectin type I domain;
187-226 8.46e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 8.46e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1174-1257 2.05e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.74  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1174 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQGTaLEEVVHADQSSCTFENLNPGLEYNVSVYTVK 1250
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGEPW-NEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 186972114  1251 DDKESAP 1257
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 2.29e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.29e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114    810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 186972114    885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 2.50e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1436 ES 1437
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 2.83e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 63.12  E-value: 2.83e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
726-797 4.62e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 4.62e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186972114   726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 4.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.37  E-value: 4.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114     98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
997-1075 5.83e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 5.83e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   997 DAPTNLQFVNETDRTVLVTWTPPRAR---IAGYRLTVGLTRGGQPKQ-YNVGPMASKYPLRNLQPGSEYTVTLMAVKGNQ 1072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 186972114  1073 QSP 1075
Cdd:pfam00041   81 EGP 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2384-2423 7.01e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.01e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114 2384 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2423
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 7.47e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.95  E-value: 7.47e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1994-2072 1.12e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.63  E-value: 1.12e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1994 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2070
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   2071 KS 2072
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.25e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.21  E-value: 1.25e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 186972114    142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 186972114 1436 ESIP 1439
Cdd:cd00063    82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
619-688 1.38e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.38e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186972114   619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 1.49e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.49e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.53e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 1.53e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTAPKNGlgPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 186972114   1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 997-1083 1.74e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  997 DAPTNLQFVNETDRTVLVTWTPPR---ARIAGYRLTVGLTRGGQPKQYNVGPM-ASKYPLRNLQPGSEYTVTLMAVKGNQ 1072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 186972114 1073 QSPKATGV-FTT 1083
Cdd:cd00063    82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 2.62e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 2.62e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1449 DSPTGFDSSDVTANSFTVHWVAPRAP-ITGYIIRHHAEHSAGRPRQDRV--PPSRNSITLTNLNPGTEYIVTIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1526 ES 1527
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 3.06e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  907 PAPKDLQFVEVTDVKVTIMWTPP---NSAVTGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114  984 ESKPLTAQQTT 994
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 4.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 4.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1616 DS 1617
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 4.45e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.65  E-value: 4.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 186972114   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2341-2378 5.59e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 59.25  E-value: 5.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2341 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2378
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2294-2338 5.90e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.90e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114 2294 DSCFDPYTVSHYAVGEEWERLSDsGFKLTCQCLGfGSGHFRCDSS 2338
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1813-1900 6.55e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1813 PAPTNLKFTQVSPTTLTAQWTAPS---VKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTL 1889
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1890 TSRPAQGVVTT 1900
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1810 1.07e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1723 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1799
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 186972114 1800 ESQPLIGVQST 1810
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.28e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 1.28e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.79e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 1.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  1723 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGDEDTAELHGLRPGSEYTVSVVALHGG 1798
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 186972114  1799 MESQP 1803
Cdd:pfam00041   80 GEGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2385-2425 1.81e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 58.13  E-value: 1.81e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114   2385 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2425
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 3.28e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.28e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 186972114   524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1183-1709 3.35e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.41  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1183 ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTALEEVVHADQ--SSCTFENLNPGLEYNVSVYTVKDDKESAPISD 1260
Cdd:COG3401    49 KESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLttLTGSGSVGGATNTGLTSSDEVPSPAVGTATTA 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1261 TVIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVA----AGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDIS 1336
Cdd:COG3401   129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSpdtsATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1337 VITLINGGESAPT---TLTQQTAVP-PPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNE--EDVAELSispsD 1410
Cdd:COG3401   209 VAATDTGGESAPSnevSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGpfTKVATVT----T 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1411 NAVVLTNLLPGTEYLVSVSSVYEQHESIPLRG-----RQKTGLDSPTGFDSSDVTANSFTVHW-VAPRAPITGYIIrHHA 1484
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNvvsvtTDLTPPAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRS 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1485 EHSAGRPRQDRVPPSRNSITLTNLNPGTEYI--VTIIAVNGREE--SPPLIGQQSTVSDVPRDLEVIASTPTSLLISWEP 1560
Cdd:COG3401   364 TSGGGTYTKIAETVTTTSYTDTGLTPGTTYYykVTAVDAAGNESapSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1561 PAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYQTEIDKPSQMQV 1640
Cdd:COG3401   444 AASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGA 523

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186972114 1641 TDVQDNSISVrwlpSTSPVTGYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:COG3401   524 PDGTPNVTGA----SPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTN 588
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 3.97e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.96  E-value: 3.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 5.70e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 5.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1264 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1341
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 186972114 1342 NGGESAPTTLTQQT 1355
Cdd:cd00063    79 GGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1174-1263 5.87e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1174 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGTALEeVVHADQSSCTFENLNPGLEYNVSVYTVKD 1251
Cdd:cd00063     2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|..
gi 186972114 1252 DKESAPISDTVI 1263
Cdd:cd00063    80 GGESPPSESVTV 91
fn1 pfam00039
Fibronectin type I domain;
142-180 6.13e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.17  E-value: 6.13e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 186972114   142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-956 7.41e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 7.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  563 DSETRTFYQIGDSWEKFVHGVRYQCY--CYGRGIGEWHCQPLQTYPGTTGPVQVI-ITETPSQPNSHPIQWNAPEPSHIT 639
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRvaATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  640 KYILrWRPKTSTGRWKE-ATIPGhlNSYTIKGLTPGVIYEgqlisiqqYGhqeVTRFDFTTSASTPvtSNTVTGETAPFS 718
Cdd:COG3401   263 GYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTYY--------YR---VTAVDAAGNESAP--SNVVSVTTDLTP 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  719 PVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:COG3401   327 PAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGN 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  798 QSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPI--------------TGYRIVYSPSVEGSSTELNLPETANS 863
Cdd:COG3401   406 ESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAAsaasnpgvsaavlaDGGDTGNAVPFTTTSSTVTATTTDTT 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  864 VTLSDLQPGVQYNITIYAVEENQESTPVF-IQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWTPPNSAVTGYRVDVLP 942
Cdd:COG3401   486 TANLSVTTGSLVGGSGASSVTNSVSVIGAsAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAG 565

                         410
                  ....*....|....
gi 186972114  943 VNLPGEHGQRLPVN 956
Cdd:COG3401   566 LGSGNLYLITTLGG 579
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.17e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 1.17e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1905-1985 1.48e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1905 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RTISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1980
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 186972114 1981 RSSPV 1985
Cdd:cd00063    82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 1.62e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 55.43  E-value: 1.62e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114     53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
704-898 1.92e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 63.43  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  704 PVTSNTVTGETAPFSPVVATSESVTEITassfvVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPG 782
Cdd:COG4733   528 PPQWPPVNVTTSESLSVVAQGTAVTTLT-----VSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAG 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  783 RkYIVNVYQISEEGKQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELN 856
Cdd:COG4733   598 D-YEVRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVA 676

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 186972114  857 LPE-TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 898
Cdd:COG4733   677 QALyPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2340-2381 2.27e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.27e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114 2340 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2381
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1813-1884 6.03e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 6.03e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186972114   1813 PAPTNLKFTQVSPTTLTAQWTAPSVK-LTGYRV--RVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYA 1884
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 997-1074 9.83e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 9.83e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114    997 DAPTNLQFVNETDRTVLVTWTPP-----RARIAGYRLtVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGN 1071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRV-EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 186972114   1072 QQS 1074
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1824-2066 1.19e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1824 SPTTLTAQWTAPSVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLEN 1903
Cdd:COG3401    75 TTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAN 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1904 VSPPRRARVTDATETTITISWRTKTETITGFqvdaipangqtpvqrTISPDVRSYTITGLQPGTDYKIHLYTLNDNARSS 1983
Cdd:COG3401   155 ASGTTASSVAGAGVVVSPDTSATAAVATTSL---------------TVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESA 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1984 PV----VIDASTAIDAPSNLRFLTTTPNSLLVSWQA-PRARITGYIIKYEKPGSPPREVVPRPRpgVTEATITGLEPGTE 2058
Cdd:COG3401   220 PSnevsVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVT--TTSYTDTGLTNGTT 297


                  ....*...
gi 186972114 2059 YTIYVIAL 2066
Cdd:COG3401   298 YYYRVTAV 305
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 2.22e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.22e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186972114  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061     1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2385-2420 4.20e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 51.16  E-value: 4.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114  2385 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2420
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1174-1255 4.97e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 4.97e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1174 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTALEEV-VHADQSSCTFENLNPGLEYNVSVYTVKDD 1252
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 186972114   1253 KES 1255
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 6.20e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.79  E-value: 6.20e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 186972114  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
53-88 1.38e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.62  E-value: 1.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 186972114    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1821-2063 1.76e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1821 TQVSPTTLTAQWTAPSVKLTGYRVRVTPKEKTGPM---KEINLSPDSTSVIVsglmvATKYEVSVYALKDT--LTSRPAQ 1895
Cdd:COG4733   456 QSVAGRTLTVSTAYSETPEAGAVWAFGPDELETQLfrvVSIEENEDGTYTIT-----AVQHAPEKYAAIDAgaFDDVPPQ 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1896 GVVTTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQ-TPVQRTISPdvrSYTITGLQPGtDYKIHLY 1974
Cdd:COG4733   531 WPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTSGT---SFEVPGIYAG-DYEVRVR 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1975 TLNDNARSSPVVIDASTAI----DAPSNLRFLTTTPNSLLV--SW-QAPRARITGYIIKYEKPGSPPREVVPRPRPGVTE 2047
Cdd:COG4733   605 AINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGNT 684

                         250
                  ....*....|....*.
gi 186972114 2048 ATITGLEPGTEYTIYV 2063
Cdd:COG4733   685 YTLAGLKAGQTYYYRA 700
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1905-1979 2.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1905 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRTISPDVRSYTITGLQPGTDYKIHLYTLNDN 1979
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 5.35e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 5.35e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114    907 PAPKDLQFVEVTDVKVTIMWTPPNSAV-TGYRVDVLPVNLPGEHGQR--LPVNRNTFAEVTGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114    984 ES 985
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 726-808 7.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 7.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  726 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLIL 802
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 186972114  803 STSQTT 808
Cdd:cd00063    88 SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2210-2268 8.11e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186972114  2210 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQ 2268
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1091-1158 8.43e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 8.43e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186972114  1091 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYTYTIQVLRDG 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1270-1346 2.02e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 2.02e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186972114   1270 TDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1346
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1725-1801 5.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 5.54e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114   1725 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELfpAPDGDEDTAELHGLRPGSEYTVSVVALHGGM 1799
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 186972114   1800 ES 1801
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 726-790 9.30e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 9.30e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186972114    726 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 790
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 1.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.10e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186972114    616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRPK--TSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEyrEEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1095-1160 2.95e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.95e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186972114   1095 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 9.98e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.57  E-value: 9.98e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 186972114    308 CVTD-SGVVYSVGMQWLK-SQGDKQMLCTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERpYEGGHVLQCTCLGGGrgeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 1.01e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 1.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063     4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 1.47e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 41.16  E-value: 1.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186972114  307 HCVTDS-GVVYSVGMQWLKSQGDKQMLCTCLGN--GVSCQET 345
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1465-1995 2.26e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.86  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1465 TVHWVAP---RAPITGYIIRHHAEHSAGRPRQDRV-PPSRNSITL---TNLNPGTEYI-----------VTIIAVNGREe 1526
Cdd:COG4733   384 TVTFSVGldgLVATPGDVIAVADDVLAGRRIGGRVsSVDGRVVTLdrpVTMEAGDRYLrvrlpdgtsvaRTVQSVAGRT- 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1527 spplIGQQSTVSDVPRDLEVIAStptslliswEPPAVSVRYYRITYGETGGNSpvqEFTVpgsksTATINNikPGADYTI 1606
Cdd:COG4733   463 ----LTVSTAYSETPEAGAVWAF---------GPDELETQLFRVVSIEENEDG---TYTI-----TAVQHA--PEKYAAI 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1607 TLYAVTGRGDSPAsskPVSINYQTEIDKPSQMQVTdvqdNSISVRWLPSTSpVTGYRVTTAPKNGlgptkSQTVSPDQTE 1686
Cdd:COG4733   520 DAGAFDDVPPQWP---PVNVTTSESLSVVAQGTAV----TTLTVSWDAPAG-AVAYEVEWRRDDG-----NWVSVPRTSG 586

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1687 MTIEGLQPTV-EYVVSVYAQNRNGESQPLVQTAVTNID-------RPKGLAFTdVDVDSIKIAWESPQG-QVSRYRVTYS 1757
Cdd:COG4733   587 TSFEVPGIYAgDYEVRVRAINALGVSSAWAASSETTVTgktapppAPTGLTAT-GGLGGITLSWSFPVDaDTLRTEIRYS 665

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1758 SPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVAL-HGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQ---WT 1833
Cdd:COG4733   666 TTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVSAWWVSGQASADAAGILDAITGQILETELGQeldAI 745

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1834 APSVKLTGYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVY-ALKDTLTSRPAQGVVTTLENVSPPRRARV 1912
Cdd:COG4733   746 IQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESAtAAAATGTAADAAGDASGGVTAGTSGTTGA 825

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1913 TDATETTITISWRTKTETITG---FQVDAIPANGQTPVQRTISPDVRSYTiTGLQPGTDYKIHLYTLNDNARSSPVVIDA 1989
Cdd:COG4733   826 GDTAASTTRVAAAVVLAGVVVygdAIIESGNTGDIVATGDIASAAAGAVA-TTVSGTTAADVSAVADSTAASLTAIVIAA 904


                  ....*.
gi 186972114 1990 STAIDA 1995
Cdd:COG4733   905 TTIIDA 910
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1095-1160 3.14e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 3.14e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186972114 1095 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-1224 3.22e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.09  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  723 TSESVTEITASSFVVSWVSASDTVSGFRVEyelSEEGDE----PQYLDLPSTATSVNI-PDLLPGRKYIV--------NV 789
Cdd:COG4733   427 TLDRPVTMEAGDRYLRVRLPDGTSVARTVQ---SVAGRTltvsTAYSETPEAGAVWAFgPDELETQLFRVvsieenedGT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  790 YQIS----EEGKQSLILSTSQTTAPDAPPDPTV----------DQVDDTSIVVRWSRPQAPITgYRIVYSPsveGSSTEL 855
Cdd:COG4733   504 YTITavqhAPEKYAAIDAGAFDDVPPQWPPVNVttseslsvvaQGTAVTTLTVSWDAPAGAVA-YEVEWRR---DDGNWV 579

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  856 NLPET-ANSVTLSDLQPGvQYNITIYAVEENQESTPVFIQQETTGVPRSDDVPAPKDLQfVEVTDVKVTIMWT-PPNSAV 933
Cdd:COG4733   580 SVPRTsGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT-ATGGLGGITLSWSfPVDADT 657

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114  934 TGYRVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAV-HQGRESkPLTAQQTTKLDAPTNLQFVN----ET 1008
Cdd:COG4733   658 LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGILDAITgqilET 736

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1009 DRTVLVTWTPPRARIAGY-RLTVGLTRGGQPKQYNVGPMASkyplrNLQPGSEYTVTLMAVkGNQQSPKATGVFTTLQPL 1087
Cdd:COG4733   737 ELGQELDAIIQNATVAEVvAATVTDVTAQIDTAVLFAGVAT-----AAAIGAEARVAATVA-ESATAAAATGTAADAAGD 810

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1088 RSIppYNTEVTETTIVITWTPAPRIgfklgvrpsqggeapREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVN 1167
Cdd:COG4733   811 ASG--GVTAGTSGTTGAGDTAASTT---------------RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGA 873

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 186972114 1168 RVVTplspPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTALEEVV 1224
Cdd:COG4733   874 VATT----VSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTREPAGDIGAS 926
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1097-1249 8.95e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.47  E-value: 8.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1097 VTETTIVITWTPAP-RIGFKLGVRPSqGGEAPREVTSDSGSIVVSGLTPGvEYTYTIQ-VLRDGQERDAPIVNRV----- 1169
Cdd:COG4733   549 TAVTTLTVSWDAPAgAVAYEVEWRRD-DGNWVSVPRTSGTSFEVPGIYAG-DYEVRVRaINALGVSSAWAASSETtvtgk 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186972114 1170 VTPLSPPTNLhlEANPDTGVLTVSWERSTTPDITGYRITTTPTNGqQGTALEEVVHADQSSCTFENLNPGLEYNVSVYTV 1249
Cdd:COG4733   627 TAPPPAPTGL--TATGGLGGITLSWSFPVDADTLRTEIRYSTTGD-WASATVAQALYPGNTYTLAGLKAGQTYYYRARAV 703
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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